Krzysztof Safranow

Summary

Affiliation: Medical University
Country: Poland

Publications

  1. pmc Circulating hematopoietic stem cell count is a valuable predictor of prematurity complications in preterm newborns
    Maciej Kotowski
    Department of General Pathology, Pomeranian Medical University in Szczecin, Powstancow Wlkp, 72, Szczecin 70 111, Poland
    BMC Pediatr 12:148. 2012
  2. ncbi request reprint ADA*2 allele of the adenosine deaminase gene may protect against coronary artery disease
    Krzysztof Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Cardiology 108:275-81. 2007
  3. ncbi request reprint [Influence of gastric juice pH on the metabolism of vitamin C in gastric mucosa and juice]
    Krzysztof Safranow
    Pomorska Akademia Medyczna w Szczecinie, Katedra i Zakład Biochemii i Chemii
    Pol Merkur Lekarski 20:168-72. 2006
  4. ncbi request reprint Methylated purines in urinary stones
    Krzysztof Safranow
    Department of Biochemistry and Chemistry, Pomeranian Medical University, Szczecin, Poland
    Clin Chem 51:1493-8. 2005
  5. doi request reprint Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease
    K Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Tissue Antigens 74:386-92. 2009
  6. doi request reprint Association of C34T AMPD1 gene polymorphism with features of metabolic syndrome in patients with coronary artery disease or heart failure
    Krzysztof Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Scand J Clin Lab Invest 69:102-12. 2009
  7. ncbi request reprint Simultaneous determination of 16 purine derivatives in urinary calculi by gradient reversed-phase high-performance liquid chromatography with UV detection
    Krzysztof Safranow
    Department of Biochemistry and Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111 Szczecin, Poland
    J Chromatogr B Analyt Technol Biomed Life Sci 819:229-35. 2005
  8. ncbi request reprint Myocardial and coronary sinus purines as indicators of pig heart energy metabolism during reperfusion after extracorporeal circulation
    K Safranow
    Department of Biochemistry and Chemistry, Pomeranian Medical University, Szczecin, Poland
    Acta Physiol Scand 185:13-23. 2005
  9. pmc AMPD1 gene mutations are associated with obesity and diabetes in Polish patients with cardiovascular diseases
    Krzysztof Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111, Szczecin, Poland
    J Appl Genet 52:67-76. 2011
  10. pmc PIN1 gene variants in Alzheimer's disease
    Aleksandra Maruszak
    Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warszawa, Poland
    BMC Med Genet 10:115. 2009

Collaborators

Detail Information

Publications81

  1. pmc Circulating hematopoietic stem cell count is a valuable predictor of prematurity complications in preterm newborns
    Maciej Kotowski
    Department of General Pathology, Pomeranian Medical University in Szczecin, Powstancow Wlkp, 72, Szczecin 70 111, Poland
    BMC Pediatr 12:148. 2012
    ..Here, we studied the association of the number of circulating stem cell populations with the incidence of complications typical of prematurity...
  2. ncbi request reprint ADA*2 allele of the adenosine deaminase gene may protect against coronary artery disease
    Krzysztof Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Cardiology 108:275-81. 2007
    ..In a case-control study, we investigated the association between ADA polymorphism and coronary artery disease (CAD)...
  3. ncbi request reprint [Influence of gastric juice pH on the metabolism of vitamin C in gastric mucosa and juice]
    Krzysztof Safranow
    Pomorska Akademia Medyczna w Szczecinie, Katedra i Zakład Biochemii i Chemii
    Pol Merkur Lekarski 20:168-72. 2006
    ..The aim of the work was to analyse relations between gastric juice pH and concentrations of Asc and dAsc in plasma, gastric mucosa and juice as well as other factors modifying metabolism of vitamin C and function of gastric mucosa...
  4. ncbi request reprint Methylated purines in urinary stones
    Krzysztof Safranow
    Department of Biochemistry and Chemistry, Pomeranian Medical University, Szczecin, Poland
    Clin Chem 51:1493-8. 2005
    ..The aim of the study was to measure the content of methylated purines that appear as admixtures in uric acid stones...
