The oncogenic activation of beta-cateninP Polakis
Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA
Curr Opin Genet Dev 9:15-21. 1999
..Once activated, beta-catenin most likely promotes tumor progression through its persistent interaction with one or more of its numerous downstream targets...
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor proteinS Munemitsu
Onyx Pharmaceuticals, Richmond, CA 94806, USA
Proc Natl Acad Sci U S A 92:3046-50. 1995
..These results suggest that the tumor-suppressor activity of mutant APC may be compromised due to a defect in its ability to regulate beta-catenin...
- Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
M J Hart
Onyx Pharmaceuticals, Richmond, California 94806, USA
Curr Biol 8:573-81. 1998
..This suggests a possible link between Axin, the Wnt-1 signaling components beta-catenin and glycogen synthase kinase 3 beta (GSK3 beta), and APC...
- Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin
E Porfiri
Onyx Pharmaceuticals, Richmond, California 94806, USA
Oncogene 15:2833-9. 1997
..The results suggest that a cancer pathway driven by wnt-1, or mutant forms of beta-catenin, may involve the formation of a persistent transcriptionally active complex of beta-catenin and LEF1...
- Association of the APC gene product with beta-catenin
B Rubinfeld
Onyx Pharmaceuticals, Richmond, CA 94806
Science 262:1731-4. 1993
..An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion...
- Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
B Rubinfeld
Onyx Pharmaceuticals, Richmond, CA 94806, USA
Science 272:1023-6. 1996
..APC was a good substrate for GSK3 beta in vitro, and the phosphorylation sites were mapped to the central region of APC. Binding of beta-catenin to this region was dependent on phosphorylation by GSK3 beta...
- Identification of a novel guanine nucleotide exchange factor for the Rho GTPase
M J Hart
Onyx Pharmaceuticals, Richmond, California 94806, USA
J Biol Chem 271:25452-8. 1996
..Northern and Western analysis suggests that p115-RhoGEF is ubiquitously expressed. These results indicate that p115-RhoGEF may be a general regulator of Rho and its associated cellular phenotypes...
- The adenomatous polyposis coli (APC) tumor suppressor
P Polakis
Onyx Pharmaceuticals Inc, Richmond, CA 94806, USA
Biochim Biophys Acta 1332:F127-47. 1997
..Inactivation of APC in cancer is likely due to loss of function(s) normally associated with the deleted protein structure...
- IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs
M J Hart
Onyx Pharmaceuticals, Richmond, CA 94806, USA
EMBO J 15:2997-3005. 1996
..These results suggest that IQGAP1 is an effector target for cdc42Hs and may mediate the effects of this GTPase on cell morphology...
- The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin
B Rubinfeld
Onyx Pharmaceuticals, Richmond, California 94806
J Biol Chem 270:5549-55. 1995
..Thus, APC forms distinct heteromeric complexes containing combinations of alpha-catenin, beta-catenin, and plakoglobin which are independent from the cadherin-catenin complexes...
