Tomasz Gos

Summary

Country: Poland

Publications

  1. doi request reprint Demonstration of disturbed activity of orbitofrontal pyramidal neurons in depressed patients by the AgNOR staining method
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland
    J Affect Disord 118:131-8. 2009
  2. doi request reprint Suicide and depression in the quantitative analysis of glutamic acid decarboxylase-Immunoreactive neuropil
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland
    J Affect Disord 113:45-55. 2009
  3. doi request reprint Demonstration of decreased activity of dorsal raphe nucleus neurons in depressed suicidal patients by the AgNOR staining method
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    J Affect Disord 111:251-60. 2008
  4. doi request reprint Demonstration of disturbed activity of external globus pallidus projecting neurons in depressed patients by the AgNOR staining method
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland
    J Affect Disord 119:149-55. 2009
  5. ncbi request reprint The changes of AgNOR parameters of anterior cingulate pyramidal neurons are region-specific in suicidal and non-suicidal depressive patients
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdask, Gdask, Poland
    World J Biol Psychiatry 8:245-55. 2007
  6. ncbi request reprint The changes in AgNOR parameters of dorsal raphe nucleus neurons are related to suicide
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Debowa 23, 80 204 Gdansk, Poland
    Leg Med (Tokyo) 9:251-7. 2007
  7. doi request reprint Demonstration of disturbed activity of the lateral amygdaloid nucleus projection neurons in depressed patients by the AgNOR staining method
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland
    J Affect Disord 126:402-10. 2010
  8. doi request reprint Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depressive patients
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, ul Debowa 23, 80 204 Gdansk, Poland
    Eur Arch Psychiatry Clin Neurosci 258:513-20. 2008
  9. ncbi request reprint Differences in activation of the dorsal raphe nucleus depending on performance of suicide
    Hendrik Bielau
    Department of Psychiatry, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Brain Res 1039:43-52. 2005
  10. pmc Differences between unipolar and bipolar I depression in the quantitative analysis of glutamic acid decarboxylase-immunoreactive neuropil
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Gdansk, Poland
    Eur Arch Psychiatry Clin Neurosci 262:647-55. 2012

