Jerzy Bełtowski

Summary

Affiliation: Medical University
Country: Poland

Publications

  1. ncbi request reprint Guanylin and related peptides
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 52:351-75. 2001
  2. ncbi request reprint The effect of dietary-induced obesity on lipid peroxidation, antioxidant enzymes and total plasma antioxidant capacity
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 51:883-96. 2000
  3. ncbi request reprint Spectrophotometric assay of renal ouabain-resistant Na(+)-ATPase and its regulation by leptin and dietary-induced obesity
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Acta Biochim Pol 51:1003-14. 2004
  4. ncbi request reprint Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Acta Biochim Pol 51:757-72. 2004
  5. ncbi request reprint [Hydrogen sulfide as a biologically active mediator in the cardiovascular system]
    Jerzy Bełtowski
    Katedra i Zakład Patofizjologii Akademii Medycznej w Lublinie
    Postepy Hig Med Dosw (Online) 58:285-91. 2004
  6. ncbi request reprint Leptin decreases renal medullary Na(+), K(+)-ATPase activity through phosphatidylinositol 3-kinase dependent mechanism
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 55:391-407. 2004
  7. ncbi request reprint Up-regulation of renal Na+, K+-ATPase: the possible novel mechanism of leptin-induced hypertension
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pol J Pharmacol 56:213-22. 2004
  8. ncbi request reprint [Heme oxygenase and carbon monoxide in the physiology and pathology of the cardiovascular system]
    Jerzy Bełtowski
    Katedra i Zakład Patofizjologii, Akademii Medycznej, w Lublinie
    Postepy Hig Med Dosw (Online) 58:83-99. 2004
  9. ncbi request reprint Oxidative stress, nitric oxide production, and renal sodium handling in leptin-induced hypertension
    Jerzy Beltowski
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Life Sci 74:2987-3000. 2004
  10. ncbi request reprint Adrenomedullin--what do we know 10 years since its discovery?
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pol J Pharmacol 56:5-27. 2004

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Guanylin and related peptides
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 52:351-75. 2001
    ..Guanylin peptides possess antiproliferative activity in intestinal cells culture and their expression decreases in colonic carcinoma indicating that their deficiency may contribute to the pathogenesis of this disease...
  2. ncbi request reprint The effect of dietary-induced obesity on lipid peroxidation, antioxidant enzymes and total plasma antioxidant capacity
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 51:883-96. 2000
    ..001) and with TAS (r = -0.47, p < 0.05). These results indicate that obesity leads to oxidative stress which can contribute to obesity-associated diseases such as atherosclerosis, diabetes mellitus and arterial hypertension...
  3. ncbi request reprint Spectrophotometric assay of renal ouabain-resistant Na(+)-ATPase and its regulation by leptin and dietary-induced obesity
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Acta Biochim Pol 51:1003-14. 2004
    ..These data indicate that both renal Na(+)-dependent ATPases are separately regulated and that up-regulation of Na(+)-ATPase may contribute to Na(+) retention and arterial hypertension induced by chronic hyperleptinemia...
  4. ncbi request reprint Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Acta Biochim Pol 51:757-72. 2004
    ..The inhibitory effect is mediated by cytochrome P450-dependent arachidonate metabolites and PI3K, and is caused by redistribution of the sodium pump from the plasma membrane to the inactive intracellular pool...
  5. ncbi request reprint [Hydrogen sulfide as a biologically active mediator in the cardiovascular system]
    Jerzy Bełtowski
    Katedra i Zakład Patofizjologii Akademii Medycznej w Lublinie
    Postepy Hig Med Dosw (Online) 58:285-91. 2004
    ..On the other hand, excess of H2S may lead to mental retardation in patients with Down's syndrome and may be involved in the pathogenesis of hypotension associated with septic shock...
