Research Topics
Genomes and Genes | Monika Puzianowska-KuznickaSummaryAffiliation: Medical University of Warsaw Country: Poland Publications
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Publications
[Genetic factors predisposing to the development of papillary thyroid cancer]Monika Puzianowska-Kuznicka
Department of Endocrinology, Medical Research Center, Warsaw
Endokrynol Pol 56:339-45. 2005..Progression from papillary to anaplastic cancer is most possibly caused by the occurrence of additional anomalies within P53, RAS, NM23,b-catenin gene and other genes...
Functionally impaired TR mutants are present in thyroid papillary cancerMonika Puzianowska-Kuznicka
Department of Endocrinology, Medical Research Center, Polish Academy of Sciences, 02 097 Warsaw, Poland
J Clin Endocrinol Metab 87:1120-8. 2002..These findings suggest a possible role for mutated thyroid hormone receptors in the tumorigenesis of human papillary thyroid carcinoma...
Thyroid hormones and their receptors in the regulation of cell proliferationMonika Puzianowska-Kuznicka
Department of Endocrinology, Medical Research Center, Polish Academy of Sciences, Warszawa, Poland
Acta Biochim Pol 53:641-50. 2006..Therefore, it is not possible to uniformly recommend T3 treatment or T3 depletion to stop or initiate proliferation of all cell types. Instead, a very individual and careful action should be considered...
Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?Monika Puzianowska-Kuznicka
Department of Endocrinology, Medical Research Center, Polish Academy of Sciences, 1A Banacha Street, 02 097 Warsaw, Poland
Int J Biochem Cell Biol 37:947-60. 2005..In this paper we present the clinical and molecular features of selected progeroid syndromes and describe the potential implications of these data for studies of ageing and cancer development...
p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoterMaciej Pietrzak
Department of Endocrinology, Medical Research Center, Polish Academy of Sciences, 02 106 Warsaw, Poland
Biol Chem 389:383-93. 2008..We propose a novel, promoter-based mechanism by which p53 down-regulates expression of the antiapoptotic MCL-1 protein...
Overexpression of E2F1 in clear cell renal cell carcinoma: a potential impact of erroneous regulation by thyroid hormone nuclear receptorsOlga Turowska
Department of Biochemistry and Molecular Biology, Medical Center of Postgraduate Education, 99 Marymoncka Street, Warsaw, Poland
Thyroid 17:1039-48. 2007..In summary, we show that ccRCC is characterized by the overexpression of E2F1, which is likely a result of a deregulated control of T3-dependent molecular processes...
Elevated cyclin E level in human clear cell renal cell carcinoma: possible causes and consequencesAlicja Nauman
Department of Biochemistry and Molecular Biology, Medical Center of Postgraduate Education, Warszawa, Poland
Acta Biochim Pol 54:595-602. 2007..The overexpression of cyclin E positively correlated with the decreasing degree of tumor differentiation, implicating a role for cyclin E in the promotion of tumorigenesis...
Aging is accompanied by a progressive decrease of expression of the WRN gene in human blood mononuclear cellsJacek Polosak
Department of Biochemistry and Molecular Biology, Medical Center of Postgraduate Education, Warsaw, Poland
J Gerontol A Biol Sci Med Sci 66:19-25. 2011..We suggest that age-related decrease of the WRN expression but not its common genetic variants might contribute to human immunosenescence...
Triiodothyronine utilizes phosphatidylinositol 3-kinase pathway to activate anti-apoptotic myeloid cell leukemia-1Maciej Pietrzak
Department of Endocrinology, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warsaw, Poland
J Mol Endocrinol 41:177-86. 2008..Therefore, MCL-1 expression is activated by T(3), which increases its promoter activity by a non-genomic mechanism using the PI3-K signal transduction pathway. We propose that this is another mechanism by which T(3) regulates apoptosis...
Vitamin D receptor binding to DNA is altered without the change in its expression in human renal clear cell cancerAgnieszka Madej
Department of Endocrinology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
Nephron Exp Nephrol 93:e150-7. 2003..It remains to be elucidated if altered VDR function due to its impaired binding to DNA contributes to the process of tumorigenesis, and what potential vitamin D-dependent mechanisms are involved in this process...
Total and high molecular weight adiponectin and level-modifying polymorphisms of ADIPOQ in centenariansMałgorzata Roszkowska-Gancarz
Department of Geriatrics and Gerontology, Medical Centre of Postgraduate Education, Warsaw, Poland
Endokrynol Pol 63:439-46. 2012..We checked if the expression and concentration-modifying polymorphisms of ADIPOQ are associated with extreme longevity...
The ER and ageing II: calcium homeostasisMonika Puzianowska-Kuznicka
Department of Endocrinology, Medical Research Center, Polish Academy of Sciences, 02 106 Warsaw, Poland
Ageing Res Rev 8:160-72. 2009..Disturbances of Ca(2+) homeostasis and of signaling are potential targets for intervention in aged humans...
ESR1 in myocardial infarctionMonika Puzianowska-Kuznicka
Department of Human Epigenetics, Mossakowski Medical Research Centre, Warsaw, Poland
Clin Chim Acta 413:81-7. 2012..An association of the common ESR1 -397T>C and -351A>G polymorphisms and of other polymorphisms with cardiovascular disease and with myocardial infarction is still not firmly established...
P53-dependent suppression of the human calcyclin gene (S100A6): the role of Sp1 and of NFkappaBWeronika Króliczak
Department of Biochemistry, Medical Center of Postgraduate Education, Warszawa, Poland
Acta Biochim Pol 55:559-70. 2008..Insufficient suppression of this gene by p53 mutants could well be responsible for calcyclin overexpression and cell cycle deregulation observed in cancer tissues...
Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevityJacek Polosak
Department of Biochemistry and Molecular Biology, Medical Center of Postgraduate Education, Warsaw, Poland
Biogerontology 11:287-97. 2010..In summary, we showed for the first time that both the XPD polymorphic variants and the decreased level of its expression might be associated with aging...
A bHLH transcriptional network regulating the specification of retinal ganglion cellsLidia Matter-Sadzinski
University of Lausanne, Eye Hospital Jules Gonin and Institute for Research in Ophthalmology, 15 avenue de France, 1004 Lausanne, Switzerland
Development 132:3907-21. 2005..This coordinated pattern initiates the transcription of ganglion cell-specific traits and determines the size of the ganglion cell population...
Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinomaYuji Kamiya
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4255, Bethesda, MD 20892 4255, USA
Carcinogenesis 23:25-33. 2002..These results indicate that the normal functions of TRs in RCCC tissues were impaired. Together with the aberrant expression patterns, these mutated TRs could contribute to the carcinogenesis of RCCC...
