Andrzej Dziembowski

Summary

Affiliation: Institute of Biochemistry and Biophysics
Country: Poland

Publications

  1. ncbi request reprint A single subunit, Dis3, is essentially responsible for yeast exosome core activity
    Andrzej Dziembowski
    Equipe Labellisée La Ligue, Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique UPR2167, associée à l Université Pierre et Marie Curie, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Nat Struct Mol Biol 14:15-22. 2007
  2. doi request reprint Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family
    Esben Lorentzen
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Mol Cell 29:717-28. 2008
  3. doi request reprint Endonucleolytic RNA cleavage by a eukaryotic exosome
    Alice Lebreton
    Equipe Labellisée La Ligue, Centre de Genetique Moleculaire, CNRS UPR 2167, 91198 Gif sur Yvette, France
    Nature 456:993-6. 2008
  4. pmc Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing
    Andrzej Dziembowski
    Centre de Genetique Moleculaire, Avenue de la Terrasse, Gif sur Yvette, France
    EMBO J 23:4847-56. 2004
  5. ncbi request reprint Recent developments in the analysis of protein complexes
    Andrzej Dziembowski
    Equipe labelisée La Ligue, Centre de Genetique Moleculaire, CNRS UPR 2167 Associated with University Paris 6, Avenue de la Terrasse, 91198 Cedex, Gif sur Yvette, France
    FEBS Lett 556:1-6. 2004
  6. pmc RNA channelling by the archaeal exosome
    Esben Lorentzen
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    EMBO Rep 8:470-6. 2007
  7. pmc Subunit architecture of multimeric complexes isolated directly from cells
    Helena Hernandez
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    EMBO Rep 7:605-10. 2006
  8. pmc Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase
    Rafal Tomecki
    Department of Genetics, Warsaw University, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    Nucleic Acids Res 32:6001-14. 2004
  9. pmc Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA
    Michal Minczuk
    Department of Genetics, University of Warsaw, Pawinskiego 5A, 02 106 Warsaw, Poland
    Nucleic Acids Res 30:5074-86. 2002
  10. ncbi request reprint The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism
    Andrzej Dziembowski
    Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    J Biol Chem 278:1603-11. 2003

Collaborators

  • Esben Lorentzen
  • Rafal Tomecki
  • Alice Lebreton
  • Bertrand Seraphin
  • Helena Hernandez
  • Aleksandra Dmochowska
  • Piotr P Stepien
  • Michal Minczuk
  • Thomas Taverner
  • Carol V Robinson
  • Kamil Gewartowski
  • Ewa Bartnik
  • Peter Borowski
  • Monika A Papworth
  • Jan Piwowarski
  • Sarah Schalinski
  • Kostas Tokatlidis
  • Karen Awiszus

Detail Information

Publications10

  1. ncbi request reprint A single subunit, Dis3, is essentially responsible for yeast exosome core activity
    Andrzej Dziembowski
    Equipe Labellisée La Ligue, Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique UPR2167, associée à l Université Pierre et Marie Curie, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Nat Struct Mol Biol 14:15-22. 2007
    ..We observed that the yeast exosome ring mediates interactions with protein partners, providing an explanation for its essential function...
  2. doi request reprint Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family
    Esben Lorentzen
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Mol Cell 29:717-28. 2008
    ..The structure provides a molecular rationale for the observed biochemical properties of the RNase R family of nucleases...
  3. doi request reprint Endonucleolytic RNA cleavage by a eukaryotic exosome
    Alice Lebreton
    Equipe Labellisée La Ligue, Centre de Genetique Moleculaire, CNRS UPR 2167, 91198 Gif sur Yvette, France
    Nature 456:993-6. 2008
    ..The mode of action of eukaryotic exosome cores in RNA processing and degradation should be reconsidered, taking into account the cooperation between its multiple ribonucleolytic activities...
  4. pmc Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing
    Andrzej Dziembowski
    Centre de Genetique Moleculaire, Avenue de la Terrasse, Gif sur Yvette, France
    EMBO J 23:4847-56. 2004
    ..The corresponding complex was named pre-mRNA REtention and Splicing (RES). The presence of RES subunit homologues in numerous eukaryotes suggests that its function is evolutionarily conserved...
  5. ncbi request reprint Recent developments in the analysis of protein complexes
    Andrzej Dziembowski
    Equipe labelisée La Ligue, Centre de Genetique Moleculaire, CNRS UPR 2167 Associated with University Paris 6, Avenue de la Terrasse, 91198 Cedex, Gif sur Yvette, France
    FEBS Lett 556:1-6. 2004
    ..We suggest that the next level of analysis in this area will be the definition of internal subunit arrangement in complexes as a first step toward more detailed structural analyses...
  6. pmc RNA channelling by the archaeal exosome
    Esben Lorentzen
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    EMBO Rep 8:470-6. 2007
    ..Multiple substrate-binding sites and the entrapment of the substrate in the central channel provide a rationale for the processive degradation of extended RNAs and the stalling of structured RNAs...
  7. pmc Subunit architecture of multimeric complexes isolated directly from cells
    Helena Hernandez
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    EMBO Rep 7:605-10. 2006
    ....
  8. pmc Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase
    Rafal Tomecki
    Department of Genetics, Warsaw University, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    Nucleic Acids Res 32:6001-14. 2004
    ....
  9. pmc Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA
    Michal Minczuk
    Department of Genetics, University of Warsaw, Pawinskiego 5A, 02 106 Warsaw, Poland
    Nucleic Acids Res 30:5074-86. 2002
    ..The presented analysis of the hSuv3p NTPase/helicase suggests that new functions of the protein have been acquired in the course of evolution...
  10. ncbi request reprint The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism
    Andrzej Dziembowski
    Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    J Biol Chem 278:1603-11. 2003
    ..We suggest that the degradosome is a central part of a mitochondrial RNA surveillance system responsible for degradation of aberrant and unprocessed RNAs...