Collaborators

Detail Information

Publications28

  1. doi request reprint Demonstration of disturbed activity of orbitofrontal pyramidal neurons in depressed patients by the AgNOR staining method
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland
    J Affect Disord 118:131-8. 2009
    ..The aim to find the morphological biomarker of disturbed activity of the orbitofrontal cortex (OFC) in depression was approached by the karyometric analysis of pyramidal neurons...
  2. doi request reprint Suicide and depression in the quantitative analysis of glutamic acid decarboxylase-Immunoreactive neuropil
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland
    J Affect Disord 113:45-55. 2009
    ..Alterations of GABAergic neurotransmission are assumed to play a crucial role in the pathophysiology of mood disorders. Glutamic acid decarboxylase (GAD) is the key enzyme of GABA synthesis...
  3. doi request reprint Demonstration of decreased activity of dorsal raphe nucleus neurons in depressed suicidal patients by the AgNOR staining method
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    J Affect Disord 111:251-60. 2008
    ..The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of limbic structures crucial for the regulation of emotionally influenced behaviour...
  4. doi request reprint Demonstration of disturbed activity of external globus pallidus projecting neurons in depressed patients by the AgNOR staining method
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland
    J Affect Disord 119:149-55. 2009
    ..The aim to find a morphological biomarker of disturbed EGP activity in depression was approached by the karyometric analysis of large projecting neurons...
  5. ncbi request reprint The changes of AgNOR parameters of anterior cingulate pyramidal neurons are region-specific in suicidal and non-suicidal depressive patients
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdask, Gdask, Poland
    World J Biol Psychiatry 8:245-55. 2007
    ..028). The results suggest that regionally differentiated depression- and suicide-specific disturbed function of the most important AC output cells exists in depressive patients...
  6. ncbi request reprint The changes in AgNOR parameters of dorsal raphe nucleus neurons are related to suicide
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Debowa 23, 80 204 Gdansk, Poland
    Leg Med (Tokyo) 9:251-7. 2007
    ..The results suggest DRN neurons hypoactivity specific for suicide. Whether observed phenomenon is a "common trait" existing also in other diagnostic groups of mental disorders remains an open question...
  7. doi request reprint Demonstration of disturbed activity of the lateral amygdaloid nucleus projection neurons in depressed patients by the AgNOR staining method
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland
    J Affect Disord 126:402-10. 2010
    ..The aim to find a morphological biomarker of disturbed activity of the lateral amygdaloid nucleus in depression was approached by a karyometric analysis of projection neurons...
  8. doi request reprint Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depressive patients
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, ul Debowa 23, 80 204 Gdansk, Poland
    Eur Arch Psychiatry Clin Neurosci 258:513-20. 2008
    ..Traditional antidepressants may, therefore, regulate noradrenergic activity of the LC in suicide patients, however, without demonstrating the suicide-preventing effect...
  9. ncbi request reprint Differences in activation of the dorsal raphe nucleus depending on performance of suicide
    Hendrik Bielau
    Department of Psychiatry, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Brain Res 1039:43-52. 2005
    ..Antidepressants appear to contribute to cellular activation in the rostral part of the dorsal raphe...
  10. pmc Differences between unipolar and bipolar I depression in the quantitative analysis of glutamic acid decarboxylase-immunoreactive neuropil
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Gdansk, Poland
    Eur Arch Psychiatry Clin Neurosci 262:647-55. 2012
    ....
  11. doi request reprint Increased nuclear Olig1-expression in the pregenual anterior cingulate white matter of patients with major depression: a regenerative attempt to compensate oligodendrocyte loss?
    Jennifer Mosebach
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 47:1069-79. 2013
    ..Olig1, an oligodendroglial transcription factor, might be important in this context, but has not been systematically studied so far...
  12. doi request reprint Immunohistochemical evidence for impaired nitric oxide signaling of the locus coeruleus in bipolar disorder
    Hendrik Bielau
    Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany
    Brain Res 1459:91-9. 2012
    ..The current data on nNOS suggest a dysregulation of the nitrergic system in bipolar disorder. Future studies may clarify the potential role of glial cells in the context of the described nNOS deficit...
  13. doi request reprint A postmortem assessment of mammillary body volume, neuronal number and densities, and fornix volume in subjects with mood disorders
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:637-46. 2012
    ..Furthermore, the fornix volumes were significantly reduced only in the control subjects with heart failure. Taken together, these results show that the mammillary bodies are compromised in depression...
  14. doi request reprint Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    World J Biol Psychiatry 13:482-92. 2012
    ..It is not clear, however, whether such changes are associated with corresponding neuroinflammatory responses and disturbances of neurotransmission...
  15. doi request reprint Ribosomal DNA transcription in the anterior cingulate cortex is decreased in unipolar but not bipolar I depression
    Tomasz Gos
