Magdalena Czarnecka-Operacz

..Therapy with topical calcineurin inhibitors should be managed by an experienced specialist and each patient should receive proper education on how to use them and what possible unwanted effects may be expected...

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..There was no significant correlation between the clinical score and serum level of any of the investigated cytokines in either group of patients before the treatment or after 48 months of therapy...

..Further evaluation of the duration/persistence and stability of the phenomenon is planned for the future...

..It is concluded that SIT may be highly promising method of controlling skin inflammation in AD with the potential to prevent the development of AD into respiratory allergy...

..Using petrolatum as a vehicle, allergen concentration of 500000 SBE/ml and evaluation time of 24 and 48 h of allergen application may lead to improved atopy patch test results...

..Specific immunotherapy should therefore be at least considered in the treatment of selected cases of atopic dermatitis patients presenting airborne IgE-mediated allergy...

..Increased Th2 activity in the acute phase of AD is associated with IL-5 expression and results in enhanced eosinophilopoiesis, eosinophilic activation, and chemotaxis...

..For this purpose, we suggest to name an intact skin in AD as seemingly healthy skin...

..The results are also promising for the usefulness of selected eosinophil proteins in the diagnosis of AD in children, however, thorough analysis on a larger group of patients is needed...

..We suggest that glucocorticosteroid contact allergy should be considered as a crucial clinical problem in patients with inflammatory dermatoses like CVLU, AD and CD...

..Complex pathophysiological processes, including inflammatory reactions, in course of CVI may influence development of allergic contact reaction in CVLU patients...

..Changes in the qualitative and quantitative composition of bacterial flora, presence of multiple isolates, and concomitant diseases that may influence the characteristics of leg ulcer disease were closely monitored...

..The study pointed to an increasing tendency of antibiotic resistance in the study group of patients...

..Early diagnosis and appropriate treatment is important to avoid further complications. This review aims to analyze available literature on the treatment of this disease entity..

..There is a strong necessity to standardize clinical evaluation of the extent and severity of skin diseases such as atopic dermatitis, as laboratory techniques and parameters are not really of great use for practitioners...

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..Standard therapy includes high doses of corticosteroids, immunosuppressive drugs such as methotrexate, cyclosporin A, cyclophosphamide or azathioprine and others such as psoralen and ultraviolet A radiation...

..Although skin ultrasonography and its clinical applications are still being explored, most probably it will be implemented in the routine dermatologic diagnosis in the forthcoming future...

..The most probable explanation of these findings are the polypragmasy applied in the elderly patients and interdrug interaction as well as decreased efficiency of the organic clearances...

..Further research on genetic and environmental relationships is necessary for better understanding of atopic processes and development of new therapeutic approaches...

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..The aim of the study was to evaluate the immediate type of immunological reaction initiated by main types of airborne allergens in the pathomechanism of atopic dermatitis in relation to the age of patients...

..Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with hyperproduction of immunoglobulin E directed against common environmental allergens...

..There is no reason for the use of anti-leukotriene drugs...

..However, the amount of Alnus pollen released into the atmosphere in places such as Poznan may increase its impact on the population and make it one of the more important aeroallergens present...

..CONCLUSION: Allergen specific immunotherapy appeared to be an effective method of treatment for atopic dermatitis as judged by significant improvement in clinical index in cases with well documented IgE-mediated allergic disease...

..The exacerbation of skin inflammation of patients with AD in relation to the seasons was also evaluated...

..Severity of AD clinical symptoms was analyzed and correlated with the results of allergological diagnostics...

..001). It was concluded that in selected patients with atopic dermatitis with IgE-mediated airborne allergy this method of treatment could be a promising alternative...

..Specific immunotherapy seems to be an effective therapeutic approach in selected cases of atopic dermatitis...

..Correct instruction of the patient in case of appearance of a very late response to contact allergen will facilitate the diagnostic procedure and will enable correct interpretation of results...

..It seems that proper education of patients provided by health care staff might improve clinical efficacy of treatment and patients' compliance...

..001) as well as sIL-2R (p < 0.01). On the contrary in the control group serum tIgE increased and IL-4 as well as IL-5 concentrations tended to increase significantly (p < 0.01; p < 0.05 respectively)...

..Both medications present similar mechanism of action, good therapeutic and safety profiles and should be considered as important factors in the treatment of atopic dermatitis...

..The paper presents the basic problems concerning urticaria, taking into particular account pathogenesis and diagnostic possibilities in autoimmune chronic idiopathic urticaria. New therapeutic directions are also presented...