Ewa Łucja Gregoraszczuk

Summary

Affiliation: Jagiellonian University
Country: Poland

Publications

  1. ncbi request reprint Dioxin exposure and porcine reproductive hormonal activity
    Ewa L Gregoraszczuk
    Laboratory of Reproductive Physiology and Toxicology of Domestic Animals, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Cad Saude Publica 18:453-62. 2002
  2. ncbi request reprint Congener-specific accumulation of polychlorinated biphenyls in ovarian follicular wall follows repeated exposure to PCB 126 and PCB 153. Comparison of tissue levels of PCB and biological changes
    E L Gregoraszczuk
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, Krakow 30 060, Poland
    Chemosphere 50:481-8. 2003
  3. ncbi request reprint Comparison of the actions of 4-chlorobiphenyl and its hydroxylated metabolites on estradiol secretion by ovarian follicles in primary cells in culture
    Anna Ptak
    Laboratory of Reproductive Physiology and Toxicology of Domestic Animals, Department of Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Reprod Toxicol 20:57-64. 2005
  4. ncbi request reprint In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity
    Anna Ptak
    Laboratory of Physiology and Toxicology of Reproduction, Department of Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Toxicol Lett 164:113-22. 2006
  5. ncbi request reprint Expression of atrial natriuretic peptide, progesterone, apoptosis-related proteins and caspase-3 in in vitro luteinized and leptin-treated porcine granulosa cells
    Julieta Dineva
    Institute of Biology and Immunology of Reproduction, Acad K Bratanov, Bulgarian Academy of Science, Sofia, Bulgaria
    Endocr Regul 41:11-8. 2007
  6. ncbi request reprint Steroid secretion following exposure of ovarian follicular cells to three different natural mixtures of persistent organic pollutants (POPs)
    Ewa L Gregoraszczuk
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Reprod Toxicol 25:58-66. 2008
  7. ncbi request reprint Gh and IGF-I increase leptin receptor expression in prepubertal pig ovaries: the role of leptin in steroid secretion and cell apoptosis
    Ewa L Gregoraszczuk
    Laboratory of Reproductive Physiology and Toxicology, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Acta Vet Hung 54:413-26. 2006
  8. ncbi request reprint Action of IGF-I on expression of the long form of the leptin receptor (ObRb) in the prepubertal period and throughout the estrous cycle in the mature pig ovary
    Ewa Łucja Gregoraszczuk
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Krakow, Poland
    J Reprod Dev 53:289-95. 2007
  9. ncbi request reprint The action of low- and high-chlorinated biphenyl mixture on prepubertal porcine ovary: steroid secretion and cells apoptosis
    Ewa Lucia Gregoraszczuk
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Endocr Regul 39:33-41. 2005
  10. ncbi request reprint In vitro effect of leptin on growth hormone (GH)- and insulin-like growth factor-I (IGF-I)-stimulated progesterone secretion and apoptosis in developing and mature corpora lutea of pig ovaries
    Ewa Łucja Gregoraszczuk
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    J Reprod Dev 51:727-33. 2005

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Dioxin exposure and porcine reproductive hormonal activity
    Ewa L Gregoraszczuk
    Laboratory of Reproductive Physiology and Toxicology of Domestic Animals, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Cad Saude Publica 18:453-62. 2002
    ..Endocrine disruptors that interfere with estradiol production in the follicles can act as ovulatory disruptors, and while interfering with progesterone production by luteal cells they can act as abortifacients...
  2. ncbi request reprint Congener-specific accumulation of polychlorinated biphenyls in ovarian follicular wall follows repeated exposure to PCB 126 and PCB 153. Comparison of tissue levels of PCB and biological changes
    E L Gregoraszczuk
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, Krakow 30 060, Poland
    Chemosphere 50:481-8. 2003
    ..24 h after the last treatment follicles were frozen for further polychlorinated biphenyls (PCB) content analysis. PCB concentrations in the follicular wall were analysed by mass spectrometry...
  3. ncbi request reprint Comparison of the actions of 4-chlorobiphenyl and its hydroxylated metabolites on estradiol secretion by ovarian follicles in primary cells in culture
    Anna Ptak
    Laboratory of Reproductive Physiology and Toxicology of Domestic Animals, Department of Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Reprod Toxicol 20:57-64. 2005
    ..Such a response would in vivo be expected to disrupt reproductive processes, through enhanced aging of the follicle and negative feedback to the hypothalamus, and perhaps increase the risk for ovarian and breast cancer...
