Marcin Baranowski

Summary

Country: Poland

Publications

  1. pmc Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide
    Marcin Baranowski
    Departments of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 222 Bialystok, Poland
    J Lipid Res 51:74-80. 2010
  2. doi request reprint Heart sphingolipids in health and disease
    Marcin Baranowski
    Department of Physiology, Medical University of Białystok, Poland
    Adv Exp Med Biol 721:41-56. 2011
  3. doi request reprint Exercise increases plasma levels of sphingoid base-1 phosphates in humans
    M Baranowski
    Department of Physiology, Medical University of Białystok, Poland
    Acta Physiol (Oxf) 203:373-80. 2011
  4. ncbi request reprint Biological role of liver X receptors
    M Baranowski
    Department of Physiology, Medical University of Bialystok, Bialystok, Poland
    J Physiol Pharmacol 59:31-55. 2008
  5. doi request reprint LXR activation prevents exhaustive exercise-induced hypoglycaemia and spares muscle glycogen but does not enhance running endurance in untrained rats
    M Baranowski
    Department of Physiology, Medical University of Białystok, Mickiewicza 2c, Białystok, Poland
    Acta Physiol (Oxf) 201:373-9. 2011
  6. doi request reprint The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver
    Piotr Zabielski
    Department of Physiology, Medical University of Białystok, Poland
    Prostaglandins Other Lipid Mediat 93:75-83. 2010
  7. doi request reprint Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle
    Agnieszka Blachnio-Zabielska
    Department of Physiology, Medical University of Bialystok, Bialystok, Poland
    J Cell Physiol 225:786-91. 2010
  8. ncbi request reprint Partial hepatectomy activates production of the pro-mitotic intermediates of the sphingomyelin signal transduction pathway in the rat liver
    Piotr Zabielski
    Department of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 089 Bialystok, Poland
    Prostaglandins Other Lipid Mediat 83:277-84. 2007
  9. doi request reprint Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver
    Piotr Zabielski
    Department of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 089 Bialystok, Poland
    Prostaglandins Other Lipid Mediat 93:120-5. 2010
  10. doi request reprint Pioglitazone induces lipid accumulation in the rat heart despite concomitant reduction in plasma free fatty acid availability
    Marcin Baranowski
    Department of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 230 Bialystok, Poland
    Arch Biochem Biophys 477:86-91. 2008

