C Zekanowski

Summary

Affiliation: International Institute of Molecular and Cell Biology
Country: Poland

Publications

  1. ncbi [In search of genetic determinants of obesity]
    C Zekanowski
    Zaklad Genetyki Medycznej, Instytut Matki i Dziecka, Kasprzaka 17a, 01 211, Warszawa, Poland
    Med Wieku Rozwoj 5:5-15. 2001
  2. ncbi Genetic aspects of Alzheimer's disease
    Cezary Zekanowski
    Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Acta Neurobiol Exp (Wars) 64:19-31. 2004
  3. ncbi Should newborn mutation scanning for hyperphenylalaninaemia and galactosaemia be implemented? A Polish experience
    C Zekanowski
    Department of Medical Genetics, National Research Institute of Mother and Child, Warszawa, Poland
    J Med Screen 8:132-6. 2001
  4. ncbi [Novel PKU treatment methods]
    Cezary Zekanowski
    Pracownia Neurodegradacji, Miedzynarodowy Instytut Biologii Molekularnej i Komórkowej, ul Trojdena 4, 02 109 Warszawa, Poland
    Med Wieku Rozwoj 6:171-92. 2002
  5. ncbi Mutations in presenilin 1, presenilin 2 and amyloid precursor protein genes in patients with early-onset Alzheimer's disease in Poland
    Cezary Zekanowski
    Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, 02 109 Warsaw, Poland
    Exp Neurol 184:991-6. 2003
  6. ncbi Mutation screening of the MAPT and STH genes in Polish patients with clinically diagnosed frontotemporal dementia
    Cezary Zekanowski
    Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, Poland
    Dement Geriatr Cogn Disord 16:126-31. 2003
  7. ncbi Two polymorphisms of presenilin-2 gene (PSEN2) 5' regulatory region are not associated with Alzheimer's disease (AD) in the Polish population
    M Gacia
    Medical Research Center, Department of Neurodegenerative Disorders, Polish Academy of Sciences, Warszawa, Poland
    J Neural Transm 115:85-90. 2008
  8. ncbi Prion protein gene M129 allele is a risk factor for Alzheimer's disease
    M Gacia
    Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Warszawa, Poland
    J Neural Transm 113:1747-51. 2006
  9. ncbi Mutations in exon 3 of the PAH gene causing mild hyperphenylalaninemia
    C Zekanowski
    Department of Genetics, National Research Institute of Mother and Child, Warszawa, Poland
    Genet Test 3:297-9. 1999
  10. ncbi Association between minihaplotypes and mutations at the PAH locus in Polish hyperphenylalaninemic patients
    C Zekanowski
    Department of Medical Genetics, National Research Institute of Mother and Child, Warsaw, Poland
    Hum Hered 51:117-20. 2001

