J R Wilczynski

Summary

Affiliation: Medical University
Country: Poland

Publications

  1. ncbi Immunotherapy of patients with recurrent spontaneous miscarriage and idiopathic infertility: does the immunization-dependent Th2 cytokine overbalance really matter?
    Jacek R Wilczynski
    Chair of Obstetrics and Gynecological Surgery, Department of Gynecology, Medical University of Lodz, Kosciuszki 4, 90 419, Lodz, Poland
    Arch Immunol Ther Exp (Warsz) 60:151-60. 2012
  2. ncbi Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part I
    Jacek Wilczyński
    Polish Mother s Health Center Research Institute, Lodz, Poland
    Arch Immunol Ther Exp (Warsz) 59:289-99. 2011
  3. ncbi Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II
    Jacek Wilczyński
    Polish Mother s Health Center Research Institute, Lodz, Poland
    Arch Immunol Ther Exp (Warsz) 59:301-7. 2011
  4. ncbi How do tumors actively escape from host immunosurveillance?
    Jacek R Wilczynski
    Department of Gynecology, Medical University of Lodz, Kosciuszki 4, 90 419 Lodz, Poland
    Arch Immunol Ther Exp (Warsz) 58:435-48. 2010
  5. ncbi Fetal rejection: infertility and immunity
    Jacek R Wilczynski
    Polish Mother s Health Center Research Institute, Department of Gynecological Surgery, 281 289 Rzgowska Street, , Poland
    Expert Rev Clin Immunol 3:871-82. 2007
  6. ncbi The role of T-regulatory cells in pregnancy and cancer
    Jacek R Wilczynski
    Department of Gynecological Surgery, Polish Mother s Health Center Research Institute, Lodz, Poland
    Front Biosci 13:2275-89. 2008
  7. ncbi The characterization and role of regulatory T cells in immune reactions
    Jacek R Wilczynski
    Department of Gynecological Surgery, Polish Mother s Health Center Research Institute, Lodz, Poland
    Front Biosci 13:2266-74. 2008
  8. ncbi [Is MDR 1 gene a key to successful chemotherapy?]
    Jacek R Wilczynski
    III Katedra Połoznictwa i Ginekologii UM w Lodzi
    Ginekol Pol 77:476-84. 2006
  9. ncbi Immunological analogy between allograft rejection, recurrent abortion and pre-eclampsia - the same basic mechanism?
    Jacek R Wilczynski
    Department of Gynecological Surgery, Polish Mother s Health Center Research Institute, Lodz, Poland
    Hum Immunol 67:492-511. 2006
  10. ncbi [Laparoscopic treatment of benign ovarian tumors]
    Jacek R Wilczyńqski
    III Katedra Ginekologii i Połoinictwa UM w Lodzi
    Ginekol Pol 77:40-7. 2006

