Genomes and Genes
- [Non-alcoholic fatty liver disease (NAFLD) in patients with metabolic syndrome and type 2 diabetes mellitus. Pathomechanism, new diagnostic markers]Beata Kiec-Wilk
Katedra i Klinika Chorób Metabolicznych, UJ CM, Krakow
Przegl Lek 67:496-501. 2010..The manuscript is a review of new biochemical markers allowing for early detection of metabolic disorders leading to NAFLD development, thus to sufficient prevention of this pathology in patients...
- [Growth factors and cytokines (TGFBeta, bFGF and IGF-1) and cardiac left ventricular hypertrophy in hypertension]Beata Kiec-Wilk
Zaklad Biochemii Klinicznej Katedry Biochemii Klinicznej, Collegium Medicum, Uniwersytet Jagiellonski, Krakow
Kardiol Pol 64:S586-90. 2006..Discussed growth factors and cytokines and cell signalling pathways related to them might in future appear as targets for therapeutic intervention...
- DNA methylation, induced by beta-carotene and arachidonic acid, plays a regulatory role in the pro-angiogenic VEGF-receptor (KDR) gene expression in endothelial cellsB Kiec-Wilk
Department of Medical Biochemistry, Jagiellonian University Medical College, Cracow, Poland
J Physiol Pharmacol 60:49-53. 2009..This study was aimed to investigate a possible role of CpG island methylation on regulation of the pro-angiogenic KDR gene expression after incubation of human endothelial cells with BC and/or AA...
- Beta-carotene and arachidonic acid induced DNA methylation and the regulation of pro-chemotactic activity of endothelial cells and its progenitorsB Kiec-Wilk
Department of Clinical Biochemistry, Jagiellonian University, Krakow, Poland
J Physiol Pharmacol 58:757-66. 2007....
- A724A polymorphism of sarco(endo)plasmic reticulum Ca2+-ATPase 2 (SERCA2) in hypertensive patientsBeata Kiec-Wilk
Clinical Biochemistry Department, Medical College Jagiellonian University, Krakow, Poland
Clin Chem Lab Med 45:467-70. 2007..The aim of this study was to screen for mutations in the ATP2A2 gene, in hypertensive patients compared to healthy controls...
- Analysis of candidate genes in Polish families with obesityMałgorzata Malczewska-Malec
Department of Clinical Biochemistry, The Jagiellonian University Medical College, Krakow, Poland
Clin Chem Lab Med 42:487-93. 2004..We conclude that the polymorphisms we investigated were weakly correlated with obesity but significantly modified the risk factors of the metabolic syndrome...
- An analysis of the link between polymorphisms of the beta2 and beta3 adrenergic receptor gene and metabolic parameters among Polish Caucasians with familial obesityMałgorzata Malczewska-Malec
Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow Poland
Med Sci Monit 9:CR225-34. 2003..The aim of this study was to evaluate the influence of beta2 (Gln27>Glu) and beta3 (Trp64>Arg) adrenoreceptor gene polymorphisms on BMI and carbohydrate-lipid metabolism in Polish obese families...
- beta-Carotene stimulates chemotaxis of human endothelial progenitor cellsBeata Kiec-Wilk
Department of Clinical Biochemistry, Medical College, Jagiellonian University, Krakow, Poland
Clin Chem Lab Med 43:488-98. 2005....
- [Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities]Barbara Zapała
Katedra i Zakład Biochemii Klinicznej, Uniwersytet Jagiellonski, Collegium Medicum, Krakow
Przegl Lek 68:372-7. 2011..The in vivo studies suggest that humanin may protect against cognitive impairment, also due to ischemia/reperfusion injury...
- Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistanceUrszula Razny
Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a Street, 31 501 Cracow, Poland
Cardiovasc Diabetol 10:68. 2011..The purpose of this study was to investigate the effect of high fat diet on metabolism in mice with decreased (eNOS-/-) and increased (DDAH overexpressed) NO bioavailability...