  4. ncbi request reprint In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity
    Anna Ptak
    Laboratory of Physiology and Toxicology of Reproduction, Department of Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Toxicol Lett 164:113-22. 2006
    ..We infer that: (1) metabolism of PCB3 does not protect against endocrine disruption and (2) the estrogenic effect of these compounds is due to stimulation of aromatase activity...
  5. ncbi request reprint Expression of atrial natriuretic peptide, progesterone, apoptosis-related proteins and caspase-3 in in vitro luteinized and leptin-treated porcine granulosa cells
    Julieta Dineva
    Institute of Biology and Immunology of Reproduction, Acad K Bratanov, Bulgarian Academy of Science, Sofia, Bulgaria
    Endocr Regul 41:11-8. 2007
    ....
  6. ncbi request reprint Steroid secretion following exposure of ovarian follicular cells to three different natural mixtures of persistent organic pollutants (POPs)
    Ewa L Gregoraszczuk
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Reprod Toxicol 25:58-66. 2008
    ..A higher steroidogenic response in low dose ranges, compared with high dose ranges indicated xenobiotic-conditioning hormesis. This could complicate predictions of effects in risk assessments...
  7. ncbi request reprint Gh and IGF-I increase leptin receptor expression in prepubertal pig ovaries: the role of leptin in steroid secretion and cell apoptosis
    Ewa L Gregoraszczuk
    Laboratory of Reproductive Physiology and Toxicology, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Acta Vet Hung 54:413-26. 2006
    ....
  8. ncbi request reprint Action of IGF-I on expression of the long form of the leptin receptor (ObRb) in the prepubertal period and throughout the estrous cycle in the mature pig ovary
    Ewa Łucja Gregoraszczuk
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Krakow, Poland
    J Reprod Dev 53:289-95. 2007
    ..Moreover, this data points to an important role of IGF-I in leptin receptor expression during the entire estrous cycle, with a special role during the prepubertal period...
  9. ncbi request reprint The action of low- and high-chlorinated biphenyl mixture on prepubertal porcine ovary: steroid secretion and cells apoptosis
    Ewa Lucia Gregoraszczuk
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Endocr Regul 39:33-41. 2005
    ....
  10. ncbi request reprint In vitro effect of leptin on growth hormone (GH)- and insulin-like growth factor-I (IGF-I)-stimulated progesterone secretion and apoptosis in developing and mature corpora lutea of pig ovaries
    Ewa Łucja Gregoraszczuk
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    J Reprod Dev 51:727-33. 2005
    ....
  11. ncbi request reprint Estrus cycle-dependent action of leptin on basal and GH or IGF-I stimulated steroid secretion by whole porcine follicles
    Ewa L Gregoraszczuk
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Endocr Regul 38:15-21. 2004
    ..To determine the levels of leptin in the follicular fluid and using culture of whole ovarian follicles, to test the hypothesis that leptin may directly influence GH and IGF-I stimulated ovarian function...
  12. ncbi request reprint In vitro effect of leptin on steroids' secretion by FSH- and LH-treated porcine small, medium and large preovulatory follicles
    Ewa Łucja Gregoraszczuk
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, 30 060 Krakow, Ingardena 6, Poland
    Reprod Biol 3:227-39. 2003
    ..They also suggest a synergistic action of leptin and FSH on E(2) secretion by small and medium follicles as well as leptin and LH on P(4) secretion by large follicles in pigs...
  13. ncbi request reprint In vitro exposure of porcine ovarian follicular cells to PCB 153 alters steroid secretion but not their viability--preliminary study
    Ewa L Gregoraszczuk
    Laboratory of Physiology and Toxicology of Reproduction, Department of Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    ScientificWorldJournal 2:261-7. 2002
    ..These findings suggest different time of exposure-dependent action of PCB 153 on particular steps of steroidogenesis but not action on cell viability. These results should be considered preliminary, pending confirmation by other studies...
  14. ncbi request reprint Triiodothyronine stimulates 3beta-hydroxysteroid dehydrogenase activity in the porcine corpus luteum
    E L Gregorasczuk
    Department of Animal Physiology, Institute of Zoology, Jagiellonian University, 30 060 Krakow, Poland
    Endocr Regul 33:155-60. 1999
    ..To study the mechanism of thyroid hormone action on the activity of 3beta-hydroxysteroid dehydrogenase in the porcine corpus luteum...
