Krzysztof Sobczak

Summary

Affiliation: Adam Mickiewicz University
Country: Poland

Publications

  1. pmc RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy
    Krzysztof Sobczak
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Ther 21:380-7. 2013
  2. pmc Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel
    Zhen Zhi Tang
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Mol Genet 21:1312-24. 2012
  3. pmc Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy
    Robert J Osborne
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Mol Genet 18:1471-81. 2009
  4. doi request reprint Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA
    Thurman M Wheeler
    Departments of Neurology, Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    Science 325:336-9. 2009
  5. pmc Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1)
    Peter C Gareiss
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York 14642, USA
    J Am Chem Soc 130:16254-61. 2008
  6. pmc Scaled-down genetic analysis of myotonic dystrophy type 1 and type 2
    Masayuki Nakamori
    Department of Neurology, Box 673, University of Rochester Medical Center, Rochester, NY 14642, USA
    Neuromuscul Disord 19:759-62. 2009

Collaborators

Detail Information

Publications6

  1. pmc RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy
    Krzysztof Sobczak
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Ther 21:380-7. 2013
    ..These data suggest that the expanded CUG repeats are a potential target for allele-selective RNA interference...
  2. pmc Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel
    Zhen Zhi Tang
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Mol Genet 21:1312-24. 2012
    ..Together, these results indicate that DM-associated splicing defects alter Ca(V)1.1 function, with potential for exacerbation of myopathy...
  3. pmc Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy
    Robert J Osborne
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Mol Genet 18:1471-81. 2009
    ....
  4. doi request reprint Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA
    Thurman M Wheeler
    Departments of Neurology, Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    Science 325:336-9. 2009
    ..These findings suggest an alternative use of antisense methods, to inhibit deleterious interactions of proteins with pathogenic RNAs...
  5. pmc Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1)
    Peter C Gareiss
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York 14642, USA
    J Am Chem Soc 130:16254-61. 2008
    ..These compounds were also able to inhibit the interaction of GGG-(CUG)(109)-GGG RNA with MBNL1 in vitro, with K(i) values in the low micromolar range...
  6. pmc Scaled-down genetic analysis of myotonic dystrophy type 1 and type 2
    Masayuki Nakamori
    Department of Neurology, Box 673, University of Rochester Medical Center, Rochester, NY 14642, USA
    Neuromuscul Disord 19:759-62. 2009
    ..These methods can facilitate genetic analysis in cells and tissues obtained from individuals with myotonic dystrophy...