J Chorostowska-Wynimko

Summary

Affiliation: National Institute of Tuberculosis and Lung Diseases
Country: Poland

Publications

  1. ncbi request reprint The impact of genetic markers on the diagnosis of lung cancer: a current perspective
    Joanna Chorostowska-Wynimko
    Laboratory of Molecular Diagnostics, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Thorac Oncol 2:1044-51. 2007
  2. ncbi request reprint Theophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition
    J Chorostowska-Wynimko
    Laboratory of Molecular Diagnostics, Department of Lung Diseases, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 58:95-103. 2007
  3. ncbi request reprint [The beta2-adrenergic receptor agonists in the treatment of chronic obstructive pulmonary disease]
    Joanna Chorostowska-Wynimko
    Samodzielna Pracowni Diagnostyki, Molekularnej Instytutu Gruźlicy i Chorób Płuc w Warszawie
    Przegl Lek 62:724-8. 2005
  4. ncbi request reprint Leptin measurement in urine is a reliable method of monitoring its secretion in patients with obstructive sleep apnea syndrome
    J Chorostowska-Wynimko
    Laboratory of Molecular Diagnostics, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 58:105-15. 2007
  5. ncbi request reprint Disturbed angiogenic activity in sera from obstructive sleep apnea patients
    J Chorostowska-Wynimko
    Department of Molecular Diagnostics, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 56:71-7. 2005
  6. ncbi request reprint In vitro angiomodulatory activity of sera from type 2 diabetic patients with background retinopathy
    J Chorostowska-Wynimko
    Department of Molecular Diagnostics, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 56:65-70. 2005
  7. ncbi request reprint Plasminogen activator inhibitor type-1 controls the process of the in vitro sprout formation
    J Chorostowska-Wynimko
    Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 55:49-56. 2004
  8. ncbi request reprint Cellular components of the bronchoalveolar lavage correlate with lung function impairment and extrapulmonary involvement markers in active sarcoidosis
    J Chorostowska-Wynimko
    Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 55:41-7. 2004
  9. ncbi request reprint Multiple effects of theobromine on fetus development and postnatal status of the immune system
    J Chorostowska-Wynimko
    Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Int J Tissue React 26:53-60. 2004
  10. ncbi request reprint Plasminogen activator inhibitor type-1 mutants regulate angiogenesis of human umbilical and lung vascular endothelial cells
    Joanna Chorostowska-Wynimko
    Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Oncol Rep 12:1155-62. 2004

