Beata Kiec-Wilk

Summary

Country: Poland

Publications

  1. ncbi DNA methylation, induced by beta-carotene and arachidonic acid, plays a regulatory role in the pro-angiogenic VEGF-receptor (KDR) gene expression in endothelial cells
    B Kiec-Wilk
    Department of Medical Biochemistry, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 60:49-53. 2009
  2. ncbi [Non-alcoholic fatty liver disease (NAFLD) in patients with metabolic syndrome and type 2 diabetes mellitus. Pathomechanism, new diagnostic markers]
    Beata Kiec-Wilk
    Katedra i Klinika Chorób Metabolicznych, UJ CM, Krakow
    Przegl Lek 67:496-501. 2010
  3. ncbi [Growth factors and cytokines (TGFBeta, bFGF and IGF-1) and cardiac left ventricular hypertrophy in hypertension]
    Beata Kiec-Wilk
    Zaklad Biochemii Klinicznej Katedry Biochemii Klinicznej, Collegium Medicum, Uniwersytet Jagiellonski, Krakow
    Kardiol Pol 64:S586-90. 2006
  4. ncbi A724A polymorphism of sarco(endo)plasmic reticulum Ca2+-ATPase 2 (SERCA2) in hypertensive patients
    Beata Kiec-Wilk
    Clinical Biochemistry Department, Medical College Jagiellonian University, Krakow, Poland
    Clin Chem Lab Med 45:467-70. 2007
  5. ncbi Beta-carotene and arachidonic acid induced DNA methylation and the regulation of pro-chemotactic activity of endothelial cells and its progenitors
    B Kiec-Wilk
    Department of Clinical Biochemistry, Jagiellonian University, Krakow, Poland
    J Physiol Pharmacol 58:757-66. 2007
  6. ncbi Analysis of candidate genes in Polish families with obesity
    Małgorzata Malczewska-Malec
    Department of Clinical Biochemistry, The Jagiellonian University Medical College, Krakow, Poland
    Clin Chem Lab Med 42:487-93. 2004
  7. ncbi beta-Carotene stimulates chemotaxis of human endothelial progenitor cells
    Beata Kiec-Wilk
    Department of Clinical Biochemistry, Medical College, Jagiellonian University, Krakow, Poland
    Clin Chem Lab Med 43:488-98. 2005
  8. ncbi An analysis of the link between polymorphisms of the beta2 and beta3 adrenergic receptor gene and metabolic parameters among Polish Caucasians with familial obesity
    Małgorzata Malczewska-Malec
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow Poland
    Med Sci Monit 9:CR225-34. 2003
  9. ncbi [Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities]
    Barbara Zapała
    Katedra i Zakład Biochemii Klinicznej, Uniwersytet Jagiellonski, Collegium Medicum, Krakow
    Przegl Lek 68:372-7. 2011
  10. ncbi Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance
    Urszula Razny
    Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a Street, 31 501 Cracow, Poland
    Cardiovasc Diabetol 10:68. 2011

