Christine Poitou

Summary

Publications

  1. ncbi Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery
    Christine Poitou
    INSERM Avenir EA 3502, Paris 6 University, Nutrition Department, AP HP, Hotel Dieu, Paris, France
    Obes Surg 15:11-23. 2005
  2. ncbi Serum amyloid A: a marker of adiposity-induced low-grade inflammation but not of metabolic status
    Christine Poitou
    INSERM U755, Paris, France
    Obesity (Silver Spring) 14:309-18. 2006
  3. doi Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation
    Nadia Naour
    Institut National de la Santé et de la Recherche Méédicale, Unite 872, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Clin Endocrinol Metab 95:1861-8. 2010
  4. pmc Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss
    Adeline Divoux
    INSERM, U872, Nutriomique, Paris, France
    Diabetes 59:2817-25. 2010
  5. doi Dynamics of change in total and regional body composition after gastric bypass in obese patients
    Cecile Ciangura
    Department of Nutrition, Pitié Salpêtrière Hospital AP HP, University Pierre et Marie Curie Paris6, Human Nutrition Research Center CRNH Ile de France, Paris, France
    Obesity (Silver Spring) 18:760-5. 2010
  6. doi Structural and inflammatory heterogeneity in subcutaneous adipose tissue: relation with liver histopathology in morbid obesity
    Joan Tordjman
    ICAN Institut Cardiométabolisme et Nutrition, Paris, France
    J Hepatol 56:1152-8. 2012
  7. ncbi Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese women
    Soraya Taleb
    Institut National de la Santé et de la Recherche Médicale U755, Nutrition Department, Hotel Dieu, Place du Parvis Notre Dame, 75004 Paris, France
    J Clin Endocrinol Metab 91:1042-7. 2006
  8. doi Potential contribution of adipose tissue to elevated serum cystatin C in human obesity
    Nadia Naour
    INSERM, U872, Paris, France
    Obesity (Silver Spring) 17:2121-6. 2009
  9. pmc Orosomucoid, a new biomarker in the association between obesity and periodontitis
    Hélène Rangé
    Department of Periodontology, Service of Odontology, Rothschild Hospital, AP HP, Paris 7 Denis Diderot University, U F R of Odontology, Paris, France
    PLoS ONE 8:e57645. 2013
  10. doi Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles
    David M Mutch
    INSERM, Nutriomique U872 Team 7, Paris, France
    Am J Clin Nutr 89:51-7. 2009

