Bielenica A, Sanna G, Madeddu S, Giliberti G, Stefanska J, Kozioł A, et al
. Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies. Molecules. 2018;23: pubmed publisher
..The influence of derivatives 11, 13 and 25 on viability, mortality and the growth rate of immortalized human keratinocytes (HaCaT) was observed. ..
Bielenica A, StefaÅ„ska J, StÄ™pieÅ„ K, NapiÃ³rkowska A, Augustynowicz KopeÄ‡ E, Sanna G, et al
. Synthesis, cytotoxicity and antimicrobial activity of thiourea derivatives incorporating 3-(trifluoromethyl)phenyl moiety. Eur J Med Chem. 2015;101:111-25 pubmed publisher
..Moreover, all obtained thioureas were evaluated for cytotoxicity and antiviral activity against a large panel of DNA and RNA viruses. Compounds 5, 6, 8-12, 15 resulted cytotoxic against MT-4 cells (CC50Â â‰¤Â 10Â Î¼M). ..
Bielenica A, Kedzierska E, Koliński M, Kmiecik S, Kolinski A, Fiorino F, et al
. 5-HT2 receptor affinity, docking studies and pharmacological evaluation of a series of 1,3-disubstituted thiourea derivatives. Eur J Med Chem. 2016;116:173-186 pubmed publisher
..Molecular docking studies using a homology model of 5-HT2A revealed a significant role of hydrogen bonds between both thiourea NH groups and Asp155/Tyr370 residues, as well as ?-? interaction with Phe339. ..
Bielenica A, Drzewiecka Antonik A, Rejmak P, StefaÅ„ska J, KoliÅ„ski M, Kmiecik S, et al
. Synthesis, structural and antimicrobial studies of type II topoisomerase-targeted copper(II) complexes of 1,3-disubstituted thiourea ligands. J Inorg Biochem. 2018;182:61-70 pubmed publisher
..The title derivatives were found to be effective inhibitors of DNA gyrase and topoisomerase IV isolated from Staphylococcus aureus. The binding modes of the ligand L3 with DNA gyrase and topoisomerase IV were presented. ..
Bielenica A, Szulczyk D, Olejarz W, Madeddu S, Giliberti G, Materek I, et al
. 1H-Tetrazol-5-amine and 1,3-thiazolidin-4-one derivatives containing 3-(trifluoromethyl)phenyl scaffold: Synthesis, cytotoxic and anti-HIV studies. Biomed Pharmacother. 2017;94:804-812 pubmed publisher
..The compound shows significant influence on cancer, but not on normal cells. Obtained results can provide some constructive data for further designing of novel family of potentially bioactive analogs. ..