Sławomir Milewski

Summary

Country: Poland

Publications

  1. ncbi request reprint Enzymes of UDP-GlcNAc biosynthesis in yeast
    Sławomir Milewski
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland
    Yeast 23:1-14. 2006
  2. ncbi request reprint Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase
    Sławomir Milewski
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 11 12 Narutowicza St, 80 952 Gdansk, Poland
    Arch Biochem Biophys 450:39-49. 2006
  3. doi request reprint Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug
    Iwona Gabriel
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland
    FEMS Yeast Res 13:143-55. 2013
  4. ncbi request reprint Rational design of N-alkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P as antifungal agents
    Anna Melcer
    Department of Chemistry, University of Gdansk, 18 Sobieskiego Street, 80 952 Gdansk, Poland
    Bioorg Med Chem Lett 17:6602-6. 2007
  5. doi request reprint Antifungal activity of homoaconitate and homoisocitrate analogs
    Maria J Milewska
    Department of Organic Chemistry, Gdansk University of Technology, 11 12 Narutowicza Str, 80 233 Gdansk, Poland
    Molecules 17:14022-36. 2012
  6. doi request reprint Engineering Candida albicans glucosamine-6-phosphate synthase for efficient enzyme purification
    Justyna Czarnecka
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Poland
    J Mol Recognit 25:564-70. 2012
  7. pmc Functional domains and interdomain communication in Candida albicans glucosamine-6-phosphate synthase
    Jarosław Olchowy
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 11 12 Narutowicza St, 80 952 Gdansk, Poland
    Biochem J 404:121-30. 2007
  8. ncbi request reprint Construction, purification, and functional characterization of His-tagged Candida albicans glucosamine-6-phosphate synthase expressed in Escherichia coli
    Jarosław Olchowy
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 11 12 Narutowicza St, 80 952 Gdansk, Poland
    Protein Expr Purif 46:309-15. 2006
  9. doi request reprint Chemical reactivity and antimicrobial activity of N-substituted maleimides
    Natalia Salewska
    Department of Organic Chemistry, Gdansk University of Technology, Organic Chemistry, Gdansk, Poland
    J Enzyme Inhib Med Chem 27:117-24. 2012
  10. pmc Long range molecular dynamics study of regulation of eukaryotic glucosamine-6-phosphate synthase activity by UDP-GlcNAc
    Aleksandra Miszkiel
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, ul Narutowicza 11 12, 80 233 Gdansk, Poland
    J Mol Model 17:3103-15. 2011