  5. doi request reprint Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease
    K Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Tissue Antigens 74:386-92. 2009
    ..Metabolic syndrome and diabetes are associated with higher plasma concentrations of TNF-alpha and its receptors...
  6. doi request reprint Association of C34T AMPD1 gene polymorphism with features of metabolic syndrome in patients with coronary artery disease or heart failure
    Krzysztof Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Scand J Clin Lab Invest 69:102-12. 2009
    ..The aim of this study was to assess genotype-phenotype correlations in such patients, with emphasis on components of the metabolic syndrome...
  7. ncbi request reprint Simultaneous determination of 16 purine derivatives in urinary calculi by gradient reversed-phase high-performance liquid chromatography with UV detection
    Krzysztof Safranow
    Department of Biochemistry and Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111 Szczecin, Poland
    J Chromatogr B Analyt Technol Biomed Life Sci 819:229-35. 2005
    ....
  8. ncbi request reprint Myocardial and coronary sinus purines as indicators of pig heart energy metabolism during reperfusion after extracorporeal circulation
    K Safranow
    Department of Biochemistry and Chemistry, Pomeranian Medical University, Szczecin, Poland
    Acta Physiol Scand 185:13-23. 2005
    ..We attempted to gain a comprehensive insight into the purine metabolism of the porcine heart during reperfusion by measuring concentrations of nucleotides, nucleosides and oxypurines simultaneously in the myocardium and coronary sinus...
  9. pmc AMPD1 gene mutations are associated with obesity and diabetes in Polish patients with cardiovascular diseases
    Krzysztof Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111, Szczecin, Poland
    J Appl Genet 52:67-76. 2011
    ....
  10. pmc PIN1 gene variants in Alzheimer's disease
    Aleksandra Maruszak
    Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warszawa, Poland
    BMC Med Genet 10:115. 2009
    ..There are confounding results concerning PIN1 activity in AD brains. Also PIN1 genetic variation was inconsistently associated with AD risk...
  11. doi request reprint The association of -262C/T polymorphism in the catalase gene and delayed graft function of kidney allografts
    Grazyna Dutkiewicz
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Nephrology (Carlton) 15:587-91. 2010
    ..The aim of the present study was to examine the association between the -262C/T polymorphism in the catalase gene and delayed graft function (DGF), acute rejection and chronic allograft nephropathy of kidney allografts...
  12. ncbi request reprint Early phase of reperfusion of human kidney allograft does not affect an erythrocyte anti-oxidative system
    Leszek Domanski
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczeci, Poland
    Nephrology (Carlton) 11:467-70. 2006
    ..Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione (GSH) are involved in protection against free radicals...
  13. ncbi request reprint Lack of association of C599T polymorphism in the glutathione peroxidase (GPX1) gene with delayed graft function, acute kidney graft rejection and chronic allograft nephropathy
    Grazyna Dutkiewicz
    Department of Nephrology, Transplantology and Internal Medicine of Pomeranian Medical University, Szczecin, Poland
    Ann Transplant 15:30-4. 2010
    ..The aim of the present study was to examine the association between the C599T polymorphism in the glutathione peroxidase (GPX1) gene and delayed graft function of kidney allografts, acute rejection and chronic allograft nephropathy...
  14. doi request reprint Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead
    Irena Baranowska-Bosiacka
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp 72 str, 70 111 Szczecin, Poland
    Brain Res 1435:56-71. 2012
    ..Disruption of pro- and antioxidant balance should be considered as a potential mechanism of the observed Pb adverse effects, leading to the impaired learning ability caused by Pb exposure in children...
  15. ncbi request reprint Oxypurine and nucleoside concentrations in renal veins during reperfusion are predictors of early graft function
    Leszek Domanski
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Scand J Urol Nephrol 41:161-7. 2007
    ..To examine whether purine and pyrimidine nucleoside concentrations as well as oxypurine concentrations in renal and peripheral veins during reperfusion correlate with graft function parameters...
