Affiliation: Medical University
- Sarecka B, Zak I, Krauze J. Synergistic effects of the polymorphisms in the PAI-1 and IL-6 genes with smoking in determining their associated risk with coronary artery disease. Clin Biochem. 2008;41:467-73 pubmed publisher..18 and p=0.0005, OR=9.20, respectively). There are synergistic and cumulative effects of 5G allele of PAI-1 polymorphism and C allele of IL-6 polymorphism with smoking in determining their associated risk with CAD. ..
- Sarecka Hujar B, Zak I, Krauze J. Carrier-state of two or three polymorphic variants of MTHFR, IL-6 and ICAM1 genes increases the risk of coronary artery disease. Kardiol Pol. 2008;66:1269-77 pubmed..007, OR=10.32 and for MTHFR+ ICAM1+IL-6, p=0.005, OR=17.95 in females). The present study showed that simultaneous carrier-state of MTHFR, IL-6 and ICAM1 genes increased the risk of CAD. ..
- Sarecka Hujar B, Zak I. [Role of the polymorphisms within genes encoding proteins related to endothelial dysfunction in coronary artery disease]. Wiad Lek. 2011;64:294-300 pubmed..The 1405A>G polymorphism in ICAM1 gene may affect mRNA splicing patterns that modify cell-cell interactions and influence inflammatory response. ..