  15. ncbi request reprint Progesterone and estradiol secretion by porcine luteal cells is influenced by individual and combined treatment with prostaglandins E2 and F2alpha throughout the estrus cycle
    E L Gregoraszczuk
    Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Prostaglandins Other Lipid Mediat 57:231-41. 1999
    ....
  16. ncbi request reprint Response of porcine theca and granulosa cells to GH during short-term in vitro culture
    E L Gregoraszczuk
    Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060, Krakow, Poland
    Anim Reprod Sci 58:113-25. 2000
    ..In conclusion, the present studies indicate that there are direct and follicular development stage dependent actions of GH on steroidogenesis of porcine follicular cells...
  17. ncbi request reprint Placental lactogen as a regulator of luteal cells function during pregnancy in sheep
    E L Gregoraszczuk
    Department of Animal Physiology, Institute of Zoology Jagiellonian University, Krakow, Poland
    Theriogenology 53:877-85. 2000
    ....
  18. ncbi request reprint Dose-and-time dependent effect of 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD) on progesterone secretion by porcine luteal cells cultured in vitro
    E L Gregoraszczuk
    Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Cracow, Poland
    J Physiol Pharmacol 51:127-35. 2000
    ..Endocrine disrupters that interfere with progesterone production can act as abortifacients...
  19. ncbi request reprint Valproate-induced alterations in testosterone, estradiol and progesterone secretion from porcine follicular cells isolated from small- and medium-sized ovarian follicles
    E Gregoraszczuk
    Laboratory of Reproductive Physiology and Toxicology in Domestic Animals, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Seizure 9:480-5. 2000
    ..The effect seems to differ to some extent depending on the follicular stage of development. The elevated ratio of testosterone to estradiol suggests that VPA inhibits the conversion of testosterone to estradiol...
  20. ncbi request reprint Effect of exogenous ovine placental lactogen on basal and prostaglandin-stimulated progesterone production by porcine luteal cells
    E L Gregoraszczuk
    Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Cracow, Poland
    Acta Vet Hung 48:199-208. 2000
    ..Future studies of structural and functional proteins secreted by the porcine conceptus will help resolve this uncertainty...
  21. ncbi request reprint Aryl hydrocarbon receptor (AhR)-linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells
    E L Gregoraszczuk
    Department of Physiology, Jagiellonian University, Krakow, Poland
    J Physiol Pharmacol 52:303-11. 2001
    ..Moreover points to AhR dependent but not ER-dependent mechanisms in TCDD action in luteal cells...
  22. ncbi request reprint Supraphysiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17b-HSD: a tissue culture approach
    Ewa Łucja Gregoraszczuk
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University in Kracow, Gronostajowa 9, 30 387 Kracow, Poland
    Reproduction 145:311-7. 2013
    ....
  23. doi request reprint Halowax 1051 affects steroidogenesis, 17β-hydroxysteroid dehydrogenase (17β-HSD) and cytochrome P450arom (CYP19) activity, and protein expression in porcine ovarian follicles
    Ewa Łucja Gregoraszczuk
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Gronostajowa 9, Krakow, Poland
    Reprod Toxicol 32:379-84. 2011
    ..In conclusion, we suggest non-linear dose-response effect of Halowax 1051 on steroidogenesis and steroidogenic enzymes activity and protein expression...
  24. ncbi request reprint Induction of cytochromes P450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary
    Anna Ptak
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, Krakow, Poland
    Toxicol Lett 166:200-11. 2006
    ..These results show for the first time that granulose-theca cells in co-culture express CYP1A1, 2B and 1A2 activities and that PCBs at concentrations that are reached in the environment induce genotoxicity in granulosa cells...
  25. ncbi request reprint Local feedback loop of ghrelin-GH in the pig ovary: action on estradiol secretion, aromatase activity and cell apoptosis
    Agnieszka Rak
    Department of Physiology and Toxicology of Reproduction, Chair of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Growth Horm IGF Res 18:221-7. 2008
    ..In conclusion, our study provides novel evidence for the gonadal feedback loop between GH and ghrelin secretion in the ovary. However, results of the presented research suggest independent action of GH and ghrelin in the ovary...