  16. doi request reprint Polymorphisms of superoxide dismutase, glutathione peroxidase and catalase genes in patients with post-transplant diabetes mellitus
    Grazyna Dutkiewicz
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 41:350-5. 2010
    ..The aim of this study was to examine the association of polymorphisms in superoxide dismutase, catalase and glutathione peroxidase genes with PTDM in patients after kidney transplantation...
  17. ncbi request reprint The impact of rs231775 (+49AG) CTLA4 gene polymorphism on transplanted kidney function
    Leszek Domanski
    Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland
    Ann Transplant 17:29-35. 2012
    ..The aim of this study was to examine the impact of the rs231775 (+49AG) CTLA4 gene polymorphism on transplanted kidney function...
  18. ncbi request reprint CD36 gene is associated with thickness of atheromatous plaque and ankle-brachial index in patients with early coronary artery disease
    Monika Ewa Rać
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Kardiol Pol 70:918-23. 2012
    ..CD36 is a multifunctional molecule engaged in the removal of oxidised LDL from plasma. It is unclear whether mutation of the CD36 gene protects against, or increases, the risk of hypercholesterolaemia, atherosclerosis and its complications...
  19. doi request reprint Metabolic syndrome components in patients with autosomal-dominant polycystic kidney disease
    Maria Pietrzak-Nowacka
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Kidney Blood Press Res 32:405-10. 2009
    ....
  20. doi request reprint The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide
    Andrzej Pawlik
    Department of Pharmacology, Pomeranian Medical University, ul Powst Wlkp 72, 70111 Szczecin, Poland
    Pharmacogenomics 10:303-9. 2009
    ..The aim of the study was to examine the effect of this polymorphism on leflunomide treatment outcome in rheumatoid arthritis (RA) patients...
  21. doi request reprint Circulating endothelial progenitor cells in premature infants: is there an association with premature birth complications?
    Krzysztof Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    J Perinat Med 40:455-62. 2012
    ..Endothelial progenitor cells (EPCs) have been implicated in repair of the vasculature, but their role in the pathogenesis of prematurity complications is not clear...
  22. ncbi request reprint Lack of association of the rs2476601 PTPN22 gene polymorphism with transplanted kidney function
    Leszek Domanski
    Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstańców Wlkp 72 St, Szczecin, Poland
    Ann Transplant 16:63-8. 2011
    ..The aim of this study was to examine the association of the rs2476601 (C1858T) PTPN22 gene polymorphism with transplanted kidney function...
  23. doi request reprint Effect of trimetazidine on xanthine oxidoreductase expression in rat kidney with ischemia--reperfusion injury
    Tadeusz Sulikowski
    Department of General and Transplantation Surgery of Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 39:459-62. 2008
    ....
  24. doi request reprint The association between eNOS intron 4 VNTR polymorphism and delayed graft function of kidney allografts
    Grazyna Dutkiewicz
    Department of Nephrology, Transplantology, and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Clin Transplant 24:E130-6. 2010
    ..The results of this study suggest that patients with the a allele of the eNOS intron 4 VNTR polymorphism may be predisposed to delayed graft function...
  25. ncbi request reprint Oxypurine and purine nucleoside concentrations in renal vein of allograft are potential markers of energy status of renal tissue
    Leszek Domanski
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 38:240-6. 2007
    ....
  26. doi request reprint Influence of angiotensin I-converting enzyme polymorphism on development of post-transplant erythrocytosis in renal graft recipients
    Karolina Kedzierska
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Clin Transplant 22:156-61. 2008
    ..Angiotensin II generated by angiotensin I-converting enzyme (ACE) stimulates erythropoiesis. The highest activity of ACE is observed in DD genotype. The question arises if ACE gene polymorphism influences PTE...
  27. doi request reprint Is CD36 gene polymorphism in region encoding lipid-binding domain associated with early onset CAD?
    Monika Rac
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland Electronic address
    Gene 530:134-7. 2013
    ..50%) with both IVS3-6C and 591T variant alleles. In conclusion, CD36 variants: rs3173798, rs3211892, rs138897347, rs5956, rs143150225 rs141680676 and C311T do not seem to be involved in the risk of early-onset CAD in Caucasian population...
  28. ncbi request reprint Can we predict urinary stone composition based on an analysis of microelement concentration in the hair and urine?
