Zbigniew Kmiec

Summary

Country: Poland

Publications

  1. ncbi Cooperation of liver cells in health and disease
    Z Kmiec
    Medical University of Gdansk, Department of Histology and Immunology, 80211 Gdansk, Poland
    Adv Anat Embryol Cell Biol 161:III-XIII, 1-151. 2001
  2. ncbi The effects of galactosamine on UTP levels in the livers of young, adult and old rats
    Z Kmiec
    Department of Histology and Immunology, University Medical School of Gdansk, Poland
    Acta Biochim Pol 47:349-53. 2000
  3. ncbi Central regulation of food intake in ageing
    Z Kmiec
    Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
    J Physiol Pharmacol 57:7-16. 2006
  4. ncbi Effects of fasting and refeeding on serum leptin, adiponectin and free fatty acid concentrations in young and old male rats
    Zbigniew Kmiec
    Department Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
    Gerontology 51:357-62. 2005
  5. ncbi Central control of food intake in aging
    Zbigniew Kmiec
    Department of Histology, Medical University of Gdansk, Gdansk, Poland
    Interdiscip Top Gerontol 37:37-50. 2010
  6. ncbi Thyroid C cell function during fasting and refeeding of young and old rats
    Z Kmiec
    Department of Histology and Embryology, Medical University, Gdansk, Poland
    Folia Histochem Cytobiol 40:185-6. 2002
  7. ncbi Aging and peptide control of food intake
    Zbigniew Kmiec
    Department of Histology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Curr Protein Pept Sci 12:271-9. 2011
  8. ncbi [Role of tumor necrosis factor family ligands in the pathogenesis of rheumatoid arthritis--new therapeutical opportunities]
    Zbigniew Kmiec
    Akademia Medyczna w Gdansku, Katedra Histologii i Immunologii
    Pol Merkur Lekarski 22:300-4. 2007
  9. ncbi Ultrastructure of the ventromedial hypothalamic nucleus in fasted and refed young and old rats
    Jolanta Kubasik-Juraniec
    Laboratory of Electron Microscopy, Medical University of Gdansk, Poland
    Folia Morphol (Warsz) 62:89-98. 2003
  10. ncbi Transforming growth factor β1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts
    Anna Liberek
    Faculty of Health Sciences with Subfaculty of Nursing, Medical University of Gdansk, Gdansk, Poland
    Acta Biochim Pol 60:683-8. 2013

