Irina Kowalska

Summary

Affiliation: Medical University
Country: Poland

Publications

  1. ncbi request reprint [Polycystic ovary syndrome in type 1 diabetes]
    Agnieszka Lebkowska
    Klinika Endokrynologii, Diabetologii i Chorob Wewnetrznych Uniwersytetu Medycznego
    Pediatr Endocrinol Diabetes Metab 16:306-9. 2010
  2. doi request reprint Impact of the FTO gene variation on fat oxidation and its potential influence on body weight in women with polycystic ovary syndrome
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
    Clin Endocrinol (Oxf) 77:120-5. 2012
  3. doi request reprint Adipocytokines, gut hormones and growth factors in anorexia nervosa
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Poland
    Clin Chim Acta 412:1702-11. 2011
  4. doi request reprint Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance
    Irina Kowalska
    Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok, M C Sklodowskiej 24a, Bialystok, Poland
    J Clin Endocrinol Metab 93:2786-9. 2008
  5. ncbi request reprint Plasma adiponectin concentration and tumor necrosis factor-alpha system activity in lean non-diabetic offspring of type 2 diabetic subjects
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Poland
    Eur J Endocrinol 154:319-24. 2006
  6. doi request reprint Insulin resistance, serum adiponectin, and proinflammatory markers in young subjects with the metabolic syndrome
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, 15 276 Białystok, Poland
    Metabolism 57:1539-44. 2008
  7. doi request reprint Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, ul M C Skłodowskiej 24a, 15 276, Białystok, Poland
    Endocrine 40:95-101. 2011
  8. ncbi request reprint Plasma adiponectin and E-selectin concentrations in patients with coronary heart disease and newly diagnosed disturbances of glucose metabolism
    I Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, ul M Skłodowskiej Curie 24A, 15 276 Białystok, Poland
    Adv Med Sci 51:94-7. 2006
  9. doi request reprint The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes
    I Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Poland
    Diabetes Metab 35:328-31. 2009
  10. ncbi request reprint Disturbances of glucose metabolism in men referred for coronary arteriography. Postload glycemia as predictor for coronary atherosclerosis
    I Kowalska
    Department of Endocrinology, University Hospital, Medical Academy, Bialystok, Poland
    Diabetes Care 24:897-901. 2001

Collaborators

Detail Information

Publications45

  1. ncbi request reprint [Polycystic ovary syndrome in type 1 diabetes]
    Agnieszka Lebkowska
    Klinika Endokrynologii, Diabetologii i Chorob Wewnetrznych Uniwersytetu Medycznego
    Pediatr Endocrinol Diabetes Metab 16:306-9. 2010
    ..According to the published studies, PCOS is also prevalent in type 1 diabetes mellitus. In this review we present the potential mechanisms involved in pathogenesis of PCOS in type 1 diabetes mellitus...
  2. doi request reprint Impact of the FTO gene variation on fat oxidation and its potential influence on body weight in women with polycystic ovary syndrome
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
    Clin Endocrinol (Oxf) 77:120-5. 2012
    ..It has recently been shown that the FTO gene modifies weight, fat mass and insulin sensitivity in women with PCOS, where its role might be larger than in other phenotypes...
  3. doi request reprint Adipocytokines, gut hormones and growth factors in anorexia nervosa
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Poland
    Clin Chim Acta 412:1702-11. 2011
    ..In this review we have described the role of adipocytokines, neurotrophins, peptides of the gastrointestinal system and growth factors in appetite regulation, energy balance and insulin sensitivity in anorexia nervosa patients...
  4. doi request reprint Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance
    Irina Kowalska
    Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok, M C Sklodowskiej 24a, Bialystok, Poland
    J Clin Endocrinol Metab 93:2786-9. 2008
    ..Retinol-binding protein (RBP) 4 is secreted by adipose tissue and is postulated to be a determinant of insulin sensitivity. The mechanisms of RBP4 insulin desensitizing action remain unclear...
