J J Luszczki

Summary

Affiliation: Medical University
Country: Poland

Publications

  1. doi request reprint Effects of amlodipine, diltiazem, and verapamil on the anticonvulsant action of topiramate against maximal electroshock-induced seizures in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Can J Physiol Pharmacol 86:113-21. 2008
  2. ncbi request reprint How significant is the difference between drug doses influencing the threshold for electroconvulsions?
    Jarogniew J Łuszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 950 Lublin, Poland
    Pharmacol Rep 57:782-6. 2005
  3. ncbi request reprint 2-Chloro-N6-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure model
    Jarogniew J Łuszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 57:787-94. 2005
  4. ncbi request reprint Non-competitive metabotropic glutamate subtype 5 receptor antagonist (SIB-1893) decreases body temperature in rats
    Jarogniew J Łuszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 57:795-801. 2005
  5. doi request reprint Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves
    J J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    Adv Med Sci 54:75-81. 2009
  6. ncbi request reprint Biphasic characteristic of interactions between stiripentol and carbamazepine in the mouse maximal electroshock-induced seizure model: a three-dimensional isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
    Naunyn Schmiedebergs Arch Pharmacol 374:51-64. 2006
  7. ncbi request reprint Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:652-9. 2006
  8. ncbi request reprint 7-Nitroindazole enhances dose-dependently the anticonvulsant activities of conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:660-71. 2006
  9. ncbi request reprint Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 31:529-38. 2007
  10. ncbi request reprint Gabapentin synergistically interacts with topiramate in the mouse maximal electroshock seizure model: an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:944-54. 2006

Collaborators

Detail Information

Publications82

  1. doi request reprint Effects of amlodipine, diltiazem, and verapamil on the anticonvulsant action of topiramate against maximal electroshock-induced seizures in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Can J Physiol Pharmacol 86:113-21. 2008
    ....
  2. ncbi request reprint How significant is the difference between drug doses influencing the threshold for electroconvulsions?
    Jarogniew J Łuszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 950 Lublin, Poland
    Pharmacol Rep 57:782-6. 2005
    ..The application of log-probit method and linear regression analysis in the search for significant drug-dose effects should be substantially restricted to specific experimental conditions...
  3. ncbi request reprint 2-Chloro-N6-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure model
    Jarogniew J Łuszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 57:787-94. 2005
    ..125 mg/kg. It may be concluded that CCPA, acting selectively on adenosine A1 receptors, enhances pharmacodynamically the antiseizure effect of CBZ in the MES test...
  4. ncbi request reprint Non-competitive metabotropic glutamate subtype 5 receptor antagonist (SIB-1893) decreases body temperature in rats
    Jarogniew J Łuszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 57:795-801. 2005
    ..In contrast, the drug at 10 and 20 mg/kg remained without effect on the body temperature in rats. Based on our preclinical study, one can conclude that SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner...
  5. doi request reprint Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves
    J J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    Adv Med Sci 54:75-81. 2009
    ....
  6. ncbi request reprint Biphasic characteristic of interactions between stiripentol and carbamazepine in the mouse maximal electroshock-induced seizure model: a three-dimensional isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
    Naunyn Schmiedebergs Arch Pharmacol 374:51-64. 2006
    ....
  7. ncbi request reprint Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:652-9. 2006
    ..In conclusion, the acute exposure to CAF may diminish the antiseizure protection offered by ETS in epileptic patients. Therefore, patients treated with ETS should avoid CAF...
  8. ncbi request reprint 7-Nitroindazole enhances dose-dependently the anticonvulsant activities of conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:660-71. 2006
    ....
  9. ncbi request reprint Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 31:529-38. 2007
    ..Based on this preclinical study, one can ascertain that the combination of VGB with TGB would provide an adequate seizure control in epileptic patients...
  10. ncbi request reprint Gabapentin synergistically interacts with topiramate in the mouse maximal electroshock seizure model: an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:944-54. 2006
    ....
  11. ncbi request reprint Influence of NG-nitro-L-arginine on the anticonvulsant and acute adverse effects of some newer antiepileptic drugs in the maximal electroshock-induced seizures and chimney test in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:955-60. 2006
    ....
