M Kurzawski

Summary

Affiliation: Medical University
Country: Poland

Publications

  1. pmc Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus
    Mateusz Kurzawski
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 68:1587-94. 2012
  2. pmc Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Bla Straket 15, 413 45 Gothenburg, Sweden
    BMC Med Genet 11:36. 2010
  3. doi request reprint Polymorphism of matrix metalloproteinase genes (MMP1 and MMP3) in patients with varicose veins
    M Kurzawski
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Clin Exp Dermatol 34:613-7. 2009
  4. doi request reprint TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, Szczecin 70 111, Poland
    Eur J Clin Pharmacol 65:533-40. 2009
  5. ncbi request reprint Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon cancer patients
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Powstańców Wlkp 72 str, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 61:389-94. 2005
  6. ncbi request reprint The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Ther Drug Monit 27:435-41. 2005
  7. ncbi request reprint Frequencies of the common promoter polymorphisms in cytokine genes in a Polish population
    M Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Int J Immunogenet 32:285-91. 2005
  8. doi request reprint Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth
    A Drozdzik
    Department of Periodontology, Pomeranian Medical University, Szczecin, Poland
    J Periodontal Res 45:143-7. 2010
  9. ncbi request reprint The effect of 677C>T and 1298A>C MTHFR polymorphisms on sulfasalazine treatment outcome in rheumatoid arthritis
    A Pawlik
    Department of Pharmacology, Pomeranian Medical University, 70 111 Szczecin, Poland
    Braz J Med Biol Res 42:660-4. 2009
  10. doi request reprint Interleukin-18 gene (IL18) promoter polymorphisms in patients with rheumatoid arthritis
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland
    Scand J Rheumatol 38:159-65. 2009

Collaborators

  • T Sulikowski
  • Jan Lubinski
  • J Rozanski
  • Janina Suchy
  • Grzegorz Kurzawski
  • Monika Bialecka
  • Eng King Tan
  • Andrzej Oko
  • M Drozdzik
  • Leszek Domanski
  • A Pawlik
  • Andrzej Pawlik
  • V Dziedziejko
  • A Drozdzik
  • K Safranow
  • M Kozak
  • Z Juzyszyn
  • J Banach
  • B Gawronska-Szklarz
  • M Herczynska
  • Malin von Otter
  • Zygmunt Juzyszyn
  • Wanda Gornik
  • Lilianna Bartnicka
  • B Czerny
  • Magdalena Herczynska
  • Maria Chrzanowska
  • Barbara Gawronska-Szklarz
  • A Wajda
  • M Lipski
  • D Chlubek
  • J Lapczuk
  • K Dziewanowski
  • Ola Hammarsten
  • Kaj Blennow
  • Dragana Celojevic
  • Michael Nilsson
  • Staffan Nilsson
  • Sara Landgren
  • Petra Bergström
  • Henrik Zetterberg
  • Anna Håkansson
  • Hans Nissbrandt
  • A Lener
  • W Gornik
  • Z Borowiec-Chłopek
  • Agnieszka Lener
  • S Giedrys-Kalemba
  • A Modrzejewski
  • Andrzej Modrzejewski
  • T Szczepanik
  • M Adamska
  • Edyta Plonska-Gosciniak
  • M Kaminski
  • P Kusnierczyk
  • Agnieszka Drozdzik
  • Ewa Dabrowska-Zamojcin
  • Marta Mazik
  • K Safronow
  • Stanisław Czekalski
  • M Florczak
  • B Gawronska Szklarz
  • Barbara Gawronska Szklarz
  • Bogusław Machaliński
  • Magdalena Baskiewicz-Masiuk

