Dariusz Pogocki

Summary

Affiliation: Institute of Nuclear Chemistry and Technology
Country: Poland

Publications

  1. ncbi request reprint Alzheimer's beta-amyloid peptide as a source of neurotoxic free radicals: the role of structural effects
    Dariusz Pogocki
    Institute of Nuclear Chemistry and Technology, 16 Dorodna St, 03 195 Warsaw, Poland
    Acta Neurobiol Exp (Wars) 63:131-45. 2003
  2. ncbi request reprint Mutation of the Phe20 residue in Alzheimer's amyloid beta-peptide might decrease its toxicity due to disruption of the Met35-cupric site electron transfer pathway
    Dariusz Pogocki
    Institute of Nuclear Chemistry and Technology, Dorodna 16, 03 195 Warsaw, Poland
    Chem Res Toxicol 17:325-9. 2004
  3. doi request reprint Efficient alpha-(alkylthio)alkyl-type radical formation in (*)OH-induced oxidation of alpha-(methylthio)acetamide
    Pawel B Wisniowski
    Centre of Radiation Research and Technology, Institute of Nuclear Chemistry and Technology, 03 195 Warsaw, Poland
    J Phys Chem A 114:105-16. 2010
  4. ncbi request reprint EPR and DFT study on the stabilization of radiation-generated methyl radicals in dehydrated Na-A zeolite
    Marek Danilczuk
    Institute of Nuclear Chemistry and Technology, Dorodna 16, 03 195 Warsaw, Poland
    J Phys Chem B 110:24492-7. 2006
  5. ncbi request reprint EPR spectroscopy and theoretical study of gamma-irradiated asparagine and aspartic acid in solid state
    Grazyna Strzelczak
    Institute of Nuclear Chemistry and Technology, 03 195 Warsaw, Poland
    Biophys Chem 125:92-103. 2007
  6. ncbi request reprint Stabilization of sulfide radical cations through complexation with the peptide bond: mechanisms relevant to oxidation of proteins containing multiple methionine residues
    Krzysztof Bobrowski
    Institute of Nuclear Chemistry and Technology, 03 195 Warsaw, Poland
    J Phys Chem B 111:9608-20. 2007
  7. ncbi request reprint Sulfur radical cation-peptide bond complex in the one-electron oxidation of S-methylglutathione
    Krzysztof Bobrowski
    Institute of Nuclear Chemistry and Technology, 03 195 Warsaw, Poland
    J Am Chem Soc 129:9236-45. 2007
  8. ncbi request reprint Molecular sieves in medicine
    Marek Danilczuk
    Institute of Nuclear Chemistry and Technology, Dorodna, Warsaw, Poland
    Mini Rev Med Chem 8:1407-17. 2008
  9. ncbi request reprint Free radical reactions of methionine in peptides: mechanisms relevant to beta-amyloid oxidation and Alzheimer's disease
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Am Chem Soc 125:13700-13. 2003
  10. ncbi request reprint Redox properties of Met(35) in neurotoxic beta-amyloid peptide. A molecular modeling study
    Dariusz Pogocki
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    Chem Res Toxicol 15:408-18. 2002

