Jolanta Artym

Summary

Country: Poland

Publications

  1. ncbi request reprint [The role of lactoferrin in the iron metabolism. Part II. Antimicrobial and antiinflammatory effect of lactoferrin by chelation of iron]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im L Hirszfelda we Wrocławiu, 53 114 Wrocław
    Postepy Hig Med Dosw (Online) 64:604-16. 2010
  2. doi request reprint [A remedy against obesity? The role of lactoferrin in the metabolism of glucose and lipids]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im L Hirszfelda we Wrocławiu, ul Weigla 12, 53 114 Wrocław, Poland
    Postepy Hig Med Dosw (Online) 66:937-53. 2012
  3. ncbi request reprint [The role of lactoferrin in the iron metabolism. Part I. Effect of lactofferin on intake, transport and iron storage]
    Jolanta Artym
    Zakład Terapii Doświadczalnej, Instytut Immunologii i Terapii Doświadczalnej PAN im L Hirszfelda, Wrocław
    Postepy Hig Med Dosw (Online) 62:599-612. 2008
  4. ncbi request reprint [Antitumor and chemopreventive activity of lactoferrin]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN, im Ludwika Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw (Online) 60:352-69. 2006
  5. doi request reprint Prophylactic effect of bacteriophages on mice subjected to chemotherapy-induced immunosuppression and bone marrow transplant upon infection with Staphylococcus aureus
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Med Microbiol Immunol 199:71-9. 2010
  6. pmc Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wrocław, Poland
    BMC Microbiol 9:169. 2009
  7. doi request reprint A novel immunosuppressory peptide originating from the ubiquitin sequence
    Paweł Pasikowski
    Faculty of Chemistry, University of Wrocław, Wrocław, Poland
    Peptides 32:2418-27. 2011
  8. doi request reprint Dimeric analogs of immunosuppressive decapeptide fragment of ubiquitin
    Alicja Kluczyk
    Faculty of Chemistry, University of Wrocław, Wrocław, Poland
    J Pept Sci 18:456-65. 2012
  9. doi request reprint The immunosuppressive activities of newly synthesized azaphenothiazines in human and mouse models
    Michał Zimecki
    Polish Academy of Sciences, Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, R Weigla 12, 53 114, Wrocław, Poland
    Cell Mol Biol Lett 14:622-35. 2009
  10. pmc Lactoferrin restrains allergen-induced pleurisy in mice
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Wrocław, Poland
    Inflamm Res 61:1247-55. 2012

