Małgorzata Latocha


Affiliation: Medical University of Silesia
Country: Poland


  1. Morak Młodawska B, Pluta K, Latocha M, Jeleń M, Kusmierz D. Synthesis, Anticancer Activity, and Apoptosis Induction of Novel 3,6-Diazaphenothiazines. Molecules. 2019;24: pubmed publisher
    ..The transformation of the propynyl substituent into amino-2-butynyl can be a method applicable to the search for more anticancer-active azaphenothiazines. ..
  2. Kadela M, Jastrzebska M, Bębenek E, Chrobak E, Latocha M, Kusz J, et al. Synthesis, Structure and Cytotoxic Activity of Mono- and Dialkoxy Derivatives of 5,8-Quinolinedione. Molecules. 2016;21:156 pubmed publisher
    ..Most of the compounds showed higher cytotoxicity than the starting compound, 6,7-dichloro-5,8-quinolinedione, and cisplatin, which was used as a reference agent. ..
  3. Chrobak E, Bębenek E, Kadela Tomanek M, Latocha M, Jelsch C, Wenger E, et al. Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity. Molecules. 2016;21: pubmed publisher
    ..All new compounds were tested in vitro for their antiproliferative activity against human T47D (breast cancer), SNB-19 (glioblastoma), and C32 (melanoma) cell lines. ..
  4. Zieba A, Latocha M, Sochanik A, Nycz A, Kusmierz D. Synthesis and In Vitro Antiproliferative Activity of Novel Phenyl Ring-Substituted 5-Alkyl-12(H)-quino[3,4-b][1,4]benzothiazine Derivatives. Molecules. 2016;21: pubmed
    ..Finally, the ability of the selected compounds to bind DNA was checked in the presence of ethidium bromide. ..
  5. Marciniec K, Pawełczak B, Latocha M, Skrzypek L, Maciążek Jurczyk M, Boryczka S. Synthesis, Anti-Breast Cancer Activity, and Molecular Docking Study of a New Group of Acetylenic Quinolinesulfonamide Derivatives. Molecules. 2017;22: pubmed publisher
    ..These data indicate that some of the title compounds display significant cytotoxic activity, possibly targeting the CYPs pathways. ..
  6. Kadela Tomanek M, Bębenek E, Chrobak E, Latocha M, Boryczka S. Alkoxy and Enediyne Derivatives Containing 1,4-Benzoquinone Subunits-Synthesis and Antitumor Activity. Molecules. 2017;22: pubmed publisher
    ..The synthesized derivatives fulfill the Lipinski Rule of Five and have low permeability through the blood-brain barrier. ..
  7. Bębenek E, Jastrzebska M, Kadela Tomanek M, Chrobak E, Orzechowska B, Zwolinska K, et al. Novel Triazole Hybrids of Betulin: Synthesis and Biological Activity Profile. Molecules. 2017;22: pubmed publisher
    ..i>Klebsiellapneumoniae and Escherichia coli (minimal inhibitory concentration (MIC) range of 0.95-1.95 μM). ..