    Marcin Słojewski
    Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin, Poland
    Adv Clin Exp Med 21:469-75. 2012
    ..In recent years the role of trace elements in lithogenesis has received steadily increasing attention...
  29. ncbi request reprint Effect of ESR1 and ESR2 gene polymorphisms on rheumatoid arthritis treatment with methotrexate
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Powstancow Wlkp 72, PL 70 111 Szczecin, Poland
    Pharmacol Rep 64:185-90. 2012
    ..The results of the present study suggest that the polymorphisms rs9340799:A>G and rs2234693:T>C in ESR1 gene and rs4986938:G>A and 1256049:G>A in ESR2 gene are not associated with response to RA treatment with MTX...
  30. ncbi request reprint GNB3 C825T and ACE I/D polymorphisms on the sodium-proton exchanger and the prevalence of essential hypertension in males
    Karolina Kedzierska
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 37:150-7. 2006
    ....
  31. ncbi request reprint The influence of gender, weight, height and BMI on pentosidine concentrations in plasma of hemodialyzed patients
    Dorota Slowick-Zylka
    Department of Physiology, Pomeranian Medical University, Szczecin, Poland
    J Nephrol 19:65-9. 2006
    ..This study was undertaken to determine the influence of anthropometric parameters and inflammation on plasma pentosidine concentrations...
  32. doi request reprint Characterisation of rat and human tissue alkaline phosphatase isoforms by high-performance liquid chromatography and agarose gel electrophoresis
    Violetta Dziedziejko
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Al Powstancow Wlkp 72, 70 111 Szczecin, Poland
    Biochimie 91:445-52. 2009
    ..HPLC offers a higher resolution than electrophoresis with respect to tissue ALP fractions in rats and in humans, but electrophoresis visualises high-molecular-mass insoluble enzyme forms...
  33. pmc Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age
    Monika Ewa Rać
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111, Szczecin, Poland
    Biochem Genet 50:103-11. 2012
    ..The A allele of the IVS4-10 G/A polymorphism was associated with older age of myocardial infarction and higher white blood cell count. The functional role of CD36 polymorphisms in CAD development needs further research...
  34. ncbi request reprint Impaired synthesis is not the reason for decreased activity of extracellular superoxide dismutase in patients with diabetes
    Kazimierz Ciechanowski
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 36:148-53. 2005
    ..The aim of the study was to find the cause of decreased activity of extracellular superoxide dismutase (EC SOD) in patients with diabetes-is it the decreased synthesis or increased glycation?..
  35. doi request reprint Microelements in stones, urine, and hair of stone formers: a new key to the puzzle of lithogenesis?
    Marcin Słojewski
    Department of Urology, Pomeranian Medical University, Szczecin, Poland
    Biol Trace Elem Res 137:301-16. 2010
    ..This study showed, for the first time, correlations between the levels of vanadium, lead, and aluminum in the stones, urine, and hair of stone formers...
  36. doi request reprint Analysis of human CD36 gene sequence alterations in the oxidized low-density lipoprotein-binding region using denaturing high-performance liquid chromatography
    Monika Ewa Rać
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Genet Test Mol Biomarkers 14:551-7. 2010
    ..DHPLC is a specific and cost-effective technique that may prove to be particularly useful for the identification of polymorphisms and mutations in the CD36 gene...
  37. ncbi request reprint The effect of dialysis membrane type on plasma concentrations of pentosidine, a marker of carbonyl stress, in hemodialyzed patients
    Dorota Słowik-Zyłka
    Department of Physiopathology, Pomeranian Medical University, Szczecin, Poland
    Pol Arch Med Wewn 119:614-20. 2009
    ..Carbonyl stress plays an essential role in the formation of AGEs, including pentosidine...
  38. ncbi request reprint Guanine and inosine nucleotides, nucleosides and oxypurines in snail muscles as potential biomarkers of fluoride toxicity
    Monika E Rać
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111 Szczecin, Poland
    Folia Biol (Krakow) 55:153-60. 2007
    ..The measuring of fluoride accumulation in the shell is the most suitable bioindicator of fluoride pollution in the environment...