  12. ncbi request reprint Characterization of the anticonvulsant profile of isonicotinic acid benzylamide in various experimental seizure models in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Neurosci Lett 421:87-90. 2007
    ..p. administration), deserves more attention as a potential antiepileptic drug for patients in status epilepticus...
  13. doi request reprint Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
    Naunyn Schmiedebergs Arch Pharmacol 378:483-92. 2008
    ..At present, there are no recommendations to use this drug combination in epileptic patients...
  14. ncbi request reprint Dose-response relationship analysis of vigabatrin doses and their antinociceptive effects in the hot-plate test in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 60:409-14. 2008
    ....
  15. ncbi request reprint Effects of three calcium channel antagonists (amlodipine, diltiazem and verapamil) on the protective action of lamotrigine in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 59:672-82. 2007
    ..In conclusion, one can ascertain that the favorable combination of lamotrigine with amlodipine deserves more attention from a clinical viewpoint because of the enhanced antiseizure action of lamotrigine...
  16. doi request reprint Interactions of MRZ 2/576 with felbamate, lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    Pharmacology 81:259-65. 2008
    ..In conclusion, the isobolographic analysis revealed that MRZ 2/576 additively cooperates with newer antiepileptic drugs in terms of suppression of maximal electroshock-induced seizures in mice...
  17. ncbi request reprint Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 61:197-216. 2009
    ..These novel antiepileptic drugs undergo intensive clinical investigations to assess their efficacy and usefulness in the treatment of patients with refractory epilepsy...
  18. ncbi request reprint Effect of NG-nitro-L-arginine on the anticonvulsant action of four second-generation antiepileptic drugs in pentetrazole-induced clonic seizures in mice
    Jarogniew J Łuszczki
    Department of Pathophysiology, Medical Institute of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 59:467-73. 2007
    ..Based on this preclinical study, one can conclude that L-NA reduced the anticonvulsant activities of VGB and OXC in the mouse PTZ-induced seizure model. Only, GBP and TGB were resistant to the action of L-NA in this model...
  19. doi request reprint Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University, Lublin, Poland
    Naunyn Schmiedebergs Arch Pharmacol 379:163-79. 2009
    ..All remaining combinations of RTG with VPA, CBZ, and LTG were pharmacodynamic in nature. RTG synergistically interacted with VPA and exerted additive interaction with CBZ and LTG in the mouse MES model...
  20. doi request reprint Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Epilepsy Res 89:207-19. 2010
    ..The combinations of MeTHIQ with LTG, OXC and PGB were neutral in the mouse MES model...
  21. ncbi request reprint Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    Epilepsia 47:1841-54. 2006
    ....
  22. ncbi request reprint Preclinical profile of combinations of some second-generation antiepileptic drugs: an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Skubiszewski Medical University of Lublin, Lublin, Poland
    Epilepsia 45:895-907. 2004
    ....
  23. ncbi request reprint Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock
    Kinga K Borowicz
    Department of Pathophysiology, Medical University, Lublin, Poland
    Epilepsy Behav 11:6-12. 2007
    ..However, the concurrent pharmacokinetic interactions associated with remacemide complicate these observations and do not make remacemide a good candidate for adjunctive treatment of epilepsy...
  24. ncbi request reprint Tiagabine synergistically interacts with gabapentin in the electroconvulsive threshold test in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University, Lublin, Poland
    Neuropsychopharmacology 28:1817-30. 2003
    ..Combinations of TGB with GBP (very promising from a preclinical point of view) should be clinically verified for elaborating the most effective treatment regimen in patients with intractable seizures...
  25. ncbi request reprint Influence of aminophylline on the anticonvulsive action of gabapentin in the mouse maximal electroshock seizure threshold model
    J J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    J Neural Transm 114:1539-45. 2007
    ..The observed interaction between gabapentin and aminophylline in both acute and chronic experiments was pharmacodynamic in nature...
  26. ncbi request reprint Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Skubiszewski Medical University of Lublin, Lublin, Poland
    Epilepsia 46:344-55. 2005
    ....