Collaborators

Detail Information

Publications35

  1. ncbi request reprint The impact of genetic markers on the diagnosis of lung cancer: a current perspective
    Joanna Chorostowska-Wynimko
    Laboratory of Molecular Diagnostics, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Thorac Oncol 2:1044-51. 2007
    ..The adequacy of their sensitivity and specificity for cancer screening and early detection is discussed in detail...
  2. ncbi request reprint Theophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition
    J Chorostowska-Wynimko
    Laboratory of Molecular Diagnostics, Department of Lung Diseases, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 58:95-103. 2007
    ..The suppressant effect was concentration-dependent. We conclude that theophylline in therapeutic and subtherapeutic concentrations suppresses human monocyte metabolic activity via phosphodiesterase inhibition...
  3. ncbi request reprint [The beta2-adrenergic receptor agonists in the treatment of chronic obstructive pulmonary disease]
    Joanna Chorostowska-Wynimko
    Samodzielna Pracowni Diagnostyki, Molekularnej Instytutu Gruźlicy i Chorób Płuc w Warszawie
    Przegl Lek 62:724-8. 2005
    ..This paper evaluates main differences between the mechanism of action and pharmacokinetic profile of the key beta2-mimetics, discusses consequences of those diversities for their the clinical application and potential side effects...
  4. ncbi request reprint Leptin measurement in urine is a reliable method of monitoring its secretion in patients with obstructive sleep apnea syndrome
    J Chorostowska-Wynimko
    Laboratory of Molecular Diagnostics, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 58:105-15. 2007
    ..However, night-time urine leptin levels better reflect differences in its turnover due to gender and OSAS severity...
  5. ncbi request reprint Disturbed angiogenic activity in sera from obstructive sleep apnea patients
    J Chorostowska-Wynimko
    Department of Molecular Diagnostics, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 56:71-7. 2005
    ..The disordered angiogenic activity might be related to the pathophysiology of OSA and should be considered an important causative factor for the increased prevalence of cardiovascular diseases in OSA patients...
  6. ncbi request reprint In vitro angiomodulatory activity of sera from type 2 diabetic patients with background retinopathy
    J Chorostowska-Wynimko
    Department of Molecular Diagnostics, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 56:65-70. 2005
    ....
  7. ncbi request reprint Plasminogen activator inhibitor type-1 controls the process of the in vitro sprout formation
    J Chorostowska-Wynimko
    Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 55:49-56. 2004
    ..This effect was achieved mainly via PAI-1's antiproteinase activity...
  8. ncbi request reprint Cellular components of the bronchoalveolar lavage correlate with lung function impairment and extrapulmonary involvement markers in active sarcoidosis
    J Chorostowska-Wynimko
    Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 55:41-7. 2004
    ..However, more detailed phenotypic and functional characteristics of this cellular population are needed...
  9. ncbi request reprint Multiple effects of theobromine on fetus development and postnatal status of the immune system
    J Chorostowska-Wynimko
    Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Int J Tissue React 26:53-60. 2004
    ..Consequently, particular attention should be paid to the reduction of theobromine consumption, and most probably that of other methyloxanthines, during pregnancy and lactation...
  10. ncbi request reprint Plasminogen activator inhibitor type-1 mutants regulate angiogenesis of human umbilical and lung vascular endothelial cells
    Joanna Chorostowska-Wynimko
    Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Oncol Rep 12:1155-62. 2004
    ..We conclude that while the anti-proteolytic properties of PAI-1 constructs are preserved, these proteins inhibit angiogenesis and inhibitory activity dominates over any stimulatory effects of PAI-1...
  11. pmc Neoadjuvant therapy affects tumor growth markers in early stage non-small-cell lung cancer
    J Chorostowska-Wynimko
    Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Eur J Med Res 14:42-4. 2009
    ..Also, data concerning potential effects of neo-adjuvant therapy on cellular level are scarce...
  12. ncbi request reprint Assessment of the VEGF, bFGF, aFGF and IL8 angiogenic activity in urinary bladder carcinoma, using the mice cutaneous angiogenesis test
    E Rogala
    Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Anticancer Res 21:4259-63. 2001
    ..There was no reduction of angiogenic activity after Il-8 absorption...
