P Polakis

Summary

Publications

  1. ncbi request reprint The oncogenic activation of beta-catenin
    P Polakis
    Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA
    Curr Opin Genet Dev 9:15-21. 1999
  2. ncbi request reprint Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin
    E Porfiri
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Oncogene 15:2833-9. 1997
  3. pmc Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
    S Munemitsu
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    Proc Natl Acad Sci U S A 92:3046-50. 1995
  4. ncbi request reprint Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Curr Biol 8:573-81. 1998
  5. ncbi request reprint Association of the APC gene product with beta-catenin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806
    Science 262:1731-4. 1993
  6. ncbi request reprint Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    Science 272:1023-6. 1996
  7. ncbi request reprint Identification of a novel guanine nucleotide exchange factor for the Rho GTPase
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    J Biol Chem 271:25452-8. 1996
  8. ncbi request reprint The adenomatous polyposis coli (APC) tumor suppressor
    P Polakis
    Onyx Pharmaceuticals Inc, Richmond, CA 94806, USA
    Biochim Biophys Acta 1332:F127-47. 1997
  9. pmc IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs
    M J Hart
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    EMBO J 15:2997-3005. 1996
  10. ncbi request reprint The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, California 94806
    J Biol Chem 270:5549-55. 1995

Collaborators

  • S Sharma
  • G Bollag
  • B Rubinfeld
  • M J Hart
  • I Albert
  • S Munemitsu
  • E Porfiri
  • B Souza
  • I N Albert
  • R de los Santos
  • K Hovanes
  • M Waterman
  • R G Qiu
  • M G Callow
  • N elMasry
  • C Fiol
  • P McCabe
  • S H Chamberlain
  • F R Masiarz
  • O Muller

Detail Information

Publications10

  1. ncbi request reprint The oncogenic activation of beta-catenin
    P Polakis
    Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA
    Curr Opin Genet Dev 9:15-21. 1999
    ..Once activated, beta-catenin most likely promotes tumor progression through its persistent interaction with one or more of its numerous downstream targets...
  2. ncbi request reprint Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin
    E Porfiri
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Oncogene 15:2833-9. 1997
    ..The results suggest that a cancer pathway driven by wnt-1, or mutant forms of beta-catenin, may involve the formation of a persistent transcriptionally active complex of beta-catenin and LEF1...
  3. pmc Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
    S Munemitsu
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    Proc Natl Acad Sci U S A 92:3046-50. 1995
    ..These results suggest that the tumor-suppressor activity of mutant APC may be compromised due to a defect in its ability to regulate beta-catenin...
  4. ncbi request reprint Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Curr Biol 8:573-81. 1998
    ..This suggests a possible link between Axin, the Wnt-1 signaling components beta-catenin and glycogen synthase kinase 3 beta (GSK3 beta), and APC...
  5. ncbi request reprint Association of the APC gene product with beta-catenin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806
    Science 262:1731-4. 1993
    ..An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion...
  6. ncbi request reprint Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    Science 272:1023-6. 1996
    ..APC was a good substrate for GSK3 beta in vitro, and the phosphorylation sites were mapped to the central region of APC. Binding of beta-catenin to this region was dependent on phosphorylation by GSK3 beta...
  7. ncbi request reprint Identification of a novel guanine nucleotide exchange factor for the Rho GTPase
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    J Biol Chem 271:25452-8. 1996
    ..Northern and Western analysis suggests that p115-RhoGEF is ubiquitously expressed. These results indicate that p115-RhoGEF may be a general regulator of Rho and its associated cellular phenotypes...
  8. ncbi request reprint The adenomatous polyposis coli (APC) tumor suppressor
    P Polakis
    Onyx Pharmaceuticals Inc, Richmond, CA 94806, USA
    Biochim Biophys Acta 1332:F127-47. 1997
    ..Inactivation of APC in cancer is likely due to loss of function(s) normally associated with the deleted protein structure...
  9. pmc IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs
    M J Hart
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    EMBO J 15:2997-3005. 1996
    ..These results suggest that IQGAP1 is an effector target for cdc42Hs and may mediate the effects of this GTPase on cell morphology...
  10. ncbi request reprint The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, California 94806
    J Biol Chem 270:5549-55. 1995
    ..Thus, APC forms distinct heteromeric complexes containing combinations of alpha-catenin, beta-catenin, and plakoglobin which are independent from the cadherin-catenin complexes...