  6. ncbi request reprint Leptin decreases renal medullary Na(+), K(+)-ATPase activity through phosphatidylinositol 3-kinase dependent mechanism
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 55:391-407. 2004
    ..inhibition of medullary Na(+),K(+)-ATPase by leptin is mediated by PI3K and requires integrity of actin cytoskeleton...
  7. ncbi request reprint Up-regulation of renal Na+, K+-ATPase: the possible novel mechanism of leptin-induced hypertension
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pol J Pharmacol 56:213-22. 2004
    ..Abnormal renal sodium retention and vasoconstriction associated with NO deficiency may contribute to leptin-induced hypertension and to blood pressure elevation in hypertensive obese individuals...
  8. ncbi request reprint [Heme oxygenase and carbon monoxide in the physiology and pathology of the cardiovascular system]
    Jerzy Bełtowski
    Katedra i Zakład Patofizjologii, Akademii Medycznej, w Lublinie
    Postepy Hig Med Dosw (Online) 58:83-99. 2004
    ..Pharmacological and genetic induction of HO-1 as well as the delivery of exogenous CO are promising therapeutic strategies for the treatment of cardiovascular diseases...
  9. ncbi request reprint Oxidative stress, nitric oxide production, and renal sodium handling in leptin-induced hypertension
    Jerzy Beltowski
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Life Sci 74:2987-3000. 2004
    ..NO deficiency and abnormal renal Na+ handling may contribute to leptin-induced hypertension...
  10. ncbi request reprint Adrenomedullin--what do we know 10 years since its discovery?
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pol J Pharmacol 56:5-27. 2004
    ..Proadrenomedullin N-terminal peptide (PAMP) is another product of ADM gene which is co-secreted by ADM-producing tissues, with some effects similar and some opposite to ADM...
  11. ncbi request reprint Differential effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on plasma paraoxonase 1 activity in the rat
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pol J Pharmacol 54:661-71. 2002
    ..These results suggest that fluvastatin but not pravastatin decreases plasma PON1 activity in normolipidemic rats, however, the former drug is more effective in reducing the level of oxidative stress...
  12. ncbi request reprint Nitric oxide decreases renal medullary Na+, K+-ATPase activity through cyclic GMP-protein kinase G dependent mechanism
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 54:191-210. 2003
    ..In contrast, NO has no effect on Na+,K(+)-ATPase in the renal cortex and on either cortical or medullary ouabain-sensitive H+,K(+)-ATPase...
  13. ncbi request reprint Species- and substrate-specific stimulation of human plasma paraoxonase 1 (PON1) activity by high chloride concentration
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Acta Biochim Pol 49:927-36. 2002
    ....
  14. ncbi request reprint Regulation of renal Na(+),K(+)-ATPase and ouabain-sensitive H(+),K(+)-ATPase by the cyclic AMP-protein kinase A signal transduction pathway
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Acta Biochim Pol 50:103-14. 2003
    ..In contrast, medullary Na(+),K(+)-ATPase is inhibited by cAMP through a mechanism involving cytochrome p450-dependent arachidonate metabolites...
  15. ncbi request reprint The effect of peroxisome proliferator-activated receptors alpha (PPARalpha) agonist, fenofibrate, on lipid peroxidation, total antioxidant capacity, and plasma paraoxonase 1 (PON 1) activity
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 53:463-75. 2002
    ..These effects can contribute to the influence of PPARalpha agonists on pathological processes involved in atherogenesis...
  16. ncbi request reprint Spectrophotometric method for the determination of renal ouabain-sensitive H+,K+-ATPase activity
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Acta Biochim Pol 49:515-27. 2002
    ..1% at 1 h after injection but had no effect on H+,K+-ATPase activity suggesting that the two renal ouabain-sensitive ATPases are separately regulated...
  17. ncbi request reprint Human leptin stimulates systemic nitric oxide production in the rat
    Jerzy Beltowski
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Obes Res 10:939-46. 2002
    ..Apart from having an effect on energy balance, leptin is also involved in cardiovascular regulation and in the pathogenesis of obesity-associated hypertension. We investigated the effect of leptin on nitric oxide (NO) production...