Detail Information

Publications44

  1. pmc Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus
    Mateusz Kurzawski
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 68:1587-94. 2012
    ..Here we report the results of our study on the potential effect of single nucleotide polymorphisms (SNPs) previously associated with T2DM on the risk of NODAT in kidney transplant patients medicated with tacrolimus...
  2. pmc Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Bla Straket 15, 413 45 Gothenburg, Sweden
    BMC Med Genet 11:36. 2010
    ..Here, we hypothesize that variation in NFE2L2 and KEAP1, the genes encoding the two major regulators of the phase II response, may affect the risk of Parkinson's disease...
  3. doi request reprint Polymorphism of matrix metalloproteinase genes (MMP1 and MMP3) in patients with varicose veins
    M Kurzawski
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Clin Exp Dermatol 34:613-7. 2009
    ..Extracellular matrix composition, predominantly maintained by matrix metalloproteinases (MMPs), may affect the vein-wall structure, which may lead to dilation of vessels and cause varicosities...
  4. doi request reprint TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, Szczecin 70 111, Poland
    Eur J Clin Pharmacol 65:533-40. 2009
    ....
  5. ncbi request reprint Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon cancer patients
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Powstańców Wlkp 72 str, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 61:389-94. 2005
    ..In the present study, an association of MDR1 gene polymorphism and the occurrence of colon cancer were evaluated...
  6. ncbi request reprint The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Ther Drug Monit 27:435-41. 2005
    ..5% of all leukopenia episodes in renal transplant recipients treated with azathioprine. Genotyping for the major TPMT variant alleles may be a valuable tool in preventing AZA toxicity and optimization of immunosuppressive therapy...
  7. ncbi request reprint Frequencies of the common promoter polymorphisms in cytokine genes in a Polish population
    M Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Int J Immunogenet 32:285-91. 2005
    ..6%; interleukin-10 (-1082 G/A, -819 G/T, -592 C/A): GCC -44.1%, ACC -32.0, ATA -23.9%; TNFalpha (-307 G/A): G -85.1%, A -14.9%. We also compared our results with other populations studied to date, describing some significant differences...
  8. doi request reprint Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth
    A Drozdzik
    Department of Periodontology, Pomeranian Medical University, Szczecin, Poland
    J Periodontal Res 45:143-7. 2010
    ..The aim of this study was to investigate whether an association exists between MMP-3 genotypes and gingival enlargement in kidney transplant patients medicated with cyclosporine A...
  9. ncbi request reprint The effect of 677C>T and 1298A>C MTHFR polymorphisms on sulfasalazine treatment outcome in rheumatoid arthritis
    A Pawlik
    Department of Pharmacology, Pomeranian Medical University, 70 111 Szczecin, Poland
    Braz J Med Biol Res 42:660-4. 2009
    ....
  10. doi request reprint Interleukin-18 gene (IL18) promoter polymorphisms in patients with rheumatoid arthritis
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland
    Scand J Rheumatol 38:159-65. 2009
    ..The aim of the present study was to examine the IL18 promoter polymorphism in patients with RA in association with disease susceptibility and activity...
  11. ncbi request reprint SPARC gene polymorphism in renal transplant patients with gingival overgrowth
    A Drozdzik
    Department of Periodontology, Pomeranian Medical University, Szczecin, Poland
    J Periodontol 78:2185-9. 2007
    ..The aim of the study was to determine whether there is an association between SPARC genotypes and gingival enlargement in kidney transplant patients given CsA...
  12. doi request reprint TGF-β1 gene polymorphism in renal transplant patients with and without gingival overgrowth
    M Kozak
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Oral Dis 17:414-9. 2011
    ..We studied the determination of association between TGF-β1 (TGFB1) gene polymorphism and gingival overgrowth in kidney transplant patients medicated with cyclosporin A...
  13. ncbi request reprint Association of allograft inflammatory factor-1 gene polymorphism with rheumatoid arthritis
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland
    Tissue Antigens 72:171-5. 2008
    ..Our results show that the AIF1 rs2269475 T allele is associated with increased risk of RA development. Moreover, the frequency of individuals positive for anti-CCP antibodies is significantly increased among T allele carriers...
  14. ncbi request reprint Interleukin-18 promoter polymorphism in patients with atopic asthma
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, ul Polst Wlkp 72, 70 111 Szczecin, Poland
    Tissue Antigens 70:314-8. 2007
    ..006). The results of the present study suggest that the -137 G allele and the C-G/C-G diplotype seem to be involved in the pathogenesis of the severe form of asthma...
  15. ncbi request reprint Interleukin-18 promoter polymorphism in patients with rheumatoid arthritis
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland
    Tissue Antigens 67:415-8. 2006
    ..Above results suggest that IL-18-137 and - 607 promoter polymorphisms are not the significant factors influencing RA course and severity in a Polish population...