  5. ncbi request reprint Plasma adiponectin concentration and tumor necrosis factor-alpha system activity in lean non-diabetic offspring of type 2 diabetic subjects
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Poland
    Eur J Endocrinol 154:319-24. 2006
    ..The aim of the study was to look for adiponectin's role in the pathogenesis of insulin resistance in offspring of type 2 diabetic patients, and its relation to the activity of the tumor necrosis factor (TNF)-alpha system...
  6. doi request reprint Insulin resistance, serum adiponectin, and proinflammatory markers in young subjects with the metabolic syndrome
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, 15 276 Białystok, Poland
    Metabolism 57:1539-44. 2008
    ..16 and .32, all Ps < .01). Young subjects with metabolic syndrome demonstrate an increased inflammatory response and lower adiponectin concentration...
  7. doi request reprint Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, ul M C Skłodowskiej 24a, 15 276, Białystok, Poland
    Endocrine 40:95-101. 2011
    ..01), whereas adiponectin concentration remained unchanged. We concluded that L-thyroxine treatment in patients with subclinical hypothyroidism might exert a beneficial effect by reducing cardiovascular risk factors...
  8. ncbi request reprint Plasma adiponectin and E-selectin concentrations in patients with coronary heart disease and newly diagnosed disturbances of glucose metabolism
    I Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, ul M Skłodowskiej Curie 24A, 15 276 Białystok, Poland
    Adv Med Sci 51:94-7. 2006
    ..In the fasting state, the plasma adiponectin, soluble form of E-selectin, HbA1c and lipid parameters were estimated...
  9. doi request reprint The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes
    I Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Poland
    Diabetes Metab 35:328-31. 2009
    ..The aim of the present study was to assess the effect of FTO variation on obesity, insulin sensitivity, and metabolic and hormonal profiles in PCOS...
  10. ncbi request reprint Disturbances of glucose metabolism in men referred for coronary arteriography. Postload glycemia as predictor for coronary atherosclerosis
    I Kowalska
    Department of Endocrinology, University Hospital, Medical Academy, Bialystok, Poland
    Diabetes Care 24:897-901. 2001
    ..Therefore, we investigated the relationship between fasting and postload glucose concentrations and coronary status in 363 men referred for coronary arteriography without a previous history of diabetes...
  11. ncbi request reprint Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome
    Irina Kowalska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M C Sklodowskiej 24a, 15 276 Bialystok, Poland
    Hum Reprod 22:1824-9. 2007
    ..The aim of the study was to asses the relation between serum visfatin concentration and insulin sensitivity and markers of hyperandrogenism in lean and obese PCOS patients...
  12. ncbi request reprint Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-alpha system
    Marek Straczkowski
    Department of Endocrinology, Diabetology and Internal Medicine, Medical Academy, Bialystok 15 276, Poland
    J Clin Endocrinol Metab 87:4602-6. 2002
    ..We conclude that plasma IL-8 levels are increased in obese subjects, and are related to FM and TNF-alpha system. Increase in circulating IL-8 might be one of the factors linking obesity with greater cardiovascular risk...
  13. pmc Plasma levels of soluble tumor necrosis factor-alpha receptors are related to total and LDL-cholesterol in lean, but not in obese subjects
    Marek Straczkowski
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M, C, Sklodowskiej 24a, 15 276 Bialystok, Poland
    Cardiovasc Diabetol 5:14. 2006
    ..TNFalpha is also a regulator of lipid metabolism, however, data about impact of obesity on the relationships between TNFalpha and plasma lipids remain controversial...
  14. ncbi request reprint Circulating E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in men with coronary artery disease assessed by angiography and disturbances of carbohydrate metabolism
    Irina Kowalska
    Department of Endocrinology, Diabetology, and Internal Medicine, Medical Academy in Białystok, Poland
    Metabolism 51:733-6. 2002
    ..27, P =.025). This would suggest that hyperglycemia increases sE-selectin and sVCAM-1 in plasma, which reflects excessive formation of atherosclerotic plaques in patients with disturbances of glucose metabolism...
