Małgorzata Lehner

Summary

Affiliation: Institute of Psychiatry and Neurology
Country: Poland

Publications

  1. doi The expression of c-Fos and colocalisation of c-Fos and glucocorticoid receptors in brain structures of low and high anxiety rats subjected to extinction trials and re-learning of a conditioned fear response
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Neurobiol Learn Mem 92:535-43. 2009
  2. ncbi Expression of N-methyl-D-aspartate (R)(GluN2B) - subunits in the brain structures of rats selected for low and high anxiety
    M Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    J Physiol Pharmacol 62:473-82. 2011
  3. ncbi Colocalisation of c-Fos and glucocorticoid receptor as well as of 5-HT(1A) and glucocorticoid receptor immunoreactivity-expressing cells in the brain structures of low and high anxiety rats
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 02 957 Warsaw, 9 Sobieskiego Street, Poland
    Behav Brain Res 200:150-9. 2009
  4. ncbi The relationship between pain sensitivity and conditioned fear response in rats
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Acta Neurobiol Exp (Wars) 70:56-66. 2010
  5. doi Differences in the density of GABA-A receptor alpha-2 subunits and gephyrin in brain structures of rats selected for low and high anxiety in basal and fear-stimulated conditions, in a model of contextual fear conditioning
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 02 957 Warsaw, 9 Sobieskiego Street, Poland
    Neurobiol Learn Mem 94:499-508. 2010
  6. doi The effects of midazolam and D-cycloserine on the release of glutamate and GABA in the basolateral amygdala of low and high anxiety rats during extinction trial of a conditioned fear test
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 02 957 Warsaw, 9 Sobieskiego Street, Poland
    Neurobiol Learn Mem 94:468-80. 2010
  7. doi The role of the dorsomedial part of the prefrontal cortex serotonergic innervation in rat responses to the aversively conditioned context: behavioral, biochemical and immunocytochemical studies
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Behav Brain Res 192:203-15. 2008
  8. ncbi Behavioral, immunocytochemical and biochemical studies in rats differing in their sensitivity to pain
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Behav Brain Res 171:189-98. 2006
  9. ncbi Rat behavior in two models of anxiety and brain [3H]muscimol binding: pharmacological, correlation, and multifactor analysis
    Helena Sienkiewicz-Jarosz
    First Department of Neurology, Medical University, Warsaw, Poland
    Behav Brain Res 145:17-22. 2003
  10. ncbi Expression of c-Fos and CRF in the brains of rats differing in the strength of a fear response
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Behav Brain Res 188:154-67. 2008