  16. ncbi request reprint Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population
    Z Juzyszyn
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Dig Liver Dis 40:122-5. 2008
    ..There is growing evidence that gallstone formation may be genetically determined. It was recently presented that a common polymorphism in the LRPAP1 gene might be associated with gallstone disease...
  17. doi request reprint Interleukin-10 (IL10) and tumor necrosis factor alpha (TNF) gene polymorphisms in Parkinson's disease patients
    M Bialecka
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Parkinsonism Relat Disord 14:636-40. 2008
    ..0021). The results from our study revealed that the TNF -308AA genotype might increase the risk of early onset of PD...
  18. ncbi request reprint Interleukin-6 gene polymorphism in renal transplant patients with and without gingival overgrowth
    M Drozdzik
    Department of Pharmacology, Pomeranian Medical University, 70 111 Szczecin, Poland
    J Clin Periodontol 32:955-8. 2005
    ..To determine whether there is an association between genotypes of interleukin-6 (IL-6) and gingival overgrowth in kidney transplant patients...
  19. ncbi request reprint Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis
    M Drozdzik
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Pharmacogenomics J 7:404-7. 2007
    ..The present data suggest that evaluation of RFC-1 gene 80G>A polymorphism may be a useful tool to optimize MTX therapy in patients with RA...
  20. doi request reprint Oestrogen receptor polymorphisms in female patients with rheumatoid arthritis
    V Dziedziejko
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Scand J Rheumatol 40:329-33. 2011
    ..There is compelling evidence that autoimmunity is under genetic control and that oestrogens and their receptors (ESRs) can play a role in the high prevalence of RA in females...
  21. doi request reprint Interleukin-6 level and gene polymorphism in spontaneous miscarriage
    M Drozdzik
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Tissue Antigens 82:171-6. 2013
    ..However, no correlation between circulating IL-6 and IL6 gene polymorphism, as well as IL-6 and IL-6R polymorphisms associations with spontaneous miscarriage were revealed. ..
  22. ncbi request reprint Polymorphism in interleukin-1beta gene and the risk of periodontitis in a Polish population
    A Drozdzik
    Department of Periodontology, Pomeranian Medical University, Szczecin, Poland
    Adv Med Sci 51:13-7. 2006
    ..In multivariate logistic regression the association of the following parameters: genotype, age, sex, smoking status, and approximal space plaque index (API) > 50% with the risk of periodontitis was analyzed...
  23. ncbi request reprint IL1beta+3953 exon 5 and IL-2 -330 promoter polymorphisms in patients with rheumatoid arthritis
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland
    Clin Exp Rheumatol 23:159-64. 2005
    ..The aim of present study was to evaluate the exon 5 +3953 IL-1beta and IL-2 -330 promoter polymorphisms in patients with RA in association with disease activity and severity...
  24. ncbi request reprint Impact of ABCB1 (MDR1) gene polymorphism and P-glycoprotein inhibitors on digoxin serum concentration in congestive heart failure patients
    Mateusz Kurzawski
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, PL 70 111 Szczecin, Poland
    Pharmacol Rep 59:107-11. 2007
    ....
  25. ncbi request reprint Frequency distribution of thiopurine S-methyltransferase alleles in a polish population
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Ther Drug Monit 26:541-5. 2004
    ..The general pattern of TPMT allele disposition in the Polish population is similar to those determined for other white populations, but the frequency of total variant alleles is lower than in other European populations studied to date...
  26. ncbi request reprint Severe azathioprine-induced myelotoxicity in a kidney transplant patient with thiopurine S-methyltransferase-deficient genotype (TPMT*3A/*3C)
    Mateusz Kurzawski
    Transpl Int 18:623-5. 2005
  27. ncbi request reprint Involvement of C3435T and G2677T multidrug resistance gene polymorphisms in release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, ul Powst Wlkp 72, Poland
    Eur J Pharmacol 528:27-36. 2005
    ..Moreover, determination of C3435T and G2677T MDR1 polymorphisms might be useful in response prediction to therapy with methotrexate and dexamethasone...
  28. ncbi request reprint Frequency of common MDR1 gene variants in a Polish population
    Mateusz Kurzawski
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, PL 70 111 Szczecin, Poland
    Pharmacol Rep 58:35-40. 2006
    ..015, 2677T-3435T--0.370, 2677A-3435C--0.008, 2677A-3435T--0.011. The results of our study may give the basis for predicting pharmacokinetic and pharmacodynamic effects of many commonly used drugs in the Polish population...
  29. ncbi request reprint Effect of CYP2C19*17 gene variant on Helicobacter pylori eradication in peptic ulcer patients
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 62:877-80. 2006
    ..In the present study, a potential association between CYP2C19*17 allele and lower H. pylori eradication efficacy was tested in a group of peptic ulcer patients...
  30. ncbi request reprint The effect of 3435C>T MDR1 gene polymorphism on rheumatoid arthritis treatment with disease-modifying antirheumatic drugs
    Marek Drozdzik
