Katarzyna Młyniec

Summary

Affiliation: Jagiellonian University
Country: Poland

Publications

  1. doi request reprint Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder
    Katarzyna Młyniec
    Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland Electronic address
    J Neuroimmunol 291:11-7. 2016
  2. doi request reprint Up-regulation of the GPR39 Zn2+-sensing receptor and CREB/BDNF/TrkB pathway after chronic but not acute antidepressant treatment in the frontal cortex of zinc-deficient mice
    Katarzyna Młyniec
    Department of Pharmacobiology, Jagiellonian University Medical College, Krakow, Poland Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland Electronic address
    Pharmacol Rep 67:1135-40. 2015
  3. doi request reprint Study of antidepressant drugs in GPR39 (zinc receptor⁻/⁻) knockout mice, showing no effect of conventional antidepressants, but effectiveness of NMDA antagonists
    Katarzyna Młyniec
    Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland Electronic address
    Behav Brain Res 287:135-8. 2015
  4. doi request reprint Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission
    Katarzyna Młyniec
    Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland Electronic address
    Brain Res Bull 115:23-9. 2015
  5. doi request reprint GPR39 Zn(2+)-sensing receptor: a new target in antidepressant development?
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland Electronic address
    J Affect Disord 174:89-100. 2015
  6. doi request reprint Essential elements in depression and anxiety. Part II
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Krakow, Poland Electronic address
    Pharmacol Rep 67:187-94. 2015
  7. ncbi request reprint Chronic but not acute antidepresant treatment alters serum zinc/copper ratio under pathological/zinc-deficient conditions in mice
    K Mlyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 65:673-8. 2014
  8. doi request reprint Essential elements in depression and anxiety. Part I
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Collegium Medicum, Krakow, Poland Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland Electronic address
    Pharmacol Rep 66:534-44. 2014
  9. doi request reprint The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims
    Katarzyna Młyniec
    Department of Toxicology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland Institute of Pharmacology, Polish Academy of Sciences and Center of Excellence in Neuropsychopharmacology, Smetna 12, Pl 31 343 Krakow, Poland Electronic address
    Neuropharmacology 79:290-7. 2014
  10. ncbi request reprint Zinc deficiency alters responsiveness to antidepressant drugs in mice
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Krakow, Poland
    Pharmacol Rep 65:579-92. 2013