- Genetic factors in hypertension. Angiotensin-converting enzyme polymorphismDanuta Czarnecka
First Cardiac Department, Medical College, Jagiellonian University, Cracow, Poland
Kardiol Pol 61:1-10; discussion 11. 2004....
- Influence of fatty acids on mitochondrial metabolism of adipocyte progenitors and endothelial cellsAnna Knapp
Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
Arch Physiol Biochem 118:128-34. 2012..In obesity, the cells are exposed to excessive amounts of nutrients, especially free fatty acids (FFAs) that induce a variety of metabolic changes...
- Modulatory effect of high saturated fat diet-induced metabolic disturbances on angiogenic response in hepatocyte RXRα knockout miceUrszula Razny
Department of Clinical Biochemistry, Medical College, Jagiellonian University, Kopernika 15A, PL 31 501 Krakow, Poland
Pharmacol Rep 62:1078-89. 2010..These results argue for independent participation of dyslipidemia and hyperleptinemia in pathology of angiogenic response associating metabolic syndrome...
- Evidence for potential functionality of nuclearly-encoded humanin isoformsMarek Bodzioch
Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Kopernika 15A, 31 501 Krakow, Poland
Genomics 94:247-56. 2009..Cytoprotection against the STS-induced apoptosis conferred by the polymorphic HN5 variant, in which threonine in position 13 is replaced with isoleucine, is reduced compared to the wild type HN5 peptide...
- Peripheral blood concentrations of TGFβ1, IGF-1 and bFGF and remodelling of the left ventricle and blood vessels in hypertensive patientsBeata Kiec-Wilk
Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
Kardiol Pol 68:996-1002. 2010..Studies performed on animal models as well as clinical trials on aetiology of left ventricular hypertrophy (LVH), documented elevated level of both mRNA and proteins of TGFβ1 and IGF-1...
- Variants of the adiponectin gene and type 2 diabetes in a Polish populationMagdalena Szopa
Department of Metabolic Diseases, Medical College, Jagiellonian University, 15 Kopernika Street, 31 501, Krakow, Poland
Acta Diabetol 46:317-22. 2009..391G>A and +276G>T were independently associated with T2DM. Finally, we conclude that the adiponectin gene polymorphisms are associated with T2DM and prediabetic quantitative traits in Polish Caucasians...
- The CpG island methylation regulated expression of endothelial proangiogenic genes in response to β-carotene and arachidonic acidBeata Kiec-Wilk
Department of Medical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
Nutr Cancer 63:1053-63. 2011..However more research is necessary to confirm this hypothesis...
- Role of microRNAs in endothelial cell pathophysiologyTeresa Staszel
Genetic Diagnostics and Nutrigenomics Unit, Department of Clinical Biochemistry, Jagiellonian University, Medical College, Krakow, Poland
Pol Arch Med Wewn 121:361-6. 2011..Studies show that miRNA expression analysis can be used in the diagnosis and treatment of various diseases; however, additional research is needed before it is used in routine clinical setting...
- [Role of the M235T (c.704c>T) polymorphism of angiotensynogen gene as well as A724A (c.2171G>A) polymorphism of SERCA2a gene in ethiopathogenesis of left ventricular hypertrophy in essential hypertension]Beata Kiec-Wilk
Katedra i Klinika Chorób Metabolicznych, CM UJ, Krakow
Przegl Lek 67:151-6. 2010..2171G>A polymorphism of the ATP2A2 gene against the hypertension as well as LVH development. It seems also that c.704C>T polymorphism of AGT gene does not play crucial role in the essential hypertension development...
- The microarray expression analysis identifies BAX as a mediator of beta-carotene effects on apoptosisMarek Bodzioch
Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland
Nutr Cancer 51:226-35. 2005..However, beta-carotene-induced expression changes of BAX and other BCL2 pathway genes did not lead to the predicted induction of apoptosis in the A375 cells...
- Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)Iwona Wybranska
Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
Clin Chem Lab Med 45:1124-32. 2007..The aim of this study was to identify correlation between the risk originating from gene variation and diet-dependent development of insulin resistance...