  15. pmc Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome
    Agnieszka Nikolajuk
    Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
    Diabetes 59:1026-9. 2010
    ..Gp130 is present in the circulation in the soluble form (sgp130), which inhibits intracellular gp130 signaling. The aim of the present study was to estimate the relation between sgp130 and insulin sensitivity in women with PCOS...
  16. ncbi request reprint Increased plasma-soluble tumor necrosis factor-alpha receptor 2 level in lean nondiabetic offspring of type 2 diabetic subjects
    Marek Straczkowski
    Department of Endocrinology, Diabetology and Internal Medicine, Medical Academy, Bialystok, Poland
    Diabetes Care 25:1824-8. 2002
    ....
  17. ncbi request reprint Soluble tumor necrosis factor-alpha receptors in young obese subjects with normal and impaired glucose tolerance
    Stella Dzienis-Straczkowska
    Department of Endocrinology, Academy, Bialystok, Poland
    Diabetes Care 26:875-80. 2003
    ..The aim of the present study was to assess plasma TNF-alpha, sTNFR1, and sTNFR2 levels and to evaluate the relationships with insulin resistance in obese subjects with IGT...
  18. ncbi request reprint Normal metabolic flexibility despite insulin resistance women with polycystic ovary syndrome
    Agnieszka Adamska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
    Endocr J 60:1107-13. 2013
    ..001) but it was not influenced by the presence of PCOS (P=0.78). Our data indicate that PCOS women have normal metabolic flexibility, which could suggest a distinct pathophysiological mechanism for insulin resistance in this group...
  19. ncbi request reprint Insulin resistance in the first-degree relatives of persons with type 2 diabetes
    Marek Straczkowski
    Department of Endocrinology, Diabetology and Internal Medicine, Medical Academy, Białystok, Poland
    Med Sci Monit 9:CR186-90. 2003
    ..The aim of the present study was to assess insulin sensitivity in lean normoglycemic offspring of parents with type 2 diabetes...
  20. doi request reprint Increased suppression of serum ghrelin concentration by hyperinsulinemia in women with anorexia nervosa
    Monika Karczewska-Kupczewska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M Curie Sklodowskiej 24a, 15 276 Bialystok, Poland
    Eur J Endocrinol 162:235-9. 2010
    ..Anorexia nervosa (AN) is an eating disorder, which is characterized by high serum ghrelin concentration; however, the regulation of circulating ghrelin by insulin in this disorder remains unclear...
  21. ncbi request reprint Plasma interleukin-10 concentration is positively related to insulin sensitivity in young healthy individuals
    Marek Straczkowski
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M C Sklodowskiej 24a, 15 276 Bialystok, Poland
    Diabetes Care 28:2036-7. 2005
  22. doi request reprint The influence of insulin infusion on the metabolism of amyloid β peptides in plasma
    Monika Karczewska-Kupczewska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
    Alzheimers Dement 9:400-5. 2013
    ....
  23. doi request reprint Hyperinsulinemia acutely increases serum macrophage inhibitory cytokine-1 concentration in anorexia nervosa and obesity
    Monika Karczewska-Kupczewska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
    Clin Endocrinol (Oxf) 76:46-50. 2012
    ..MIC-1 has also been implicated in mediation of tumour-induced anorexia and weight loss. Increased serum concentrations of MIC-1 were found in patients with anorexia nervosa (AN), obesity and type 2 diabetes...
  24. doi request reprint Insulin sensitivity, metabolic flexibility, and serum adiponectin concentration in women with anorexia nervosa
    Monika Karczewska-Kupczewska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15 276 Bialystok, Poland
    Metabolism 59:473-7. 2010
    ..High adiponectin concentration and normal insulin sensitivity in anorectic women suggest that in AN the adipocytes are still capable of functioning at the level that is sufficient to prevent the metabolic consequences...
  25. doi request reprint Serum visfatin is differentially regulated by insulin and free Fatty acids in healthy men
    Irina Kowalska
    Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok, M C Sklodowskiej 24a, 15 276 Bialystok, Poland
    J Clin Endocrinol Metab 98:E293-7. 2013
    ..Objective: Our objective was to evaluate the effect of hyperinsulinemia and the acute elevation of free fatty acids (FFAs) on serum visfatin in humans...