Collaborators

Detail Information

Publications23

  1. ncbi Cooperation of liver cells in health and disease
    Z Kmiec
    Medical University of Gdansk, Department of Histology and Immunology, 80211 Gdansk, Poland
    Adv Anat Embryol Cell Biol 161:III-XIII, 1-151. 2001
    ..Thus, hepatocytes are target cells for the action of eicosanoids and the site of their transformation and degradation, but can not directly oxidate arachidonic acid to eicosanoids. (ABSTRACT TRUNCATED)..
  2. ncbi The effects of galactosamine on UTP levels in the livers of young, adult and old rats
    Z Kmiec
    Department of Histology and Immunology, University Medical School of Gdansk, Poland
    Acta Biochim Pol 47:349-53. 2000
    ..The lower hepatic content of UTP may partially explain the increased sensitivity of hepatocytes and livers of old rats to the action of galactosamine, and possibly to other hepatotoxic compounds that decrease transcription in the liver...
  3. ncbi Central regulation of food intake in ageing
    Z Kmiec
    Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
    J Physiol Pharmacol 57:7-16. 2006
    ..If similar changes of the central control of food intake underly "anorexia of ageing" observed in some elderly, it is possible that therapeutic intervention at this regulatory level may be possible in the future...
  4. ncbi Effects of fasting and refeeding on serum leptin, adiponectin and free fatty acid concentrations in young and old male rats
    Zbigniew Kmiec
    Department Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
    Gerontology 51:357-62. 2005
    ..The age-related changes become often evident only during stimulation of basic functions that occurs, e.g. during fasting and refeeding which represent natural challenge to energy metabolism...
  5. ncbi Central control of food intake in aging
    Zbigniew Kmiec
    Department of Histology, Medical University of Gdansk, Gdansk, Poland
    Interdiscip Top Gerontol 37:37-50. 2010
    ..If similar changes at the level of CNS underlie the 'anorexia of aging' observed in some elderly, therapeutic interventions at this regulatory level may be possible in the future...
  6. ncbi Thyroid C cell function during fasting and refeeding of young and old rats
    Z Kmiec
    Department of Histology and Embryology, Medical University, Gdansk, Poland
    Folia Histochem Cytobiol 40:185-6. 2002
    ..These observations suggest that C-cell function is altered in ageing...
  7. ncbi Aging and peptide control of food intake
    Zbigniew Kmiec
    Department of Histology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Curr Protein Pept Sci 12:271-9. 2011
    ..Further studies of the central and peripheral mechanisms that control food intake during aging may provide novel therapeutic strategies to improve the nutritional status of the elderly...
  8. ncbi [Role of tumor necrosis factor family ligands in the pathogenesis of rheumatoid arthritis--new therapeutical opportunities]
    Zbigniew Kmiec
    Akademia Medyczna w Gdansku, Katedra Histologii i Immunologii
    Pol Merkur Lekarski 22:300-4. 2007
    ..Recently, therapeutics for pathological bone destruction targeting RANKL pathways have been used for the treatment of postmenopausal osteoporosis...
  9. ncbi Ultrastructure of the ventromedial hypothalamic nucleus in fasted and refed young and old rats
    Jolanta Kubasik-Juraniec
    Laboratory of Electron Microscopy, Medical University of Gdansk, Poland
    Folia Morphol (Warsz) 62:89-98. 2003
    ..However, starvation and subsequent refeeding cause similar alterations in the hypothalamic neurones of "satiety centre" of both young and old rats...
  10. ncbi Transforming growth factor β1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts
    Anna Liberek
    Faculty of Health Sciences with Subfaculty of Nursing, Medical University of Gdansk, Gdansk, Poland
    Acta Biochim Pol 60:683-8. 2013
    ..Levels of TGF-β1 and corresponding mRNA are elevated during the active stage of IBD but not during the remission. Longitudinal assessment of this cytokine in a single patient may help to monitor the clinical course of IBD. ..
  11. ncbi The effect of fasting and refeeding on the ultrastructure of the hypothalamic paraventricular nucleus in young and old rats
    Jolanta Kubasik-Juraniec
    Laboratory of Electron Microscopy, Medical University, Gdansk, Poland
    Folia Morphol (Warsz) 63:25-35. 2004
    ..Our observations suggest that at the ultrastructural level the process of ageing does not change the responsiveness of magnocellular PVN neurons to fasting-refeeding...
  12. ncbi [Role of transforming growth factor beta1 (TGF-beta1) in the pathogenesis and clinical course of chronic hepatitis in children]
    Anna Liberek
    Katedra i Klinika Pediatrii, Gastroenterologii, Hepatologii i Zywienia Dzieci Gdańskiego Uniwersytetu Medycznego, ul Nowe Ogrody 1 6, 80 803 Gdansk