  18. ncbi request reprint Cerivastatin modulates plasma paraoxonase/arylesterase activity and oxidant-antioxidant balance in the rat
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Pol J Pharmacol 54:143-50. 2002
    ..These effects can contribute to pleiotropic actions of statins in the cardiovascular system...
  19. ncbi request reprint The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 53:211-31. 2002
    ..The inhibitory effect is partially mediated by cytochrome P450-dependent arachidonate metabolites and possibly also by PKA-dependent inhibition of protein phosphatases...
  20. ncbi request reprint Human leptin administered intraperitoneally stimulates natriuresis and decreases renal medullary Na+, K+-ATPase activity in the rat -- impaired effect in dietary-induced obesity
    Jerzy Bełtowski
    Department of Pathophysiology, Lublin Medical University, Lublin, Poland
    Med Sci Monit 8:BR221-9. 2002
    ..In this study we examined the effect of leptin on renal Na+, K+-ATPase responsible for active tubular sodium reabsorption, and compared the renal effects of leptin in lean and obese rats...
  21. ncbi request reprint Regulation of renal tubular sodium transport by cardiac natriuretic peptides: two decades of research
    Jerzy Bełtowski
    Department of Pathophysiology, Lublin Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Med Sci Monit 8:RA39-52. 2002
    ..ANP(1-30), ANP(31-67) and ANP(79-98) decrease Na+, K+-ATPase activity in tubular cells through a prostaglandin E2-dependent mechanism...
  22. doi request reprint Resistance to acute NO-mimetic and EDHF-mimetic effects of leptin in the metabolic syndrome
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Life Sci 85:557-67. 2009
    ..We examined mechanisms leading to the impairment of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-dependent vasorelaxation in response to acutely administered leptin in rats with the metabolic syndrome...
  23. doi request reprint Chronic hyperleptinemia induces resistance to acute natriuretic and NO-mimetic effects of leptin
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Peptides 31:155-63. 2010
    ..These results suggest that hyperleptinemia may mediate "renal" and "vascular" leptin resistance observed in obesity...
  24. doi request reprint Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension
    Grazyna Wojcicka
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Life Sci 82:402-12. 2008
    ....
  25. doi request reprint Transactivation of epidermal growth factor receptor in vascular and renal systems in rats with experimental hyperleptinemia: role in leptin-induced hypertension
    Anna Jamroz-Wisniewska
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8 20 090 Lublin, Poland
    Biochem Pharmacol 75:1623-38. 2008
    ..g. in patients with obesity and metabolic syndrome...
  26. ncbi request reprint Antioxidant treatment normalizes renal Na+,K+-ATPase activity in leptin-treated rats
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 57:219-28. 2005
    ..Antioxidant treatment is effective in leptin-induced hypertension and should be considered in controlling blood pressure in hyperleptinemic obese individuals...
  27. ncbi request reprint Role of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the regulation of blood pressure by leptin in lean and obese rats
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Life Sci 79:63-71. 2006
    ..In contrast, leptin increases BP in 3-month obesity because its effect on EDHF is also attenuated...
  28. ncbi request reprint Influence of intravenously administered leptin on nitric oxide production, renal hemodynamics and renal function in the rat
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8 20 090 Lublin, Poland
    Regul Pept 120:59-67. 2004
    ..7% (61-90 min) and 88.9% (91-120 min). This was accompanied by increase in plasma and urinary cyclic GMP. These data indicate that leptin stimulates systemic NO production but has no effect on arterial pressure and renal hemodynamics...
  29. doi request reprint The differentiating effect of glimepiride and glibenclamide on paraoxonase 1 and platelet-activating factor acetylohydrolase activity
    Grazyna Wojcicka
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Life Sci 87:126-32. 2010
    ....
