- Wisniewska M, Ameyar Zazoua M, Bakiri L, Kaminska B, Yaniv M, Weitzman J. Dimer composition and promoter context contribute to functional cooperation between AP-1 and NFAT. J Mol Biol. 2007;371:569-76 pubmed..Hence changes in AP-1 composition and the level of participating NFAT proteins can differentially influence cytokine gene expression, resulting in biological consequences for the modulation and dynamics of the immune response. ..
- Wisniewska M, Misztal K, Michowski W, Szczot M, Purta E, Lesniak W, et al. LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. J Neurosci. 2010;30:4957-69 pubmed publisher..We propose that beta-catenin contributes to neuronal excitability not only by a local action at the synapse but also by activating gene expression in thalamic neurons. ..
- Wisniewska M, Nagalski A, Dabrowski M, Misztal K, Kuznicki J. Novel ?-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability. BMC Genomics. 2012;13:635 pubmed publisher..This implies that the transcriptional activity of ?-catenin is necessary for the proper excitability of thalamic neurons, may influence activity in the thalamocortical circuit, and may contribute to thalamic pathologies. ..
- Wisniewska M. Physiological role of ?-catenin/TCF signaling in neurons of the adult brain. Neurochem Res. 2013;38:1144-55 pubmed publisher..The data are still very preliminary and often based on circumstantial or indirect evidence. Further research might help to understand the etiology of the aforementioned pathologies. ..