Research Topics

Genomes and Genes


M H Lewandowski


Affiliation: Jagiellonian University
Country: Poland


  1. Palus K, Chrobok L, Lewandowski M. Orexins/hypocretins modulate the activity of NPY-positive and -negative neurons in the rat intergeniculate leaflet via OX1 and OX2 receptors. Neuroscience. 2015;300:370-80 pubmed publisher
    ..An increase in miniature excitatory postsynaptic current frequency was not observed within the IGL. Our findings reinforce the connection between circadian clock physiology and the orexinergic system. ..
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    Palus K, Chrobok Å, Lewandowski M. Electrophysiology of GABAergic transmission of single intergeniculate leaflet neurons in rat. Acta Neurobiol Exp (Wars). 2015;75:27-35 pubmed
    ..Most neurons were hyperpolarized by GABA application and this effect was caused by activation of GABAA as well as GABAB receptors. The presence of GABAB receptors in rat's IGL has been suggested for the first time. ..
  3. Chrobok L, Palus K, Lewandowski M. Two distinct subpopulations of neurons in the thalamic intergeniculate leaflet identified by subthreshold currents. Neuroscience. 2016;329:306-17 pubmed publisher
    ..Those differences are promising for possible pharmacological manipulations of specified cell types in pathophysiologies including absence epilepsy. ..
  4. Orlowska Feuer P, Jeczmien Lazur J, Szkudlarek H, Lewandowski M. Retinal gap junctions are involved in rhythmogenesis of neuronal activity at remote locations - Study on infra-slow oscillations in the rat olivary pretectal nucleus. Neuroscience. 2016;339:150-161 pubmed publisher
    ..We conclude that electrical coupling between various types of retinal cells and resultant synchronous firing of retinal ganglion cells is necessary for the generation of infra-slow oscillations in the rat OPN. ..
  5. Chrobok L, Palus K, Lewandowski M. Orexins excite ventrolateral geniculate nucleus neurons predominantly via OX2 receptors. Neuropharmacology. 2016;103:236-46 pubmed publisher
    ..These findings strengthen the postulated link between orexins and the circadian system, and propose a new role of these neuropeptides in the modulation of visuomotor functions. ..
  6. Palus K, Chrobok L, Kepczynski M, Lewandowski M. Enkephalin and neuropeptide-Y interaction in the intergeniculate leaflet network, a part of the mammalian biological clock. Neuroscience. 2017;343:10-20 pubmed publisher
    ..Based on this and previous studies, we hypothesize that IGL enkephalinergic neurons may act as powerful interneurons that inhibit themselves and NPY-synthesizing neurons, also in the contralaterally located IGL. ..
  7. Chrobok L, Palus K, Jeczmien Lazur J, Chrzanowska A, Kepczynski M, Lewandowski M. Disinhibition of the intergeniculate leaflet network in the WAG/Rij rat model of absence epilepsy. Exp Neurol. 2017;289:103-116 pubmed publisher
    ..Altogether, the data presented here show for the first time the disinhibition of IGL neurons in a model of AE, thereby proposing the possible involvement of circadian-related brain structures in the epileptic phenotype. ..
  8. Chrobok L, Palus Chramiec K, Chrzanowska A, Kepczynski M, Lewandowski M. Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal. Sci Rep. 2017;7:7713 pubmed publisher
    ..Thus, the action of orexin on DLG TC neurons may underlie the circadian/behavioural modulation of vision. ..