Research Topics
Genomes and Genes | Iwnoa ZakSummaryAffiliation: Medical University of Silesia Country: Poland Publications
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Detail Information
Publications
Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677-->T transition in the MTHFR geneIwona Zak
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medykow 18, 40 752 Katowice, Poland
Acta Biochim Pol 50:527-34. 2003..Our data indicate that in Silesian CAD patients the disease is strongly associated with carrier-state of the ACE D allele, but not with the C677-->T transition in the MTHFR gene...- Cigarette smoking, carrier state of A or G allele of 46A>G and 79C>G polymorphisms of beta2-adrenergic receptor gene, and the risk of coronary artery diseaseIwnoa Zak
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
Kardiol Pol 66:380-6; discussion 387. 2008..The 46A>G and 79C>G polymorphisms of the beta2-adrenergic receptor gene (ADRB2) have been associated with altered response to sympathetic stimulation... - Contemporaneous carrier-state of two or three "proatherosclerotic" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individualsIwona Zak
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
Clin Chim Acta 362:110-8. 2005.... - [Vascular NAD(P)H oxidases--role in the pathogenesis of atherosclerosis]Paweł Niemiec
Department of Medical Biochemistry and Genetics, Medical University of Silesia, 18 Medykow St, 40 752 Katowice, Poland
Postepy Biochem 51:1-11. 2005..Specific inhibitors of NAD(P)H oxidases may be useful experimental tools for atherosclerosis research and may have potential therapeutic significance in the future... 
The M235T polymorphism of the AGT gene modifies the risk of coronary artery disease associated with the presence of hypercholesterolemiaPawel Niemiec
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medykow Str 18, 40 752 Katowice, Poland
Eur J Epidemiol 23:349-54. 2008..Recent evidence show that many traditional risk factors of coronary artery disease (CAD) influence synthesis of AGT. This report focuses on the interactions between M235T polymorphism of AGT gene and traditional risk factors of CAD...- Synergistic effects of the polymorphisms in the PAI-1 and IL-6 genes with smoking in determining their associated risk with coronary artery diseaseBeata Sarecka
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medykow Str 18, 40 752 Katowice, Poland
Clin Biochem 41:467-73. 2008..To assess the relationship between IL-6 and PAI-1 polymorphisms and coronary artery disease (CAD) and to observe the interactions between these polymorphic variants and smoking in the CAD risk... - The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of atherosclerosisPawel Niemiec
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
Clin Chem Lab Med 46:446-52. 2008.... - Modification of the coronary artery disease risk associated with the presence of traditional risk factors by insertion/deletion polymorphism of the ACE genePawel Niemiec
Department of Biochemistry and Medical Genetics, Medical University of Silesia, 40 752 Katowice, Poland
Genet Test 11:353-9. 2007..The statistical significance was also confirmed by a multiplicative model of synergy. The DD genotype/D allele of the ACE gene increases the risk of CAD associated with the presence of traditional risk factors... - Protective effect of R allele of PON1 gene on the coronary artery disease in the presence of specific genetic backgroundAnna Balcerzyk
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medykow Str 18, 40 752 Katowice, Poland
Dis Markers 24:81-8. 2008..Participation of single polymorphic variants is relatively small, however its significance may increase in the presence of specific genetic or environmental background... - [Apolipoprotein E--the role of polymorphism in pathogenesis of many diseases]Anna Balcerzyk
, Slaska Akademia Medyczna, , 40-752 Katowice
Postepy Biochem 50:344-52. 2004 - The 242T variant of the CYBA gene polymorphism increases the risk of coronary artery disease associated with cigarette smoking and hypercholesterolemiaPawel Niemiec
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
Coron Artery Dis 18:339-46. 2007..This report focuses on the interactions between C242T CYBA polymorphism and traditional risk factors of coronary artery disease (CAD), such as cigarette smoking and hypercholesterolemia... - Synergistic effect between polymorphisms of PPARA and ABCA1 genes on the premature coronary artery diseaseAnna Balcerzyk
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
Acta Cardiol 62:233-8. 2007..The aim of the present study was to evaluate a possible interaction between R219K polymorphism of ABCA1 gene and G > C polymorphism in intron 7 of PPARA gene in determining the risk of the CAD... - Synergistic effects between Q192R polymorphism of paraoxonase 1 gene and some conventional risk factors in premature coronary artery diseaseAnna Balcerzyk
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
Arch Med Res 38:545-50. 2007.... - Synergistic effects of apolipoprotein E gene epsilon polymorphism and some conventional risk factors on premature ischaemic heart disease developmentAnna Balcerzyk
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
Kardiol Pol 65:1058-65; discussion 1066-7. 2007..However, it seems that its significance may increase in the presence of a specific genetic or environmental background...