  39. doi request reprint Autosomal dominant polycystic kidney disease and hypertension are associated with left ventricular mass in a gender-dependent manner
    Maria Pietrzak-Nowacka
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Kidney Blood Press Res 36:301-9. 2012
    ..The aim of this study was to compare echocardiographic parameters in patients with autosomal dominant polycystic kidney disease (ADPKD) and in controls with normal kidney function taking into account gender and the presence of hypertension...
  40. doi request reprint Polymorphism of CD36 gene, carbohydrate metabolism and plasma CD36 concentration in obese children. A preliminary study
    Monika E Rać
    Department of Biochemistry and Medical Chemistry Pomeranian Medical University, 70 111 Szczecin, Poland
    Postepy Hig Med Dosw (Online) 66:954-8. 2012
    ..The aim of the study was to search for an association between CD36 gene polymorphism and carbohydrate metabolism disturbances or variability of plasma soluble CD36 concentrations in obese children...
  41. doi request reprint Common genetic variants of the BMP4, BMPR1A, BMPR1B, and ACVR1 genes, left ventricular mass, and other parameters of the heart in newborns
    Iwona Goracy
    Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland
    Genet Test Mol Biomarkers 16:1309-16. 2012
    ..0004 and p=0.046, respectively). The 455C allele of BMP4 and the 8474T allele of ACVR1 may play a role as significant predictors for decreased LVEF in newborns...
  42. pmc The common C49620T polymorphism in the sulfonylurea receptor gene SUR1 (ABCC8) in patients with gestational diabetes and subsequent glucose metabolism abnormalities
    Piotr Moleda
    Department of Diabetology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland
    Exp Diabetes Res 2012:712617. 2012
    ....
  43. pmc Lack of association between CAG repeat polymorphism in the androgen receptor gene and the outcome of rheumatoid arthritis treatment with leflunomide
    Violetta Dziedziejko
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 68:371-7. 2012
    ..The aim of this study was to examine the association between CAG repeat polymorphism in the androgen receptor (AR) gene and the response to treatment with LEF in women with RA...
  44. doi request reprint Association of plasma pentosidine concentrations with renal function in kidney graft recipients
    Dorota Slowik-Zylka
    Department of Physiopathology, Pomeranian Medical University, Szczecin, Poland
    Clin Transplant 24:839-47. 2010
    ..We aimed to assess the changes of free (P(free)) and total (P(tot)) plasma pentosidine concentrations in kidney graft recipients, create a model describing their profile and analyze associations with clinical parameters...
  45. doi request reprint The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women
    Bogusław Czerny
    Department of Pharmacology, Pomeranian Medical University, ul Powst Wlkp 72, 70 111 Szczecin, Poland
    Eur J Obstet Gynecol Reprod Biol 149:82-5. 2010
    ..Osteoporosis is a common disorder with a strong genetic component. The genetics of osteoporosis impacts on the prediction, diagnosis, prognosis, and treatment of the disease...
  46. ncbi request reprint Creatinine clearance after cimetidine administration: is it useful in the monitoring of the function of transplanted kidney?
    Joanna Kabat-Koperska
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Ren Fail 29:667-72. 2007
    ..This error can be reduced by determining the clearance after administration of cimetidine, which competitively blocks creatinine tubular transport...
  47. doi request reprint Does smoking have any effect on urinary stone composition and the distribution of trace elements in urine and stones?
    Marcin Słojewski
    Department of Urology, Pomeranian Medical University, ul Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Urol Res 37:317-22. 2009
    ..Our findings do not support the concept of possible association between smoking and urinary lithogenesis, but we believe that further investigations are needed in this area...
  48. ncbi request reprint Simple dietary interventions reduce the risk factors of atherosclerosis in renal graft recipients
    Ewa Stachowska
    Department of Biochemistry and Chemistry, Transplantology, and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    J Ren Nutr 15:291-7. 2005
  49. doi request reprint Platelets arachidonic acid metabolism in patients with essential hypertension
    Barbara Dołęgowska
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Platelets 20:242-9. 2009
    ..Moreover, we hypothesize that platelets AA metabolism may exert a pro-atherosclerotic effect. Finally, we suggest the use of (5-HETE+12-HETE)/TxB(2) parameter in further studies...
