Anna Filipek

Summary

Affiliation: Nencki Institute of Experimental Biology
Country: Poland

Publications

  1. doi request reprint Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein
    Anna Filipek
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Neural Transm 115:1257-64. 2008
  2. ncbi request reprint S100A6 and CacyBP/SIP - two proteins discovered in ehrlich ascites tumor cells that are potentially involved in the degradation of beta-catenin
    Anna Filipek
    Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw
    Chemotherapy 52:32-4. 2006
  3. ncbi request reprint Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins
    Marcin Nowotny
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Biol Chem 278:26923-8. 2003
  4. ncbi request reprint CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies
    Gabriela Schneider
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochim Biophys Acta 1773:1628-36. 2007
  5. doi request reprint Tubulin binding protein, CacyBP/SIP, induces actin polymerization and may link actin and tubulin cytoskeletons
    Gabriela Schneider
    Nencki Institute of Experimental Biology, Warsaw, Poland
    Biochim Biophys Acta 1803:1308-17. 2010
  6. doi request reprint CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1
    Ewa Kilanczyk
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochem Biophys Res Commun 380:54-9. 2009
  7. doi request reprint S100A6 is transcriptionally regulated by β-catenin and interacts with a novel target, lamin A/C, in colorectal cancer cells
    Ewa Kilanczyk
    Nencki Institute of Experimental Biology, Warsaw, Poland
    Cell Calcium 51:470-7. 2012
  8. ncbi request reprint Hsp70 is a new target of Sgt1--an interaction modulated by S100A6
    Magdalena Spiechowicz
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochem Biophys Res Commun 357:1148-53. 2007
  9. doi request reprint S100A6 mediates nuclear translocation of Sgt1: a heat shock-regulated protein
    Wiktor Prus
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093, Warsaw, Poland
    Amino Acids 41:781-7. 2011
  10. doi request reprint Nuclear translocation of Sgt1 depends on its phosphorylation state
    Wiktor Prus
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Int J Biochem Cell Biol 43:1747-53. 2011

