Anna Wozniacka

..There are presented some relevant, putative and possible mechanisms by which antimalarials provide benefit in lupus patients...

..Chloroquine treatment reduces the number of antigen presenting cells in the skin of SLE patients, and this effect may explain the antimalarials beneficial immunoregulatory and anti-inflammatory properties...

..NAD(+) therapy combines good efficacy, cosmetic acceptability and convenient twice-daily application...

..Similarly, no changes in heart rate variability or repolarization parameters were observed...

..The results indicate that chloroquine treatment lowers some proinflammatory cytokines and may provide a photoprotective effect...

..Cyclosporin-A treatment led to clinical improvement and maintained remission...

..Not only does antimalarials treatment reduce the risk of atherosclerosis development but it also minimizes corticosteroids side effects, which are considered to be the basic medication in lupus patients...

..Our patient also had type I diabetes mellitus, mild hypertension and lipid abnormalities. The diagnosis and treatment of KLC is often challenging...

..In only one case was skin irritation given as the reason for treatment withdrawal. These results indicate that MNA(+) might be a useful agent for treating rosacea...

..The aim of the study was to investigate the prevalence of those features in active and inactive systemic lupus erythematosus patients, and in the control group as well...

..In particular, the paper shows a clinical picture of skin lesions and various dermatological entities in which drugs are triggering factors...

..The knowledge of the UV mechanisms, phototherapy schedules, appropriate indications and restrictions allows to achieve better therapeutic results and decreases the risk of side effects...

..Clinically, it is characterised by solitary or multiple, red to brown cutaneous papules or nodules, usually located on the head and neck. ALHE occurs mainly in young to middle-aged adults, and more frequently affects women...

..The effect on the CHS and LCs is cumulative, indicating that photoadaptation for these parameters does not develop over the 30 day irradiation period...

..5.21 pg/ml for TNF-alpha, respectively). The evaluation of serum levels of proinflammatory cytokines may be a sensitive marker of disease activity which may be helpful in maintaining or withdrawing chronic therapy in SLE patients...

..However, new therapeutic strategies must be tested according to the established principles of clinical trial methods...

..Local erythemal UVB irradiation does not alter the BDC subsets in blood or skin...

..The method used in the study allowed the determination of BDCs and their subset numbers in a relatively small blood volume...

..05) and strong tendency in TNF-alpha (P=.05) were observed. The applied schedules of irradiation have minor impact on serum cytokine level and still a threshold dose of UVR causing systemic immune impairment is unknown...

..The aim of this review is to discuss the many facets of antimalarials that will help clinicians optimally utilize these agents when treating cutaneous LE...

..Few review articles on psoriasis discuss the rare variant termed psoriasis rupioides. We report a case of psoriasis rupioides and discuss the unique features of this unusual form of psoriasis...

..Now the malignancy is in partial remission after CHOP therapy and the skin lesions have returned to their initial status. To our knowledge, this is the first case to be reported with coexistence of these four diseases...

..01). There was high positive correlation between SLE duration and cumulative dose of corticosteroids (r = 0.684, P < 0.001). Shorter SLE duration in patients with anxiety disorder seems to reflect its adaptative nature...

..The lesion was removed with the final diagnosis of acantholytic dyskeratotic acanthoma. We discuss this case with special regard to the differential diagnosis of other isolated acantholytic acanthomas...

..Thus small daily doses of SSR induce suppression of CHS in human subjects and the effect is cumulative, indicating that there is no adaptation to the immunomodulating effects of UVR, at least over the test period of 30 days...

..However, they do not correlate with disease activity and seem to be unresponsive to immunosuppressive treatment...

..This case demonstrates the importance of looking for other causes of pulmonary disease in neonatal LE patients...

..We describe an unusual case of scabies with bullae formation that mimicked bullous pemphigoid in clinical and histopathologic examination but not direct and indirect immunofluorescence examination...

..Currently applied diagnostic methods and their usefulness in diagnosis of CNS involvement in lupus patients, especially single photon emission computed tomography (SPECT), are presented...

..For those who do develop lupus vulgaris, it can be persistent for a long period, in some cases for many decades. In the second patient we describe a lengthy duration and cutaneous reactivation at distant sites after more than 40 years...