Collaborators

Detail Information

Publications33

  1. doi The expression of c-Fos and colocalisation of c-Fos and glucocorticoid receptors in brain structures of low and high anxiety rats subjected to extinction trials and re-learning of a conditioned fear response
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Neurobiol Learn Mem 92:535-43. 2009
    ..Our data indicate that recovery of a context-related behaviour upon re-learning of contextual fear is accompanied in HR animals by a selective increase in c-Fos expression and GRs-ir in the DG area of the hippocampus...
  2. ncbi Expression of N-methyl-D-aspartate (R)(GluN2B) - subunits in the brain structures of rats selected for low and high anxiety
    M Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    J Physiol Pharmacol 62:473-82. 2011
    ..Together, these data suggest that animals that are more anxious have altered patterns of GluN2B subunit expression in the frontal cortex and limbic structures, which control emotional behaviour...
  3. ncbi Colocalisation of c-Fos and glucocorticoid receptor as well as of 5-HT(1A) and glucocorticoid receptor immunoreactivity-expressing cells in the brain structures of low and high anxiety rats
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 02 957 Warsaw, 9 Sobieskiego Street, Poland
    Behav Brain Res 200:150-9. 2009
    ..The present data add to the arguments for the neurobiological background of differences in individual responses to aversive conditioned stimuli...
  4. ncbi The relationship between pain sensitivity and conditioned fear response in rats
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Acta Neurobiol Exp (Wars) 70:56-66. 2010
    ..These results indicate that pain sensitivity and conditioned emotional responses to pain are not directly correlated...
  5. doi Differences in the density of GABA-A receptor alpha-2 subunits and gephyrin in brain structures of rats selected for low and high anxiety in basal and fear-stimulated conditions, in a model of contextual fear conditioning
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 02 957 Warsaw, 9 Sobieskiego Street, Poland
    Neurobiol Learn Mem 94:499-508. 2010
    ..The obtained data may also help to better explain the neurobiological mechanisms that operate in clinical situations where anxious patients subjected to exposure therapy are exposed to an aversive, contextual and conditioning stimulus...
  6. doi The effects of midazolam and D-cycloserine on the release of glutamate and GABA in the basolateral amygdala of low and high anxiety rats during extinction trial of a conditioned fear test
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 02 957 Warsaw, 9 Sobieskiego Street, Poland
    Neurobiol Learn Mem 94:468-80. 2010
    ..These results contribute to our understanding of observed individual differences in the effects of anxiolytic drugs among patients with anxiety disorders...
  7. doi The role of the dorsomedial part of the prefrontal cortex serotonergic innervation in rat responses to the aversively conditioned context: behavioral, biochemical and immunocytochemical studies
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Behav Brain Res 192:203-15. 2008
    ....
  8. ncbi Behavioral, immunocytochemical and biochemical studies in rats differing in their sensitivity to pain
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Behav Brain Res 171:189-98. 2006
    ..It appears also that response to pain may determine other patterns of emotional behavior, probably reflecting different activation thresholds of some brain structures controlling anxiety, e.g. prefrontal and secondary motor cortex...
  9. ncbi Rat behavior in two models of anxiety and brain [3H]muscimol binding: pharmacological, correlation, and multifactor analysis
    Helena Sienkiewicz-Jarosz
    First Department of Neurology, Medical University, Warsaw, Poland
    Behav Brain Res 145:17-22. 2003
    ..The present results indicate that the origin of emotions is a complex phenomenon, probably involving the interaction between GABA-ergic innervation of many brain structures...
  10. ncbi Expression of c-Fos and CRF in the brains of rats differing in the strength of a fear response
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Behav Brain Res 188:154-67. 2008
    ..It was shown that different natural patterns of responding to conditioned aversive stimuli are associated with different involvement of brain structures and with dissimilar neurochemical mechanisms...
  11. doi The effect of CRF and alpha-helical CRF((9-41)) on rat fear responses and amino acids release in the central nucleus of the amygdala
    Anna Skórzewska
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Neuropharmacology 57:148-56. 2009
    ....
  12. ncbi Sensitivity to pain and c-Fos expression in brain structures in rats
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Neurosci Lett 370:74-9. 2004
    ..The reactivity of LHAB may be responsible for the genetically determined differences in sensitivity to pain...
  13. ncbi Hippocampal mGluR1 and consolidation of contextual fear conditioning
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957, Warsaw, Poland
    Brain Res Bull 62:39-45. 2003
    ..Furthermore, they indicate that changes of glutamatergic activity within brain limbic structures can affect the threshold for the induction of the long-term neuronal plasticity, involved in some forms of learning and memory...
  14. ncbi Lack of changes in cortical [3H]-muscimol binding in rats sensitized to nicotine-induced enhancement of dopamine metabolism
    Halina Sienkiewicz-Jarosz
    Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, PL 02 957 Warszawa, Poland
    Pol J Pharmacol 55:165-70. 2003
    ..Thus, the hypothesis about the role of adaptive changes in GABAA receptors in the enhancement of the biochemical and behavioral effects of nicotine was not confirmed...
  15. ncbi The effects of acute and chronic administration of corticosterone on rat behavior in two models of fear responses, plasma corticosterone concentration, and c-Fos expression in the brain structures
    Anna Skórzewska
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Pharmacol Biochem Behav 85:522-34. 2006
    ....
  16. doi The influence of CRF and alpha-helical CRF(9-41) on rat fear responses, c-Fos and CRF expression, and concentration of amino acids in brain structures
    Anna Skórzewska
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Horm Behav 54:602-12. 2008
    ..The obtained results underline also the role of frontal cortex and amygdala in mediating the effects of CRF on the conditioned fear response...