Collaborators

Detail Information

Publications32

  1. ncbi request reprint [The role of lactoferrin in the iron metabolism. Part II. Antimicrobial and antiinflammatory effect of lactoferrin by chelation of iron]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im L Hirszfelda we Wrocławiu, 53 114 Wrocław
    Postepy Hig Med Dosw (Online) 64:604-16. 2010
    ....
  2. doi request reprint [A remedy against obesity? The role of lactoferrin in the metabolism of glucose and lipids]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im L Hirszfelda we Wrocławiu, ul Weigla 12, 53 114 Wrocław, Poland
    Postepy Hig Med Dosw (Online) 66:937-53. 2012
    ....
  3. ncbi request reprint [The role of lactoferrin in the iron metabolism. Part I. Effect of lactofferin on intake, transport and iron storage]
    Jolanta Artym
    Zakład Terapii Doświadczalnej, Instytut Immunologii i Terapii Doświadczalnej PAN im L Hirszfelda, Wrocław
    Postepy Hig Med Dosw (Online) 62:599-612. 2008
    ..Many observations indicate also that LF participates in the process of iron storage,predominantly in the liver. Contradictory data exist, however, regarding the role of LF in iron transport to other cell types and organs...
  4. ncbi request reprint [Antitumor and chemopreventive activity of lactoferrin]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN, im Ludwika Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw (Online) 60:352-69. 2006
    ..In this way it prevents the generation of tumors and their development at early stages of carcinogenesis...
  5. doi request reprint Prophylactic effect of bacteriophages on mice subjected to chemotherapy-induced immunosuppression and bone marrow transplant upon infection with Staphylococcus aureus
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Med Microbiol Immunol 199:71-9. 2010
    ..The results suggest a potential benefit of phage therapy in immunocompromised patients subjected to bone marrow transplant procedures...
  6. pmc Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wrocław, Poland
    BMC Microbiol 9:169. 2009
    ..In this work we investigated the prophylactic efficacy of specific bacteriophages in CBA mice treated with cyclophosphamide (CP) and infected with Staphylococcus aureus...
  7. doi request reprint A novel immunosuppressory peptide originating from the ubiquitin sequence
    Paweł Pasikowski
    Faculty of Chemistry, University of Wrocław, Wrocław, Poland
    Peptides 32:2418-27. 2011
    ..We also tested their immunosuppressory activity in in vitro experiments...
  8. doi request reprint Dimeric analogs of immunosuppressive decapeptide fragment of ubiquitin
    Alicja Kluczyk
    Faculty of Chemistry, University of Wrocław, Wrocław, Poland
    J Pept Sci 18:456-65. 2012
    ..Our results suggest that such orientation of peptide components may correspond to orientation of the hypothetic ubiquitin receptors responsible for the immunomodulatory activity...
  9. doi request reprint The immunosuppressive activities of newly synthesized azaphenothiazines in human and mouse models
    Michał Zimecki
    Polish Academy of Sciences, Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, R Weigla 12, 53 114, Wrocław, Poland
    Cell Mol Biol Lett 14:622-35. 2009
    ..As there were only two subjects in this study, the effects of these compounds on human blood cells need to be confirmed. In this paper, we also discuss the structure-activity relationships of selected compounds...
  10. pmc Lactoferrin restrains allergen-induced pleurisy in mice
    Michał Zimecki
    Institute of Immunology and Experimental Therapy, Wrocław, Poland
    Inflamm Res 61:1247-55. 2012
    ..The aim of this study was to assess the utility of lactoferrin (LF), a natural immunomodulator, to restrain allergen-induced pleurisy in mice...
  11. pmc Homologous lactoferrin triggers mobilization of the myelocytic lineage of bone marrow in experimental mice
    Michał Zimecki
    1 The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Stem Cells Dev 22:3261-70. 2013
    ..In conclusion, the homologous LF elicits significant and transient myelopoiesis in experimental mice...
  12. ncbi request reprint Endogenous steroids are responsible for lactoferrin-induced myelopoiesis in mice
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 61:705-10. 2009
    ..We conclude that LF-induced upregulation of endogenous steroid levels is responsible for the stimulation of myelopoiesis...
  13. ncbi request reprint Synthesis and immunomodulatory activites of new 5-hydrazino-3-methyl-4-isothiazolecarboxylic acid ethyl esters
    Urszula Lipnicka
    Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, Grodzka 9, 50 137 Wrocław, Poland
    Acta Pol Pharm 66:501-11. 2009
    ..The immunotropic activities of the new isothiazole derivatives and potential application of the compounds in therapy are discussed...
  14. ncbi request reprint RM-11, an isoxazole derivative, accelerates restoration of the immune function in mice treated with cyclophosphamide
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 60:183-9. 2008
    ..We conclude that RM11 may be of potential therapeutic value in restoration of the immune status in patients undergoing chemotherapy...
  15. ncbi request reprint The concerted action of lactoferrin and bacteriophages in the clearance of bacteria in sublethally infected mice
    Michał Zimecki
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
    Postepy Hig Med Dosw (Online) 62:42-6. 2008
    ..Both lactoferrin (LF) and bacteriophages are potent antibacterial agents. LF is contained in the secretory fluids of mammals and bacteriophages are specific bacterial viruses...
  16. ncbi request reprint Immunoregulatory function of lactoferrin in immunosuppressed and autoimmune animals
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy of the Polish Academy of Science, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 61:283-7. 2007
    ..In summary, in a series of studies we demonstrated a benefit of orally administered LF in immunocompromised animals...
  17. ncbi request reprint [The effect of psychic stress on the immune response]
    Michał Zimecki
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im Ludwika Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw (Online) 58:166-75. 2004
    ..Our studies revealed a benefit of oral lactoferrin application in reversing stress-induced changes in the humoral and cellular immune response in mice...