  27. ncbi request reprint Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090, Lublin, Poland
    Naunyn Schmiedebergs Arch Pharmacol 372:41-54. 2005
    ..In contrast, during the combining of TGB with FBM, or TGB with LCZ, the utmost caution is advised because of their unfavourable profiles in this preclinical study...
  28. ncbi request reprint Isobolographic analysis of interaction between drugs with nonparallel dose-response relationship curves: a practical application
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090, Lublin, Poland
    Naunyn Schmiedebergs Arch Pharmacol 375:105-14. 2007
    ....
  29. doi request reprint Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis
    Monika Dudra-Jastrzebska
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    Eur J Pharmacol 605:87-94. 2009
    ..Levetiracetam in combination with tiagabine and vigabatrin appear to be neutral combinations producing only additivity in the mouse pentylenetetrazole model...
  30. ncbi request reprint Synergistic interaction of gabapentin and oxcarbazepine in the mouse maximal electroshock seizure model--an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Eur J Pharmacol 515:54-61. 2005
    ..Finally, based on preclinical data presented here the combination of oxcarbazepine and gabapentin is of particular importance for further therapy in patients with refractory partial seizures...
  31. ncbi request reprint Levetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: an isobolographic analysis in the mouse maximal electroshock model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego, Lublin, Poland
    Epilepsia 48:806-15. 2007
    ..The present study sought to ascertain the potential usefulness of levetiracetam (LEV) and felbamate (FBM) in combination in the mouse maximal electroshock (MES)-induced seizure model...
  32. doi request reprint Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model
    Monika Dudra-Jastrzebska
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Seizure 18:607-14. 2009
    ..The combinations of CZP with LEV (1:20,000); VPA and ETS with LEV (1:2); and PB with LEV (1:20) appear to be favorable combinations exerting supra-additive interactions in suppressing PTZ-induced seizures...
  33. doi request reprint Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model
    Ewa Wojda
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Epilepsy Res 86:163-74. 2009
    ..LEV is associated with favorable anticonvulsant synergism with PB and is additive with regards to CZP, OXC, TGB and VPA in the mouse 6 Hz psychomotor seizure model...
  34. ncbi request reprint Pharmacodynamic and pharmacokinetic characterization of interactions between levetiracetam and numerous antiepileptic drugs in the mouse maximal electroshock seizure model: an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    Epilepsia 47:10-20. 2006
    ..Brain AED concentrations were determined to ascertain any pharmacokinetic contribution to the observed antiseizure effect...
  35. doi request reprint Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, Lublin, Poland
    Epilepsy Res 90:188-98. 2010
    ..In contrast, the antagonism between STP and VPA was surprising since synergism is observed clinically...
  36. ncbi request reprint 7-Nitroindazole potentiates the anticonvulsant action of some second-generation antiepileptic drugs in the mouse maximal electroshock-induced seizure model
    J J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    J Neural Transm 113:1157-68. 2006
    ....
  37. ncbi request reprint Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Epilepsy Behav 7:639-51. 2005
    ..75-0.91) used in this study. However, these conclusions are confounded by the fact that LCZ is associated with significant pharmacokinetic interactions...
  38. ncbi request reprint 2-phosphonomethyl-pentanedioic acid (glutamate carboxypeptidase II inhibitor) increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Eur J Pharmacol 531:66-73. 2006
    ..Unfortunately, the favourable interaction between 2-PMPA and valproate was associated with a pharmacokinetic increase in total brain valproate concentrations...
  39. doi request reprint Interactions between tiagabine and conventional antiepileptic drugs in the rat model of complex partial seizures
    K K Borowicz
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Neural Transm 115:661-7. 2008
    ....
  40. doi request reprint Indapamide enhances the protective action of carbamazepine, phenobarbital, and valproate against maximal electroshock-induced seizures in mice
    J Kozinska
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    Adv Med Sci 54:66-74. 2009
    ....
  41. ncbi request reprint Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Skubiszewski Medical University, Lublin, Poland
    Neuropsychopharmacology 30:958-73. 2005
    ....
