Research Topics
Genomes and GenesSpecies | Włodzimierz LuczyńskiSummaryAffiliation: Medical University Country: Poland Publications
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Publications
Generation of functional T-regulatory cells in children with metabolic syndromeWłodzimierz Luczyński
Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Białystok, Waszyngtona 17, 15 274, Białystok, Poland
Arch Immunol Ther Exp (Warsz) 60:487-95. 2012..The results of our study could be used in the design of therapeutic interventions in obesity associated immunologic disturbances...
The association of the FTO rs9939609 polymorphism with obesity and metabolic risk factors for cardiovascular diseases in Polish childrenW Luczynski
Department of Pediatrics, Endocrinology and Diabetes with a Cardiology Unit, Medical University of Bialystok, Bialystok, Poland
J Physiol Pharmacol 63:241-8. 2012..The potential effect on the remaining cardiovascular risk factors seems indirect and dependent on BMI changes. The polymorphism may be independently associated with insulin resistance...- [Polymorphism rs9939609 of FTO gene is related to the body mass index in children from Podlaskie voievodship]Magdalena Tercjak-Rećko
Klinika Pediatrii, Endokrynologii z Pododdziałem Kardiologii UM w Białymstoku, Białystok
Med Wieku Rozwoj 16:53-60. 2012..One of the genes probably related to the body weight is the Fat Mass and Obesity Associated Gene (FTO)... - Generation of T regulatory cells in children with newly diagnosed type 1 diabetes mellitusW Łuczyński
Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Poland
Exp Clin Endocrinol Diabetes 120:101-9. 2012..IN SUMMARY: Despite some disturbances at mRNA level in the critical gene expression, the suppressive properties of induced Treg cells from diabetic and control children were effective... - Transformation of conventional T cells into regulatory T cells in children with metabolic syndromeWłodzimierz Luczyński
Department of Paediatrics, Endocrinology and Diabetes with a Cardiology Unit, Medical University in Bialystok, Bialystok, Poland
Kardiol Pol 69:1221-6. 2011..Numerous data suggest that the decreased number and/or function of regulatory T cells (Treg cells) can lead to chronic minimal inflammation present in patients with obesity and trigger formation of atherosclerotic plaque... - Acute lymphoblastic leukemia-derived dendritic cells express tumor associated antigens: PNPT1, PMPCB, RHAMM, BSG and ERCC1W Luczynski
Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland
Neoplasma 56:428-34. 2009..CD40L stimulation leading to the differentiation of leukemic cells into DCs which combine both antigen presenting function and expression of tumor associated antigens represents an interesting approach in cancer immunotherapy... - [The assessment of T regulatory cells in the peripheral blood of children with metabolic syndrome]Włodzimierz Łuczyński
Uniwersytet Medyczny w Białymstoku, II Klinika Chorób Dzieci
Pol Merkur Lekarski 27:453-7. 2009..It is possible that they play a role in a pathogenesis of chronic inflammation accompanying obesity. THE AIM OF THE STUDY was to determine the percentages of T regulatory cells in children with metabolic syndrome... - [Higher percentages of T regulatory cells in children at risk for developing type 1 diabetes mellitus]Włodzimierz Luczyński
II Klinika Chorob Dzieci Uniwersytetu Medycznego w Bialymstoku
Pediatr Endocrinol Diabetes Metab 16:7-10. 2010..The last decade revealed some evidence of the participation of T regulatory lymphocytes - cells which suppress immune response - in the pathogenesis of type 1 diabetes and prediabetes... - The mRNA expression of pro- and anti-inflammatory cytokines in T regulatory cells in children with type 1 diabetesWłodzimierz Łuczyński
Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Białystok, Białystok, Poland
Folia Histochem Cytobiol 48:93-100. 2010..Further studies with the goal of developing new strategies to potentiate Treg function in autoimmune diseases are warranted... - [Overweight, obesity and metabolic syndrome in children with type 1 diabetes melllitus]Włodzimierz Luczyński
Klinika Pediatrii, Endokrynologii, Diabetologii z Pododdzialem kardiologii Uniwersytetu Medycznego w Białymstoku ul Waszyngtona, Białystok