    Department of Pharmacology, Pomeranian Medical University, ul Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 62:933-7. 2006
    ..The aim of this study was to examine the effect of the 3435C>T MDR1 gene polymorphism on the efficacy of RA treatment with disease-modifying antirheumatic drugs, i.e. MTX plus methylprednisolone (MP), and SL...
  31. ncbi request reprint Matrix metalloproteinase-1 gene polymorphism in renal transplant patients with and without gingival enlargement
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    J Periodontol 77:1498-502. 2006
    ..The aim of this study was to determine whether there is an association between genotypes of the MMP-1 gene and gingival enlargement in kidney transplant patients...
  32. ncbi request reprint [Thiopurine methyltransferase (TPMP) polymorphism: a model of clinical application for pharmacogenetics]
    Mateusz Kurzawski
    Katedra Farmakologii Pomorskiej AM w Szczecinie
    Pol Arch Med Wewn 109:535-40. 2003
  33. ncbi request reprint Effect of ABCB1 (MDR1) 3435C >T and 2677G >A,T polymorphisms and P-glycoprotein inhibitors on salivary digoxin secretion in congestive heart failure patients
    Lilianna Bartnicka
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, PL 70 111 Szczecin, Poland
    Pharmacol Rep 59:323-9. 2007
    ..01). The results from the present study suggest that administration of P-glycoprotein inhibitors as well as ABCB1 gene polymorphism may affect salivary digoxin secretion...
  34. doi request reprint Cholesterol 7alpha-hydrolase (CYP7A1) c.-278A>C promoter polymorphism in gallstone disease patients
    Zygmunt Juzyszyn
    Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Genet Test 12:97-100. 2008
    ..48). No significant gender-related differences of allele frequencies or distribution were noted. We conclude that CYP7A1 promoter polymorphism is not a valuable marker of gallstone disease susceptibility in a Polish population...
  35. ncbi request reprint 677C > T and 1298A > C MTHFR polymorphisms affect arechin treatment outcome in rheumatoid arthritis
    Andrzej Pawlik
    Department of Therapeutic Drug Monitoring, Pomeranian Medical University, Powstancow Wielkopolskich 72, PL 70 111 Szczecin, Poland
    Pharmacol Rep 59:721-6. 2007
    ....
  36. ncbi request reprint Apolipoprotein B (APOB) gene polymorphism in patients with gallbladder disease
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 38:360-3. 2007
    ..04). Our results suggest that SNPs in APOB, potentially considered as one of lith genes as well as certain haplotypes, may be risk factors for GSD...
  37. ncbi request reprint CARD15 variants in patients with sporadic Parkinson's disease
    Monika Bialecka
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Neurosci Res 57:473-6. 2007
    ..5% of healthy controls (p<0.02, OR=1.73). The results of the study suggest, that the polymorphism in CARD15/NOD2 gene may be a risk factor for sporadic PD development, and support the concept of inflammatory pathogenesis of PD...
  38. ncbi request reprint Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients
    Maria Chrzanowska
    Department of Physical Pharmacy and Pharmacokinetics, University of Medical Sciences, Swiecickiego 6, PL 60 781 Poznan, Poland
    Pharmacol Rep 58:973-8. 2006
    ..Such tests could be helpful in AZA dose individualization, and thus in reducing the risk of myelosuppression during AZA therapy following renal transplantation...
  39. ncbi request reprint Interleukin-10 gene polymorphism in Parkinson's disease patients
    Monika Bialecka
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 38:858-63. 2007
    ..To prove this hypothesis, two DNA polymorphisms at IL-10 promoter (-1082 and -519) were examined in sporadic PD patients...
  40. ncbi request reprint Interleukin-10 promoter polymorphism in patients with rheumatoid arthritis
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Merical University, 70 111, Szczecin, ul Powst Wlkp 72, Poland
    Clin Rheumatol 24:480-4. 2005
    ..We suggest that IL-10 promoter polymorphism is not a genetic risk factor for RA activity...
  41. ncbi request reprint Polymorphism in semaphorin 5A (Sema5A) gene is not a marker of Parkinson's disease risk
    Monika Bialecka
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111 Szczecin, Poland
    Neurosci Lett 399:121-3. 2006
    ..It can be concluded that rs7702187 SNP in Sema5a gene is not a marker of PD risk in the studied populations...
  42. ncbi request reprint 677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis
    Mateusz Kurzawski
    Pomeranian Medical University, Department of Pharmacology, ul Powstancow Wlkp 72 70 111 Szczecin, Poland
    Pharmacogenomics 8:1551-9. 2007
    ..Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and has been shown to be polymorphic, affecting the enzyme activity...
  43. ncbi request reprint The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications
    Monika Bialecka
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wikp 72, Szczecin, Poland
    Pharmacogenet Genomics 18:815-21. 2008
    ..The role of functional COMT haplotypes in PD susceptibility and treatment response has not been examined...
  44. ncbi request reprint NOD2 allele variants in patients with rheumatoid arthritis
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, ul Powst Wlkp 72, Szczecin, 70 111, Poland
    Clin Rheumatol 26:868-71. 2007
    ..The results of the present study suggest that NOD2 allele variants have no significant influence on RA susceptibility, activity, and severity...