  13. ncbi request reprint Inhibitory effect of Greenland shark liver oil combined with squalen and arctic birch ashes on angiogenesis and L-1 sarcoma growth in Balb/c mice
    E Skopinska-Rozewska
    Dept Lab Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, 01 138 Warsaw, 26 Płocka street, Poland
    Pol J Vet Sci 6:54-6. 2003
    ..All substances tested, alone or in combinations, significantly diminished cutaneous angiogenesis induced by tumor cells, and tumor growth...
  14. ncbi request reprint Evaluation of fluorescence-based methods for total vs. amplifiable DNA quantification in plasma of lung cancer patients
    A Szpechcinski
    Laboratory of Molecular Diagnostics, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 59:675-81. 2008
    ..Consequently, intercalating fluorochromes, like PicoGreen, might serve as a rapid, accurate, and inexpensive alternative to real-time qPCR for routine dsDNA quantification and multicenter standardization...
  15. doi request reprint Angiogenic activity of sera from interstitial lung disease patients in relation to angiotensin-converting enzyme activity
    T M Zielonka
    Department of Family Medicine, Medical University of Warsaw, Warsaw, Poland
    Adv Exp Med Biol 756:213-21. 2013
    ..52; p < 0.01). This correlation was highest in the sarcoidosis group (r = -0.6; p < ). Sera from ILD patient constitute the source of factors modulating angiogenesis...
  16. pmc Real-time PCR quantification of plasma DNA in non-small cell lung cancer patients and healthy controls
    A Szpechcinski
    Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Eur J Med Res 14:237-40. 2009
    ..The objective of this research was the evaluation of the plasma DNA quantification capacity to distinguish between healthy subjects and non-small cell lung cancer (NSCLC) patients...
  17. ncbi request reprint Induced sputum in patients with interstitial lung disease: a non-invasive surrogate for certain parameters in bronchoalveolar lavage fluid
    M Sobiecka
    First Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland
    J Physiol Pharmacol 59:645-57. 2008
    ..A strong correlation of the T-lymphocyte subsets in induced sputum and BALF in patients with interstitial lung disease shows that induced sputum may be a non-invasive surrogate for certain parameters in BALF in these patients...
  18. ncbi request reprint [Molecular diagnostics of alpha-1-antitrypsin deficiency in clinical practice]
    Radosław Struniawski
    Samodzielna Pracownia Diagnostyki Molekularnej Instytutu Gruźlicy i Chorób Płuc, ul Płocka 26, Warsaw
    Pneumonol Alergol Pol 76:253-64. 2008
    ..The aim of present review is to outline the major methods of AATD diagnosis and discuss with the special issuing of their potential benefits and disadvantages...
  19. ncbi request reprint [Effects of smoking on the cellular mechanisms in the respiratory system]
    Joanna Chorostowska-Wynimko
    Samodzielna Pracownia Diagnostyki Molekularnej Instytutu Gruźlicy i Chorób Płuc w Warszawie
    Pneumonol Alergol Pol 76:174-9. 2008
    ..This paper presents a review of key processes occuring in the smokers' lungs, particularly these responsible for the persistent inflammatory response and neoplastic transformation...
  20. ncbi request reprint Inflammatory markers in the exhaled breath condensate of patients with pulmonary sarcoidosis
    A Rozy
    Laboratory of Molecular Diagnostics, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    J Physiol Pharmacol 57:335-40. 2006
    ..Further studies are required before accepting EBC samples as an equivalent to BALF...
  21. ncbi request reprint The synergistic effect of lactic acid bacteria and alkylglycerols on humoral immunity in mice
    J Chorostowska-Wynimko
    Department of Immunology, National Institute of Tuberculosis and Lung Diseases, 26 Plocka str, 01-138 Warsaw, Poland
    Int J Tissue React 23:81-7. 2001
    ..However, their concomitant administration exerted stronger immunomodulatory effect than did the alternative route of treatment...
  22. doi request reprint Rapid DNA extraction protocol for detection of alpha-1 antitrypsin deficiency from dried blood spots by real-time PCR
    R Struniawski
    Laboratory of Molecular Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Adv Exp Med Biol 756:29-37. 2013
    ..Consequently, it is ideally suited for large-scale AAT deficiency screening programs and should be method of choice...
  23. ncbi request reprint Vascular-endothelial growth factor (VEGF) in patients with peripheral ischemia
    R M Proczka
    Second Department of General, Vascular, and Oncological Surgery, Warsaw Medical University, Warsaw, Poland
    J Physiol Pharmacol 57:305-11. 2006
    ..We conclude that mechanisms other than hypoxia might drive the observed up-regulation of VEGF production in peripheral ischemia...