Pediatr Endocrinol Diabetes Metab 16:83-8. 2010..Aim of the study was the assessment of overweight, obesity and other elements of the metabolic syndrome in children with type 1 diabetes mellitus... - Overweight, obesity and features of metabolic syndrome in children with diabetes treated with insulin pump therapyWłodzimierz Łuczyński
Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Białystok, Białystok, Poland
Eur J Pediatr 170:891-8. 2011..Our study shows a high prevalence of overweight/obesity and dyslipidemia in children with T1DM including those treated with an insulin pump... - Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetesWłodzimierz Łuczyński
IInd Department of Pediatrics, Medical University of Białystok, Białystok, Poland
Acta Biochim Pol 56:361-70. 2009..The results of our study should be used in future research in the field of immunotherapy in pediatric diabetes... - [The role of T-regulatory cells in the pathogenesis of immunological disturbances accompanying obesity and atherosclerosis]Włodzimierz Luczyński
Klinika Pediatrii, Endokrynologii, Diabetologii z Pododdziałem Kardiologii, Uniwersytetu Medycznego w Białymstoku, Ul Waszyngtona 17, 15 274 Białystok
Postepy Hig Med Dosw (Online) 64:156-60. 2010..The results of experiments performed so far are encouraging and give some hope for the future use of T-regulatory cells in the therapy of obesity and atherosclerosis... - CD40 stimulation induces differentiation of acute lymphoblastic leukemia cells into dendritic cellsWłodzimierz Luczyński
Department of Pediatric Oncology, Medical University of Białystok, Poland
Acta Biochim Pol 53:377-82. 2006..These results confirm the possibility of enhancing the immunogenicity of ALL cells with the CD40L system and indicate that this approach can be used in immunotherapeutic trials... - [Experimental and selected clinical aspects of active immunotherapy in leukemia]Włodzimierz Luczyński
Klinika Onkologii Dzieciecej Samodzielnego Publicznego Dzieciecego Szpitala Klinicznego, Akademii Medycznej w Białymstoku
Postepy Hig Med Dosw (Online) 60:379-86. 2006..Clinical experience with such vaccines is limited, but the results of some preliminary reports are quite promising. Cancer vaccines are safe, result in host response, and probably prolong patients survival... - Acute lymphoblastic leukaemia cells express CCR7 but not higher amounts of IL-10 after CD40 ligationW Luczynski
Department of Pediatric Hematology, Medical University in Białystok, Poland
Scand J Clin Lab Invest 66:695-703. 2006..This time we assess the cytokine and chemokine gene expression profile in CD40-stimulated ALL cells... - Upregulation of antigen-processing machinery components at mRNA level in acute lymphoblastic leukemia cells after CD40 stimulationWłodzimierz Luczyński
Department of Pediatric Oncology, Medical University of Białystok, Bialystok, Poland
Ann Hematol 86:339-45. 2007..This confirms specific stimulation of the antigen-processing system in ALL cells by CD40L. Future work should focus on the clinical significance of these findings for immunotherapy in leukemias... - Immature reticulocyte fraction (IRF)--an universal marker of hemopoiesis in children with cancer?W Luczynski
Department of Pediatric Oncology, Medical University of Białystok, al Waszyngtona 17, 15 274 Białystok, Poland
Adv Med Sci 51:188-90. 2006..The amount of RNA in these cells can be assessed with flow cytometry and divided into low- (LFR), middle- (MFR) and high-fluorescence reticulocytes (HFR). This distribution is correlated with their maturation... - CD40L and IL-4 stimulation of acute lymphoblastic leukemia cells results in upregulation of mRNA level of FLICE--an important component of apoptosisWłodzimierz Łuczyński
Departments of Pediatric Hematology and Oncology, Medical University in Białystok, Poland
Folia Histochem Cytobiol 45:15-20. 2007..Concluding, we showed upregulation of important elements of apoptosis at mRNA level in ALL cells after CD40 ligation... - B-cell chronic lymphocytic leukemia-derived dendritic cells stimulate allogeneic T-cell response and express chemokines involved in T-cell migrationW Łuczyński
Department of Pediatric Oncology, Medical University of Białystok, Poland
