Inhibitory effect of ascorbic acid post-treatment on radiation-induced chromosomal damage in human lymphocytes in vitroMaria Konopacka
Department of Experimental and Clinical Radiobiology, Institute of Oncology, Gliwice, Poland
Teratog Carcinog Mutagen 22:443-50. 2002
..The removal of DNA breaks in cells exposed to 2 Gy of gamma-radiation was accelerated in the presence of ascorbic acid as determined by the comet assay, suggesting that it may stimulate DNA repair processes...
Effect of smoking and aging on micronucleus frequencies in human exfoliated buccal cellsM Konopacka
Department of Experimental and Clinical Radiobiology Institute of Oncology, 44 100 Gliwice, Poland
Neoplasma 50:380-2. 2003
..In the present study the calculated background frequency of micronuclei (per mille) in oral epithelial cells of 50 smokers and 70 non-smokers were 1.50 (+/-0.47) and 0.55 (+/-0.32), respectively...
Thiamine prevents X-ray induction of genetic changes in human lymphocytes in vitroMaria Konopacka
Department of Experimental and Clinical Radiobiology, Institute of Oncology, Gliwice, Poland
Acta Biochim Pol 51:839-43. 2004
..Vitamin B1 had no effect on radiation-induced cytotoxicity as measured by nuclear division index. The results indicate that vitamin B1 protects human cells from radiation-induced genetic changes...
[Role of vitamin C in oxidative DNA damage]Maria Konopacka
Zakład Radiobiologii Doświadczalnej i Klinicznej, Centrum Onkologii Oddział Gliwice, Instytut im M Skłodowskiej w Gliwicach
Postepy Hig Med Dosw (Online) 58:343-8. 2004
..The purpose of this review is to provide a summary of the role of vitamin C in oxidative DNA damage...
Antioxidant vitamins C, E and beta-carotene reduce DNA damage before as well as after gamma-ray irradiation of human lymphocytes in vitroM Konopacka
Department of Experimental and Clinical Radiobiology, Institute of Oncology, ul Armii Krajowej 15, 44 100, Gliwice, Poland
Mutat Res 491:1-7. 2001
..The radioprotective action of antioxidant Vitamins C, E and beta-carotene was dependent upon their concentration as well as time and sequence of application...
Modulation of cellular defense processes in human lymphocytes in vitro by a 1,4-dihydropyridine derivativeNadezhda I Ryabokon
Department of Experimental and Clinical Radiobiology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Branch Gliwice, Wybrzeze Armii Krajowej 15, 44 101 Gliwice, Poland
Mutat Res 679:33-8. 2009
..It suggests that the major target of the compound's action on genotoxic stress is DNA repair, followed by reduction of the number of damaged cells entering apoptosis...
The bystander effect-induced formation of micronucleated cells is inhibited by antioxidants, but the parallel induction of apoptosis and loss of viability are not affectedMaria Konopacka
Department of Experimental and Clinical Radiobiology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Armii Krajowej 15, 44 100 Gliwice, Poland
Mutat Res 593:32-8. 2006
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Bystander effects induced by medium from irradiated cells: similar transcriptome responses in irradiated and bystander K562 cellsRobert Herok
Department of Experimental and Clinical Radiobiology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland
Int J Radiat Oncol Biol Phys 77:244-52. 2010
..This work analyzes and compares changes in global transcript levels induced by direct irradiation and by bystander effects in K562 (human erythroleukemia) cells...
The cytotoxic and genotoxic effects of conjugated trans-2-nonenal (T2N), an off-flavor compound in beer and heat processed food arising from lipid oxidationEstera Szwajcer Dey
Lund University, Pure and Applied Biochemistry, Box 124, 221 00 Lund, Sweden
Pol J Microbiol 54:47-52. 2005
..It suggests that higher level of such aldehyde might create in organism severe potential of toxicity...