Collaborators

Detail Information

Publications29

  1. doi request reprint Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein
    Anna Filipek
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Neural Transm 115:1257-64. 2008
    ..Thus, our results show that localization of CacyBP/SIP in brain neurons is similar to that observed for tau and tubulin, which points to the involvement of CacyBP/SIP in cytoskeletal physiology...
  2. ncbi request reprint S100A6 and CacyBP/SIP - two proteins discovered in ehrlich ascites tumor cells that are potentially involved in the degradation of beta-catenin
    Anna Filipek
    Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw
    Chemotherapy 52:32-4. 2006
    ..Thus, this review describes the discovery and characterization of S100A6 and Cacy BP/SIP, the function of these two proteins in ubiquitination and degradation processes and their possible role in tumorigenesis...
  3. ncbi request reprint Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins
    Marcin Nowotny
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Biol Chem 278:26923-8. 2003
    ..These findings suggest that protein ubiquitination via Sgt1-dependent pathway can be regulated by S100 proteins...
  4. ncbi request reprint CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies
    Gabriela Schneider
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochim Biophys Acta 1773:1628-36. 2007
    ..Altogether, our results suggest that CacyBP/SIP, via its interaction with tubulin, might contribute to the differentiation of neuroblastoma NB2a cells...
  5. doi request reprint Tubulin binding protein, CacyBP/SIP, induces actin polymerization and may link actin and tubulin cytoskeletons
    Gabriela Schneider
    Nencki Institute of Experimental Biology, Warsaw, Poland
    Biochim Biophys Acta 1803:1308-17. 2010
    ..Interestingly, the co-sedimentation and proximity ligation assays indicated that CacyBP/SIP could simultaneously interact with tubulin and actin, suggesting that CacyBP/SIP might link actin and tubulin cytoskeletons...
  6. doi request reprint CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1
    Ewa Kilanczyk
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochem Biophys Res Commun 380:54-9. 2009
    ....
  7. doi request reprint S100A6 is transcriptionally regulated by β-catenin and interacts with a novel target, lamin A/C, in colorectal cancer cells
    Ewa Kilanczyk
    Nencki Institute of Experimental Biology, Warsaw, Poland
    Cell Calcium 51:470-7. 2012
    ..Our results reveal a novel and important network of relations and interactions between proteins potentially involved in colorectal cancer development and progression...
  8. ncbi request reprint Hsp70 is a new target of Sgt1--an interaction modulated by S100A6
    Magdalena Spiechowicz
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochem Biophys Res Commun 357:1148-53. 2007
    ..This suggests that the interaction of Sgt1 with Hsp70 and Hsp90 is regulated by S100A6 in a Ca(2+)-dependent manner...
  9. doi request reprint S100A6 mediates nuclear translocation of Sgt1: a heat shock-regulated protein
    Wiktor Prus
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093, Warsaw, Poland
    Amino Acids 41:781-7. 2011
    ..Thus, our results suggest that increase in intracellular concentration of Ca(2+), transduced by S100A6, is necessary for nuclear translocation of the Sgt1 protein...
  10. doi request reprint Nuclear translocation of Sgt1 depends on its phosphorylation state
    Wiktor Prus
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Int J Biochem Cell Biol 43:1747-53. 2011
    ..Altogether, our results suggest that S100A6-Ca(2+)-mediated Sgt1 dephosphorylation promotes its nuclear translocation, most likely due to disruption of the Sgt1-Hsp90 complex...
  11. ncbi request reprint CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family
    Anna Filipek
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Biol Chem 277:28848-52. 2002
    ....
  12. doi request reprint Sgt1 has co-chaperone properties and is up-regulated by heat shock
    Magdalena Zabka
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochem Biophys Res Commun 370:179-83. 2008
    ..These results indicate that Sgt1 is a co-chaperone protein with an expression pattern matching that of the well known heat shock proteins...
  13. ncbi request reprint Density of Sgt1-immunopositive neurons is decreased in the cerebral cortex of Alzheimer's disease brain
    Magdalena Spiechowicz
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Neurochem Int 49:487-93. 2006
    ..Decreased immunostaining in AD cortex point to Sgt1 as a possible marker of neurons degenerating in AD...
  14. doi request reprint Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function
    Urszula Wasik
    Nencki Institute of Experimental Biology, Warsaw, Poland
    Neurobiol Aging 34:1380-8. 2013
    ..We found that indeed it exhibited phosphatase activity toward tau. Altogether, our results suggest that CacyBP/SIP might play a role in AD pathology...
  15. doi request reprint S100A6 binding protein and Siah-1 interacting protein (CacyBP/SIP): spotlight on properties and cellular function
    Gabriela Schneider
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093, Warsaw, Poland
    Amino Acids 41:773-80. 2011
    ..This review describes the properties of CacyBP/SIP and summarizes all findings concerning its cellular function...
  16. doi request reprint CacyBP/SIP as a novel modulator of the thin filament
    Ewelina Jurewicz
    Nencki Institute of Experimental Biology, 02 093 Warsaw, Poland
    Biochim Biophys Acta 1833:761-6. 2013
    ..Thus, our results suggest that CacyBP/SIP, through its interaction with both actin and tropomyosin, regulates the organization and functional properties of the thin filament...
  17. ncbi request reprint The expression and function of Sgt1 protein in eukaryotic cells
    Magdalena Spiechowicz
    Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, 02 093 Warsaw, Poland
    Acta Neurobiol Exp (Wars) 65:161-5. 2005
    ..Using immunohistochemistry we found that the Sgt1 protein is present in both neurons and glial cells...
  18. doi request reprint ERK1/2 is dephosphorylated by a novel phosphatase--CacyBP/SIP
    Ewa Kilanczyk
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochem Biophys Res Commun 404:179-83. 2011
    ..Our experimental results are supported by a theoretical analysis which revealed important sequence similarities between CacyBP/SIP and the phosphatase-like proteins as well as certain MAP kinase phosphatases...
  19. doi request reprint Status epilepticus induces long lasting increase in S100A6 expression in astrocytes
    Ewelina Jurewicz
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093, Warsaw, Poland
    Neurochem Res 38:1941-8. 2013
    ..Altogether, our data show a widespread and prolonged up-regulation of S100A6 in the epileptic brain and indicate that an increase in S100A6 immunoreactivity is related to astrogliosis. ..
  20. doi request reprint CacyBP/SIP phosphatase activity in neuroblastoma NB2a and colon cancer HCT116 cells
    Ewa Kilanczyk
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochem Cell Biol 90:558-64. 2012
    ..Since NB2a cells have differentiation potential and HCT116 cells do not, our data suggest that different activity of CacyBP/SIP in these 2 cell lines might affect the ERK1/2 pathway in the differentiation or proliferation processes...
  21. doi request reprint Identification and localization of S100A6 in human umbilical cord
    Ewelina Jurewicz
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02093 Warsaw, Poland
    Cell Biol Int 36:109-12. 2012
    ..Thus these novel results show the presence of S100A6 in umbilical cord and suggest the involvement of this protein in intra- and extra-cellular signalling pathways in this tissue...
  22. pmc Tau protein modifications and interactions: their role in function and dysfunction
    Anna Mietelska-Porowska
    Nencki Institute of Experimental Biology, Polish Academy of Science, 3 Pasteur Street, Warsaw 02 093, Poland
    Int J Mol Sci 15:4671-713. 2014
    ..These disturbances in intraneuronal signaling may compromise synaptic transmission as well as trophic support mechanisms in neurons. ..
  23. doi request reprint S100A6 - new facts and features
    Wiesława Leśniak
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 02 093 Warsaw, Poland
    Biochem Biophys Res Commun 390:1087-92. 2009
    ..Additionally, S100A6 might have some extracellular activities. This review presents new facts and features concerning the S100A6 protein...
  24. ncbi request reprint Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells
    Anna Filipek
    Nencki Institute of Experimental Biology, Warsaw, Poland
    J Biol Chem 277:21103-9. 2002
    ..Thus, phosphorylation of CacyBP occurs in the same [Ca(2+)](i) range that leads to its perinuclear translocation...
  25. pmc Up-regulation of CacyBP/SIP during rat breast cancer development
    Ewa Kilanczyk
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093, Warsaw, Poland
    Breast Cancer 21:350-7. 2014
    ..CacyBP/SIP (calcyclin binding protein/Siah-1 interacting protein) was originally discovered in Ehrlich ascities tumor cells but was later found also in many different tumors...
  26. doi request reprint Ultrafiltrate of blood plasma modulates amyloid-β aggregation
    Aleksandra Nowicka
    Warsaw University of Life Sciences SGGW, Warsaw, Poland
    J Alzheimers Dis 23:1-5. 2011
    ..The observed effect was independent of copper and other EDTA chelatable ions...
  27. pmc Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition
    Young Tae Lee
    Departments of Biochemistry and Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
    Biochemistry 47:10921-32. 2008
    ..A series of structure-based SIP mutations showed reduced S100A6 binding affinity, setting the stage for direct functional analysis of S100A6-SIP interactions...
  28. ncbi request reprint The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies
    Shibani Bhattacharya
    Department of Biochemistry, Center for Structural Biology, 5140 BIOSCI MRBIII, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
    Biochemistry 44:9462-71. 2005
    ..The principal role of the modular structure of SIP appears to be in bringing these two proteins into physical proximity and orchestrating the orientation required for polyubiquitination of beta-catenin in the intact SCF-type complex...