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Alzheimer's beta-amyloid peptide as a source of neurotoxic free radicals: the role of structural effects
    Dariusz Pogocki
    Institute of Nuclear Chemistry and Technology, 16 Dorodna St, 03 195 Warsaw, Poland
    Acta Neurobiol Exp (Wars) 63:131-45. 2003
    ..The pro-oxidant character of betaPAP is not associated with its beta-sheet insoluble form. On the contrary, the alpha-helically organised structure is responsible for betaAP redox-related cytotoxicity...
  2. ncbi request reprint Mutation of the Phe20 residue in Alzheimer's amyloid beta-peptide might decrease its toxicity due to disruption of the Met35-cupric site electron transfer pathway
    Dariusz Pogocki
    Institute of Nuclear Chemistry and Technology, Dorodna 16, 03 195 Warsaw, Poland
    Chem Res Toxicol 17:325-9. 2004
    ..Thus, I would like to propose the mutation Phe20Ala in betaA as a potential way to reduce its neurotoxicity...
  3. doi request reprint Efficient alpha-(alkylthio)alkyl-type radical formation in (*)OH-induced oxidation of alpha-(methylthio)acetamide
    Pawel B Wisniowski
    Centre of Radiation Research and Technology, Institute of Nuclear Chemistry and Technology, 03 195 Warsaw, Poland
    J Phys Chem A 114:105-16. 2010
    ..These features of the mechanism of the (*)OH-induced oxidation of alpha-MTA are quite different from those seen in other organic sulfides in neutral solutions...
  4. ncbi request reprint EPR and DFT study on the stabilization of radiation-generated methyl radicals in dehydrated Na-A zeolite
    Marek Danilczuk
    Institute of Nuclear Chemistry and Technology, Dorodna 16, 03 195 Warsaw, Poland
    J Phys Chem B 110:24492-7. 2006
    ..The hyperfine coupling constants calculated for the (.-)CH(3)...Na(+) adsorption complex for both applied models show very good agreement with those obtained experimentally...
  5. ncbi request reprint EPR spectroscopy and theoretical study of gamma-irradiated asparagine and aspartic acid in solid state
    Grazyna Strzelczak
    Institute of Nuclear Chemistry and Technology, 03 195 Warsaw, Poland
    Biophys Chem 125:92-103. 2007
    ..Conversely, Asp cation loses hydrogen atom from amine group, which triggers decarboxylation...
  6. ncbi request reprint Stabilization of sulfide radical cations through complexation with the peptide bond: mechanisms relevant to oxidation of proteins containing multiple methionine residues
    Krzysztof Bobrowski
    Institute of Nuclear Chemistry and Technology, 03 195 Warsaw, Poland
    J Phys Chem B 111:9608-20. 2007
    ..Density functional theory computations were performed on the model c-(L-Met-Gly) and its radicals in order to obtain optimizations and energies to aid in the interpretation of the experiments on c-(L-Met-L-Met)...
  7. ncbi request reprint Sulfur radical cation-peptide bond complex in the one-electron oxidation of S-methylglutathione
    Krzysztof Bobrowski
    Institute of Nuclear Chemistry and Technology, 03 195 Warsaw, Poland
    J Am Chem Soc 129:9236-45. 2007
    ..Conclusions from experimental observations were supported by molecular modeling calculations...
  8. ncbi request reprint Molecular sieves in medicine
    Marek Danilczuk
    Institute of Nuclear Chemistry and Technology, Dorodna, Warsaw, Poland
    Mini Rev Med Chem 8:1407-17. 2008
    ..Zeolites have been investigated as drug carriers, and as adjuvants in anticancer therapy, dietetic supplements or antimicrobial agents. This review gives a brief overview of the major aspects of molecular sieves applications in medicine...
  9. ncbi request reprint Free radical reactions of methionine in peptides: mechanisms relevant to beta-amyloid oxidation and Alzheimer's disease
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Am Chem Soc 125:13700-13. 2003
    ....
  10. ncbi request reprint Redox properties of Met(35) in neurotoxic beta-amyloid peptide. A molecular modeling study
    Dariusz Pogocki
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    Chem Res Toxicol 15:408-18. 2002
    ....
  11. ncbi request reprint Computational characterization of sulfur-cxygen-bonded sulfuranyl radicals derived from alkyl- and (carboxyalkyl)thiopropionic acids: evidence for sigma-type radicals
    Dariusz Pogocki
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Org Chem 67:1526-35. 2002
    ..Characteristic optical absorption bands, vibrational frequencies, and hyperfine coupling tensors are evaluated to facilitate the identification of such radicals by time-resolved UV, IR, and ESR spectroscopy...