  30. ncbi request reprint Regulation of renal ouabain-resistant Na+-ATPase by leptin, nitric oxide, reactive oxygen species, and cyclic nucleotides: implications for obesity-associated hypertension
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Clin Exp Hypertens 29:189-207. 2007
    ..Chronic hyperleptinemia is associated with increased Na(+)-ATPase activity due to excessive oxidative stress...
  31. ncbi request reprint Role of PI3K and PKB/Akt in acute natriuretic and NO-mimetic effects of leptin
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Regul Pept 140:168-77. 2007
    ..These results suggest that leptin-induced natriuresis is mediated by PI3K but not Akt, whereas NO-mimetic effect of leptin results from PI3K-independent stimulation of Akt...
  32. doi request reprint Renal antioxidant enzymes and glutathione redox status in leptin-induced hypertension
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Mol Cell Biochem 319:163-74. 2008
    ..versus H(2)O(2) in later phase of leptin treatment, thus shifting the mechanism of BP elevation from H(2)O(2)-ERK to (O(2-.))-NO dependent...
  33. ncbi request reprint Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: the possible novel mechanism for proatherogenic effect of chronic hyperleptinemia
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Atherosclerosis 170:21-9. 2003
    ..These mechanisms may be involved in atherogenesis in hyperleptinemic obese individuals...
  34. ncbi request reprint Time-dependent effect of leptin on renal Na+,K+-ATPase activity
    Andrzej Marciniak
    Department of Pathophysiology, Medical University, Lublin, Poland
    Acta Biochim Pol 52:803-9. 2005
    ..This mechanism may contribute to the abnormal renal Na(+) handling in diseases associated with chronic hyperleptinemia such as diabetes and obesity...
  35. doi request reprint Opposite effects of pravastatin and atorvastatin on insulin sensitivity in the rat: role of vitamin D metabolites
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Atherosclerosis 219:526-31. 2011
    ..We examined the effect of pravastatin and atorvastatin on insulin sensitivity in a rat model...
  36. doi request reprint Differential effects of statins on endogenous H2S formation in perivascular adipose tissue
    Grazyna Wojcicka
    Department of Pathophysiology, Medical University, Jaczewskiego 8, 20 090 Lublin, Poland
    Pharmacol Res 63:68-76. 2011
    ..This effect is mediated by statin-induced CoQ(9) deficiency and results in the augmentation of anticontractile effect of perivascular adipose tissue...
  37. ncbi request reprint Antioxidant treatment normalizes nitric oxide production, renal sodium handling and blood pressure in experimental hyperleptinemia
    Jerzy Beltowski
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Life Sci 77:1855-68. 2005
    ..These results indicate that oxidative stress-induced NO deficiency is involved in the pathogenesis of leptin-induced hypertension...
  38. ncbi request reprint Time-dependent transition from H(2)O(2)-extracellular signal-regulated kinase- to O(2)-nitric oxide-dependent mechanisms in the stimulatory effect of leptin on renal Na+/K+/-ATPase in the rat
    Andrzej Marciniak
    Department of Pathophysiology, Medical University, Lublin, Poland
    Clin Exp Pharmacol Physiol 33:1216-24. 2006
    ..e. by H(2)O(2)-dependent stimulation of ERK in normoleptinaemic animals and by superoxide-dependent impairment of the nitric oxide-cGMP pathway in hyperleptinaemic rats)...
  39. ncbi request reprint Stimulatory effect of leptin on nitric oxide production is impaired in dietary-induced obesity
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Obes Res 11:1571-80. 2003
    ..We investigated the effect of leptin on nitric oxide production in lean and rats made obese by a high-calorie diet...
  40. ncbi request reprint Liver X receptors (LXRs). Part I: structure, function, regulation of activity, and role in lipid metabolism
    Grazyna Wojcicka
    Department of Pathophysiology, Medical University, Lublin, Poland
    Postepy Hig Med Dosw (Online) 61:736-59. 2007
    ..In the accompanying article we characterize other effects of LXRs, alterations in LXR expression, and changes in the level of their endogenous agonists in pathological conditions as well as therapeutic implications...
