E Sikora

Summary

Affiliation: Nencki Institute of Experimental Biology
Country: Poland

Publications

  1. ncbi request reprint [Molecular and cellular mechanisms of curcumin action--beneficial effect on organism]
    Marta Sikora-Polaczek
    Centrum Medyczne MacierzyƄstwo, Krakow
    Postepy Biochem 57:74-84. 2011
  2. doi request reprint Rejuvenation of senescent cells-the road to postponing human aging and age-related disease?
    Ewa Sikora
    Laboratory of the Molecular Bases of Aging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteura 3, Warsaw, Poland
    Exp Gerontol 48:661-6. 2013
  3. pmc Curcumin, inflammation, ageing and age-related diseases
    E Sikora
    Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland
    Immun Ageing 7:1. 2010
  4. doi request reprint Impact of cellular senescence signature on ageing research
    Ewa Sikora
    Molecular Bases of Aging Laboratory, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
    Ageing Res Rev 10:146-52. 2011
  5. ncbi request reprint The promise of slow down ageing may come from curcumin
    E Sikora
    Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland
    Curr Pharm Des 16:884-92. 2010
  6. ncbi request reprint Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells
    Ewa Sikora
    Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, 3 Pasteura, 02 093 Warsaw, Poland
    Mol Cancer Ther 5:927-34. 2006
  7. doi request reprint Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells
    Z Korwek
    Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02 093 Warsaw, Poland
    DNA Repair (Amst) 11:864-73. 2012
  8. doi request reprint Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity
    A Bielak-Zmijewska
    Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland
    Cell Prolif 43:354-64. 2010
  9. ncbi request reprint Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells
    K Piwocka
    Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Warsaw, Poland
    Free Radic Biol Med 31:670-8. 2001
  10. ncbi request reprint Curcumin induces cell death without oligonucleosomal DNA fragmentation in quiescent and proliferating human CD8+ cells
    Adriana Magalska
    Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Warszawa, Poland
    Acta Biochim Pol 53:531-8. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint [Molecular and cellular mechanisms of curcumin action--beneficial effect on organism]
    Marta Sikora-Polaczek
    Centrum Medyczne MacierzyƄstwo, Krakow
    Postepy Biochem 57:74-84. 2011
    ..Despite its low bioactivity curcumin can exert beneficial influence on organism, thus confirming its hormetic propensity...
  2. doi request reprint Rejuvenation of senescent cells-the road to postponing human aging and age-related disease?
    Ewa Sikora
    Laboratory of the Molecular Bases of Aging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteura 3, Warsaw, Poland
    Exp Gerontol 48:661-6. 2013
    ..However, knowing that aging is unavoidable we cannot expect its elimination, but prolonging healthy life span is a goal worth serious consideration...
  3. pmc Curcumin, inflammation, ageing and age-related diseases
    E Sikora
    Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland
    Immun Ageing 7:1. 2010
    ..In this review we consider the possibility of the spice curcumin, a powerful antioxidant and anti-inflammatory agent possibly capable of improving the health status of the elderly...
  4. doi request reprint Impact of cellular senescence signature on ageing research
    Ewa Sikora
    Molecular Bases of Aging Laboratory, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
    Ageing Res Rev 10:146-52. 2011
    ....
  5. ncbi request reprint The promise of slow down ageing may come from curcumin
    E Sikora
    Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland
    Curr Pharm Des 16:884-92. 2010
    ....
  6. ncbi request reprint Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells
    Ewa Sikora
    Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, 3 Pasteura, 02 093 Warsaw, Poland
    Mol Cancer Ther 5:927-34. 2006
    ..Instead, molecular modeling indicates that the inhibitory effect of curcumin on DFF40/CAD activity results from curcumin binding to the active center of DFF40/CAD endonuclease...
  7. doi request reprint Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells
    Z Korwek
    Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02 093 Warsaw, Poland
    DNA Repair (Amst) 11:864-73. 2012
    ..We discuss the possible beneficial and adverse effects of drugs affecting the DDR in cancer cells that are currently in preclinical anticancer trials...
  8. doi request reprint Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity
    A Bielak-Zmijewska
    Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland
    Cell Prolif 43:354-64. 2010
    ..The aim of this study was to verify the hypothesis that curcumin affects normal cell division by influencing microtubule stability, using mouse oocyte and early embryo model systems...
  9. ncbi request reprint Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells
    K Piwocka
    Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Warsaw, Poland
    Free Radic Biol Med 31:670-8. 2001