  42. ncbi request reprint Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Eur J Pharmacol 547:65-74. 2006
    ..To elucidate the protective role of cannabinoids in the brain during seizures, more advanced neurochemical studies are required...
  43. doi request reprint Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090, Lublin, Poland
    J Neural Transm 116:57-66. 2009
    ....
  44. ncbi request reprint Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy
    Kinga K Borowicz
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Epilepsia 44:640-6. 2003
    ..The objective of this study was to evaluate the interaction of the novel antiepileptic drug (AED), topiramate (TPM), with conventional AEDs against amygdala-kindled seizures in rats and pentylenetetrazol-induced convulsions in mice...
  45. doi request reprint Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090, Lublin, Poland
    J Neural Transm 115:1485-94. 2008
    ..It seems that modulation of AGM concentration in the brain may occur favorable in further clinical practice...
  46. doi request reprint N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    Neurosci Res 64:267-72. 2009
    ..The combinations of AMIPPS with carbamazepine and phenytoin are neutral from a preclinical viewpoint...
  47. doi request reprint Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves
    J J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    Adv Med Sci 55:43-52. 2010
    ....
  48. ncbi request reprint Isobolographic and subthreshold methods in the detection of interactions between oxcarbazepine and conventional antiepileptics--a comparative study
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Epilepsy Res 56:27-42. 2003
    ..The former clearly and adequately detects the exact types of interactions between two AEDs, becoming a potent and powerful paradigm for further studies evaluating the character of interactions among AEDs...
  49. ncbi request reprint Synergistic interaction of gabapentin with tiagabine in the hot-plate test in mice: an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 61:459-67. 2009
    ..If the results from this study could be extrapolated to clinical settings, the combination of tiagabine with gabapentin might be beneficial for pain relief in humans...
  50. doi request reprint Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 34:18-25. 2010
    ..The combinations of ACEA and PMSF with carbamazepine, lamotrigine, oxcarbazepine, phenytoin, and topiramate are neutral from a preclinical viewpoint...
  51. ncbi request reprint Influence of agmatine on the protective action of numerous antiepileptic drugs against pentetrazole-induced seizures in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 61:252-60. 2009
    ..Therefore, the utmost caution is advised when combining agmatine with vigabatrin in further clinical settings...
  52. ncbi request reprint Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis
    Jarogniew J Luszczki
    Departments of Pathophysiology, Medical University Isotope Laboratory, Institute of Agricultural Medicine, Jaczewskiego, Lublin, Poland
    Epilepsia 44:1003-13. 2003
    ..The study investigated the types of interactions between lamotrigine (LTG) and first-generation antiepileptic drugs (AEDs) or topiramate (TPM) with isobolographic analysis...
  53. ncbi request reprint Interactions between oxcarbazepine and conventional antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University, Jaczewskiego, Lublin, Poland
    Epilepsia 44:489-99. 2003
    ....
  54. ncbi request reprint Furosemide potentiates the anticonvulsant action of valproate in the mouse maximal electroshock seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Epilepsy Res 76:66-72. 2007
    ....
  55. ncbi request reprint Imperatorin enhances the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Eur J Pharmacol 574:133-9. 2007
    ....
  56. doi request reprint Isobolographic analysis of interactions between 1-methyl-1,2,3,4-tetrahydroisoquinoline and four conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
    Eur J Pharmacol 602:298-305. 2009
    ..The supra-additive interaction of MeTHIQ with phenobarbital against maximal electroshock-induced seizures makes their combination of pivotal importance from a clinical viewpoint...
  57. ncbi request reprint Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090, Lublin, Poland
    Naunyn Schmiedebergs Arch Pharmacol 373:169-81. 2006
    ..Furthermore, the fact that LCZ and PB have similar mechanisms of action would suggest that drugs with similar mechanisms of action may provide rational polytherapy regimens...
  58. ncbi request reprint Pharmacokinetic and pharmacodynamic interactions of aminophylline and topiramate in the mouse maximal electroshock-induced seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Eur J Pharmacol 562:53-9. 2007
    ....