  50. ncbi request reprint Plasma prekallikrein as a risk factor for diabetic retinopathy
    Karolina Kedzierska
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 36:539-43. 2005
    ..The aim of the study was to verify the hypothesis that in diabetes there is an increased activation of coagulation system leading in consequence to diabetic retinopathy...
  51. doi request reprint Presence of glucose in dialyzing fluid and synthesis of selected lipoxygenase-derived eicosanoids during hemodialysis
    Barbara Dołęgowska
    Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Al Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Int Urol Nephrol 44:1799-804. 2012
    ....
  52. doi request reprint Allograft inflammatory factor-1 gene polymorphisms in patients with rheumatoid arthritis
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland
    Genet Test Mol Biomarkers 16:341-5. 2012
    ..The aim of this study was to examine the association between AIF1 rs2259571:A>C, rs2736182:G>A, and rs13195276:C>T polymorphisms and RA. We examined 380 patients with RA and 376 control subjects...
  53. doi request reprint CAG repeat polymorphism in the androgen receptor gene in women with rheumatoid arthritis
    Violetta Dziedziejko
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111 Szczecin, Poland
    J Rheumatol 39:10-7. 2012
    ..We examined the association between CAG repeat polymorphism in the androgen receptor (AR) gene and susceptibility to RA and its clinical features in white women...
  54. pmc Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study
    Rafal Kurzawa
    Department of Reproductive Medicine and Gynecology, Pomeranian Medical University, Szczecin Police, Poland
    J Assist Reprod Genet 25:365-74. 2008
    ..Embryological and clinical efficacy of gonadotropin-releasing hormone (GnRH) antagonist and agonist stimulation protocols in non-obese women with polycystic ovarian syndrome (PCOS) were compared...
  55. doi request reprint Influence of ranibizumab on vascular endothelial growth factor plasma level and endothelial progenitor cell mobilization in age-related macular degeneration patients: safety of intravitreal treatment for vascular homeostasis
    Anna Machalinska
    Department of Histology and Embryology, Pomeranian Medical University, Szczecin, Poland
    J Ocul Pharmacol Ther 27:471-5. 2011
    ..However, its potential systemic effect on vascular homeostasis as the consequence of such therapy has not been extensively investigated...
  56. ncbi request reprint IL-1beta, IL-6, and TNF gene polymorphisms do not affect the treatment outcome of rheumatoid arthritis patients with leflunomide
    Andrzej Pawlik
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Pharmacol Rep 61:281-7. 2009
    ..The results of the present study suggest that IL1beta, IL6, and TNF gene polymorphisms are not significant factors influencing the therapy outcome of RA patients with leflunomide...
  57. ncbi request reprint The use of neural networks in evaluation of the direction and dynamics of changes in lipid parameters in kidney transplant patients on the Mediterranean diet
    Ewa Stachowska
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    J Ren Nutr 16:150-9. 2006
    ..The objective of the study was to assess whether neural networks can be a tool useful in the evaluation of the effect of the Mediterranean diet (MD) on the direction and dynamics of selected parameters...
  58. ncbi request reprint Effect of conjugated linoleic acids on the activity and mRNA expression of 5- and 15-lipoxygenases in human macrophages
    Ewa Stachowska
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland al Powstancow Wlkp 72, 70 111 Szczecin, Poland
    J Agric Food Chem 55:5335-42. 2007
    ..Linoleic acid induced 15-LO-1 expression (2.6 times, p < 0.05). CLAs may perform the function of an inhibitor of lipoxygenase 15-LO-1 activity in macrophages...
  59. doi request reprint Haptoglobin 2-1 phenotype predicts rapid growth of abdominal aortic aneurysms
    Ireneusz Wiernicki
    Department of Vascular Surgery and Angiology, Pomeranian Medical University, Szczecin, Poland
    J Vasc Surg 52:691-6. 2010
    ..Elastase and C-reactive protein (CRP) levels are elevated in patients with AAAs. This study assessed the relationship between AAA expansion and Hp phenotypes, neutrophil count, elastase, and CRP levels...