Collaborators

Detail Information

Publications19

  1. ncbi Immunotherapy of patients with recurrent spontaneous miscarriage and idiopathic infertility: does the immunization-dependent Th2 cytokine overbalance really matter?
    Jacek R Wilczynski
    Chair of Obstetrics and Gynecological Surgery, Department of Gynecology, Medical University of Lodz, Kosciuszki 4, 90 419, Lodz, Poland
    Arch Immunol Ther Exp (Warsz) 60:151-60. 2012
    ..Th1 shift in both RSM and IIF patients was observed in comparison to fertile women. Treatment with PLI-induced pre-conceptionally cytokine changes which neither indicated Th2 shift nor correlated with subsequent pregnancy success...
  2. ncbi Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part I
    Jacek Wilczyński
    Polish Mother s Health Center Research Institute, Lodz, Poland
    Arch Immunol Ther Exp (Warsz) 59:289-99. 2011
    ....
  3. ncbi Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II
    Jacek Wilczyński
    Polish Mother s Health Center Research Institute, Lodz, Poland
    Arch Immunol Ther Exp (Warsz) 59:301-7. 2011
    ..g. topotecan, heat shock protein 90 and mTOR inhibitors, YC-1, pleurotin or 2-methoxyestradiol), which are being subjected into intensive investigation in clinical trials...
  4. ncbi How do tumors actively escape from host immunosurveillance?
    Jacek R Wilczynski
    Department of Gynecology, Medical University of Lodz, Kosciuszki 4, 90 419 Lodz, Poland
    Arch Immunol Ther Exp (Warsz) 58:435-48. 2010
    ..The results of studies devoted to the problem of immunoregulation in the tumor environment seem to support the "escape" hypothesis...
  5. ncbi Fetal rejection: infertility and immunity
    Jacek R Wilczynski
    Polish Mother s Health Center Research Institute, Department of Gynecological Surgery, 281 289 Rzgowska Street, , Poland
    Expert Rev Clin Immunol 3:871-82. 2007
    ..Immunotherapy is believed to correct the detrimental immune reactions; however, its real effectiveness and safety for the treatment of distinct forms of pregnancy loss need to be reconsidered...
  6. ncbi The role of T-regulatory cells in pregnancy and cancer
    Jacek R Wilczynski
    Department of Gynecological Surgery, Polish Mother s Health Center Research Institute, Lodz, Poland
    Front Biosci 13:2275-89. 2008
    ..Resolving the secrets of Tregs cells will probably offer new options of cancer treatment and will help to improve the management of pregnancy failure...
  7. ncbi The characterization and role of regulatory T cells in immune reactions
    Jacek R Wilczynski
    Department of Gynecological Surgery, Polish Mother s Health Center Research Institute, Lodz, Poland
    Front Biosci 13:2266-74. 2008
    ..Tregs have a privileged place in the net of immunological interactions which makes them a possible common target for therapeutic interventions in different diseases...
  8. ncbi [Is MDR 1 gene a key to successful chemotherapy?]
    Jacek R Wilczynski
    III Katedra Połoznictwa i Ginekologii UM w Lodzi
    Ginekol Pol 77:476-84. 2006
    ..It seems that genotyping of multidrug resistance genes and identifying specific haplotypes can become an important tool in predicting individual sensibility to chemotherapy...
  9. ncbi Immunological analogy between allograft rejection, recurrent abortion and pre-eclampsia - the same basic mechanism?
    Jacek R Wilczynski
    Department of Gynecological Surgery, Polish Mother s Health Center Research Institute, Lodz, Poland
    Hum Immunol 67:492-511. 2006
    ..According to that supposition, an analogy might exist between acute graft rejection and recurrent abortion, and between chronic graft rejection and pre-eclampsia...
  10. ncbi [Laparoscopic treatment of benign ovarian tumors]
    Jacek R Wilczyńqski
    III Katedra Ginekologii i Połoinictwa UM w Lodzi
    Ginekol Pol 77:40-7. 2006
    ..laparoscopic surgery is one of the most common procedures performed in the presence of benign ovarian tumor...
  11. ncbi Cytokine secretion by decidual lymphocytes in transient hypertension of pregnancy and pre-eclampsia
    Jacek R Wilczynski
    Department of Obstetrics and Gynecology, Institute of Basic Sciences, Military Medical Academy, Lodz, Poland
    Mediators Inflamm 11:105-11. 2002
    ....
  12. ncbi 'In vitro' cytokine secretion by peripheral blood and decidual lymphocytes during the third trimester of normal pregnancy
    J R Wilczynski
    Department of Obstetrics and Gynecology, Military Medical Academy, Polish Mother s Health Center Research Institute, Lodz, Poland
    Gynecol Obstet Invest 55:68-72. 2003
    ..It demonstrates that DL play an active role in local Th2-like immunoregulation and that their cytokine secretion pattern estimated in 'in vitro' conditions is biased towards Th2 activity more than that of PBL...
  13. ncbi Lymphocyte subset distribution and cytokine secretion in third trimester decidua in normal pregnancy and preeclampsia
    Jacek R Wilczynski
    Department of Obstetrics and Gynecology, Military Medical Academy, Lodz, Poland
    Eur J Obstet Gynecol Reprod Biol 109:8-15. 2003
    ..Excessive Th1 activity in peripheral blood plays a probable role in the pathogenesis of preeclampsia. The aim of the study was to investigate whether disturbed local immune reactions are also present in decidua...
  14. ncbi [Usefulness of Doppler ultrasound imaging in monitoring of hypoxic-ischemic encephalopathy in preterm infants]
    Małgorzata Wilczyńska
    Pol Merkur Lekarski 15:436-40. 2003
    ..Doppler imaging is useful in identification of patients having increased risk of HIE and supplements routine transfontanellar ultrasound in estimation of HIE progression...
  15. ncbi Th1/Th2 cytokines balance--yin and yang of reproductive immunology
    Jacek R Wilczynski
    Department of Gynecological Surgery, Polish Mother s Health Center Research Institute, 93 338 Lodz, 281 289 Rzgowska St, Poland
    Eur J Obstet Gynecol Reprod Biol 122:136-43. 2005
    ..So paradigm of "Th1-Th2 cooperation" is much closer to reality than "Th2 phenomenon"...
  16. ncbi Cancer and pregnancy share similar mechanisms of immunological escape
    Jacek R Wilczynski
    Department of Gynecological Surgery, Polish Mother s Health Center Research Institute, Medical University, Lodz, Poland
    Chemotherapy 52:107-10. 2006
    ..Despite the fact that trophoblasts and cancer are both immunogenic, they are able to escape from host immunosurveillance, and the precise mechanisms involved in this process are surprisingly similar in both situations...
  17. ncbi Expression of intercellular adhesion molecule-1 on the surface of peripheral blood and decidual lymphocytes of women with pregnancy-induced hypertension
    Jacek R Wilczynski
    Department of Obstetrics and Gynecology, Military Medical Academy, Polish Mother s Health Center Research Institute, 93 338, 281 289, Rzgowska St, Lodz, Poland
    Eur J Obstet Gynecol Reprod Biol 102:15-20. 2002
    ..If overexpression of intercellular adhesion molecule-1 (CD54) on lymphocytes exists it could have important implications for the pathophysiology of pregnancy-induced hypertension (PIH)...
  18. ncbi Profile of peripheral blood neutrophil cytokines in diabetes type 1 pregnant women and its correlation with selected parameters in the newborns
    Magdalena Pertyńska-Marczewska
    Department of Fetal Maternal Medicine and Gynaecology, Polish Mother s Memorial Hospital Research Institute, Lodz, Poland
    Am J Reprod Immunol 63:150-60. 2010
    ..We aimed to evaluate the peripheral blood neutrophil-derived production of these cytokines in the course of pregnancy complicated by type 1 diabetes...
  19. ncbi Role of progesterone and progestin therapy in threatened abortion and preterm labour
    Julia Szekeres-Bartho
    Department of Medical Microbiology and Immunology, Medical School, Pecs University, H 7643 Pecs, Hungary
    Front Biosci 13:1981-90. 2008
    ..The possible mechanisms by which progesterone contributes to the maintenance of early and late pregnancy are discussed...