  59. ncbi request reprint Interaction between lamotrigine and felbamate in the maximal electroshock-induced seizures in mice: an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Skubiszewski Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Eur Neuropsychopharmacol 15:133-42. 2005
    ....
  60. doi request reprint Synergistic interaction of gabapentin with tiagabine in the formalin test in mice: an isobolographic analysis
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Eur J Pain 13:665-72. 2009
    ..If the results from this study could be extrapolated to clinical settings, the combination of tiagabine with gabapentin might be beneficial in the pain relief in humans...
  61. ncbi request reprint Is a hypothermic effect of LY300164, valproate and phenobarbital evident in mice?
    M J Swiader
    Department of Pharmacology and Toxicology, Medical University of Lublin, Poland
    Rocz Akad Med Bialymst 49:270-4. 2004
    ..The aim of this study was to evaluate the influence of LY300164 (an AMPA/kainate receptor antagonist) administered alone or in combination with valproate (VPA) or phenobarbital (PB) on body temperature in mice...
  62. doi request reprint Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: a comparative study
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Epilepsy Res 85:293-9. 2009
    ....
  63. ncbi request reprint Levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the rotarod test in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
    Eur Neuropsychopharmacol 15:609-16. 2005
    ..These data support both experimental and clinical published data advocating that LEV may interact with some AEDs by pharmacodynamic mechanisms...
  64. ncbi request reprint 1-Methyl-1,2,3,4-tetrahydroisoquinoline enhances the anticonvulsant action of carbamazepine and valproate in the mouse maximal electroshock seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
    Neuropharmacology 50:133-42. 2006
    ..The antiseizure properties of 1-MeTHIQ (an endogenous parkinsonism-preventing substance) and its exact physiological role in the brain need extensive examination in further neuropharmacological studies...
  65. doi request reprint Pharmacodynamic and pharmacokinetic interactions between common antiepileptic drugs and acetone, the chief anticonvulsant ketone body elevated in the ketogenic diet in mice
    Iwona Zarnowska
    Department of Pathophysiology, Medical University, Lublin, Poland
    Epilepsia 50:1132-40. 2009
    ..Therefore, we investigated whether acetone could affect the anticonvulsant activity and pharmacokinetic properties of several AEDs against maximal electroshock (MES)-induced seizures in mice...
  66. ncbi request reprint Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University, Jaczewskiego 8, 20 090 Lublin, Poland
    Naunyn Schmiedebergs Arch Pharmacol 369:434-46. 2004
    ....
  67. ncbi request reprint Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice
    Kinga K Borowicz
    Department of Pathophysiology, Lublin Medical University School, Lublin, Poland
    Epilepsia 45:1176-83. 2004
    ....
  68. doi request reprint Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University, Lublin, Poland
    Eur J Pharmacol 595:13-21. 2008
    ..Vigabatrin and gabapentin have a favorable pharmacodynamic interaction in animal seizure models in the absence of acute adverse effects or concurrent pharmacokinetic changes...
  69. ncbi request reprint Interactions between zonisamide and conventional antiepileptic drugs in the mouse maximal electroshock test model
    Kinga K Borowicz
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Eur Neuropsychopharmacol 17:265-72. 2007
    ..Finally, one can conclude that because of the synergistic pharmacodynamic interaction between ZNS and VPA, this combination might be useful in clinical practice...
  70. ncbi request reprint Chronically administered fluoxetine enhances the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model
    Kinga K Borowicz
    Department of Pathophysiology, Lublin Medical University, Jaczewskiego 8, 20 090 Lublin, Poland
    Eur J Pharmacol 567:77-82. 2007
    ..In conclusion, long-term treatment with fluoxetine exhibited some favorable effects on the anticonvulsant properties of conventional antiepileptic drugs, resulting, however, from pharmacokinetic interactions...
  71. ncbi request reprint Interactions between two enantiomers of losigamone and conventional antiepileptic drugs in the mouse maximal electroshock model--an isobolographic analysis
    Kinga K Borowicz
    Department of Pathophysiology, Medical University, Lublin, Poland
    Eur J Pharmacol 567:110-6. 2007
    ..In conclusion, the present results suggest both AO-242 and AO-294 as promising candidate drugs in the add-on therapy of refractory epilepsy...