  41. ncbi request reprint Liver X receptors (LXRs). Part II: non-lipid effects, role in pathology, and therapeutic implications
    Anna Jamroz-Wisniewska
    Department of Pathophysiology, Medical University, Lublin, Poland
    Postepy Hig Med Dosw (Online) 61:760-85. 2007
    ..The function of LX receptors is also modulated by many currently used drugs such as statins, fibrates, and thazolidinedione derivatives...
  42. ncbi request reprint Effect of 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins) on tissue paraoxonase 1 and plasma platelet activating factor acetylhydrolase activities
    Jerzy Bełtowski
    Department of Paraphysiology, Medical University, Lublin, Poland
    J Cardiovasc Pharmacol 43:121-7. 2004
    ..Reducing effect on PON1 may negatively modulate atheroprotective potential of statins and may contribute to differences in antiatherosclerotic properties of different drugs in this group...
  43. doi request reprint Modulation of paraoxonase 1 (PON1) activity and protein N-homocysteinylation by bisphosphonates in rats
    Marta Rusek
    Department of Pathophysiology, Medical University of Lublin, 8b Jaczewskiego Street, 20 090 Lublin, Poland Electronic address
    Chem Biol Interact 259:401-406. 2016
    ....
  44. ncbi request reprint Nitric oxide -- superoxide cooperation in the regulation of renal Na(+),K(+)-ATPase
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Acta Biochim Pol 51:933-42. 2004
    ..Excessive intrarenal generation of superoxide anion may upregulate medullary Na(+),K(+)-ATPase leading to sodium retention and blood pressure elevation...
  45. doi request reprint Leptin and the regulation of endothelial function in physiological and pathological conditions
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Clin Exp Pharmacol Physiol 39:168-78. 2012
    ..Resistance to the vasodilatory effects of leptin may contribute to the development of arterial hypertension owing to unopposed stimulation of the sympathetic nervous system by this hormone...
  46. ncbi request reprint Adverse effects of statins - mechanisms and consequences
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Curr Drug Saf 4:209-28. 2009
    ....
  47. doi request reprint Effects of antiretroviral treatment on paraoxonase 1 (PON1) activity in rats
    Jolanta Elżbieta Pastryk
    Department of Pathophysiology, Medical University of Lublin, 8b Jaczewskiego Street, 20 090 Lublin, Poland Electronic address
    Chem Biol Interact 259:407-412. 2016
    ..In conclusion, dyslipidemia induced by PIs is associated with reduced PON1 activity as well as increased protein homocysteinylation. PON1 deficiency may contribute to increased risk of atherosclerosis in these patients...
  48. ncbi request reprint Role of leptin in blood pressure regulation and arterial hypertension
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Hypertens 24:789-801. 2006
    ..Here, current knowledge about the role of leptin in the regulation of blood pressure and in the pathogenesis of arterial hypertension is presented...
  49. ncbi request reprint H2O2 and Src-dependent transactivation of the EGF receptor mediates the stimulatory effect of leptin on renal ERK and Na+, K+-ATPase
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Peptides 27:3234-44. 2006
    ..Leptin and H(2)O(2) increased Src phosphorylation at Tyr(418). We conclude that leptin-induced stimulation of renal Na(+), K(+)-ATPase involves H(2)O(2) generation, Src kinase, transactivation of the EGF receptor, and stimulation of ERK...
  50. ncbi request reprint Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity?
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Med Sci Monit 12:RA112-9. 2006
    ..Thus, apelin and visfatin are unique among adipose tissue hormones in that they are upregulated in the obese state and both exert primarily beneficial effects...