Collaborators

Detail Information

Publications31

  1. ncbi DNA methylation, induced by beta-carotene and arachidonic acid, plays a regulatory role in the pro-angiogenic VEGF-receptor (KDR) gene expression in endothelial cells
    B Kiec-Wilk
    Department of Medical Biochemistry, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 60:49-53. 2009
    ..0014) increased the KDR protein levels in HUVECs. CONCLUSION: The changes in CpG island methylation of the KDR the pro-angiogenic gene promoter, represents one of the mechanisms involved in regulation of angiogenic response by BC and AA...
  2. ncbi [Non-alcoholic fatty liver disease (NAFLD) in patients with metabolic syndrome and type 2 diabetes mellitus. Pathomechanism, new diagnostic markers]
    Beata Kiec-Wilk
    Katedra i Klinika Chorób Metabolicznych, UJ CM, Krakow
    Przegl Lek 67:496-501. 2010
    ..The manuscript is a review of new biochemical markers allowing for early detection of metabolic disorders leading to NAFLD development, thus to sufficient prevention of this pathology in patients...
  3. ncbi [Growth factors and cytokines (TGFBeta, bFGF and IGF-1) and cardiac left ventricular hypertrophy in hypertension]
    Beata Kiec-Wilk
    Zaklad Biochemii Klinicznej Katedry Biochemii Klinicznej, Collegium Medicum, Uniwersytet Jagiellonski, Krakow
    Kardiol Pol 64:S586-90. 2006
    ..Discussed growth factors and cytokines and cell signalling pathways related to them might in future appear as targets for therapeutic intervention...
  4. ncbi A724A polymorphism of sarco(endo)plasmic reticulum Ca2+-ATPase 2 (SERCA2) in hypertensive patients
    Beata Kiec-Wilk
    Clinical Biochemistry Department, Medical College Jagiellonian University, Krakow, Poland
    Clin Chem Lab Med 45:467-70. 2007
    ..The aim of this study was to screen for mutations in the ATP2A2 gene, in hypertensive patients compared to healthy controls...
  5. ncbi Beta-carotene and arachidonic acid induced DNA methylation and the regulation of pro-chemotactic activity of endothelial cells and its progenitors
    B Kiec-Wilk
    Department of Clinical Biochemistry, Jagiellonian University, Krakow, Poland
    J Physiol Pharmacol 58:757-66. 2007
    ....
  6. ncbi Analysis of candidate genes in Polish families with obesity
    Małgorzata Malczewska-Malec
    Department of Clinical Biochemistry, The Jagiellonian University Medical College, Krakow, Poland
    Clin Chem Lab Med 42:487-93. 2004
    ..We conclude that the polymorphisms we investigated were weakly correlated with obesity but significantly modified the risk factors of the metabolic syndrome...
  7. ncbi beta-Carotene stimulates chemotaxis of human endothelial progenitor cells
    Beata Kiec-Wilk
    Department of Clinical Biochemistry, Medical College, Jagiellonian University, Krakow, Poland
    Clin Chem Lab Med 43:488-98. 2005
    ....
  8. ncbi An analysis of the link between polymorphisms of the beta2 and beta3 adrenergic receptor gene and metabolic parameters among Polish Caucasians with familial obesity
    Małgorzata Malczewska-Malec
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow Poland
    Med Sci Monit 9:CR225-34. 2003
    ..The aim of this study was to evaluate the influence of beta2 (Gln27>Glu) and beta3 (Trp64>Arg) adrenoreceptor gene polymorphisms on BMI and carbohydrate-lipid metabolism in Polish obese families...
  9. ncbi [Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities]
    Barbara Zapała
    Katedra i Zakład Biochemii Klinicznej, Uniwersytet Jagiellonski, Collegium Medicum, Krakow
    Przegl Lek 68:372-7. 2011
    ..The in vivo studies suggest that humanin may protect against cognitive impairment, also due to ischemia/reperfusion injury...
  10. ncbi Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance
    Urszula Razny
    Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a Street, 31 501 Cracow, Poland
    Cardiovasc Diabetol 10:68. 2011
    ..The purpose of this study was to investigate the effect of high fat diet on metabolism in mice with decreased (eNOS-/-) and increased (DDAH overexpressed) NO bioavailability...
  11. ncbi Influence of fatty acids on mitochondrial metabolism of adipocyte progenitors and endothelial cells