- Connexin 43 and metabolic effect of fatty acids in stressed endothelial cellsBeata Kiec-Wilk
Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
Genes Nutr 7:257-63. 2012....
- Phospholamban gene mutations are not associated with hypertrophic cardiomyopathy in patients from southern PolandPaweł Petkow-Dimitrow
2nd Department of Cardiology, Collegium Medicum, Jagiellonian University, Krakow, Poland
Kardiol Pol 69:134-7. 2011..Hypertrophic cardiomyopathy (HCM) is a genetic disease. The role of phospholamban (PLN) gene mutations is the development of HCM has not been established...
- Cystatin C is not a good candidate biomarker for HNF1A-MODYNatalia Nowak
Department of Metabolic Diseases, Jagiellonian University Medical College, 15 Kopernika Street, 31 501, Krakow, Poland
Acta Diabetol 50:815-20. 2013..In HNF1A-MODY, the cystatin C-based GFR estimate is higher than the creatinine-based one. ..
- Clinical factors affecting the perception of hypoglycemia in type 1 diabetes patients treated with personal insulin pumpsBartłomiej Matejko
Department and Chair of Metabolic Diseases, Jagiellonian University, Krakow, Poland
Ann Agric Environ Med 20:152-4. 2013....
- Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory propertiesBarbara Zapała
Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Kopernika 15A, PL31 501 Kraków, Poland
Pharmacol Rep 62:767-77. 2010..In vivo studies suggest that HN may also protect against cognitive impairment due to ischemia/reperfusion injury...
- Antioxidant phytochemicals against type 2 diabetesAldona Dembinska-Kiec
Department of Clinical Biochemistry, The Jagiellonian University Collegium Medicum, Kopernika 15A, Krakow 31 501, Poland
Br J Nutr 99:ES109-17. 2008....
- Lipoprotein profile, plasma ischemia modified albumin and LDL density change in the course of postprandial lipemia. Insights from the LIPGENE studyJadwiga Hartwich
Department of Clinical Biochemistry, Jagiellonian University School of Medicine, Krakow, Poland
Scand J Clin Lab Invest 70:201-8. 2010..No expected associations between measures of central adiposity (waist, WHR), adipose tissue insulin resistance (Adipo-IR), and postprandial responses of TG, TC, LDL-C, HDL-C, LDLdens and IMA/Alb ratio were found in subgroup analysis...
- Gender does not influence event-free survival in patients with ischaemic heart disease undergoing non-emergency coronary angiography. A single centre analysisPiotr Jankowski
1st Department of Cardiology, Collegium Medicum Jagiellonian University, Cracow, Poland
Kardiol Pol 65:475-84; discussion 485. 2007..In addition, available data on the prognosis in this condition in men and women are also scarce...
- [Variants of adiponectin gene as risk factors for the metabolic syndrome]Magdalena Szopa
Zakład Biochemii Klinicznej, Collegium Medicum, Uniwersytet Jagiellonski, Krakow
Przegl Lek 66:257-62. 2009..This data may enable patients at greater risk of the adverse effects of obesity to be identified and, as such, benefit from more targeted therapy and prevention...
- Effects of oral L-arginine on the pulsatility indices of umbilical artery and middle cerebral artery in preterm laborKrzysztof Rytlewski
Department of Gynecology and Obstetrics, Jagiellonian University Medical College, Krakow, Poland
Eur J Obstet Gynecol Reprod Biol 138:23-8. 2008..The objective of the study was the estimation of the influence of oral supplementation with low-dose l-arginine on feto-placental circulation in women with threatened preterm labor...
- Proangiogenic activity of beta-carotene is coupled with the activation of endothelial cell chemotaxisA Dembinska-Kiec
Department of Clinical Biochemistry, The Jagiellonian University Medical College, Kopernika 15A, 31 501 Krakow, Poland
Biochim Biophys Acta 1740:222-39. 2005..We conclude that beta-carotene in the physiological concentration range stimulates early steps of angiogenesis by the activation of cellular migration as well as matrix reorganization and decrease of cell adhesion...