Neoplasma 54:527-35. 2007..Conclusions: our experiment confirm that B-CLL cells can be turned into dendritic-like cells, additionally, these cells express chemokines involved in T-cell migration and stimulate allogeneic response... - [Myeloid-derived suppressor cells - the new mechanism of immunosuppression in cancer]Włodzimierz Luczyński
Klinika Onkologii Dzieciecej, Ul Waszyngtona 17, 15 274 Białystok
Postepy Hig Med Dosw (Online) 62:18-22. 2008..The elucidation of MDSC characteristics can allow us to build new immunotherapeutic protocols in the future... - Lower percentages of T regulatory cells in children with type 1 diabetes - preliminary reportWłodzimierz Luczyński
IInd Department of Pediatrics, Medical University of Białystok, Poland
Pediatr Endocrinol Diabetes Metab 15:34-8. 2009..The aim of study was to determine the percentages and numbers of T regulatory cells in the peripheral blood of children with type 1 diabetes... - [Generation of T regulatory cells in children with type 1 diabetes mellitus]Włodzimierz Luczyński
klinica pediatrii, Endokrynologii, Diabetologii z Pododdzialem Kardiologii Uniwersytetu Medycznego w Bialymstoku
Pediatr Endocrinol Diabetes Metab 17:64-70. 2011..Additionally, we assessed the changes in the expression of selected genes essential for the function of these cells during Tregs generation... - Assessment of selected co-stimulatory, adhesion and activatory molecules and cytokines of Th(1)/Th(2) balance in acute lymphoblastic leukemia in childrenWłodzimierz Luczyński
Department of Pediatric Oncology, Medical University of Białystok, Poland
Arch Immunol Ther Exp (Warsz) 53:357-63. 2005..The aim of our study was to assess the function of T lymphocytes in children with acute lymphoblastic leukemia (ALL) during remission induction based on selected cytokine and co-stimulatory/activatory molecule expression... - Lower expression of mRNA for interferon-gamma in T helper cells of children with newly diagnosed lymphomasWłodzimierz Luczyński
Department of Pediatric Hematology and Oncology, Medical University, Bialystok, Poland
Folia Histochem Cytobiol 43:169-71. 2005..Comparing to the control group, we found lower expression of mRNA for IFN-gamma in CD4+ cells at the time of lymphoma diagnosis. It may be one of the pathogenetic mechanisms of impaired immunity in these patients... - [Asymmetric dimethylarginine (ADMA) in children with diabetes type 1]Barbara Głowińska-Olszewska
Klinika Pediatrii, Endokrynologii, Diabetologii z Pododdzialem Kardiologii Uniwersytetu Medycznego w Bialymstoku
Pediatr Endocrinol Diabetes Metab 16:137-41. 2010..The aim of the study was to evaluate ADMA level in children with DM1, without clinical evidence of vascular complications, with particular attention to additional cardiovascular risk factors (hypertension, obesity, hyperlipidemia)... - [Do the regulatory T cells play a role in the pathogenesis and therapy of type 1 diabetes?]Włodzimierz Luczyński
II Klinika Chorób Dzieci, Uniwersytetu Medycznego w Białymstoku
Pediatr Endocrinol Diabetes Metab 15:41-4. 2009..It is possible that further research will allow to use the immunotherapy including T regulatory cells in type 1 diabetes... - [Endothelial progenitor cells as a new marker of endothelial function with respect to risk of cardiovascular disorders]Barbara Głowińska-Olszewska
Klinika Pediatrii, Endokrynologii, Diabetologii z Pododdziałem Kardiologii, Uniwersytet Medyczny w Białymstoku
Postepy Hig Med Dosw (Online) 65:8-15. 2011..The potential possibilities of increasing EPC number and function as well as the use of EPC in the treatment of vascular pathology will also be discussed... - Low frequency of regulatory T cells in the peripheral blood of children with type 1 diabetes diagnosed under the age of fiveAgnieszka Szypowska
Department of Pediatrics, Medical University of Warsaw, Poland
Arch Immunol Ther Exp (Warsz) 60:307-13. 2012..Understanding the differences of immune system activity in the young diabetic children would open the way to identify children at risk for T1D and enables the use of novel forms of intervention... - Subclinical cardiovascular system changes in obese patients with juvenile idiopathic arthritisBarbara Głowińska-Olszewska
Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Waszyngtona 17 Street, 15 274 Białystok, Poland
Mediators Inflamm 2013:436702. 2013..Thus, medical care of children with JIA should include strategies preventing cardiovascular disease by maintenance of adequate body weight...