  18. ncbi request reprint [Effect of methotrexate on the immune response in selected experimental models]
    Michał Zimecki
    Zakład Terapii Doświadczalnej, Instytutu Immunologii i Terapii Doświadczalnej PAN im Ludwika Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw (Online) 58:226-35. 2004
    ..In summary, MTX has been an effective agent in suppressing immunological disorders (for 50 years) and is still finding many applications...
  19. ncbi request reprint [Therapeutic properties of proteins and peptides from colostrum and milk]
    Michał Zimecki
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im Ludwika Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw (Online) 59:309-23. 2005
    ..In conclusion, preparations derived from milk and colostrum are effective, easily bioaccessible, and safe, finding wide application in prevention and therapy for newborns and adults...
  20. ncbi request reprint Effects of lactoferrin on the immune response modified by the immobilization stress
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 57:811-7. 2005
    ..This is the first report on the regulatory effect of LF on the immune response modified by the psychic stress and is consistent with other reports on antinociceptive and analgesic actions of LF in experimental animals...
  21. ncbi request reprint The effect of carbohydrate moiety structure on the immunoregulatory activity of lactoferrin in vitro
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Weigla 12, 53 114, Wrocław, Poland
    Cell Mol Biol Lett 19:284-96. 2014
    ..We showed that the interaction of LF with sialic acid receptors is essential for at least some of the immunoregulatory activity of this glycoprotein. ..
  22. doi request reprint Effects of lactoferrin on elicitation of the antigen-specific cellular and humoral cutaneous response in mice
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 66:16-22. 2012
    ..The data strongly suggest that LF exerted differential actions on the activities of antigen-specific Th1 and Th2 cells involved in respective types of the cutaneous immune responses...
  23. ncbi request reprint [The role of lactoferrin in the proper development of newborns]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN, im Ludwika Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw (Online) 59:421-32. 2005
    ..Therefore commercially available baby foods (United States, Japan) are supplemented with LF...
  24. doi request reprint The immunosuppressive activity and solution structures of ubiquitin fragments
    Lukasz Jaremko
    Faculty of Chemistry, University of Wrocław, Wrocław, Poland
    Biopolymers 91:423-31. 2009
    ..Although the peptide exhibited a well-defined conformation in methanol, its structure was distinct from the corresponding 50-59 fragment in the native ubiquitin molecule. (c) 2009 Wiley Periodicals, Inc. Biopolymers 91: 423-431, 2009...
  25. ncbi request reprint Calf thymus extract attenuates severity of experimental encephalomyelitis in Lewis rats
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, Poland
    Folia Neuropathol 48:246-57. 2010
    ..We suggest that TFX® or TFX®-derived fractions have potential as therapeutics in treatment of neurodegenerative diseases such as multiple sclerosis...
  26. ncbi request reprint The effects of lactoferrin on myelopoiesis: can we resolve the controversy?
    Jolanta Artym
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 61:129-50. 2007
    ..The aim of this article is to review the available literature data regarding the effects of LF on myelopoiesis in mice and humans. Possible reasons for opposing views on this subject are presented...
  27. ncbi request reprint Enhanced clearance of Escherichia coli and Staphylococcus aureus in mice treated with cyclophosphamide and lactoferrin
    Jolanta Artym
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy of Polish Academy of Science, Rudolfa Weigla 12, 53 114 Wrocław, Poland
    Int Immunopharmacol 4:1149-57. 2004
    ..Lastly, together with our previous data, this study indicates that LF used to reconstitute the antigen-specific immune response in CP-treated mice does not impair their resistance to infection...
  28. ncbi request reprint Effect of lactoferrin on the methotrexate-induced suppression of the cellular and humoral immune response in mice
    Jolanta Artym
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Anticancer Res 24:3831-6. 2004
    ..It seems that LF also prevents the block of the activity of T memory cells in the secondary, humoral immune response. Taken together, we demonstrated that LF given orally can reduce the toxic effects of MTX...
  29. ncbi request reprint Normalization of peripheral blood cell composition by lactoferrin in cyclophosphamide-treated mice
    Jolanta Artym
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy of the Polish Academy of Science, Wrocław, Poland
    Med Sci Monit 10:BR84-9. 2004
    ..The compound induces severe leuko- and neutropenia. Lactoferrin (LF) is a protein which plays a role in the innate immunity. In this study we evaluated the usefulness of LF in reversing CP-induced lympho- and neutropenia in mice...
  30. ncbi request reprint Orally administered lactoferrin restores humoral immune response in immunocompromised mice
    Jolanta Artym
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Immunol Lett 89:9-15. 2003
    ....
  31. ncbi request reprint Reconstitution of the cellular immune response by lactoferrin in cyclophosphamide-treated mice is correlated with renewal of T cell compartment
    Jolanta Artym
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Immunobiology 207:197-205. 2003
    ..In conclusion, we showed for the first time that lactoferrin, given orally to CP-immunosuppressed mice, could reconstitute a T-cell mediated immune response by renewal of the T cell pool...
  32. ncbi request reprint [Reconstitution of cyclophosphamide-induced, impaired function of the immune system in animal models]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im L Hirszfelda we Wrocławiu
    Postepy Hig Med Dosw 57:55-66. 2003
    ..In addition, we present approaches aimed at reconstitution of lympho- and myelopoiesis using a spectrum of immunotropic factors including: thymic hormones, cytokines, low-molecular weight compounds, bacterial products and lactoferrin...