  60. doi request reprint Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease
    Urszula Adamiak
    Departments of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland
    Clin Neuropharmacol 33:135-41. 2010
    ....
  61. doi request reprint Lipoxygenase-derived hydroxyeicosatetraenoic acids--novel perioperative markers of early post-transplant allograft function?
    Barbara Dolegowska
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, al Powstancow Wielkopolskich 72, 70 111 Szczecin, Poland
    Nephrol Dial Transplant 25:4061-7. 2010
    ....
  62. doi request reprint Polymorphism of genes involved in purine metabolism (XDH, AOX1, MOCOS) in kidney transplant recipients receiving azathioprine
    Mateusz Kurzawski
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Poland
    Ther Drug Monit 34:266-74. 2012
    ....
  63. ncbi request reprint PEDF and VEGF plasma level alterations in patients with dry form of age-related degeneration--a possible link to the development of the disease
    Anna Machalinska
    Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland
    Klin Oczna 114:115-20. 2012
    ....
  64. doi request reprint Lack of association of interleukin-1 gene cluster polymorphisms with angiographically documented coronary artery disease: demonstration of association with hypertension in the Polish population
    Jarosław Goracy
    Clinic of Cardiology, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 42:426-32. 2011
    ..multivessel disease, MVD) and hypertension...
  65. pmc Neural stem/progenitor cells circulating in peripheral blood of patients with neovascular form of AMD: a novel view on pathophysiology
    Anna Machalinska
    Department of Histology and Embryology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Graefes Arch Clin Exp Ophthalmol 249:1785-94. 2011
    ..The purpose of this study was to investigate whether or not undifferentiated non-haematopoietic stem cells, including those capable of differentiating into neural phenotypes, play a role in the pathological state of CNV formation...
  66. ncbi request reprint Adenine nucleotides in snail muscles as one of biomarkers of fluoride toxicity
    Monika Rac
    Department of Biochemistry and Chemistry, Pomeranian Medical University, Szczecin, Poland
    J Environ Monit 7:631-4. 2005
    ..Determination of AMP or AEC in foot muscle of exposed snails seems to be a useful indicator of fluoride effects on metabolic activity...
  67. ncbi request reprint Elements of Mediterranean diet improve oxidative status in blood of kidney graft recipients
    Ewa Stachowska
    Department of Biochemistry and Chemistry, Pomeranian Medical University, Szczecin, Poland
    Br J Nutr 93:345-52. 2005
    ..MD appears to protect the erythrocytes against the action of free radicals, as reflected in the modified activities of some enzymes regulating the oxidative status of these blood cells...
  68. ncbi request reprint Effect of the ICAM1 and VCAM1 gene polymorphisms on delayed graft function and acute kidney allograft rejection
    Karolina Kłoda
    Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Ann Transplant 15:15-20. 2010
    ..The aim of this study was to examine the effect of ICAM1 and VCAM1 gene polymorphisms on the early period after kidney transplantation...
  69. doi request reprint The effect of ESR1 and ESR2 gene polymorphisms on the outcome of rheumatoid arthritis treatment with leflunomide
    Violetta Dziedziejko
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Pharmacogenomics 12:41-7. 2011
    ..In ESR1 and ESR2 genes, several polymorphisms have been detected. The aim of the present study was to examine the association between polymorphisms in the ESR1 and ESR2 genes and the response to treatment of RA patients with leflunomide...
  70. ncbi request reprint Effect of trimetazidine on the nucleotide profile in rat kidney with ischemia-reperfusion injury
    Leszek Domanski
    Department of Nephrology, Transplantology and Internal Medicine of Pomeranian Medical University, Szczecin, Powstancow Wlkp 72, 70 111 Szczecin, Poland
    Eur J Pharm Sci 27:320-7. 2006
    ..Moreover, significantly less pronounced acute tubular necrosis was observed in kidneys of rats treated with TMZ. These results suggest that trimetazidine protects against dephosphorylation of nucleotides and ischemic damage...
