Emmanuel Planel

Summary

Publications

  1. ncbi request reprint Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells
    Shinji Sato
    Laboratory for Alzheimer s Disease, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 277:42060-5. 2002
  2. ncbi request reprint Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease
    Emmanuel Planel
    Laboratory for Alzheimer s Disease, The Institute of Physical and Chemical Research, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 24:2401-11. 2004
  3. doi request reprint A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease
    Yasuji Matsuoka
    Department of Neurology, Georgetown University Medical Center, 4000 Reservoir Road N W, Washington, DC 20057, USA
    J Pharmacol Exp Ther 325:146-53. 2008
  4. doi request reprint Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 28:2624-32. 2008
  5. pmc Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:680-90. 2008
  6. pmc Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors
    Alexis Bretteville
    Universite Laval, Faculte de Medecine, Département de Neurosciences et Psychiatrie
    Sci Rep 2:480. 2012
  7. pmc Alzheimer's disease and anesthesia
    Marie Amélie Papon
    Département de Psychiatrie et Neurosciences, Centre Hospitalier de l Université Laval Québec, QC, Canada
    Front Neurosci 4:272. 2011
  8. pmc Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice
    Marie Amélie Papon
    Centre hospitalier de l Universite Laval, Axe Neurosciences, Quebec, Canada
    Diabetes 62:609-17. 2013
  9. ncbi request reprint Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
    Emmanuel Planel
    Columbia University Medical Center, Department of Pathology, Taub Institute for Alzheimer s Disease Research, New York, New York 10032, USA
    J Neurosci 27:3090-7. 2007
  10. ncbi request reprint Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms
    Emmanuel Planel
    Laboratory for Alzheimer s Disease, The Institute of Physical and Chemical Research, Saitama 351 0198, Japan
    J Neurosci 27:13635-48. 2007