  26. doi request reprint Expression of ghrelin receptor, GHSR-1a, and its functional role in the porcine ovarian follicles
    Agnieszka Rak
    Department of Physiology and Toxicology of Reproduction, Chair of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Growth Horm IGF Res 19:68-76. 2009
    ....
  27. ncbi request reprint Is the natural PCDD/PCDF mixture toxic for human placental JEG-3 cell line? The action of the toxicants on hormonal profile, CYP1A1 activity, DNA damage and cell apoptosis
    Katarzyna Augustowska
    Department of Physiology and Toxicology of Reproduction, Chair of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 306 Krakow, Poland
    Hum Exp Toxicol 26:407-17. 2007
    ..However, in both cases, their action was not due to the induction of the DNA damage and subsequent cell apoptosis but due to a direct influence of these toxicants on placental hormone production...
  28. doi request reprint Effect of pituitary growth hormone and insulin-like growth factor type-I on proliferation, apoptosis and hormone secretion of the placental cell line JEG-3
    Agnieszka Rak-Mardyła
    Department of Physiology and Toxicology of Reproduction, Chair of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Gynecol Endocrinol 26:302-6. 2010
    ....
  29. ncbi request reprint Combinatory effects of PBDEs and 17β-estradiol on MCF-7 cell proliferation and apoptosis
    Patrycja Kwiecińska
    Department of Physiology and Toxicology of Reproduction, Chair of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, PL 30 060 Krakow, Poland
    Pharmacol Rep 63:189-94. 2011
    ..An additive anti-apoptotic activity and ability to induce cell proliferation was observed in the presence of 17β-estradiol...
  30. pmc Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis
    Anna Ptak
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Environ Int 36:935-41. 2010
    ..These anti-apoptotic effects and the change in metabolic activity may contribute to the carcinogenic effect of PCBs...
  31. doi request reprint Comparison of combinatory effects of PCBs (118, 138, 153 and 180) with 17 beta-estradiol on proliferation and apoptosis in MCF-7 breast cancer cells
    Anna Ptak
    Department of Physiology and Toxicology of Reproduction, Chair of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Toxicol Ind Health 27:315-21. 2011
    ..In conclusion, the results of this study suggest the possibility that PCB138 and 153 contribute to the action of endogenous 17 β-estradiol on cell proliferation and apoptosis in the breast cancer cell line MCF-7...
  32. ncbi request reprint The short- and long-term effects of two isomers of DDT and their metabolite DDE on hormone secretion and survival of human choriocarcinoma JEG-3 cells
    Anna K Wojtowicz
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Ingardena 6, PL 30 060 Krakow, Poland
    Pharmacol Rep 59:224-32. 2007
    ..These findings indicate that both isomers of DDT and their metabolite DDE are able to alter main placental hormone production and survival of JEG-3 cells in the concentration- and time-dependent manner...
  33. doi request reprint Action of defined mixtures of PCBs, p,p'-DDT and its metabolite p,p'-DDE, on co-culture of porcine theca and granulosa cells: steroid secretion, cell proliferation and apoptosis
    Ewa L Gregoraszczuk
    Department of Physiology and Toxicology of Reproduction, Chair of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Toxicol 26:170-4. 2008
    ....
  34. ncbi request reprint Effect of single and repeated in vitro exposure of ovarian follicles to o,p'-DDT and p,p'-DDT and their metabolites
    Anna K Wojtowicz
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, PL 30 060 Krakow, Poland
    Pol J Pharmacol 56:465-72. 2004
    ..Given the duration of folliculogenesis, one can imagine many different potential mechanisms by which DDT could influence steroidogenesis...
  35. ncbi request reprint Effect of growth hormone and insulin-like growth factor-I on spontaneous apoptosis in cultured luteal cells collected from early, mature, and regressing porcine corpora lutea
    Anna Ptak
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University Ingardena 6, Krakow 30 060, Poland
    Anim Reprod Sci 80:267-79. 2004
    ....
  36. ncbi request reprint Growth hormone and insulin-like growth factor-I action on progesterone secretion by porcine corpora lutea isolated at various periods of the luteal phase
    Anna Ptak
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Cracow, Poland
    Acta Vet Hung 51:197-208. 2003
    ..It is suggested that both IGF and GH may exert some regulatory action during CL development in the pig...
  37. ncbi request reprint Mechanisms ensuring optimal conditions of implantation and embryo development in the pig
    Jadwiga Przała
    Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10 718 Olsztyn, Poland
    Reprod Biol 6:59-87. 2006
    ....