Collaborators

Detail Information

Publications32

  1. ncbi Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery
    Christine Poitou
    INSERM Avenir EA 3502, Paris 6 University, Nutrition Department, AP HP, Hotel Dieu, Paris, France
    Obes Surg 15:11-23. 2005
    ..We hypothesized that polymorphism effects could be better detected in a situation of negative energy balance and that modified concentrations of adiposity signal genes could change the dynamics of weight gain in obese subjects...
  2. ncbi Serum amyloid A: a marker of adiposity-induced low-grade inflammation but not of metabolic status
    Christine Poitou
    INSERM U755, Paris, France
    Obesity (Silver Spring) 14:309-18. 2006
    ..We studied the variations of expression of the SAA gene in adipose and liver tissues and of SAA serum levels, as well as their relationships with metabolic features during weight loss...
  3. doi Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation
    Nadia Naour
    Institut National de la Santé et de la Recherche Méédicale, Unite 872, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Clin Endocrinol Metab 95:1861-8. 2010
    ..Recent studies in humans and mice suggest the implication of the cysteine proteases cathepsins S, L, and K in vascular and metabolic complications of obesity...
  4. pmc Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss
    Adeline Divoux
    INSERM, U872, Nutriomique, Paris, France
    Diabetes 59:2817-25. 2010
    ..We investigated the composition of subcutaneous (scWAT) and omental WAT (oWAT) fibrosis in obesity and its relationship with metabolic alterations and surgery-induced weight loss...
  5. doi Dynamics of change in total and regional body composition after gastric bypass in obese patients
    Cecile Ciangura
    Department of Nutrition, Pitié Salpêtrière Hospital AP HP, University Pierre et Marie Curie Paris6, Human Nutrition Research Center CRNH Ile de France, Paris, France
    Obesity (Silver Spring) 18:760-5. 2010
    ..In conclusion, follow-up of these obese women revealed a differential pattern of change in FM and LBM after RYGB. Despite an important loss in LBM, especially during the 3-6 months of initial period, LBM appears to be spared thereafter...
  6. doi Structural and inflammatory heterogeneity in subcutaneous adipose tissue: relation with liver histopathology in morbid obesity
    Joan Tordjman
    ICAN Institut Cardiométabolisme et Nutrition, Paris, France
    J Hepatol 56:1152-8. 2012
    ..e. superficial (sSAT) and deep (dSAT). The aim of the present study was to test the hypothesis that these distinct compartments differentially contribute to hepatic alterations in obesity...
  7. ncbi Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese women
    Soraya Taleb
    Institut National de la Santé et de la Recherche Médicale U755, Nutrition Department, Hotel Dieu, Place du Parvis Notre Dame, 75004 Paris, France
    J Clin Endocrinol Metab 91:1042-7. 2006
    ..Obesity is characterized by high levels of CTSS in the circulation and in sc white adipose tissue (scWAT)...
  8. doi Potential contribution of adipose tissue to elevated serum cystatin C in human obesity
    Nadia Naour
    INSERM, U872, Paris, France
    Obesity (Silver Spring) 17:2121-6. 2009
    ....
  9. pmc Orosomucoid, a new biomarker in the association between obesity and periodontitis
    Hélène Rangé
    Department of Periodontology, Service of Odontology, Rothschild Hospital, AP HP, Paris 7 Denis Diderot University, U F R of Odontology, Paris, France
    PLoS ONE 8:e57645. 2013
    ..04) after adjustment for age, gender and smoking. Our study thus suggests that the severity of periodontitis, in morbidly obese patients, is associated with the increase of orosomucoid levels...
  10. doi Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles
    David M Mutch
    INSERM, Nutriomique U872 Team 7, Paris, France
    Am J Clin Nutr 89:51-7. 2009
    ....
  11. doi Urokinase plasminogen activator receptor in adipose tissue macrophages of morbidly obese subjects
    Raffaella Cancello
    Inserm U872, CRC Université Pierre et Marie Curie Paris 6, CHRU Pitié Salpétrière, Service de Nutrition, Paris, France
    Obes Facts 4:17-25. 2011
    ..We previously identified, by a pangenomic approach (microarrays), the urokinase plasminogen activator receptor (PLAUR or CD87) as a potential marker of subcutaneous adipose tissue macrophage infiltration (ATM)...
  12. ncbi Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
    Raffaella Cancello
    INSERM Avenir, Paris 6 University EA3502 and Human Research Center on Nutrition CRNH, Hotel Dieu Hospital, AP HP, Paris, France