  17. doi Mapping of c-Fos expression in the rat brain during the evolution of pentylenetetrazol-kindled seizures
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland
    Epilepsy Behav 16:216-24. 2009
    ..Piriform cortex, entorhinal cortex, prefrontal cortex, lateral septal nuclei, and CA3 area of the hippocampus appeared to be the brain structures selectively involved in the process of chemically induced kindling of seizures...
  18. ncbi The effects of acute corticosterone administration on anxiety, endogenous corticosterone, and c-Fos expression in the rat brain
    Anna Skórzewska
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Horm Behav 52:317-25. 2007
    ....
  19. doi The differential effects of protein synthesis inhibition on the expression and reconsolidation of pentylenetetrazole kindled seizures
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Epilepsy Behav 18:193-200. 2010
    ....
  20. doi The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Brain Res 1282:20-7. 2009
    ..Overall, these data suggest that there is a shift in the balance between neurotransmitters towards increased production of excitatory amino acids, and this may be mediated by group III mGluRs during seizure kindling...
  21. ncbi Effects of pentylenetetrazol-induced kindling of seizures on rat emotional behavior and brain monoaminergic systems
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University, Krakowskie Przedmiescie 26 28, 00 927, Warsaw, Poland
    Pharmacol Biochem Behav 73:851-61. 2002
    ....
  22. ncbi Age-dependent effects of 5,7-dihydroxytryptamine on serotonin transporter in different brain areas in the rat
    Wojciech Kostowski
    Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, PL 02 957 Warszawa, Poland
    Pol J Pharmacol 56:383-9. 2004
    ..Thus, it appears that the mesolimbic ventral tegmental area-nucleus accumbens systems are relatively more resistant to 5,7-DHT neurotoxicity in the early postnatal period...
  23. ncbi Changes in hippocampal amino acid concentrations after chronic administration of corticosterone
    Anna Skórzewska
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Sobieskiego 9, PL 02 957 Warszawa, Poland
    Pharmacol Rep 59:763-72. 2007
    ..In summary, the present study showed that chronic administration of corticosterone increased the hippocampal concentration of glutamate. Possible implications of this phenomenon are discussed...
  24. doi Morphine and methadone pre-exposures differently modify brain regional Fos protein expression and locomotor activity responses to morphine challenge in the rat
    Ewa Taracha
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Drug Alcohol Depend 97:21-32. 2008
    ..In summary, this study revealed differing and relatively long-lasting effects of prolonged administration of morphine and methadone on the profile of behavioral and CNS neuronal activation responses to morphine challenge in the rat...
  25. ncbi Effects of methadone and morphine on c-Fos expression in the rat brain: similarities and differences
    Ewa Taracha
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Sobieskiego 9, PL 02 957 Warszawa, Poland
    Pharmacol Rep 58:120-4. 2006
    ..Taking into account generally accepted differences in the potency of pharmacological effects of the two drugs, it is surprising that this effect was most evident after the dose of 5 mg/kg of either drug...
  26. ncbi Stress-opioid interactions: a comparison of morphine and methadone
    Ewa Taracha
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Sobieskiego 9, PL 02 957 Warszawa, Poland
    Pharmacol Rep 61:424-35. 2009
    ..The overlap between brain regions reacting to nonpharmacological stressors and those responding to exogenous opioids suggests that stress contributes to opioid-induced neuronal activation...
  27. ncbi Exploratory activity and a conditioned fear response: correlation with cortical and subcortical binding of the alpha4beta2 nicotinic receptor agonist [3H]-epibatidine
    Halina Sienkiewicz-Jarosz
    Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, PL 02 957 Warszawa, Poland
    Pol J Pharmacol 55:17-23. 2003
    ..The presented data indicate also a significant, structure dependent correlation between rat conditioned emotional reaction and the alpha4beta2 nAChR ligand binding, in the rat cortical forebrain structures...
  28. doi Methadone is substantially less effective than morphine in modifying locomotor and brain Fos responses to subsequent methadone challenge in rats
    Ewa Taracha
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego St, 02 957 Warsaw, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 33:1032-9. 2009
    ....
  29. pmc Inter-individual diversity and intra-individual stability of amphetamine-induced sensitization of frequency-modulated 50-kHz vocalization in Sprague-Dawley rats
    Ewa Taracha
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego St, 02 957 Warsaw, Poland
    Psychopharmacology (Berl) 222:619-32. 2012
    ..Propensity for drug dependence shows great diversity that is related to intrinsic neurobiological factors. This diversity is important both for the understanding of these traits and for the development of therapies...
  30. doi Changes in the brain expression of alpha-2 subunits of the GABA-A receptor after chronic restraint stress in low- and high-anxiety rats
    Aleksandra Wisłowska-Stanek
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie, Warsaw, 00 927, Poland
    Behav Brain Res 253:337-45. 2013
    ....
  31. ncbi The role of neurosteroids in the anxiolytic,antidepressive- and anticonvulsive effects of selective serotonin reuptake inhibitors
    Agnieszka Irena Członkowska
    Department of Clinical and Experimental Pharmacology, Medical University, Warsaw, Poland
    Med Sci Monit 9:RA270-5. 2003
    ..The aim of this review is to update information on the preclinical and clinical effects of SSRI, with special emphasis put on the probable role of neurosteroids and the GABAA receptor complex in the mechanism of their action...
  32. doi The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats
    Anna Skórzewska
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland Electronic address
    Horm Behav 65:6-13. 2014
    ....
  33. ncbi Combining markers of nephrotoxicity and hepatotoxicity for improved monitoring and detection of chronic alcohol abuse
    Ewa Taracha
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Clin Chem Lab Med 44:1446-52. 2006
    ..Combined use of serum markers of liver origin and urinary markers of kidney origin may be of diagnostic advantage...