  51. ncbi request reprint OP23 Role of hydrogen sulfide in leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats
    Anna Jamroz-Wisniewska
    Department of Pathophysiology, Medical University, Lublin, Poland Department of Neurology, Medical University, Lublin, Poland
    Nitric Oxide 31:S29. 2013
    ..Increase in EDHF in hyperleptinemic and obese rats is accounted for, at least in part, by greater sensitivity of endothelium to H2S. ..
  52. ncbi request reprint Adiponectin and its role in cardiovascular diseases
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Cardiovasc Hematol Disord Drug Targets 8:7-46. 2008
    ..Among currently used drugs, thiazolidinediones (peroxisome proliferator activated receptor gamma agonists) are most effective in elevating adiponectin level...
  53. doi request reprint Liver X receptors (LXR) as therapeutic targets in dyslipidemia
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Cardiovasc Ther 26:297-316. 2008
    ..Some of currently used drugs also affect LXR signaling. For example, statins may impair LXR signaling by inhibiting oxysterol synthesis, whereas fibrates and thiazolidinediones increase LXR expression and activity...
  54. doi request reprint Hypoxia in the renal medulla: implications for hydrogen sulfide signaling
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Jaczewskiego 8, 20 090 Lublin, Poland
    J Pharmacol Exp Ther 334:358-63. 2010
    ..Deficiency of endogenous H(2)S may contribute to the pathogenesis of these pathologies by compromising medullary oxygenation, and administration of H(2)S donors may be of therapeutic value in these disorders...
  55. ncbi request reprint Phosphodiesterase 5 inhibitor ameliorates renal resistance to atrial natriuretic peptide associated with obesity and hyperleptinemia
    Jerzy Beltowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Arch Med Res 37:307-15. 2006
    ..Abnormal neurohormonal regulation of renal sodium handling plays an important role in obesity-associated hypertension. We investigated the effect of experimental obesity on renal response to atrial natriuretic peptide (ANP)...
  56. doi request reprint The paraoxonase 1 (PON1), platelet-activating factor acetylohydrolase (PAF-AH) and dimethylarginine dimethylaminohydrolase (DDAH) activity in the metformin treated normal and diabetic rats
    Grazyna Wojcicka
    Department of Pathophysiology, Medical University of Lublin, ul Jaczewskiego 8b, 20 090 Lublin, Poland Electronic address
    Eur J Pharmacol 789:187-94. 2016
    ..Metformin might also exert its effect against diabetic complications by improving DDAH activity in the kidney and increasing PON1 activity in the liver. ..
  57. doi request reprint Endogenous hydrogen sulfide in perivascular adipose tissue: role in the regulation of vascular tone in physiology and pathology
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, ulica Jaczewskiego 8, 20 090 Lublin, Poland
    Can J Physiol Pharmacol 91:889-98. 2013
    ..Up-regulation of H2S signaling in short-term obesity and (or) by elevated endocannabinoids may be a compensatory mechanism that maintains vascular tone, despite endothelial dysfunction...
  58. pmc Modulation of h(2)s metabolism by statins: a new aspect of cardiovascular pharmacology
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Antioxid Redox Signal 17:81-94. 2012
    ..Consequently, statins markedly decrease the risk of acute cardiovascular events. H(2)S is synthesized in all layers of the vascular wall, including the endothelium, smooth muscle cells, and perivascular adipose tissue (PVAT)...
  59. doi request reprint Hydrogen-sulfide-mediated vasodilatory effect of nucleoside 5'-monophosphorothioates in perivascular adipose tissue
    Jerzy Bełtowski
    a Department of Pathophysiology, Medical University, ul Jaczewskiego 8, 20 090 Lublin, Poland
    Can J Physiol Pharmacol 93:585-95. 2015
    ....
  60. doi request reprint Nucleoside monophosphorothioates as the new hydrogen sulfide precursors with unique properties
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland Electronic address
    Pharmacol Res 81:34-43. 2014
    ..AMPS and GMPS can be used as the H2S donors in experimental studies and possibly also as the H2S-releasing drugs. ..