  26. pmc Circulating brain-derived neurotrophic factor concentration is downregulated by intralipid/heparin infusion or high-fat meal in young healthy male subjects
    Monika Karczewska-Kupczewska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
    Diabetes Care 35:358-62. 2012
    ..The aim of the current study was to estimate the effects of hyperinsulinemia and serum free fatty acids (FFA) elevation on circulating BDNF concentration in humans...
  27. doi request reprint Decreased serum brain-derived neurotrophic factor concentration in young nonobese subjects with low insulin sensitivity
    Monika Karczewska-Kupczewska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Poland
    Clin Biochem 44:817-20. 2011
    ..The aim of our study was to estimate serum BDNF concentration in nonobese women divided into subgroups according to their insulin sensitivity...
  28. ncbi request reprint Comparison of simple indices of insulin sensitivity using the euglycemic hyperinsulinemic clamp technique
    Marek Straczkowski
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Białystok, Poland
    Med Sci Monit 10:CR480-4. 2004
    ..Therefore, indirect indices of insulin sensitivity are proposed. The aim of the present study was to compare these simple indices with data from clamp studies...
  29. pmc The effect of insulin infusion on the metabolites in cerebral tissues assessed with proton magnetic resonance spectroscopy in young healthy subjects with high and low insulin sensitivity
    Monika Karczewska-Kupczewska
    Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Białystok, Białystok, Poland
    Diabetes Care 36:2787-93. 2013
    ..To elucidate the specific role of insulin action in the brain, we estimated neurometabolites with (1)H-MRS and assessed their regulation by insulin infusion and their relationship with insulin sensitivity...
  30. ncbi request reprint Homocysteine and progression of coronary artery disease
    Elzbieta Skibińska
    Department of Cardiology, Medical Academy, Białystok, Poland
    Kardiol Pol 60:197-205. 2004
    ..Hyperhomocysteinemia is one of the newly recognised risk factors of coronary artery disease (CAD). The role of hyperhomocysteinemia in the development of atherosclerosis has been controversial...
  31. ncbi request reprint [The role of adiponectin in pathogenesis of metabolic syndrome and cardiovascular disease]
    Agnieszka Kozłowska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok
    Endokrynol Pol 57:626-32. 2006
    ..Recent studies have indicated that adiponectin has antiinflammatory and antiatherogenic properties. Review of the data confirmed the hypothesis that adiponectin plays an important role in pathogenesis of cardiovascular disease...
  32. doi request reprint Circulating interleukin 6 and soluble forms of its receptors in relation to resting energy expenditure in women with anorexia nervosa
    Monika Karczewska-Kupczewska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok
    Clin Endocrinol (Oxf) 79:812-6. 2013
    ..Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130 respectively). sIL-6R sensitizes cells towards IL-6, whereas sgp130 inhibits gp130 signalling...
  33. doi request reprint Relationships of serum soluble E-selectin concentration with insulin sensitivity and metabolic flexibility in lean and obese women
    Agnieszka Adamska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M C Sklodowskiej 24a, 15 276, Bialystok, Poland
    Endocrine 45:422-9. 2014
    ..004) was independent of the other evaluated factors. Our data suggest that endothelial dysfunction as assessed by plasma sE-selectin is associated with metabolic flexibility, inversely and independently of the other estimated factors...
  34. ncbi request reprint Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-alpha system activity
    Marek Straczkowski
    Departments of Endocrinology and Pediatric Neurology, Medical Academy, Bialystok, Poland and the Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Metabolism 51:75-8. 2002
    ..We conclude that an increase in plasma sICAM-1 concentration in obesity is related to TNFalpha system activation and insulin resistance...
