R Olszanecki


Country: Poland


  1. Olszanecki R, Gebska A, Jawien J, Jakubowski A, Korbut R. Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP. J Physiol Pharmacol. 2006;57:109-17 pubmed
    ..2 cells. In summary, we identified 1, 5-isoquinoline as potent inhibitor of induction of NOS-2 in LPS-treated mouse macrophages. The exact mechanism of inhibitory action of this compound on NOS-2 induction requires further investigation. ..
  2. Olszanecki R, Gebska A, Korbut R. The role of haem oxygenase-1 in the decrease of endothelial intercellular adhesion molecule-1 expression by curcumin. Basic Clin Pharmacol Toxicol. 2007;101:411-5 pubmed
    ..We conclude that induction of HO-1, via decrease of endothelial ICAM-1, plays a pivotal role in curcumin-dependent prevention of pulmonary sequestration of neutrophils in a mouse model of endotoxaemia. ..
  3. Suski M, Olszanecki R, Chmura Å, Stachowicz A, Madej J, OkoÅ„ K, et al. Influence of metformin on mitochondrial subproteome in the brain of apoE knockout mice. Eur J Pharmacol. 2016;772:99-107 pubmed publisher
  4. Olszanecki R, Gebska A, Korbut R. Production of prostacyclin and prostaglandin E2 in resting and IL-1beta-stimulated A549, HUVEC and hybrid EA.HY 926 cells. J Physiol Pharmacol. 2006;57:649-60 pubmed
    ..The characteristics of EA.hy 926 cells in terms of the pattern of prostanoid formation could facilitate studies on endothelial metabolism and role of these important lipid mediators. ..
  5. Olszanecki R, Gawlik G. Pharmacotherapy of Ebola hemorrhagic fever: a brief review of current status and future perspectives. Folia Med Cracov. 2014;54:67-77 pubmed
    ..g. BCX4430, favipiravir). The scope of this article is to briefly review the most promising therapeutics for EHF, based on the data coming from rare clinical reports, studies on animals and results from in vitro models. ..
  6. Olszanecki R, Bujak Gizycka B, Madej J, Suski M, Wołkow P, Jawien J, et al. Kaempferol, but not resveratrol inhibits angiotensin converting enzyme. J Physiol Pharmacol. 2008;59:387-92 pubmed
    ..Although the mechanism of ACE inhibition by kaempferol remains to be elucidated, this observation may help in search or designing of new classes of ACE inhibitors. ..
  7. Dumnicka P, Sporek M, Mazur Laskowska M, Ceranowicz P, Kuzniewski M, Drozdz R, et al. Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis. Int J Mol Sci. 2016;17: pubmed
    ..In the early phase of AP, sFlt-1 is positively associated with the severity of AP and predicts organ failure, in particular kidney failure. Serum sFlt-1 may be a practical way to improve early assessment of AP severity. ..
  8. Tomik J, Tomik B, Gajec S, Ceranowicz P, Pihut M, Olszanecki R, et al. The Balloon-Based Manometry Evaluation of Swallowing in Patients with Amyotrophic Lateral Sclerosis. Int J Mol Sci. 2017;18: pubmed publisher
    ..Manometric examinations of the oro-pharyngeal part of the gastrointestinal tract are useful and supportive methods in the analysis of swallowing disturbances in ALS patients. ..
  9. Suski M, Wiśniewska A, Stachowicz A, Olszanecki R, Kuś K, Białas M, et al. The influence of AICAR - direct activator of AMP-activated protein kinase (AMPK) - on liver proteome in apoE-knockout mice. Eur J Pharm Sci. 2017;104:406-416 pubmed publisher
    ..On the other hand, AICAR repressed inflammatory and pro-apoptotic markers in the apoE-/- mice liver, alongside reduction in several peroxisomal proteins, possibly suggesting induction of anti-oxidative pexophagy. ..

More Information


  1. Stachyra K, Kiepura A, Olszanecki R. Air pollution and atherosclerosis - a brief review of mechanistic links between atherogenesis and biological actions of inorganic part of particulate matter. Folia Med Cracov. 2017;57:37-46 pubmed
    ..In this article, we will briefy discuss the different aspects of particulate matter activity and its implication with atherosclerosis progression. ..
  2. Olszanecki R, Madej J, Suski M, Gebska A, Bujak Gizycka B, Korbut R. Angiotensin metabolism in rat stomach wall: prevalence of angiotensin-(1-7) formation. J Physiol Pharmacol. 2009;60:191-6 pubmed
    ..In conclusion, we identified Ang-(1-7) as the main product of Ang I conversion in rat stomach wall. The biological role of prevalence of Ang-(1-7) formation in stomach require further investigation. ..
  3. Stachowicz A, Głombik K, Olszanecki R, Basta Kaim A, Suski M, Lasoń W, et al. The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression. Brain Behav Immun. 2016;51:144-53 pubmed publisher
    ..The pattern of changes suggested mitoprotective effect of Alda-1, however the exact functional consequences of the revealed alterations require further investigation. ..
  4. Stachowicz A, Olszanecki R, Suski M, Głombik K, Basta Kaim A, Adamek D, et al. Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci. 2017;18: pubmed publisher
    ..The pattern of alterations implies mitoprotective action of Alda-1, however, the accurate functional consequences of the revealed changes require further research. ..
  5. Wiśniewska A, Olszanecki R, Totoń Żurańska J, Kuś K, Stachowicz A, Suski M, et al. Anti-Atherosclerotic Action of Agmatine in ApoE-Knockout Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..In conclusion, prolonged administration of agmatine inhibits atherosclerosis in apoE-/- mice; however, the exact mechanisms linking observed changes and elevations of HDL plasma require further investigation. ..