  72. ncbi request reprint Influence of imperatorin on the anticonvulsant activity and acute adverse-effect profile of lamotrigine in maximal electroshock-induced seizures and chimney test in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 60:566-73. 2008
    ..The combination of LTG with IMPcan be of pivotal importance for epileptic patients as a potentially advantageous combination if it is proven that the results of this study can be extrapolated to clinical settings...
  73. ncbi request reprint Time-course and dose-response relationships of imperatorin in the mouse maximal electroshock seizure threshold model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Neurosci Res 59:18-22. 2007
    ..Based on this study, one can conclude that imperatorin produces the anticonvulsant effect in the maximal electroshock seizure threshold test in a dose-dependent manner...
  74. ncbi request reprint Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model
    Kinga K Borowicz
    Experimental Neuropathophysiology Unit, Department of Pathophysiology, Lublin Medical University, Jaczewskiego 8, 20 090, Lublin, Poland
    Psychopharmacology (Berl) 195:167-74. 2007
    ..Epilepsy often coexists with depression. Therefore, the probability of simultaneous treatment with antiepileptics and antidepressants and the possibility of interactions between them are relatively high...
  75. ncbi request reprint Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock
    Kinga K Borowicz
    Department of Pathophysiology, Medical University, Lublin, Poland
    Eur J Pharmacol 573:111-5. 2007
    ..Our findings show that cholecalciferol may play an anticonvulsant role in the brain and can influence the efficacy of antiepileptic drugs, at least in experimental conditions...
  76. ncbi request reprint Three-dimensional isobolographic analysis of interactions between lamotrigine and clonazepam in maximal electroshock-induced seizures in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Skubiszewski Medical University of Lublin, Jaczewskiego 8, 20 950 Lublin, Poland
    Naunyn Schmiedebergs Arch Pharmacol 370:369-80. 2004
    ..In this study, some important problems and assumptions related to statistical analysis of data in 3D isobolography are discussed...
  77. ncbi request reprint Effect of lamotrigine combined with felbamate on the horizontal (ambulatory) activity in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Skubiszewski Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 59:235-40. 2004
    ..Felbamate administered alone or combined with lamotrigine considerably impaired exploratory and spontaneous locomotor activities of the animals tested in terms of horizontal activity...
  78. ncbi request reprint Influence of LY 300164 alone or in combination with carbamazepine or diphenylhydantoin on the body temperature in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Skubiszewski Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 59:241-6. 2004
    ....
  79. ncbi request reprint Isobolographic analysis of interactions between losigamone and conventional antiepileptic drugs in the mouse maximal electroshock model
    Kinga K Borowicz
    Department of Pathophysiology, Lublin Medical University, Jaczewskiego 8, 20 090 Lublin, Poland
    Eur Neuropsychopharmacol 17:94-101. 2007
    ....
  80. ncbi request reprint Anticonvulsant and acute adverse effect profiles of picolinic acid 2-fluoro-benzylamide in various experimental seizure models and chimney test in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Fundam Clin Pharmacol 22:69-74. 2008
    ..p. administration), deserves more attention as a potential antiepileptic drug for status epilepticus patients...
  81. ncbi request reprint [Neuroprotective activity of antiepileptic drugs]
    Katarzyna Czuczwar
    Katedra i Zakład Patofizjologii, Akademia Medyczna im F Skubiszewskiego, Lublin
    Przegl Lek 61:1268-71. 2004
    ..Recently, topiramate has been documented to exert potent neuroprotective action in human oligodendrocytes exposed to hypoxic-ischemic damage...
  82. ncbi request reprint Modified western blot technique in fast detection of heme oxygenase (HO-1/HO-2) in various tissues and organs of experimental animals
    Marta M Andres
    Isotope Laboratory, Institute of Agricultural Medicine, Lublin
    Ann Univ Mariae Curie Sklodowska Med 59:298-302. 2004
    ..In conclusion, our modified western blot method permits the fast detection of HO that may be useful in further more advanced quantitative studies...