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Enzymes of UDP-GlcNAc biosynthesis in yeast
    Sławomir Milewski
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland
    Yeast 23:1-14. 2006
    ....
  2. ncbi request reprint Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase
    Sławomir Milewski
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 11 12 Narutowicza St, 80 952 Gdansk, Poland
    Arch Biochem Biophys 450:39-49. 2006
    ..The Arg272, Lys210, and Gly271 peptide bond nitrogen system, present in the corresponding space of rabbit PGI, creates an area of positive MEP, stabilizing cis-enolate intermediate and attracting its structural mimics, such as 5PA...
  3. doi request reprint Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug
    Iwona Gabriel
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland
    FEMS Yeast Res 13:143-55. 2013
    ..TMCBMA is the first reported antifungal for which an enzyme of the AAP was identified as a molecular target...
  4. ncbi request reprint Rational design of N-alkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P as antifungal agents
    Anna Melcer
    Department of Chemistry, University of Gdansk, 18 Sobieskiego Street, 80 952 Gdansk, Poland
    Bioorg Med Chem Lett 17:6602-6. 2007
    ....
  5. doi request reprint Antifungal activity of homoaconitate and homoisocitrate analogs
    Maria J Milewska
    Department of Organic Chemistry, Gdansk University of Technology, 11 12 Narutowicza Str, 80 233 Gdansk, Poland
    Molecules 17:14022-36. 2012
    ..The highest antifungal activity was found for trimethyl trans-homoaconitate, which inhibited growth of some human pathogenic yeasts with minimal inhibitory concentration (MIC) values of 16-32 mg/mL...
  6. doi request reprint Engineering Candida albicans glucosamine-6-phosphate synthase for efficient enzyme purification
    Justyna Czarnecka
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Poland
    J Mol Recognit 25:564-70. 2012
    ..The construct containing the 655-660 hexaHis insert was found to be a homodimeric protein, which is the first reported example of such quaternary structure of glucosamine-6-phosphate synthase of eukaryotic origin...
  7. pmc Functional domains and interdomain communication in Candida albicans glucosamine-6-phosphate synthase
    Jarosław Olchowy
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 11 12 Narutowicza St, 80 952 Gdansk, Poland
    Biochem J 404:121-30. 2007
    ..The W97G and V711F mutations resulted in an almost complete elimination of the GlcN-6-P-synthetic activity, with the retention of the amidohydrolase and sugar phosphate-isomerizing activities...
  8. ncbi request reprint Construction, purification, and functional characterization of His-tagged Candida albicans glucosamine-6-phosphate synthase expressed in Escherichia coli
    Jarosław Olchowy
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 11 12 Narutowicza St, 80 952 Gdansk, Poland
    Protein Expr Purif 46:309-15. 2006
    ..5% of the synthetic activity...
  9. doi request reprint Chemical reactivity and antimicrobial activity of N-substituted maleimides
    Natalia Salewska
    Department of Organic Chemistry, Gdansk University of Technology, Organic Chemistry, Gdansk, Poland
    J Enzyme Inhib Med Chem 27:117-24. 2012
    ..The membrane enzyme, β(1,3)glucan synthase has been proposed as a putative primary target of N-ethylmaleimide and some of its analogues in Candida albicans cells...
  10. pmc Long range molecular dynamics study of regulation of eukaryotic glucosamine-6-phosphate synthase activity by UDP-GlcNAc
    Aleksandra Miszkiel
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, ul Narutowicza 11 12, 80 233 Gdansk, Poland
    J Mol Model 17:3103-15. 2011
    ..The obtained results constitute an important step toward understanding of mechanism of GlcN-6-P synthase inhibition by UDP-GlcNAc molecule...
  11. ncbi request reprint Voriconazole and multidrug resistance in Candida albicans
    Roland Wakiec
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland
    Mycoses 50:109-15. 2007
    ..Voriconazole effectively competed with rhodamine 6G for the active efflux mediated by CaCdr1p and CaCdr2p...
  12. ncbi request reprint Glucosamine-6-phosphate synthase, a novel target for antifungal agents. Molecular modelling studies in drug design
    Marek Wojciechowski
    Gdansk University of Technology, Department of Pharmaceutical Technology and Biochemistry, Gdansk, Poland
    Acta Biochim Pol 52:647-53. 2005
    ..The novel ligand was designed and synthesised. Biological experiments confirmed our predictions. The new compound named ADMP is a much better inhibitor of glucosamine-6-phosphate synthase than ADGP...
  13. doi request reprint Inactivation of glucosamine-6-phosphate synthase by N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid
    Robert Jedrzejczak
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland
    Chembiochem 13:85-96. 2012
    ..Molecular mechanisms of the reactions studied are proposed...
  14. doi request reprint Disruption of homocitrate synthase genes in Candida albicans affects growth but not virulence
    Krzysztof Kur
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 11 12 Narutowicza St, 80 233, Gdansk, Poland
    Mycopathologia 170:397-402. 2010
    ..These findings strongly question a possibility of exploitation of homocitrate synthase and possibly also other enzymes of the lysine biosynthetic pathway as targets in chemotherapy of disseminated fungal infections...
  15. doi request reprint Antifungal action of the oxathiolone-fused chalcone derivative
    Izabela Łacka
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland
    Mycoses 54:e407-14. 2011
    ..The chalcone derivative may be a useful lead compound for the development of novel antifungal agents...
  16. ncbi request reprint Glucosamine-6-phosphate synthase--the multi-facets enzyme
    Sławomir Milewski
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, ul Narutowicza 11 12, 80 952 Gdansk, Poland
    Biochim Biophys Acta 1597:173-92. 2002
    ..Most of these issues, especially their molecular aspects, have been extensively studied in recent years. This article provides a comprehensive overview of the present knowledge on this multi-facets enzyme...
  17. ncbi request reprint Biofilm production and presence of ica and bap genes in Staphylococcus aureus strains isolated from cows with mastitis in the eastern Poland
    Piotr Szweda
    Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland
    Pol J Microbiol 61:65-9. 2012
    ..6 %) were classified as biofilm producers depending on the value of absorbance in the microtiter plate test. All of the isolates tested were found to possess both icaA and icaD genes, while the bap gene was absent in all strains...