Collaborators

Detail Information

Publications23

  1. ncbi [In search of genetic determinants of obesity]
    C Zekanowski
    Zaklad Genetyki Medycznej, Instytut Matki i Dziecka, Kasprzaka 17a, 01 211, Warszawa, Poland
    Med Wieku Rozwoj 5:5-15. 2001
    ..The number of genes and markers associated or linked with human obesity is more than 200. Interactions between multiple genes, environment and human personality, make the search for obesity-related genes especially challenging...
  2. ncbi Genetic aspects of Alzheimer's disease
    Cezary Zekanowski
    Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Acta Neurobiol Exp (Wars) 64:19-31. 2004
    ..In this review, we discuss the genetics of AD with a focus on the role of the APP and presenilins...
  3. ncbi Should newborn mutation scanning for hyperphenylalaninaemia and galactosaemia be implemented? A Polish experience
    C Zekanowski
    Department of Medical Genetics, National Research Institute of Mother and Child, Warszawa, Poland
    J Med Screen 8:132-6. 2001
    ..To elucidate whether screening for mutations causing hyperphenylalaninaemia (HPA) and classic galactosaemia could provide important, additional information on a clinical phenotype...
  4. ncbi [Novel PKU treatment methods]
    Cezary Zekanowski
    Pracownia Neurodegradacji, Miedzynarodowy Instytut Biologii Molekularnej i Komórkowej, ul Trojdena 4, 02 109 Warszawa, Poland
    Med Wieku Rozwoj 6:171-92. 2002
    ....
  5. ncbi Mutations in presenilin 1, presenilin 2 and amyloid precursor protein genes in patients with early-onset Alzheimer's disease in Poland
    Cezary Zekanowski
    Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, 02 109 Warsaw, Poland
    Exp Neurol 184:991-6. 2003
    ..It could be concluded that screening for mutations in the three genes could be included in a diagnostic program directed at patients with a positive family history or age of onset before 55 years...
  6. ncbi Mutation screening of the MAPT and STH genes in Polish patients with clinically diagnosed frontotemporal dementia
    Cezary Zekanowski
    Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, Poland
    Dement Geriatr Cogn Disord 16:126-31. 2003
    ..At the STH gene only a common polymorphic change was found. It is postulated that MAPT mutations are not connected with most of the FTD cases in the Polish population...
  7. ncbi Two polymorphisms of presenilin-2 gene (PSEN2) 5' regulatory region are not associated with Alzheimer's disease (AD) in the Polish population
    M Gacia
    Medical Research Center, Department of Neurodegenerative Disorders, Polish Academy of Sciences, Warszawa, Poland
    J Neural Transm 115:85-90. 2008
    ..The rare variants identified in exon 3 of the PSEN2 could have a potential influence on PSEN2 transcript splicing...
  8. ncbi Prion protein gene M129 allele is a risk factor for Alzheimer's disease
    M Gacia
    Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Warszawa, Poland
    J Neural Transm 113:1747-51. 2006
    ..035). However, no interaction was found between APOE4 status and M129V polymorphism. We conclude that MM genotype increases LOAD risk in Polish population independently from the APOE4 status...
  9. ncbi Mutations in exon 3 of the PAH gene causing mild hyperphenylalaninemia
    C Zekanowski
    Department of Genetics, National Research Institute of Mother and Child, Warszawa, Poland
    Genet Test 3:297-9. 1999
    ..We describe the phenotypic effects of seven mutations in exon 3 of the PAH gene (R68G, R68S, R71H, S87R, P89S, I95F, and A104D). We propose that mutations located between amino acid positions 71 through 94 cause MHP...
  10. ncbi Association between minihaplotypes and mutations at the PAH locus in Polish hyperphenylalaninemic patients
    C Zekanowski
    Department of Medical Genetics, National Research Institute of Mother and Child, Warsaw, Poland
    Hum Hered 51:117-20. 2001
    ..Mutation IVS10nt-11g-->a (IVS10) is strongly associated with VNTR7/STR250 minihaplotype and is possibly of Mediterranean origin...
  11. ncbi The -22c/t polymorphism in presenilin 1 gene is not connected with late-onset and early-onset familial Alzheimer's disease in Poland
    C Zekanowski
    Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland
    J Neural Transm 112:839-45. 2005
    ..The -22t allele showed a high degree of linkage disequilibrium with -2797 insertion of 13 bp. An additional -2923g/t polymorphism is also not connected with -22c/t and is not a risk factor for AD...
  12. ncbi Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene
    M P Golan
    Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warszawa, Poland
    Exp Neurol 208:264-8. 2007
    ..In silico modeling of S170F mutation impact on presenilin 1 (PS1) transmembrane structure indicates that the mutation considerably alters putative interactions of PS1 with other proteins within gamma-secretase complex...
  13. doi Mitochondrial DNA variation is associated with elite athletic status in the Polish population
    A Maruszak
    Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland
    Scand J Med Sci Sports 24:311-8. 2014
    ..We also propose that mtDNA haplogroups and subhaplogroups, as well as individual mtDNA polymorphisms favoring endurance performance, could be population-specific, reflecting complex cross-talk between nuclear and mitochondrial genomes...
  14. ncbi Two novel presenilin 1 gene mutations connected with frontotemporal dementia-like clinical phenotype: genetic and bioinformatic assessment
    Cezary Zekanowski
    Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warszawa, Poland
    Exp Neurol 200:82-8. 2006
    ..We also propose that PSEN1 mutations should be considered in FTD patients with no MAPT mutations...
  15. doi Analysis of UBQLN1 variants in a Polish Alzheimer's disease patient: control series
    Maciej P Golan
    Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Dement Geriatr Cogn Disord 25:366-71. 2008
    ..However, the association observed seems to be driven mostly by rare (<5%) haplotypes. Results suggest a need for additional association studies and in silico analysis of the UBQLN1 locus...
  16. ncbi Genetic diversity within the R408W phenylketonuria mutation lineages in Europe
    Orna Tighe
    Department of Pathology and National Centre for Newborn Screening, The Children s University Hospital, Dublin, Ireland
    Hum Mutat 21:387-93. 2003
    ..However, in the absence of a more extensive STR data-set, no such conclusions are possible for the respective R408W mutant lineages...
  17. ncbi The E318G substitution in PSEN1 gene is not connected with Alzheimer's disease in a large Polish cohort
    Cezary Zekanowski
    Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, ul Ksiecia Trojdena 4, PL 02 109 Warszawa, Poland
    Neurosci Lett 357:167-70. 2004
    ..It could be concluded that E318G mutation is not related causally to AD in the Polish population, either as a risk factor or a disease causing mutation...
  18. ncbi Sigma receptor type 1 gene variation in a group of Polish patients with Alzheimer's disease and mild cognitive impairment
    Aleksandra Maruszak
    Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Dement Geriatr Cogn Disord 23:432-8. 2007
    ..Multivariate logistic regression analysis showed no interaction between the APOE4 and SIGMAR1 polymorphisms. Further studies using data from different populations are required to elucidate the effect of SIGMAR1 polymorphisms on AD...
  19. ncbi Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction
    Krzysztof Jozwiak
    International Institute of Molecular and Cell Biology, Warsaw, Poland
    J Neurochem 98:1560-72. 2006
    ..They also comply with experimental results, such as differences in accessibility of the catalytic residues in uncleaved PS-1, and binding of PEN-2 by the PS-1 NF motif...
  20. ncbi [Atypical phenylketonuria treatment effectiveness]
    Barbara Cabalska
    Klinika Pediatrii, Instytut Matki i Dziecka, 01 211Warszawa, ul Kasprzaka 17a, Poland
    Med Wieku Rozwoj 6:193-202. 2002
    ..No explanation for this fact has been found...
  21. ncbi Strong association between Saitohin gene polymorphism and tau haplotype in the Polish population
    Beata Pepłońska
    Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warsaw, Poland
    Neurosci Lett 348:163-6. 2003
    ..We found that the R allele of the STH gene is associated with the H2 haplotype of tau in all cases. Additionally we observed no correlation between R allele frequency and AD or PD...
  22. ncbi Association study of cholesterol-related genes in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurogenetics 8:179-88. 2007
    ..004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples...
  23. ncbi Mitochondrial DNA in pathogenesis of Alzheimer's and Parkinson's diseases
    Aleksandra Maruszak
    Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warszawa, Poland
    Acta Neurobiol Exp (Wars) 66:153-76. 2006
    ..This paper reviews the current knowledge on the inherited and somatic mtDNA variations in both conditions...