Affiliation: Institute of Animal Reproduction and Food Research
Blitek A, Szymanska M. Regulation of expression and role of peroxisome proliferator-activated receptors (PPARs) in luminal epithelial and stromal cells of the porcine endometrium. Theriogenology. 2019;127:88-101 pubmed publisher
..Therefore, PPAR isoforms seem to play an important role in development and function of the porcine uterus. ..
Blitek A, Szymanska M. Expression and role of peroxisome proliferator-activated receptors in the porcine early placenta trophoblast. Domest Anim Endocrinol. 2018;67:42-53 pubmed publisher
..05), and this effect was abolished by the addition of a respective PPAR antagonist (P < 0.05). Overall, these results point to a role of PPAR isoforms in porcine placenta development and function. ..
Blitek A, Szymanska M, Morawska Pucinska E, Malysz Cymborska I, Andronowska A. Prostacyclin receptor (PTGIR) in the porcine endometrium: Regulation of expression and role in luminal epithelial and stromal cells. Theriogenology. 2015;84:969-82 pubmed publisher
..Moreover, besides its important role in vascular system, PGI2 may promote the expression of proangiogenic genes in the uterine stroma. ..
Blitek A, Szymanska M, Pieczywek M, Morawska Pucinska E. Luteal P4 synthesis in early pregnant gilts after induction of estrus with PMSG/hCG. Anim Reprod Sci. 2016;166:28-35 pubmed publisher
..Low P4 content may, in turn, induce local mechanisms involving LHR and ESR1 expression to support CL function. ..
Szymanska M, Blitek A. Endometrial and conceptus response to exogenous progesterone treatment in early pregnant gilts following hormonally-induced estrus. Anim Reprod Sci. 2016;174:56-64 pubmed publisher
..However, no effect of P4 treatment was detected in conceptuses. ..
Blitek A, Kiewisz J, Waclawik A, Kaczmarek M, Ziecik A. Effect of steroids on HOXA10 mRNA and protein expression and prostaglandin production in the porcine endometrium. J Reprod Dev. 2010;56:643-8 pubmed
..Additionally, the similar profiles of endometrial HOXA10 and PGHS-2 expression in the presence of E(2) and P(4) indicate that both genes are simultaneously regulated by steroids in the porcine uterus. ..
Blitek A, Morawska E, Kiewisz J, Ziecik A. Effect of conceptus secretions on HOXA10 and PTGS2 gene expression, and PGE2 release in co-cultured luminal epithelial and stromal cells of the porcine endometrium at the time of early implantation. Theriogenology. 2011;76:954-66 pubmed publisher
..Moreover, the co-culture system of LE and ST cells is a promising model for the study of endometrial response to conceptus-derived factors. ..
Blitek A, Morawska E, Ziecik A. Regulation of expression and role of leukemia inhibitory factor and interleukin-6 in the uterus of early pregnant pigs. Theriogenology. 2012;78:951-64 pubmed publisher
..In summary, LIF and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation. ..
Morawska Pucinska E, Szymanska M, Blitek A. Expression profile and role of prostacyclin receptor (PTGIR) in peri-implantation porcine conceptuses. Theriogenology. 2014;82:546-56 pubmed publisher
..In summary, PTGIR is expressed in porcine conceptuses, and PGI2 acting through this receptor may promote the attachment and proliferation of Tr cells, thereby facilitating conceptus implantation. ..