  61. ncbi request reprint [Protein isoprenylation]
    Anna Jamroz-Wisniewska
    Katedra i Zakład Patofizjologii Akademii Medycznej im Prof F Skubiszewskiego w Lublinie, ul Jaczewskiego 8, 20 090 Lublin
    Postepy Biochem 50:316-29. 2004
  62. ncbi request reprint Protein homocysteinylation: a new mechanism of atherogenesis?
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Postepy Hig Med Dosw (Online) 59:392-404. 2005
    ..Protein homocysteinylation may contribute to accelerated atherogenesis in individuals with hyperhomocysteinemia...
  63. ncbi request reprint Hydrogen sulfide (H2S) - the third gas of interest for pharmacologists
    Ewelina Łowicka
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 59:4-24. 2007
    ....
  64. doi request reprint Hydrogen Sulfide in the Adipose Tissue-Physiology, Pathology and a Target for Pharmacotherapy
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, 20 090 Lublin, Poland
    Molecules 22:. 2016
    ..Hyperglycemia has been consistently demonstrated to suppress CSE-H₂S pathway in various adipose tissue depots. Finally, H₂S deficiency may contribute to adipose tissue inflammation associated with obesity/metabolic syndrome...
  65. ncbi request reprint Progranulin, a new adipokine at the crossroads of metabolic syndrome, diabetes, dyslipidemia and hypertension
    Agnieszka Korolczuk
    Department of Clinical Pathomorphology, Medical University, Lublin, Poland
    Curr Pharm Des . 2017
    ..On the other hand, progranulin augments vasorelaxation, inhibits inflammatory reaction, is neuroprotective and reduces ischemia-reperfusion injury...
  66. doi request reprint Hydrogen sulfide and endothelium-dependent vasorelaxation
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, 20 150 Lublin, Poland
    Molecules 19:21183-99. 2014
    ..Finally, H2S interacts with NO to form nitroxyl (HNO)-a potent vasorelaxant. H2S appears to play an important and multidimensional role in endothelium-dependent vasorelaxation. ..
  67. pmc Leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats: role of nitric oxide and hydrogen sulfide
    Anna Jamroz-Wisniewska
    Department of Pathophysiology, Medical University, Lublin, Poland Department of Neurology, Medical University, Lublin, Poland
    PLoS ONE 9:e86744. 2014
    ..The EDHF-dependent component of leptin-induced vasorelaxation is mediated, at least partially, by H2S. ..
  68. ncbi request reprint Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:159-78. 2006
    ..This article reviews the effect of pharmacotherapy on ADMA metabolism and its possible clinical implications...
  69. ncbi request reprint Liver X receptor (LXR) and the reproductive system--a potential novel target for therapeutic intervention
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 62:15-27. 2010
    ..Adverse effects of LXR agonists include impaired trophoblast invasion, excessive transplacental cholesterol transport from the mother to the fetus leading to fetal hypercholesterolemia, and augmented estrogen deficiency after menopause...
  70. ncbi request reprint Adiponectin and resistin--new hormones of white adipose tissue
    Jerzy Bełtowski
    Department of Pathophysiology, Lublin Medical University, Lublin, Poland
    Med Sci Monit 9:RA55-61. 2003
    ..Although the role of resistin in linking human obesity with type 2 diabetes is thus questionable, this protein is detected in peripheral blood monocytes,..
  71. ncbi request reprint Inverse relationship between total testosterone and anti-oxidized low density lipoprotein antibody levels in ageing males
    Wojciech Barud
    Department of Internal Medicine, University School of Medicine in Lublin, S Staszica 16, 20 081, Lublin, Poland
    Atherosclerosis 164:283-8. 2002
    ..These data suggest a that fall of testosterone concentration in ageing men can influence either oxidative modification of LDL or the immune response to these lipoproteins which may be important in the pathogenesis of atherosclerosis...