  71. doi request reprint Glucose metabolism parameters during an oral glucose tolerance test in patients with autosomal dominant polycystic kidney disease
    Maria Pietrzak-Nowacka
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Scand J Clin Lab Invest 70:561-7. 2010
    ....
  72. doi request reprint Different populations of circulating endothelial cells in patients with age-related macular degeneration: a novel insight into pathogenesis
    Anna Machalinska
    Department of Histology and Embryology, Pomeranian Medical University, Szczecin, Poland
    Invest Ophthalmol Vis Sci 52:93-100. 2011
    ....
  73. ncbi request reprint Renal handling of uric acid in patients with type 1 diabetes in relation to glycemic control
    Edyta Gołembiewska
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 36:32-5. 2005
    ..The aim of the study was to compare the renal handling of uric acid (UA) in 16 patients with type 1 diabetes without renal failure (age 34.8 +/- 13.3 years) and in 15 healthy subjects (age 34.9 +/- 12.6 years)...
  74. ncbi request reprint Interleukin-10 gene polymorphism in Parkinson's disease patients
    Monika Bialecka
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 38:858-63. 2007
    ..To prove this hypothesis, two DNA polymorphisms at IL-10 promoter (-1082 and -519) were examined in sporadic PD patients...
  75. doi request reprint Autosomal dominant polycystic kidney disease is not a risk factor for post-transplant diabetes mellitus. Matched-pair design multicenter study
    Maria Pietrzak-Nowacka
    Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 39:312-9. 2008
    ..The aim of our work was to compare the incidence of PTDM in kidney transplant recipients with and without autosomal dominant polycystic kidney disease (ADPKD) in a matched-pair design study...
  76. ncbi request reprint Inhibition of phospholipase A(2) activity by conjugated linoleic acids in human macrophages
    Ewa Stachowska
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Al Powstancow Wlkp 72, 70 111 Szczecin, Poland
    Eur J Nutr 46:28-33. 2007
    ..The consequence of this effect may be reduction of releasing the arachidonic acid (AA) from the cellular membranes of macrophages...
  77. ncbi request reprint Increased lipid peroxidation and ascorbic Acid utilization in testis and epididymis of rats chronically exposed to lead
    Mariola Marchlewicz
    Department of Histology and Embryology, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111, Szczecin, Poland
    Biometals 20:13-9. 2007
    ..The latter may have resulted from consumption of ascorbic acid for scavenging of ROS excess in tissues of animals chronically exposed to lead...
  78. ncbi request reprint Comparison of rat and human alkaline phosphatase isoenzymes and isoforms using HPLC and electrophoresis
    Violetta Dziedziejko
    Department of Biochemistry and Chemistry, Pomeranian Medical University, Al Powstancow Wlkp 72, 70 111 Szczecin, Poland
    Biochim Biophys Acta 1752:26-33. 2005
    ..Our HPLC method offers a higher resolution than agarose gel electrophoresis with respect to ALP subfractions in rat serum...
  79. doi request reprint Circulating stem cell populations in preterm infants: implications for the development of retinopathy of prematurity
    Anna Machalinska
    Department of Physiopathology, Pomeranian Medical University, 70 111 Szczecin, Poland
    Arch Ophthalmol 128:1311-9. 2010
    ....
  80. pmc Expression of p21WAF1 in Astler-Coller stage B2 colorectal cancer is associated with survival benefit from 5FU-based adjuvant chemotherapy
    Violetta Sulzyc-Bielicka
    Department of Clinical Oncology, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111, Szczecin, Poland
    Virchows Arch 458:431-8. 2011
    ..Expression of p21(WAF1) in colorectal tumor cells identifies a subgroup of Astler-Coller stage B2 patients who could benefit significantly from 5FU-based chemotherapy and may improve the selection of patients for adjuvant chemotherapy...
  81. ncbi request reprint 677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis
    Mateusz Kurzawski
    Pomeranian Medical University, Department of Pharmacology, ul Powstancow Wlkp 72 70 111 Szczecin, Poland
    Pharmacogenomics 8:1551-9. 2007
    ..Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and has been shown to be polymorphic, affecting the enzyme activity...