Collaborators

Detail Information

Publications21

  1. doi request reprint Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder
    Katarzyna Młyniec
    Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland Electronic address
    J Neuroimmunol 291:11-7. 2016
    ..The results indicate depressive-like behavior in GPR39 KO animals with an immune response similar to that observed in depressive disorder. Here for the first time we show immunological changes under GPR39-deficient conditions. ..
  2. doi request reprint Up-regulation of the GPR39 Zn2+-sensing receptor and CREB/BDNF/TrkB pathway after chronic but not acute antidepressant treatment in the frontal cortex of zinc-deficient mice
    Katarzyna Młyniec
    Department of Pharmacobiology, Jagiellonian University Medical College, Krakow, Poland Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland Electronic address
    Pharmacol Rep 67:1135-40. 2015
    ..The GPR39-Zn(2+)-sensing receptor seems to be involved in the pathophysiology of depression. GPR39 knockout animals show depressive- and anxiety-like behavior. Chronic treatment with selective antidepressants (ADs) up-regulates GPR39...
  3. doi request reprint Study of antidepressant drugs in GPR39 (zinc receptor⁻/⁻) knockout mice, showing no effect of conventional antidepressants, but effectiveness of NMDA antagonists
    Katarzyna Młyniec
    Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland Electronic address
    Behav Brain Res 287:135-8. 2015
    ..Our results show for the first time that GPR39 is required for the antidepressant effect of monoamine-based antidepressants. ..
  4. doi request reprint Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission
    Katarzyna Młyniec
    Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland Electronic address
    Brain Res Bull 115:23-9. 2015
    ..These results indicate a possible role of the GPR39 receptor in monoaminergic and glutamatergic neurotransmission, which plays an important role in the pathophysiology of depression...
  5. doi request reprint GPR39 Zn(2+)-sensing receptor: a new target in antidepressant development?
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland Electronic address
    J Affect Disord 174:89-100. 2015
    ..Chronic administration of many antidepressants induces GPR39 up-regulation, which suggests that the Zn(2+)-sensing receptor may be considered as a new target for drug development in the field of depression. ..
  6. doi request reprint Essential elements in depression and anxiety. Part II
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Krakow, Poland Electronic address
    Pharmacol Rep 67:187-94. 2015
    ....
  7. ncbi request reprint Chronic but not acute antidepresant treatment alters serum zinc/copper ratio under pathological/zinc-deficient conditions in mice
    K Mlyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 65:673-8. 2014
    ..Observed in this study normalization of serum Zn/Cu ratio in depression-like conditions by chronic (but not acute) antidepressants suggest that this ratio may be consider as a marker of depression or treatment efficacy. ..
  8. doi request reprint Essential elements in depression and anxiety. Part I
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Collegium Medicum, Krakow, Poland Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland Electronic address
    Pharmacol Rep 66:534-44. 2014
    ..Furthermore, administration of low dose antidepressants supplemented with an element is effective and can reduce unwanted side effects in different types of depression/anxiety. ..
  9. doi request reprint The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims
    Katarzyna Młyniec
    Department of Toxicology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland Institute of Pharmacology, Polish Academy of Sciences and Center of Excellence in Neuropsychopharmacology, Smetna 12, Pl 31 343 Krakow, Poland Electronic address
    Neuropharmacology 79:290-7. 2014
    ....
  10. ncbi request reprint Zinc deficiency alters responsiveness to antidepressant drugs in mice
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Krakow, Poland
    Pharmacol Rep 65:579-92. 2013
    ..We examine also whether these changes are related to activity of the hypothalamic-pituitary-adrenal HPA axis...
  11. doi request reprint GPR39 up-regulation after selective antidepressants
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland
    Neurochem Int 62:936-9. 2013
    ..This is the first report to indicate the involvement of the GPR39 Zn²⁺-sensing receptor in the antidepressant effect of selective monoamine reuptake inhibitors...
  12. doi request reprint The role of the GPR39 receptor in zinc deficient-animal model of depression
    Katarzyna Młyniec
    Department of Biochemical Toxicology, Jagiellonian University Medical College, Medyczna 9, PL 30 0688 Kraków, Poland
    Behav Brain Res 238:30-5. 2013
    ..Our study provides evidence that the GPR39 Zn(2+)-sensing receptor may be responsible for lowering the BDNF protein level and in consequence may be involved in the pathogenesis of depression...
  13. ncbi request reprint Time course of zinc deprivation-induced alterations of mice behavior in the forced swim test
    Katarzyna Młyniec
    Department of Pharmacobiology, Jagielonian University Medical Colege, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 64:567-75. 2012
    ..It is hypothesized that zinc may be a therapeutic agent or supplement that would help to reverse the symptoms of this disease...
  14. ncbi request reprint Zinc deficiency induces behavioral alterations in the tail suspension test in mice. Effect of antidepressants
    Katarzyna Młyniec
    Department of Pharmacobiology, Faculty of Pharmacy, Jagielonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 64:249-55. 2012
    ..Recently, experimental zinc deficiency has been correlated with depression-like alterations in rodents...
  15. doi request reprint Zinc deficiency in rats is associated with up-regulation of hippocampal NMDA receptor
    Urszula Doboszewska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 56:254-63. 2015
    ..Data indicated that zinc deficiency may contribute to the development of depression; however changes induced by zinc deficiency are not fully described...
  16. doi request reprint Antidepressant activity of fluoxetine in the zinc deficiency model in rats involves the NMDA receptor complex
    Urszula Doboszewska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland Electronic address
    Behav Brain Res 287:323-30. 2015
    ..This finding adds new evidence to the predictive validity of the proposed zinc deficiency model of depression. Antidepressant-like activity of FLX in the zinc deficiency model is associated with NMDAR complex...
  17. ncbi request reprint Early lifetime zinc supplementation protects zinc-deficient diet-induced alterations
    Włodzimierz Opoka
    Department of Inorganic Chemistry, Jagiellonian University, Collegium Medicum, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 62:1211-7. 2010
    ..These results indicate that post-birth supplementation with zinc may protect zinc-deficient diet-induced rapid alterations in zinc homeostasis...
  18. ncbi request reprint Antidepressant-like effect of chromium chloride in the mouse forced swim test: involvement of glutamatergic and serotonergic receptors
    Anna Piotrowska
    Laboratory of Pharmacobiology, Department of Cytobiology and Histochemistry, Collegium Medicum, Jagiellonian University, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 60:991-5. 2008
    ....
  19. doi request reprint Evaluation of the role of NMDA receptor function in antidepressant-like activity. A new study with citalopram and fluoxetine in the forced swim test in mice
    Małgorzata Wolak
    Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Pharmacol Rep 67:490-3. 2015
    ..The NMDA/glutamate receptors are involved in the mechanism of antidepressant activity...
  20. doi request reprint Alterations of Bio-elements, Oxidative, and Inflammatory Status in the Zinc Deficiency Model in Rats
    Urszula Doboszewska
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343, Krakow, Poland
    Neurotox Res 29:143-54. 2016
    ..The obtained data suggest dynamic redistribution of bio-elements and enhancement of oxidative/inflammatory parameters after dietary zinc restriction, which may have a link with depression-like behavior/NMDAR function/neurodegeneration. ..
  21. ncbi request reprint Zinc as a marker of affective disorders
    Marcin Siwek
    Department of Psychiatry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 21a, PL 31 501 Krakow, Poland
    Pharmacol Rep 65:1512-8. 2013
    ..It seems, however, that the measurement of the concentrations of zinc might be in the future a component of the battery of tests; of markers of immune activation and oxidative stress rather than itself alone. ..