    Diabetes 54:2277-86. 2005
    ..We show that improvement of the inflammatory profile after weight loss is related to a reduced number of macrophages in scWAT. MCP-1, PLAUR, CSF-3, and HIF-1alpha may play roles in the attraction of macrophages in scWAT...
  13. ncbi Serum amyloid A and obstructive sleep apnea syndrome before and after surgically-induced weight loss in morbidly obese subjects
    Christine Poitou
    INSERM, U755 Nutriomique, Paris, France
    Obes Surg 16:1475-81. 2006
    ..To explore the potential role of SAA in the relation between OSA and CVD, we investigated relationships between changes in SAA concentrations and nocturnal respiratory events in obese subjects undergoing bariatric surgery...
  14. ncbi Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity
    Raffaella Cancello
    INSERM, U755 Nutriomique, Service de Nutrition, Hotel Dieu, 1 Place du Parvis Notre Dame, 75004 Paris, France
    Diabetes 55:1554-61. 2006
    ..These data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients...
  15. ncbi Is lean body mass decreased after obesity treatment by adjustable gastric banding?
    Muriel Coupaye
    Department of Nutrition, Hbtel Dieu Hospital AP HP, University Pierre et Marie Curie Paris 6, Human Nutrition Research Center CRNH Ile de France, Paris, France
    Obes Surg 17:427-33. 2007
    ..To address this issue, 1) we measured total and regional body composition following gastric banding in a group of obese subjects, and 2) we compared these data to those of a non-surgical control group of similar age and body size...
  16. doi CD14dimCD16+ and CD14+CD16+ monocytes in obesity and during weight loss: relationships with fat mass and subclinical atherosclerosis
    Christine Poitou
    Institut National de la Sante et de la Recherche Medicale, U, Cordeliers Research Center, Paris, France
    Arterioscler Thromb Vasc Biol 31:2322-30. 2011
    ..We aimed to determine the frequency of these subpopulations during weight loss in obesity and diabetes, conditions associated with changes in systemic inflammation, and we tested the link with subclinical atherosclerosis...
  17. ncbi Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis
    Soraya Taleb
    INSERM Avenir, Paris, France
    FASEB J 19:1540-2. 2005
    ..Since this enzyme has been implicated in the development of atherosclerotic lesions, we propose that cathepsin S represents a molecular link between obesity and atherosclerosis...
  18. doi Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction
    Elise Dalmas
    Universite Pierre et Marie Curie Paris 6, Centre de Recherche des Cordeliers, and Universite Paris Descartes, Paris, France
    Am J Clin Nutr 94:450-8. 2011
    ..Obesity is considered a low-grade inflammatory state that improves with weight loss. In addition to acute-phase proteins, other cytokines might contribute to systemic inflammation...
  19. doi Validity of leg-to-leg bioelectrical impedance analysis to estimate body fat in obesity
    Celia Lloret Linares
    Department of Nutrition, Pitié Salpêtrière Hospital AP HP, University Pierre et Marie Curie Paris 6, 83, Boulevard de l Hopital, 75013, Paris, France
    Obes Surg 21:917-23. 2011
    ....
  20. doi Sensory impairment in obese patients? Sensitivity and pain detection thresholds for electrical stimulation after surgery-induced weight loss, and comparison with a nonobese population
    Pauline Dodet
    Department of Internal Medicine, Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Unit of Therapeutic Research, Paris, France
    Clin J Pain 29:43-9. 2013
    ..Obese patients have a high prevalence of painful musculoskeletal disorders that may decrease after massive weight loss. Pain thresholds may be different in obese participants...
  21. pmc Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery
    David M Mutch
    Nutriomique U872 Team 7, Institut National de la Sante et de la Recherche Medicale, Paris, France
    PLoS ONE 4:e7905. 2009
    ..To generate further insight into the numerous metabolic adaptations associated with RYGB surgery, we profiled serum metabolites before and after gastric bypass surgery and integrated metabolite changes with clinical data...
  22. pmc Plasma NOV/CCN3 levels are closely associated with obesity in patients with metabolic disorders
    Jihane Pakradouni
    INSERM, UMR_S938, Saint Antoine Research Center, Saint Antoine Hospital, Paris, France
    PLoS ONE 8:e66788. 2013
    ..No data are available on the relationship between plasma NOV/CCN3 levels and cardiovascular risk factors in humans. This study investigated the possible relationship between plasma NOV levels and cardiovascular risk factors in humans...
