Katarzyna Bogunia Kubik


Country: Poland


  1. Bogunia Kubik K, Świerkot J, Malak A, Wysoczańska B, Nowak B, Białowąs K, et al. IL-17A, IL-17F and IL-23R Gene Polymorphisms in Polish Patients with Rheumatoid Arthritis. Arch Immunol Ther Exp (Warsz). 2015;63:215-21 pubmed publisher
    ..97; p < 0.001) and its homozygosity (OR 29.62; p < 0.001) was more frequent among patients than healthy individuals. These results suggest that the polymorphisms within the IL-17A and IL-17F genes play a significant role in RA. ..
  2. Atarod S, Turner B, Pearce K, Ahmed S, Norden J, Bogunia Kubik K, et al. Elevated level of HSPA1L mRNA correlates with graft-versus-host disease. Transpl Immunol. 2015;32:188-94 pubmed publisher
    ..012) and cGVHD (p = 0.027) patients. Our initial results in this small cohort show that quantifying HSPA1L mRNA expression in the whole blood of allo-HSCT patients at day 28 post-allo-HSCT may be a useful predictive biomarker for cGVHD. ..
  3. Łacina P, Butrym A, Mazur G, Bogunia Kubik K. BSG and MCT1 Genetic Variants Influence Survival in Multiple Myeloma Patients. Genes (Basel). 2018;9: pubmed publisher
    ..05). Taken together, our results show that BSG and SLC16A1 variants affect survival, and may play an important role in MM. ..
  4. Iwaszko M, Åšwierkot J, Kolossa K, Jeka S, Wiland P, Bogunia Kubik K. Influence of NKG2D Genetic Variants on Response to Anti-TNF Agents in Patients with Rheumatoid Arthritis. Genes (Basel). 2018;9: pubmed publisher
    ..010 and p-value = 0.002, respectively). Data from the present study provides evidence that NKG2D polymorphisms may affect response to anti-TNF inhibitors in RA patients. ..
  5. Bogunia Kubik K, Mizia S, Polak M, Gronkowska A, Nowak J, Kyrcz Krzemień S, et al. Beneficial effect of the CXCL12-3'A variant for patients undergoing hematopoietic stem cell transplantation from unrelated donors. Cytokine. 2015;76:182-186 pubmed publisher
    ..Moreover, CXCL12-3'-A-positive patients were less prone to early HHV-6 reactivation (2/34 vs. 19/69, p=0.026). The presence of the CXCL12-3'-A variant was found to facilitate outcome of unrelated HSCT. ..
  6. Sokolik R, Gębura K, Iwaszko M, Świerkot J, Korman L, Wiland P, et al. Significance of association of HLA-C and HLA-E with psoriatic arthritis. Hum Immunol. 2014;75:1188-91 pubmed publisher
    ..44, p=0.045). Therefore these results suggest that the HLA-E and HLA-C(∗)02 molecules may also play an important role in determination immune response contributing to the PsA development. ..
  7. Ząbek A, Swierkot J, Malak A, Zawadzka I, Deja S, Bogunia Kubik K, et al. Application of (1)H NMR-based serum metabolomic studies for monitoring female patients with rheumatoid arthritis. J Pharm Biomed Anal. 2016;117:544-50 pubmed publisher
    ..Metabolomics may provide relevant biomarkers to improve diagnostic accuracy, define prognosis and predict and monitor treatment efficacy in rheumatoid arthritis. ..
  8. Butrym A, Rybka J, Łacina P, Gębura K, Frontkiewicz D, Bogunia Kubik K, et al. Polymorphisms within beta-catenin encoding gene affect multiple myeloma development and treatment. Leuk Res. 2015;39:1462-6 pubmed publisher
    ..044). No association was found for the CRBN polymorphism. These results suggest that the CTNNB1 polymorphisms may affect the clinical course and response to chemotherapy in patients with multiple myeloma. ..
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    Wrobel T, Butrym A, Łacina P, Rybka J, Gębura K, Mazur G, et al. bFGF Polymorphism Is Associated with Disease Progression and Response to Chemotherapy in Multiple Myeloma Patients. Anticancer Res. 2017;37:1799-1803 pubmed
    ..040). Progression after first-line chemotherapy was more frequent among patients carrying this variant (p=0.022). Our results imply that the course of disease in MM patients is associated with a polymorphism within the bFGF gene. ..

More Information


  1. Bogunia Kubik K, Gieryng A, Gębura K, Lange A. Genetic variant of the G-CSF receptor gene is associated with lower mobilization potential and slower recovery of granulocytes after transplantation of autologous peripheral blood progenitor cells. Cytokine. 2012;60:463-7 pubmed publisher
    ..014) by multiple regression analysis considering patient age and sex, the number of transplanted CD34(+) cells, diagnosis and CSF3R polymorphism. These results imply that CSF3R gene polymorphism plays a significant role in PBPCT. ..
  2. Iwaszko M, Åšwierkot J, Kolossa K, Jeka S, Wiland P, Bogunia Kubik K. Influence of CD94 and NKG2A variants on susceptibility to rheumatoid arthritis and efficacy of anti-TNF treatment. Joint Bone Spine. 2016;83:75-9 pubmed publisher
    ..These results indicate that CD94 and NKG2A polymorphisms may contribute to genetic susceptibility to RA or affect the response to anti-TNF therapy in patients of Caucasian origin. ..
  3. Gębura K, Świerkot J, Wysoczańska B, Korman L, Nowak B, Wiland P, et al. Polymorphisms within Genes Involved in Regulation of the NF-κB Pathway in Patients with Rheumatoid Arthritis. Int J Mol Sci. 2017;18: pubmed publisher
    ..018). TLR polymorphisms affect disease susceptibility and response to therapy with TNF-α inhibitors in RA patients of Caucasian origin. ..
  4. Bogunia Kubik K, Gieryng A, Dlubek D, Lange A. The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. Bone Marrow Transplant. 2009;44:273-8 pubmed publisher
    ..003). In conclusion, the CXCL12-3'A allele was associated with a higher yield of CD34(+) cells from healthy donors of PBPC for allogeneic haematopoietic SCT. ..
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    Bogunia Kubik K, Lange A. HSP70-hom gene polymorphism in allogeneic hematopoietic stem-cell transplant recipients correlates with the development of acute graft-versus-host disease. Transplantation. 2005;79:815-20 pubmed
    ..Polymorphism of the HSP70-hom gene is associated with the development of posttransplant complications. Recipient HSP-AA homozygous genotype is a risk factor for aGVHD. ..
  6. Bogunia Kubik K, Middleton P, Norden J, Dickinson A, Lange A. Association of vitamin D receptor polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation. Int J Immunogenet. 2008;35:207-13 pubmed publisher
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    Bogunia Kubik K, Jaskula E, Lange A. The presence of functional CCR5 and EBV reactivation after allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant. 2007;40:145-50 pubmed
    ..354, P=0.024). These results suggest that the expression of functional CCR5 plays a role in initiation/perpetuation of EBV reactivation. ..
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    Bogunia Kubik K, Mazur G, Urbanowicz I, Wrobel T, Kuliczkowski K, Wozniak M, et al. Lack of association between the TNF-alpha promoter gene polymorphism and susceptibility to B-cell chronic lymphocytic leukaemia. Int J Immunogenet. 2006;33:21-4 pubmed
    ..86, P = 0.294]. These results suggest that TNFA (-308) alleles are not involved in the predisposition to the development of B-CLL. ..