  35. ncbi request reprint Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle
    Marek Straczkowski
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University Bialystok, M C Sklodowskiej 24a, 15 276 Bialystok, Poland
    Diabetes 53:1215-21. 2004
    ..68, P = 0.03) and linoleic (r = -0.66, P = 0.038) acid. Our data indicate that the sphingomyelin signaling pathway in muscle might be an important factor determining the development of insulin resistance in humans...
  36. ncbi request reprint [Assessment of insulin sensitivity during exercise training program in obese women. Comparison of simple indices with hyperinsulinemic euglycemic clamp technique]
    Marek Straczkowski
    Klinika Endokrynologii, Diabetologii i Chorób Wewnetrznych AM w Białymstoku
    Pol Arch Med Wewn 109:483-8. 2003
    ..Our study indicates that simple indices are not able to reflect changes occurring during insulin-sensitizing intervention...
  37. ncbi request reprint [Insulin resistance in obese subjects with impaired glucose tolerance. Studies with hyperinsulinemic euglycemic clamp technique]
    Marek Straczkowski
    Klinika Endokrynologii, Diabetologii i Chorób Wewnetrznych AM w Białymstoku
    Pol Arch Med Wewn 109:359-64. 2003
    ..Our study indicates that insulin resistance is an important factor determining a deterioration of glucose tolerance in subjects with overweight and obesity...
  38. ncbi request reprint [Postpartum maternal plasma leptin levels and their relationship to gestational diabetes mellitus]
    Maciej Kinalski
    Zakład Patofizjologii Ciazy, Akademia Medyczna, ul M C Skłodowskiej 24a, 15 276 Białystok, Poland
    Med Wieku Rozwoj 8:703-10. 2004
    ..Recent reports have shown a positive correlation between leptin concentrations and plasma levels of glycated haemoglobin (HbA(1c)) in patients with gestational diabetes mellitus (GDM)...
  39. ncbi request reprint [Gynecomastia--a frequent clinical problem]
    Monika Karczewska-Kupczewska
    Klinika Endokrynologii, Diabetologii i Chorob Wewnetrznych, Akademia Medyczna, ul Marii Skłodowskiej Curie 24a, 15 276 Białystok, Poland
    Med Wieku Rozwoj 10:973-83. 2006
    ..In this review we present current opinions on the etiology, pathogenesis, diagnostics and treatment of gynecomastia with special regard to the new therapeutic possibilities...
  40. pmc The role of skeletal muscle sphingolipids in the development of insulin resistance
    Marek Straczkowski
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Poland
    Rev Diabet Stud 5:13-24. 2008
    ..We describe problems that are unresolved so far and topics of potential interest for future research...
  41. ncbi request reprint Glucose homoeostatis in young adults without diagnosis of diabetes mellitus
    Irina Kowalska
    Lancet 360:1979. 2002
  42. doi request reprint Natural history of cardiovascular disease in patients with diabetes: role of hyperglycemia
    Zvonko Milicevic
    Eli Lilly Regional Operations, Vienna, Austria
    Diabetes Care 31:S155-60. 2008
    ..Based on the results of epidemiological reports, the most appropriate targets in interventional trials are postprandial hyperglycemia or A1C...
  43. doi request reprint Insulin resistance is associated with decreased circulating mannan-binding lectin concentrations in women with polycystic ovary syndrome
    Irina Kowalska
    Diabetes Care 31:e20. 2008
  44. ncbi request reprint An alternative spliced variant of circulating soluble tumor necrosis factor-alpha receptor-2 is paradoxically associated with insulin action
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Ctra França s n, 17007 Girona, Spain
    Eur J Endocrinol 154:723-30. 2006
    ..We aimed to evaluate whether this circulating DS-TNFR2 is associated with insulin action in humans...
  45. ncbi request reprint [Hearing loss in patients with diabetes mellitus type II]
    Małgorzata Rózańska-Kudelska
    Klinika Otolaryngologii AM w Białymstoku
    Otolaryngol Pol 56:607-10. 2002
    ..Evoked otoacoustic emissions found out only in 2 patients with normal hearing. The results suggest that EOAEs doesn't show subclinical cochlear damage in diabetic patients because of the significant hearing loss...