    ..On the other hand, it induces nonclassical apoptosis via a still-unrecognized mechanism, which leads to chromatin degradation and high-molecular-weight DNA fragmentation...
  10. ncbi request reprint Curcumin induces cell death without oligonucleosomal DNA fragmentation in quiescent and proliferating human CD8+ cells
    Adriana Magalska
    Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Warszawa, Poland
    Acta Biochim Pol 53:531-8. 2006
    ..Taking into account the role of CD8+ cells in tumor response, their depletion during chemotherapy could be particularly undesirable...
  11. ncbi request reprint Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment
    E Sikora
    Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland
    Biochem Pharmacol 54:899-907. 1997
    ....
  12. ncbi request reprint Pantothenic acid protects jurkat cells against ultraviolet light-induced apoptosis
    V S Slyshenkov
    Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
    Free Radic Biol Med 30:1303-10. 2001
    ..Both pantothenic acid and N-acetylcysteine alleviated the ultraviolet-induced decrease of glutathione content, diminished lipid peroxidation, and partly protected the cells against apoptosis produced by ultraviolet irradiation...
  13. ncbi request reprint Curcumin induces caspase-3-independent apoptosis in human multidrug-resistant cells
    Katarzyna Piwocka
    Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Ann N Y Acad Sci 973:250-4. 2002
    ..In all cells induced to undergo cell death with curcumin, there was no caspase-3 activation because only the unprocessed form of caspase-3 was observed using immunoblotting...
  14. ncbi request reprint P-glycoprotein expression does not change the apoptotic pathway induced by curcumin in HL-60 cells
    Anna Bielak-Mijewska
    Laboratory of Molecular Bases of Aging, Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteur St, 02 093 Warsaw, Poland
    Cancer Chemother Pharmacol 53:179-85. 2004
    ..The purpose of the present study was to verify the hypothesis postulating that P-gp expression, apart from enabling drug efflux, confers on the cells resistance to apoptosis by inhibiting caspase-8 and caspase-3...
  15. ncbi request reprint Curcumin abolishes apoptosis resistance of calcitriol-differentiated HL-60 cells
    Grazyna Mosieniak
    Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteura Street, 02 093 Warsaw, Poland
    FEBS Lett 580:4653-60. 2006
    ..Our experiments show that curcumin overcomes the resistance of calcitriol-differentiated HL-60 cells to DNA-damage-induced apoptosis by activating other cell signaling pathways leading to cell death of HL-60...
  16. doi request reprint Methotrexate-induced senescence in human adenocarcinoma cells is accompanied by induction of p21(waf1/cip1) expression and lack of polyploidy
    Magdalena Dabrowska
    Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, Warsaw 02 093, Poland
    Cancer Lett 284:95-101. 2009
    ..The fraction of C85 cells with DNA content higher than 4N is maintained at the same level (14%) in cells untreated, as well as regrown after the treatment. Multinucleation is found as the main karyotypic abnormality...
  17. ncbi request reprint Polyploidy: the link between senescence and cancer
    G Mosieniak
    Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland
    Curr Pharm Des 16:734-40. 2010
    ..Altogether, this implies polyploidy as a link between cellular senescence, cancer development and possible cancer renewal after treatment...
  18. ncbi request reprint Curcumin affects components of the chromosomal passenger complex and induces mitotic catastrophe in apoptosis-resistant Bcr-Abl-expressing cells
    Kamila Wolanin
    Laboratory of Molecular Bases of Aging, Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland
    Mol Cancer Res 4:457-69. 2006
    ..This study shows that curcumin can overcome the broad resistance to cell death caused by expression of Bcr-Abl and suggests that curcumin may be a promising agent for new combination regimens for drug-resistant chronic myeloid leukemia...
  19. ncbi request reprint Resistance to apoptosis of HCW-2 cells can be overcome by curcumin- or vincristine-induced mitotic catastrophe
    Adriana Magalska
    Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland
    Int J Cancer 119:1811-8. 2006
    ..Altogether our results show that apoptosis resistance can be overcome by inducing mitotic catastrophe in HCW-2 cells...
  20. doi request reprint Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells
    Malgorzata A Sliwinska
    Department of Biochemistry, Nencki Institute of Experimental Biology, Pasteura 3, 02 093 Warsaw, Poland
    Mech Ageing Dev 130:24-32. 2009
    ..Thus, a senescence-inducing treatment of HCT116 cancer cells had a dual effect-it stopped the proliferation of the majority of the cells, but also led to the appearance of proliferating aneuploid ones...
  21. ncbi request reprint Proliferation and apoptosis of human CD8(+)CD28(+) and CD8(+)CD28(-) lymphocytes during aging
    Agnieszka Brzezinska
    Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, 02 093 Warsaw, Poland
    Exp Gerontol 39:539-44. 2004
    ..10% died, irrespective of their CD28 status. Altogether, we showed over-representation of proliferating CD8(+)CD28(-) cells in aged people, which might not be particularly prone to undergo apoptosis...