    Med Wieku Rozwoj 13:163-70. 2009
    ..h.) and to assess whether TGF-beta1 level in plasma or its tissue expression can be useful in diagnosing and monitoring of clinical course of this disease...
  13. ncbi [Gene polymorphism of transforming growth factor beta1 (TGF-beta1) in the pathogenesis and clinical course of chronic hepatitis in children]
    Anna Liberek
    Katedra i Klinika Pediatrii, Gastroenterologii, Hepatologii i Zywienia Dzieci Gdańskiego Uniwersytetu Medycznego, ul Nowe Ogrody 1 6, 80 803 Gdansk
    Med Wieku Rozwoj 13:171-9. 2009
    ..THE AIM of the study was to assess the relation between TGF-beta1gene polymorphism and the incidence of chronic hepatitis, the course of the disease, TGF-beta1 level in plasma and TGF-beta1 mRNA expression in liver tissue...
  14. ncbi Overexpression of the fragile histidine triad (FHIT) gene in inflammatory bowel disease
    P M Wierzbicki
    Department of Histology, Medical University of Gdansk, Gdansk, Poland
    J Physiol Pharmacol 60:57-62. 2009
    ..FHIT gene encodes human diadenosine triphosphate hydrolase involved in the regulation of cell cycle and nucleotide metabolism and is a candidate tumor suppressor gene...
  15. ncbi Fragile histidine triad (FHIT) gene is overexpressed in colorectal cancer
    P M Wierzbicki
    Department of Histology, Medical University of Gdansk, Gdansk, Poland
    J Physiol Pharmacol 60:63-70. 2009
    ..Decreased FHIT gene expression was previously observed in various types of human cancer, however, quantification of FHIT mRNA was seldom performed...
  16. ncbi Decreased Toll-like receptor-5 (TLR-5) expression in the mucosa of ulcerative colitis patients
    M Stanislawowski
    Department of Histology, Medical University of Gdansk, Poland
    J Physiol Pharmacol 60:71-5. 2009
    ..Toll-like receptors (TLR) recognize various molecules of microbiota including flagellin, the principal protein of motile comensal and pathogenic bacteria implicated in the pathogenesis of IBD...
  17. ncbi The effects of fasting and refeeding on adrenal cortex morphometry and serum concentrations of ACTH and corticosterone in young and old male rats
    Z Kmiec
    Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
    J Physiol Pharmacol 57:77-84. 2006
    ..In young rats refeeding reduced the volume of reticular zone. It is concluded that refeeding revealed ageing-dependent decline in the secretion of corticosterone, the key hormone of prolonged stress response...
  18. ncbi Natural killer activity and thyroid hormone levels in young and elderly persons
    Z Kmiec
    Department of Histology, 3rd Department of Internal Medicine, Medical University of Gdansk, Poland
    Gerontology 47:282-8. 2001
    ..The purpose of the study is to compare NK cytotoxic activity and serum concentrations of TSH and thyroid hormones in healthy old and young people, and to assess in vitro the effects of triiodothyronine (T(3)) on NK activity...
  19. doi Anorexia of aging
    Zbigniew Kmiec
    Department of Histology, Medical University of Gdansk, Gdansk, Poland
    Vitam Horm 92:319-55. 2013
    ..Currently, there is no efficient pharmacological treatment for the anorexia of aging; however, it may be partially prevented by improved processing and presenting of food, physical training, and an appropriate social environment...
  20. doi The gender- and fat depot-specific regulation of leptin, resistin and adiponectin genes expression by progesterone in rat
    Ewa Stelmanska
    Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland
    J Steroid Biochem Mol Biol 132:160-7. 2012
    ....
  21. ncbi [The participation of RANK, RANKL and OPG in tumor osteolysis]
    Marcin Stanisławowski
    Zakład Histologii, Akademia Medyczna w Gdansku, 80 211 Gdansk
    Postepy Hig Med Dosw (Online) 63:234-41. 2009
    ..The elucidation of the key mechanisms of tumor osteolysis has led to clinical trials of biological therapies based on the inhibition of RANKL and stimulation of OPG activity...
  22. pmc Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation
    Piotr M Wierzbicki
    Department of Histology, Faculty of Medicine, Medical University of Gdansk, 80210 Gdansk, Poland
    World J Gastroenterol 19:4363-73. 2013
    ..To investigate large tumor suppressor 1 (LATS1) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC)...
  23. pmc The mRNA level of the transforming growth factor β1 gene, but not the amount of the gene product, can be considered as a potential prognostic parameter in inflammatory bowel diseases in children
    Anna Liberek
    Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Nowe Ogrody 1 6, 80 803, Gdansk, Poland
    Int J Colorectal Dis 28:165-72. 2013
    ..In this work, we asked whether levels of either TGF-β1 or mRNA of the corresponding gene in plasma or tissue can be useful in diagnosing and/or monitoring of the clinical course of inflammatory bowel diseases (IBD)...