Justyna Szumilo

..Management of the ectopic pancreas remains controversial. The authors describe 12 patients and try to recommend different kind of treatment in the light of the symptoms, location and size of the lesions...

..Since a lack of morphological features of trisomy 13 syndrome were found in the foetus, the ectopic spleens were regarded as incidental findings...

..Chemopreventive activity was revealed for various agents including plant-derived compounds like resveratrol, green and black tee polyphenols, as well as protocatechuic, ellagic and caffeic acids...

..Previous studies proved the relationship between cancer susceptibility and polymorphisms in genes encoding some important molecules engaged in carcinogens metabolism or DNA repair...

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..The results may suggest a relationship between syndecan-1 and cathepsins D and K with growth and invasiveness of esophageal squamous cell carcinoma, but such thesis requires further study on a larger and more heterogeneous population...

..Although the blue nevi seem to be lesions of low clinical significance, they require careful differential diagnosis with malignant melanoma, especially in scanty endocervical curettage or cervical biopsy specimens...

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..A rare case of osseous metaplasia in a moderately differentiated rectal adenocarcinoma in a 79-year-old man is reported. A possible pathogenesis of this phenomenon is discussed...

..These phenomena could be potentially induced by carcinogen exposure...

..Few reports concerning application of selective COX-2 inhibitors in patients with invasive squamous cell carcinoma are insufficient for ultimate evaluation of this method of therapy...

..Due to a number of limitations, the collected data cannot be compared directly to other populations who are exposed to different environmental factors and with different genetic predispositions...

..Introduction of genetic screening test allows effective, purpose-oriented methods of prevention and in patients suffered from the cancer--application of optimal therapy and minimization of side-effects...

..However, some agents e.g., perillyl alcohol, could enhance development of proliferative lesions in esophageal epithelium...

..The incidence and significance of the Paneth cell and endocrine differentiation in colorectal carcinomas are discussed with the review of the literature...

..One postoperative death was noted. In two other patients, lung metastases were found and the patients died 20 and 16 months after surgery...

..The histogenesis, clinicopathological features and differential diagnosis of this unusual tumor are also discussed...

..Although, the coexistence of esophageal GCTs and cancers seems to be coincidental, the necessity of a careful clinical evaluation and a close follow-up of patients with GCT is suggested...

..The results may suggest that nm23-status is not associated with metastatic ability and prognosis in esophageal squamous cell carcinoma, but such thesis requires further study on a larger population...

..It could be concluded that sebaceous glands in the ectocervix are rare lesions of unclear origin and low clinical significance. However, the glands could potentially be associated with sebaceous carcinoma of that anatomical site...

..Involvement of the external genital organs including penis is extremely rare, and until now, scarce cases have been reported in the available literature...

..Thus, 4-MP was found to be the most effective inhibitor of LDH of all compounds tested. Therefore, such effect of 4-MP seems to be an additional advantage in methanol and ethylene glycol intoxications...

..It could be stressed that aspirin, unlike other non-selective and selective COX-2 inhibitors increases the risk of the abdominal wall defects, which are observed more often in growth-retarded fetuses...

..On the other hand, decrease in fetal length has been the only sign of toxicity found after exposure to selective COX-2 inhibitor (DFU). The aim of the study was to evaluate maternal effects on selected developmental abnormalities...

..A beneficial effect may be obtained in anticancer therapy with bioreductive agents like tirapazamine...

..Tolerability of non-selective COX inhibitors was lower in both pregnant and non-pregnant groups when compared with DFU. Insignificant mortality and histological changes were noted between pregnant and non-pregnant groups...

..On the other hand, the decrease of LDH activity in the presence of Ukrain is a promising finding but definitely requires further investigation...

..Non-selective cyclooxygenase inhibitors (non-steroidal anti-inflammatory drugs--NSAID) affected pups growth and influenced mineralization of the lumbar vertebrae...

..Fourteen months after esophagectomy multiple lung metastases were detected. Patient died 2 mo later...

..It should be stressed that unlike DFU, the examined nonselective COX inhibitors decreased fetal bone mineralization when administered in high maternal toxic doses. Moreover, maternal health status determined fetal bone mineralization...

..It could be concluded that abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level...

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..The third and fourth groups comprise developmental variations and organ malformations that were not observed in evaluated patients. The last group (V) encloses mixed forms that connect two or more previous variations...

..These changes were not increased (P<0.1) in the middle drug-dose group. The experimentally-derived NOAEL for developmental toxicity was 0.05 mg/kg, and the corresponding LOAEL was 3.5 mg/kg...

..The rat Browicz-Kupffer cells revealed the highest activity of cathepsin D...

..Any disturbances of the epiphyseal development and its physiology result in various skeletal abnormalities known as dysplasia...

..A single alizarin red S and double alcian blue followed by alizarin red S staining, as well as various methods of soft tissue examination are discussed...

..Manifestations of deviant development depends on the dosage and exposure frequency. In case of abnormal development the final manifestations include death of embryo or fetus, malformation, growth retardation and functional disorder...

..It increases in inflammatory, degenerative, and neoplastic processes...

..It could be concluded that both constitutive and inducible COX isoforms are physiologically expressed in various structures of synovial joints in rat foetuses at the end of prenatal development...

..To assess the possibility of promoting esophageal squamous cell carcinoma after direct administration of diethylnitrosamine (DEN) into the wall of the esophagus...

..We present a unique case of simultaneous occurrence of cystic nephroma and renal cortical adenoma in 47-year-old man. Both tumours were situated in the lower pole of the right kidney and were clinically asymptomatic...

..Although there were differences in enzyme activity between various organs of the male reproductive system, cathepsin D immunoreactivity was seen exclusively in the Sertoli and Leydig cells in the testis...

..It should be stressed that DFU administered throughout mid and late pregnancy in rats did not change maternal or foetal pancreatic morphology or immunoexpression of either of the main COX isoforms in the organ...

..In conclusion, constitutive and inducible COX isoforms were detected in the digestive tract of pregnant female and in foetuses. COX-1 was the predominant isoform in both the adult and foetal organs...

..Total gastrectomy for gastric cardia tumours harbours a high risk of proximal resection line (PRL) involvement. The adhesion markers CD44v6 and E-cadherin were evaluated as predictive factors for PRL involvement independent of tumour stage...

..These results may also reflect destructive changes and dysfunction of the vascular endothelium in preeclamptic pregnancy with IUGR...