Collaborators

Detail Information

Publications27

  1. pmc Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide
    Marcin Baranowski
    Departments of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 222 Bialystok, Poland
    J Lipid Res 51:74-80. 2010
    ..Our results indicate that in the human heart, or at least in the atrium, ceramide is not a major factor in cardiomyocyte apoptosis associated with obesity and type 2 diabetes...
  2. doi request reprint Heart sphingolipids in health and disease
    Marcin Baranowski
    Department of Physiology, Medical University of Białystok, Poland
    Adv Exp Med Biol 721:41-56. 2011
    ..In the last section of this chapter we discuss the evidence for a role of ceramide in myocardial lipotoxicity...
  3. doi request reprint Exercise increases plasma levels of sphingoid base-1 phosphates in humans
    M Baranowski
    Department of Physiology, Medical University of Białystok, Poland
    Acta Physiol (Oxf) 203:373-80. 2011
    ..We have previously found that exercise alters skeletal muscle sphingolipid metabolism. This finding prompted us to examine whether physical activity induces similar effects in blood...
  4. ncbi request reprint Biological role of liver X receptors
    M Baranowski
    Department of Physiology, Medical University of Bialystok, Bialystok, Poland
    J Physiol Pharmacol 59:31-55. 2008
    ....
  5. doi request reprint LXR activation prevents exhaustive exercise-induced hypoglycaemia and spares muscle glycogen but does not enhance running endurance in untrained rats
    M Baranowski
    Department of Physiology, Medical University of Białystok, Mickiewicza 2c, Białystok, Poland
    Acta Physiol (Oxf) 201:373-9. 2011
    ..Moreover, it remains obscure whether LXR activation affects physical endurance. Therefore, we aimed to examine effects of selective LXR activator--T0901317--on running endurance and skeletal muscle exercise metabolism in rats...
  6. doi request reprint The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver
    Piotr Zabielski
    Department of Physiology, Medical University of Białystok, Poland
    Prostaglandins Other Lipid Mediat 93:75-83. 2010
    ..Shingosine-1-phosphate to ceramide ratio was higher in rats fed HFD. It is concluded that HFD stimulates the pro-mitotic action of the sphingolipid signaling in regenerating rat liver...
  7. doi request reprint Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle
    Agnieszka Blachnio-Zabielska
    Department of Physiology, Medical University of Bialystok, Bialystok, Poland
    J Cell Physiol 225:786-91. 2010
    ..We conclude that regulation of muscle ceramide level depends on the diet and type of skeletal muscle...
  8. ncbi request reprint Partial hepatectomy activates production of the pro-mitotic intermediates of the sphingomyelin signal transduction pathway in the rat liver
    Piotr Zabielski
    Department of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 089 Bialystok, Poland
    Prostaglandins Other Lipid Mediat 83:277-84. 2007
    ..It is concluded that partial hepatectomy induces production of the pro-mitogenic intermediates of sphingomyelin signaling pathway during the first 12h of liver regeneration in rat...
  9. doi request reprint Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver
    Piotr Zabielski
    Department of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 089 Bialystok, Poland
    Prostaglandins Other Lipid Mediat 93:120-5. 2010
    ..We conclude that partial hepatectomy stimulates de novo sphingolipid synthesis. Activation of PPARα by bezafibrate negatively affects this process, presumably by decreasing the availability of plasma-borne fatty acids...
  10. doi request reprint Pioglitazone induces lipid accumulation in the rat heart despite concomitant reduction in plasma free fatty acid availability
    Marcin Baranowski
    Department of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 230 Bialystok, Poland
    Arch Biochem Biophys 477:86-91. 2008
    ..Our data suggests that thiazolidinediones improve cardiac insulin sensitivity by mechanisms other than reduction in intramyocardial lipid content...
  11. ncbi request reprint Pioglitazone induces de novo ceramide synthesis in the rat heart
    Marcin Baranowski
    Department of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 230 Bialystok, Poland
    Prostaglandins Other Lipid Mediat 83:99-111. 2007
    ..We conclude that pioglitazone induced accumulation of CER in rat myocardium as a result of augmented CER synthesis de novo. However, in the STD group increased activity of neutral sphingomyelinase could also contributed to this effect...
  12. pmc Aerobic training in rats increases skeletal muscle sphingomyelinase and serine palmitoyltransferase activity, while decreasing ceramidase activity
    Agnieszka Błachnio-Zabielska
    Department of Physiology, Medical University of Białystok, Mickiewicza 2c, 15 222, Białystok, Poland
    Lipids 46:229-38. 2011
    ..It is concluded that training affects the activity of key enzymes of ceramide metabolism but also activates other metabolic pathways which affect ceramide metabolism in skeletal muscles...
  13. pmc Increased bioactive lipids content in human subcutaneous and epicardial fat tissue correlates with insulin resistance
    Agnieszka U Błachnio-Zabielska
    Department of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 222 Bialystok, Poland
    Lipids 47:1131-41. 2012
    ..73, p < 0.001). The study showed that in obese and obese diabetic patients, bioactive lipids content is greater in subcutaneous and epicardial fat tissue and the particular lipids content positively correlates with HOMA-IR...
  14. doi request reprint Effect of exercise duration on the key pathways of ceramide metabolism in rat skeletal muscles
    Agnieszka Błachnio-Zabielska
    Department of Physiology, Medical University of Bialystok, Białystok, Poland