  38. ncbi request reprint Effects of dioxin (2,3,7,8-TCDD) and PCDDs/PCDFs congeners mixture on steroidogenesis in human placenta tissue culture
    Katarzyna Augustowska
    Laboratory of Physiology and Toxicology of Reproduction, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Endocr Regul 37:11-9. 2003
    ..The concentration of all 17 toxic congeners was reported and the toxic equivalent (TEQ) was calculated as a 27.7 micrograms-TEQ/kg of fly ash...
  39. doi request reprint Different mechanisms of action of 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47) and its metabolites (5-OH-BDE-47 and 6-OH-BDE-47) on cell proliferation in OVCAR-3 ovarian cancer cells and MCF-7 breast cancer cells
    Anna Karpeta
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University in Krakow, Krakow, Poland
    J Appl Toxicol 36:1558-1567. 2016
    ..We suggest that studies concerning PBDEs with fewer bromine atoms should be continued to understand environmental links to different hormone-dependent cancers. Copyright © 2016 John Wiley & Sons, Ltd...
  40. doi request reprint Differences in the mechanisms of action of BDE-47 and its metabolites on OVCAR-3 and MCF-7 cell apoptosis
    Anna Karpeta
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University in Krakow, Gronostajowa 9, 30 387, Krakow, Poland
    J Appl Toxicol . 2016
    ..Copyright © 2016 John Wiley & Sons, Ltd...
  41. doi request reprint Different action of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and its hydroxylated metabolites on ERα and ERβ gene and protein expression
    Anna Karpeta
    Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Krakow, Poland Electronic address
    Toxicol Lett 229:250-6. 2014
    ..These findings indicate that BDE-47, by altering the ratio of ERα to ERβ toward ERα, and the hydroxylated metabolites of BDE-47, by increase estrogen receptors expression, may result in excessive ovarian exposure to estrogens. ..
  42. doi request reprint Valproic acid, but not levetiracetam, selectively decreases HDAC7 and HDAC2 expression in human ovarian cancer cells
    Patrycja Kwiecińska
    Department of Physiology and Toxicology of Reproduction, Chair of Animal Physiology, Institute of Zoology, Jagiellonian University, Cracow, Poland Electronic address
    Toxicol Lett 224:225-32. 2014
    ..The OVCAR-3 cell line was able to metabolize LEV to PBA, but the effect was small. Our observations suggest that VPA should be considered as a possible adjunctive drug in ovarian cancer treatment...
  43. ncbi request reprint Comparison of reproductive effects of levetiracetam and valproate studied in prepubertal porcine ovarian follicular cells
    Erik Taubøll
    Department of Neurology, Division of Clinical Neuroscience, Rikshospitalet Radiumhospitalet, University of Oslo, Oslo, Norway
    Epilepsia 47:1580-3. 2006
    ..Here the effect of LEV and VPA on basal and gonadotropin-stimulated steroid secretion from prepubertal porcine ovarian follicular cells was compared and the conversion of testosterone to estradiol is measured...
  44. ncbi request reprint Localization of atrial natriuretic peptide in pig granulosa cells isolated from ovarian follicles of various size
    Maria D Ivanova
    Institute of Biology and Immunology of Reproduction, Akad K Bratanov BAS, Sofia, Bulgaria
    Reprod Biol 3:173-81. 2003
    ..Since ANP and ANP receptors are present in reproductive organs, the three anti-ANP antibodies may be an useful tool in further studies concerning the role of ANP in granulosa cell differentiation and function...
  45. ncbi request reprint Valproate inhibits the conversion of testosterone to estradiol and acts as an apoptotic agent in growing porcine ovarian follicular cells
    Erik Taubøll
    Department of Neurology, Rikshospitalet, University of Oslo, Norway
    Epilepsia 44:1014-21. 2003
    ..Second, the action of VPA on proliferation and apoptosis of follicular cells was investigated...
  46. ncbi request reprint Valproate irreversibly alters steroid secretion patterns from porcine follicular cells in vitro
    Erik Taubøll
    Department of Neurology, Rikshospitalet, University of Oslo, 0027 Oslo, Norway
    Reprod Toxicol 16:319-25. 2002
    ..It was not possible to reverse the steroidogenic effects of valproate by removing the drug from the cell cultures...