    Department of Forensic Medicine, Medical University of Gdansk, ul Debowa 23, 80 204 Gdansk, Poland Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany Department of Zoology Developmental Neurobiology, Institute of Biology, Otto von Guericke University, Magdeburg, Germany Electronic address
    Psychiatry Res 210:338-45. 2013
    ..Furthermore, in our cohort, unipolar and bipolar I depression could be differentiated relative to the presumed AC hypoactivity and psychotropic medication did not counteract the observed effect. ..
  16. ncbi request reprint S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric study
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 42:868-76. 2008
    ..However, no histological study has been published on the cellular distribution of S100B in the brain of individuals with schizophrenia to clarify this hypothesis...
  17. pmc Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neuroinflammation 8:94. 2011
    ..These peripheral immune processes may be accompanied by microglial activation in subregions of the anterior cingulate cortex where depression-associated alterations of glutamatergic neurotransmission have been described...
  18. doi request reprint S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differentially afflicted in unipolar and bipolar depression: a postmortem study
    Tomasz Gos
    Department of Psychiatry, University of Magdeburg, Germany Institute of Forensic Medicine, Medical University of Gdansk, Gdansk, Poland
    J Psychiatr Res 47:1694-9. 2013
    ..However, brain studies on the cellular distribution pattern of S100B in depressed patients are lacking so far. Such analyses are crucial, since S100B has been detected in various other cell types, even outside the central nervous system...
  19. doi request reprint Reduced density of hypothalamic VGF-immunoreactive neurons in schizophrenia: a potential link to impaired growth factor signaling and energy homeostasis
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:365-74. 2012
    ..7 kg/m(2)). In conclusion, apart from beneficial effects on synaptic plasticity and neurogenesis, VGF may be linked to schizophrenia-related alterations in energy homeostasis...
  20. doi request reprint Protective effects of haloperidol and clozapine on energy-deprived OLN-93 oligodendrocytes
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 261:477-82. 2011
    ..A new mechanism of antipsychotic action is suggested, which may help to establish new oligodendrocyte-directed therapies of schizophrenia...
  21. doi request reprint Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 26:1273-9. 2012
    ..The identification of diverse immune endophenotypes may facilitate the development of distinct anti-inflammatory schizophrenia therapies to normalize BBB function, (auto)antibody production or microglial activity...
  22. ncbi request reprint The estimation of stature on the basis of measurements of the femur
    Roman Hauser
    Department of Forensic Medicine, Medical University of Gdansk, Curie Skłodowskiej 3a, 80 210 Gdansk, Poland
    Forensic Sci Int 147:185-90. 2005
    ..The research points to a very close relationship between the length of a dead body and the measured greatest length of the femur. This relationship was expressed in nine coefficients of correlation calculated for both sexes...
  23. ncbi request reprint Postmortem-assessed impairment of neuronal activity in depression: the dominant impact of suicide
    Tomasz Gos
    Department of Forensic Medicine, Medical University of Gdansk, ul Debowa 23, 80 204 Gdansk, Poland
    CNS Neurol Disord Drug Targets 12:930-5. 2013
    ..Our AgNOR studies show that the influence of psychotropic medication (antidepressants and typical neuroleptics, among others) is limited in the prevention of abnormal neuronal activity specific for suicide. ..
  24. doi request reprint Complex suicide by self-stabbing with subsequent drowning in the sea
    Michał Kaliszan
    Department of Forensic Medicine, Medical University of Gdansk, ul Debowa 23, 80 204, Gdansk, Poland
    J Forensic Sci 58:1370-3. 2013
    ..The circumstances preceding the suicidal act clearly suggest an underlying undiagnosed mental disorder. ..
  25. doi request reprint Olfactory and tissue markers of fear in mammals including humans
    Roman Hauser
    Department of Forensic Medicine, Medical University of Gdansk, Debowa 23, 80 204 Gdansk, Poland
    Med Hypotheses 77:1062-7. 2011
    ..Their identification could also be of significant importance for the practical utilisation of results by institutions responsible for safety and defence as well as law enforcement/crime detection and antiterrorist activities...
  26. ncbi request reprint Stress-induced synaptic changes in the rat anterior cingulate cortex are dependent on endocrine developmental time windows
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, 80 204 Gdansk, Poland
    Synapse 62:229-32. 2008
    ..These results reveal specific developmental time window for synaptic wiring within the deeper layers of the anterior cingulate cortex, which seem not to be mediated by hormonally induced mechanisms...
  27. ncbi request reprint Dysregulation of GABAergic neurotransmission in mood disorders: a postmortem study
    Hendrik Bielau
    Department of Psychiatry, Psychotherapy, and Psychosomatic Medicine, Otto von Guericke University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:157-69. 2007
    ..Possibly, existing deficits of GABAergic neurotransmission will be compensated or overcompensated by antidepressants. Additionally, albeit speculative, an imbalance between GABA production and transport might be of relevance...
  28. ncbi request reprint [Cervical fractures in autopsy records]
    Rafał Pankowski
    Katedra i Klinika Ortopedii i Traumatologii Narzadu Ruchu, Akademia Medyczna w Gdansku
    Chir Narzadow Ruchu Ortop Pol 68:157-63. 2003
    ..The most common fracture localisation was C2 with dens fracture as the most frequent injury. The most common spinal cord lesion was complete rupture mainly at the upper cervical spine level...