    J Cell Biochem 105:776-84. 2008
    ..It is concluded that exercise strongly affects the activity of key enzymes involved in ceramide metabolism and in consequence the level of sphingolipid intermediates in skeletal muscles...
  15. ncbi request reprint Bezafibrate decreases growth stimulatory action of the sphingomyelin signaling pathway in regenerating rat liver
    Piotr Zabielski
    Department of Physiology, Medical University of Białystok, Mickiewicza 2c, 15 089 Białystok, Poland
    Prostaglandins Other Lipid Mediat 85:17-25. 2008
    ..Therefore, it is concluded that activation of PPARalpha by bezafibrate decreases the growth-stimulatory activity of the sphingomyelin pathway in regenerating rat liver...
  16. ncbi request reprint Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction
    Małgorzata Knapp
    Department of Cardiology, Medical University of Białystok, Białystok, Poland
    Med Sci Monit 15:CR490-3. 2009
    ..The aim of this study was to examine the concentrations of S1P, sphinganine-1-phosphate, free sphingosine, free sphinganine, and ceramide in the plasma of patients after myocardial infarction...
  17. doi request reprint Altered sphingolipid metabolism in human endometrial cancer
    Paweł Knapp
    Department of Gynecology, Medical University of Białystok, Skłodowskiej Curie 24A, 15 276 Białystok, Poland
    Prostaglandins Other Lipid Mediat 92:62-6. 2010
    ..3- and 2.6-fold, respectively. We conclude that endometrial carcinoma is characterized by profound changes in sphingolipid metabolism that likely contribute to its progression and chemoresistance...
  18. doi request reprint Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction
    Małgorzata Knapp
    Department of Cardiology, Medical University of Białystok, Skłodowskiej Curie 24A, 15 276 Białystok, Poland
    Prostaglandins Other Lipid Mediat 106:53-61. 2013
    ..Our data suggest that cardioprotective action of S1P may be diminished in patients with acute myocardial infarction. ..
  19. doi request reprint Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis
    Alina Kułakowska
    Department of Neurology, Medical University of Białystok, Białystok, Poland
    Neurosci Lett 477:149-52. 2010
    ....
  20. doi request reprint Effects of streptozotocin-induced diabetes and elevation of plasma FFA on ceramide metabolism in rat skeletal muscle
    A Błachnio-Zabielska
    Department of Physiology, Medical University of Bialystok, Mickiewicza 2c, 15 089, Mickiewicza 2c, 5 230 Białystok, Poland
    Horm Metab Res 42:1-7. 2010
    ..It is concluded that insulin deficiency is accompanied by alterations in ceramide metabolism in skeletal muscles. Increased concentration of the plasma free fatty acids may mediate certain effects of insulin deficiency...
  21. ncbi request reprint Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles
    M Zendzian-Piotrowska
    Department of Physiology, Medical University of Bialystok, Bialystok, Poland
    J Physiol Pharmacol 57:101-14. 2006
    ..The results of our study indicate that reduction in ceramide level may be one of the mechanisms by which pioglitazone improves skeletal muscle insulin sensitivity...
  22. ncbi request reprint Effect of exercise duration on ceramide metabolism in the rat heart
    M Baranowski
    Department of Physiology, Medical University of Bialystok, Bialystok, Poland
    Acta Physiol (Oxf) 192:519-29. 2008
    ..We aimed at gaining more insight into the mechanisms underlying exercise-induced alterations in myocardial ceramide (CER) content by employing physical activity of various durations and examining all key pathways of CER metabolism...
  23. ncbi request reprint Concentrations of sphingosine and sphinganine in plasma of patients with type 2 diabetes
    Maria Gorska
    Department of Gerontology, Medical Academy of Bialystok, Białystok, Poland
    Med Sci Monit 11:CR35-8. 2005
    ..Both sphingosine and sphinganine have been shown to be present in the blood. The aim of the present study was to examine the concentrations of sphingosine and sphinganine in the plasma of patients with Type 2 diabetes...
  24. ncbi request reprint PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet
    M Baranowski
    Department of Physiology, Medical University of Bialystok, Bialystok, Poland
    J Physiol Pharmacol 58:57-72. 2007
    ..Our results demonstrated that PPARalpha activation modulates myocardial ceramide metabolism and leads to the accumulation of ceramide in the heart of the high-fat fed rats due to its increased synthesis de novo...
  25. pmc Effects of Inhibition of Serine Palmitoyltransferase (SPT) and Sphingosine Kinase 1 (SphK1) on Palmitate Induced Insulin Resistance in L6 Myotubes
    Agnieszka Mikłosz
    Department of Physiology, Medical University of Bialystok, Bialystok, Poland
    PLoS ONE 8:e85547. 2013
    ..The objective of this study was to examine the effects of short (2 h) and prolonged (18 h) inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate (PA) induced insulin resistance in L6 myotubes...
  26. ncbi request reprint Peroxisome proliferator-activated receptor alpha activation induces unfavourable changes in fatty acid composition of myocardial phospholipids
    M Baranowski
    Department of Physiology, Medical University of Bialystok, Bialystok, Poland
    J Physiol Pharmacol 60:13-20. 2009
    ..This action of WY-14643 might be detrimental to the heart since n-3 PUFA possess cardioprotective and antiarrhythmic properties...
  27. ncbi request reprint Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes
    M Straczkowski
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M C Sklodowskiej 24a, 15 276 Bialystok, Poland
    Diabetologia 50:2366-73. 2007
    ..The aim of our study was to assess parameters of the skeletal muscle sphingomyelin signalling pathway in men at risk of developing type 2 diabetes...