  23. ncbi Amiodarone-induced hyperthyroidism during massive weight loss following gastric bypass
    Olivier Bourron
    Department of Nutrition, Pitié Salpêtrière Hospital AP HP, University Pierre et Marie Curie Paris 6, Human Nutrition Research Center CRNH Ile de France, Paris, France
    Obes Surg 17:1525-8. 2007
    ..In this situation, checking thyroid status is recommended, especially when there is a history of thyroid disease or potentially toxic thyroid medication...
  24. doi Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients
    Pierre Bedossa
    Assistance Publique Hopitaux de Paris, Beaujon Hospital, Pathology Department, Clichy, France
    Hepatology 56:1751-9. 2012
    ..In the validation series, the interobserver agreement for the diagnosis of NASH was excellent (κ = 0.80) between liver pathologists. There was no discrepancy between the initial diagnosis and the diagnosis proposed using the algorithm...
  25. ncbi Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects
    Karine Clement
    INSERM Avenir Paris 6 University, EA 3502, Nutrition Department, AP HP, Hotel Dieu, Paris, France
    FASEB J 18:1657-69. 2004
    ..The beneficial effect of weight loss on obesity-related complications may be associated with the modification of the inflammatory profile in adipose tissue...
  26. ncbi Adiponectin gene expression in subcutaneous adipose tissue of obese women in response to short-term very low calorie diet and refeeding
    Yong Ming Liu
    EA 3502 and Institut National de la Santé et de la Recherche Médicale INSERM Avenir and Paris VI University, Department of Nutrition, Hotel Dieu, 75004 Paris, France
    J Clin Endocrinol Metab 88:5881-6. 2003
    ..Both the levels of adiposity and insulin sensitivity may contribute to the variation in adiponectin gene expression in response to acute energy changes...
  27. doi Salivary proteome modifications associated with periodontitis in obese patients
    Hélène Rangé
    Department of Periodontology, Service of Odontology, Garancière Rothschild Hospital, AP HP, Paris 7 Denis Diderot University, U F R of Odontology, Paris, France
    J Clin Periodontol 39:799-806. 2012
    ..To identify changes in the salivary protein/peptide profiles by differential proteomics in obese patients with or without periodontitis...
  28. doi Pilot study examining the frequency of several gene polymorphisms involved in morphine pharmacodynamics and pharmacokinetics in a morbidly obese population
    Celia Lloret Linares
    Department of Nutrition and Endocrinology, Assistance Publique Hopitaux de Paris, Pitie Salpetriere Hospital, Paris, France
    Obes Surg 21:1257-64. 2011
    ..A118G polymorphism in patients undergoing gastric bypass surgery are needed...
  29. ncbi T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes
    Elise Dalmas
    INSERM, UMR S 1166 and 1138, Paris, FranceSorbonne Universités, Pierre et Marie Curie Paris6, Paris, FranceUniversité Paris Descartes, Paris, FranceInstitute of Cardiometabolism and Nutrition, Pitie Salpetriere Hospital, Paris, France
    Diabetes 63:1966-77. 2014
    ..These results provide an additional rationale for targeting IL-1β in obesity-linked type 2 diabetes and may have important implications for the conception of novel combined anti-IL-1β and anti-IL-22 immunotherapy in human obesity...
  30. ncbi Effects of weight loss on bone status after bariatric surgery: association between adipokines and bone markers
    Hélène Wucher
    Department of Nutrition, Hôtel Dieu Hospital AP HP, Paris, France
    Obes Surg 18:58-65. 2008
    ..Our review focuses on gastric banding, vertical banded gastroplasty, and gastric bypass...
  31. pmc GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice
    Amal Ait-Omar
    INSERM, U872, Team 9, Paris, France
    Diabetes 60:2598-607. 2011
    ..Loss of insulin action maintains apical GLUT2 location. In human enterocytes, apical GLUT2 location has not been reported but may be revealed under conditions of insulin resistance...
  32. ncbi In vivo epinephrine-mediated regulation of gene expression in human skeletal muscle
    Nathalie Viguerie
    Unité de Recherches sur les Obésités, Institut National de la Sante et de la Recherche Medicale INSERM, Unité 586, Institut Louis Bugnard, Centre Hospitalier Universitaire de Toulouse, Universite Paul Sabatier, 31403 Toulouse, France
    J Clin Endocrinol Metab 89:2000-14. 2004
    ..They may contribute to the understanding of skeletal muscle alterations observed in pathological conditions characterized by sympathetic nervous system overdrive...