    Anna Knapp
    Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
    Arch Physiol Biochem 118:128-34. 2012
    ..Objective: We investigated the effect of FFAs on the mitochondrial function in different cell populations under stress conditions...
  12. ncbi Peripheral blood concentrations of TGFβ1, IGF-1 and bFGF and remodelling of the left ventricle and blood vessels in hypertensive patients
    Beata Kiec-Wilk
    Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
    Kardiol Pol 68:996-1002. 2010
    ..Studies performed on animal models as well as clinical trials on aetiology of left ventricular hypertrophy (LVH), documented elevated level of both mRNA and proteins of TGFβ1 and IGF-1...
  13. ncbi Modulatory effect of high saturated fat diet-induced metabolic disturbances on angiogenic response in hepatocyte RXRα knockout mice
    Urszula Razny
    Department of Clinical Biochemistry, Medical College, Jagiellonian University, Kopernika 15A, PL 31 501 Krakow, Poland
    Pharmacol Rep 62:1078-89. 2010
    ..These results argue for independent participation of dyslipidemia and hyperleptinemia in pathology of angiogenic response associating metabolic syndrome...
  14. ncbi Evidence for potential functionality of nuclearly-encoded humanin isoforms
    Marek Bodzioch
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Kopernika 15A, 31 501 Krakow, Poland
    Genomics 94:247-56. 2009
    ..Cytoprotection against the STS-induced apoptosis conferred by the polymorphic HN5 variant, in which threonine in position 13 is replaced with isoleucine, is reduced compared to the wild type HN5 peptide...
  15. ncbi Variants of the adiponectin gene and type 2 diabetes in a Polish population
    Magdalena Szopa
    Department of Metabolic Diseases, Medical College, Jagiellonian University, 15 Kopernika Street, 31 501, Krakow, Poland
    Acta Diabetol 46:317-22. 2009
    ..In addition, in this model, -11.391G>A and +276G>T were independently associated with T2DM. Finally, we conclude that the adiponectin gene polymorphisms are associated with T2DM and prediabetic quantitative traits in Polish Caucasians...
  16. ncbi The CpG island methylation regulated expression of endothelial proangiogenic genes in response to β-carotene and arachidonic acid
    Beata Kiec-Wilk
    Department of Medical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
    Nutr Cancer 63:1053-63. 2011
    ..However more research is necessary to confirm this hypothesis...
  17. ncbi Genetic factors in hypertension. Angiotensin-converting enzyme polymorphism
    Danuta Czarnecka
    First Cardiac Department, Medical College, Jagiellonian University, Cracow, Poland
    Kardiol Pol 61:1-10; discussion 11. 2004
    ....
  18. ncbi Role of microRNAs in endothelial cell pathophysiology
    Teresa Staszel
    Genetic Diagnostics and Nutrigenomics Unit, Department of Clinical Biochemistry, Jagiellonian University, Medical College, Krakow, Poland
    Pol Arch Med Wewn 121:361-6. 2011
    ..Studies show that miRNA expression analysis can be used in the diagnosis and treatment of various diseases; however, additional research is needed before it is used in routine clinical setting...
  19. ncbi The microarray expression analysis identifies BAX as a mediator of beta-carotene effects on apoptosis
    Marek Bodzioch
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Nutr Cancer 51:226-35. 2005
    ..However, beta-carotene-induced expression changes of BAX and other BCL2 pathway genes did not lead to the predicted induction of apoptosis in the A375 cells...
  20. ncbi [Role of the M235T (c.704c>T) polymorphism of angiotensynogen gene as well as A724A (c.2171G>A) polymorphism of SERCA2a gene in ethiopathogenesis of left ventricular hypertrophy in essential hypertension]
    Beata Kiec-Wilk
    Katedra i Klinika Chorób Metabolicznych, CM UJ, Krakow
    Przegl Lek 67:151-6. 2010
    ..2171G>A polymorphism of the ATP2A2 gene against the hypertension as well as LVH development. It seems also that c.704C>T polymorphism of AGT gene does not play crucial role in the essential hypertension development...
  21. ncbi Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
