Genomes and Genes
Affiliation: Institute of Biochemistry and Biophysics
- A single subunit, Dis3, is essentially responsible for yeast exosome core activityAndrzej Dziembowski
Equipe Labellisée La Ligue, Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique UPR2167, associée à l Université Pierre et Marie Curie, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
Nat Struct Mol Biol 14:15-22. 2007..We observed that the yeast exosome ring mediates interactions with protein partners, providing an explanation for its essential function...
- Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease familyEsben Lorentzen
European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Mol Cell 29:717-28. 2008..The structure provides a molecular rationale for the observed biochemical properties of the RNase R family of nucleases...
- Endonucleolytic RNA cleavage by a eukaryotic exosomeAlice Lebreton
Equipe Labellisée La Ligue, Centre de Genetique Moleculaire, CNRS UPR 2167, 91198 Gif sur Yvette, France
Nature 456:993-6. 2008..The mode of action of eukaryotic exosome cores in RNA processing and degradation should be reconsidered, taking into account the cooperation between its multiple ribonucleolytic activities...
- Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicingAndrzej Dziembowski
Centre de Genetique Moleculaire, Avenue de la Terrasse, Gif sur Yvette, France
EMBO J 23:4847-56. 2004..The corresponding complex was named pre-mRNA REtention and Splicing (RES). The presence of RES subunit homologues in numerous eukaryotes suggests that its function is evolutionarily conserved...
- Recent developments in the analysis of protein complexesAndrzej Dziembowski
, , CNRS UPR 2167 Associated with University Paris 6, Avenue de la Terrasse, 91198 Cedex, Gif sur Yvette, France
FEBS Lett 556:1-6. 2004..We suggest that the next level of analysis in this area will be the definition of internal subunit arrangement in complexes as a first step toward more detailed structural analyses...
- RNA channelling by the archaeal exosomeEsben Lorentzen
European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
EMBO Rep 8:470-6. 2007..Multiple substrate-binding sites and the entrapment of the substrate in the central channel provide a rationale for the processive degradation of extended RNAs and the stalling of structured RNAs...
- Subunit architecture of multimeric complexes isolated directly from cellsHelena Hernandez
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
EMBO Rep 7:605-10. 2006....
- Identification of a novel human nuclear-encoded mitochondrial poly(A) polymeraseRafal Tomecki
Department of Genetics, Warsaw University, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
Nucleic Acids Res 32:6001-14. 2004....
- Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNAMichal Minczuk
Department of Genetics, University of Warsaw, Pawinskiego 5A, 02 106 Warsaw, Poland
Nucleic Acids Res 30:5074-86. 2002..The presented analysis of the hSuv3p NTPase/helicase suggests that new functions of the protein have been acquired in the course of evolution...
- The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolismAndrzej Dziembowski
Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
J Biol Chem 278:1603-11. 2003..We suggest that the degradosome is a central part of a mitochondrial RNA surveillance system responsible for degradation of aberrant and unprocessed RNAs...