  24. ncbi request reprint Plasminogen activator inhibitor type-1: its structure, biological activity and role in tumorigenesis (Review)
    Joanna Chorostowska-Wynimko
    Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Int J Mol Med 13:759-66. 2004
    ..This review summarizes recent findings on the structure and functional activity of the plasminogen activator inhibitor type-1, and current opinions on its role in tumorigenesis...
  25. ncbi request reprint A novel form of the plasminogen activator inhibitor created by cysteine mutations extends its half-life: relevance to cancer and angiogenesis
    Joanna Chorostowska-Wynimko
    Medical College of Ohio, Urology Research Center, Department of Urology, Toledo, Ohio 43614 5807, USA
    Mol Cancer Ther 2:19-28. 2003
    ..g., in the inhibition of sprout formation. Such prolonged serpin activity, which is therapeutically desired in cancer treatment and Cys-mutated PAI-1, could launch a new class of novel anticancer agents...
  26. ncbi request reprint Suppression of angiogenic activity of sera from diabetic patients with non-proliferative retinopathy by compounds of herbal origin and sulindac sulfone
    Piotr Skopinski
    Second Department of Ophtalmology, Medical University of Warsaw, 13 Sierakowskiego street, 03 709 Warsaw, Poland
    Int J Mol Med 14:707-11. 2004
    ..We think that it might be the first step toward application of some of these compounds, in the future, in preventive anti-angiogenic therapy of these patients, as well, as in the treatment of later, proliferative stage of this disease...
  27. ncbi request reprint Morphometric and functional abnormalities of kidneys in the progeny of mice fed chocolate during pregnancy and lactation
    Janusz Patera
    Department of Pathology, Military Institute of Medicine, Warsaw, Poland
    Folia Histochem Cytobiol 44:207-11. 2006
    ..Abnormalities demonstrated in the offspring of mice fed chocolate are not related to its theobromine content. Consequently, identification of active compound(s) responsible for the observed effects is of vital importance...
  28. ncbi request reprint [Angiogenic activity and VEGF level in sera of diabetic patients with non-proliferative retinopathy]
    Piotr Skopinski
    Katedry i Kliniki Okulistyki II Wydziału Lekarskiego Akademii Medycznej w Warszawie
    Klin Oczna 106:421-3. 2004
    ..VEGF concentration in sera was mesured by ELISA (R & D Systems) test. Angiogenic activity and VEGF concentration of DM1 patients sera were highly statistically lower than these parameters in DM2 patients and controls...
  29. ncbi request reprint [Role of immune system in the pathomechanism of obstructive sleep apnea]
    Joanna Chorostowska-Wynimko
    Samodzielna Pracownia Diagnostyki Molekularnej Instytutu Gruzlicy i Chorob Pluc w Warszawie, Poland
    Pneumonol Alergol Pol 76:101-10. 2008
    ..This review summarizes current evidence on the most important regulatory mechanisms involving immune cells and mediators...
  30. ncbi request reprint Influence of Echinacea purpurea intake during pregnancy on fetal growth and tissue angiogenic activity
    Ewa Barcz
    I Dept of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland
    Folia Histochem Cytobiol 45:S35-9. 2007
    ....
  31. ncbi request reprint Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy
    Piotr Skopinski
    Department of Ophthalmology, 2nd Faculty of Medicine, Warsaw Medical University, Poland
    J Diabetes Complications 19:335-8. 2005
    ..Sera from both groups of people after neutralization with antihuman IL-18 antibodies lost substantial part of their angiogenic activity...
  32. ncbi request reprint [The role of inflammation in the pathogenesis of chronic obstructive pulmonary disease]
    Joanna Chorostowska-Wynimko
    Pol Merkur Lekarski 17:203-7. 2004
    ..Review presents recent data on the role of inflammation in the pathomechanism of COPD, emphasizing its input on different stages of disease progression...
  33. ncbi request reprint [Cigarette smoking results in the number of CD8+Fas Ligand+ T cytotoxic lymphocytes in bronchoalveolar lavage (BAL) fluid of patients with idiopathic pulmonary fibrosis (IPF)]
    Piotr Kopinski
    Katedra Terapii Genowej, Collegium Medicum Uniwersytetu Mikołaja Kopemika w Bydgoszczy
    Przegl Lek 64:689-94. 2007
    ..Cigarette smoking enhanced a percentage as well as a total number of both BAL CD8 and BAL CD8+FasL+ cells in IPF patients. BAL cytotoxic cells (CD8+FasL+ lymphocytes) seem to have impact on impaired lung function in smoking IPF patients...
  34. ncbi request reprint [Mechanism of B2-agonists action and safety aspects]
    Joanna Chorostowska-Wynimko
    Pol Merkur Lekarski 12:441-4. 2002
    ....
  35. ncbi request reprint [Global Alliance Against Chronic Respiratory Diseases (GARD)]
    Joanna Chorostowska-Wynimko
    Pneumonol Alergol Pol 76:127. 2008