    Iwona Wybranska
    Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
    Clin Chem Lab Med 45:1124-32. 2007
    ..The aim of this study was to identify correlation between the risk originating from gene variation and diet-dependent development of insulin resistance...
  22. ncbi Connexin 43 and metabolic effect of fatty acids in stressed endothelial cells
    Beata Kiec-Wilk
    Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
    Genes Nutr 7:257-63. 2012
    ....
  23. ncbi Phospholamban gene mutations are not associated with hypertrophic cardiomyopathy in patients from southern Poland
    Paweł Petkow-Dimitrow
    2nd Department of Cardiology, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Kardiol Pol 69:134-7. 2011
    ..Hypertrophic cardiomyopathy (HCM) is a genetic disease. The role of phospholamban (PLN) gene mutations is the development of HCM has not been established...
  24. ncbi Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties
    Barbara Zapała
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Kopernika 15A, PL31 501 Kraków, Poland
    Pharmacol Rep 62:767-77. 2010
    ..In vivo studies suggest that HN may also protect against cognitive impairment due to ischemia/reperfusion injury...
  25. ncbi Lipoprotein profile, plasma ischemia modified albumin and LDL density change in the course of postprandial lipemia. Insights from the LIPGENE study
    Jadwiga Hartwich
    Department of Clinical Biochemistry, Jagiellonian University School of Medicine, Krakow, Poland
    Scand J Clin Lab Invest 70:201-8. 2010
    ..No expected associations between measures of central adiposity (waist, WHR), adipose tissue insulin resistance (Adipo-IR), and postprandial responses of TG, TC, LDL-C, HDL-C, LDLdens and IMA/Alb ratio were found in subgroup analysis...
  26. ncbi Antioxidant phytochemicals against type 2 diabetes
    Aldona Dembinska-Kiec
    Department of Clinical Biochemistry, The Jagiellonian University Collegium Medicum, Kopernika 15A, Krakow 31 501, Poland
    Br J Nutr 99:ES109-17. 2008
    ....
  27. ncbi Clinical factors affecting the perception of hypoglycemia in type 1 diabetes patients treated with personal insulin pumps
    Bartłomiej Matejko
    Department and Chair of Metabolic Diseases, Jagiellonian University, Krakow, Poland
    Ann Agric Environ Med 20:152-4. 2013
    ....
  28. ncbi Effects of oral L-arginine on the pulsatility indices of umbilical artery and middle cerebral artery in preterm labor
    Krzysztof Rytlewski
    Department of Gynecology and Obstetrics, Jagiellonian University Medical College, Krakow, Poland
    Eur J Obstet Gynecol Reprod Biol 138:23-8. 2008
    ..The objective of the study was the estimation of the influence of oral supplementation with low-dose l-arginine on feto-placental circulation in women with threatened preterm labor...
  29. ncbi [Variants of adiponectin gene as risk factors for the metabolic syndrome]
    Magdalena Szopa
    Zakład Biochemii Klinicznej, Collegium Medicum, Uniwersytet Jagiellonski, Krakow
    Przegl Lek 66:257-62. 2009
    ..This data may enable patients at greater risk of the adverse effects of obesity to be identified and, as such, benefit from more targeted therapy and prevention...
  30. ncbi Gender does not influence event-free survival in patients with ischaemic heart disease undergoing non-emergency coronary angiography. A single centre analysis
    Piotr Jankowski
    1st Department of Cardiology, Collegium Medicum Jagiellonian University, Cracow, Poland
    Kardiol Pol 65:475-84; discussion 485. 2007
    ..In addition, available data on the prognosis in this condition in men and women are also scarce...
  31. ncbi Proangiogenic activity of beta-carotene is coupled with the activation of endothelial cell chemotaxis
    A Dembinska-Kiec
    Department of Clinical Biochemistry, The Jagiellonian University Medical College, Kopernika 15A, 31 501 Krakow, Poland
    Biochim Biophys Acta 1740:222-39. 2005
    ..We conclude that beta-carotene in the physiological concentration range stimulates early steps of angiogenesis by the activation of cellular migration as well as matrix reorganization and decrease of cell adhesion...