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells
    Shinji Sato
    Laboratory for Alzheimer s Disease, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 277:42060-5. 2002
    ..These results suggest that aberrant tau phosphorylation by the combination of these kinases may be involved in "pretangle," oligomeric tau fibril formation in vivo...
  2. ncbi request reprint Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease
    Emmanuel Planel
    Laboratory for Alzheimer s Disease, The Institute of Physical and Chemical Research, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 24:2401-11. 2004
    ..Our results imply that serine-threonine protein phosphatase 2A plays a major role in regulating tau phosphorylation in the adult brain and provide in vivo evidence for its crucial role in abnormal tau hyperphosphorylation in AD...
  3. doi request reprint A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease
    Yasuji Matsuoka
    Department of Neurology, Georgetown University Medical Center, 4000 Reservoir Road N W, Washington, DC 20057, USA
    J Pharmacol Exp Ther 325:146-53. 2008
    ..Our results suggest that neuronal microtubule interacting agents such as NAP may be useful therapeutic agents for the treatment or prevention of tauopathies...
  4. doi request reprint Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 28:2624-32. 2008
    ..Thus, cdk5 inhibitors may not be effective in targeting tau phosphorylation in the elderly...
  5. pmc Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:680-90. 2008
    ..These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis...
  6. pmc Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors
    Alexis Bretteville
    Universite Laval, Faculte de Medecine, Département de Neurosciences et Psychiatrie
    Sci Rep 2:480. 2012
    ..Therefore, we propose hypothermia-induced hyperphosphorylation as a reliable, fast, convenient and inexpensive tool to screen for tau kinase inhibitors...
  7. pmc Alzheimer's disease and anesthesia
    Marie Amélie Papon
    Département de Psychiatrie et Neurosciences, Centre Hospitalier de l Université Laval Québec, QC, Canada
    Front Neurosci 4:272. 2011
    ..Here, we review the literature linking anesthesia to AD, with a focus on the biochemical consequences of anesthetic exposure on AD pathogenic pathways...
  8. pmc Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice
    Marie Amélie Papon
    Centre hospitalier de l Universite Laval, Axe Neurosciences, Quebec, Canada
    Diabetes 62:609-17. 2013
    ..This model may be a useful tool to address further mechanistic association between insulin dysfunction and AD pathology...
  9. ncbi request reprint Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
    Emmanuel Planel
    Columbia University Medical Center, Department of Pathology, Taub Institute for Alzheimer s Disease Research, New York, New York 10032, USA
    J Neurosci 27:3090-7. 2007
    ..Furthermore, a thorough examination of the effect of anesthesia-induced hypothermia on the risk and progression of AD is warranted...
  10. ncbi request reprint Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms
    Emmanuel Planel
    Laboratory for Alzheimer s Disease, The Institute of Physical and Chemical Research, Saitama 351 0198, Japan
    J Neurosci 27:13635-48. 2007
    ....
  11. pmc Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo
    Emmanuel Planel
    Taub Institute for Alzheimer s Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA
    J Neurosci 28:12798-807. 2008
    ..Tau remaining on the MTs under these conditions is sufficient to maintain MT network integrity...
  12. pmc Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation
    Robert A Whittington
    Department of Anesthesiology, Columbia University Medical Center, New York, NY, USA
    Sci Rep 3:1388. 2013
    ..These data give new mechanistic insights on the regulation of immediate early genes by anesthesia and hypothermia. ..
  13. pmc Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia
    Emmanuel Planel
    Axe Neurosciences, Centre hospitalier de l Universite Laval, Universite Laval, Quebec, Quebec, Canada
    FASEB J 23:2595-604. 2009
    ....
  14. ncbi request reprint c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis
    Yoshitaka Tatebayashi
    Laboratory for Alzheimer s Disease, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    FASEB J 20:762-4. 2006
    ....
  15. doi request reprint MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy
    Pascal Y Smith
    Centre de recherche du CHUQ, Axe Neurosciences, Quebec, Canada
    Hum Mol Genet 20:4016-24. 2011
    ..Taken together, these results suggest that changes in the miR-132/PTBP2 pathway could contribute to the abnormal splicing of tau exon 10 in the brain, and sheds light into the potential role played by miRNAs in a subset of tauopathies...
  16. ncbi request reprint A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment
    Li Liu
    Department of Pathology, Taub Institute for Research on Alzheimer s Disease, Columbia University, Black Building 5 513, 650 West 168th Street, New York, NY 10032, USA
    Neurobiol Dis 31:46-57. 2008
    ....
  17. pmc Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation
    Carl Julien
    Département de Neurosciences et Psychiatrie, Faculte de Medecine, Universite Laval, Quebec, Quebec, Canada
    PLoS ONE 7:e40020. 2012
    ..These data should caution researchers working with DMSO as it can induce artifactual results both in vivo and in vitro...
  18. pmc Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons
    Veronique Dorval
    Axe Neurosciences, Centre de Recherche du CHUQ CHUL, Quebec, Quebec, Canada
    PLoS ONE 7:e44060. 2012
    ..To date, however, little is known about the genes and molecular networks regulated by neuronal miRNAs in vivo, particularly in the adult mammalian brain...
  19. pmc Propofol directly increases tau phosphorylation
    Robert A Whittington
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e16648. 2011
    ....
  20. pmc Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
    Yoshitaka Tatebayashi
    Laboratory for Alzheimer s Disease and Neural Architecture, Brain Science Institute, Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 99:13896-901. 2002
    ....
  21. doi request reprint Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
    Sébastien S Hébert
    Centre de Recherche du CHUQ CHUL, Axe Neurosciences, Quebec, Canada
    Hum Mol Genet 19:3959-69. 2010
    ..In summary, these results support the hypothesis that changes in the miRNA network may contribute to a neurodegenerative phenotype by affecting tau phosphorylation...
  22. pmc Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions
    Franck R Petry
    Universite Laval, Faculte de Medecine, Départment de Psychiatrie et Neurosciences, Quebec, Canada Centre de recherche du CHU de Québec, CHUL, Axe Neurosciences, Quebec, Canada
    PLoS ONE 9:e94251. 2014
    ..We strongly recommend the use of negative (i.e., TKO) and positive (i.e., hypothermic) controls in all experiments. ..
  23. pmc In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice
    Jose Morales-Corraliza
    Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    PLoS ONE 4:e7134. 2009
    ..Given the neurotrophic roles attributed to sAPP, the enhanced stability of sAPP in the beta-amyloid depositing Tg2576 mice may represent a neuroprotective response...
  24. doi request reprint Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)
    Mohammed Filali
    Neurobehavioral Phenotyping Platform, Department of Molecular Medicine, Laval University and Laboratory of Endocrinology and Genomics, CHUQ Research Center, 2705 Blvd Laurier, Quebec, QC G1V 4G2, Canada
    Behav Brain Res 234:334-42. 2012
    ..On the contrary, the mutants did not differ from controls in pain thresholds, nest-building, and various reflexes determined by the SHIRPA primary screen and were even better on the rotorod test of motor coordination...
  25. doi request reprint Biochemical isolation of insoluble tau in transgenic mouse models of tauopathies
    Carl Julien
    Axe Neurosciences, Centre hospitalier de l Universite Laval, Quebec, QC, Canada
    Methods Mol Biol 849:473-91. 2012
    ....
  26. pmc Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation
    Alim Muhammad
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:7327-32. 2008
    ..By recapitulating features of the disease, these animal models suggest that retromer deficiency observed in late-onset Alzheimer's disease can contribute to disease pathogenesis...
  27. pmc Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein
    Wai Haung Yu
    Dept of Pathology, Columbia University Medical Center, 630 W168th St Rm 12 461, New York NY 10032, USA
    Am J Pathol 175:736-47. 2009
    ..This study provides therapeutic and pathological implications for both synucleinopathy and Parkinson's disease, identifying conditions in which autophagy may be insufficient to degrade alpha-syn aggregates...
  28. ncbi request reprint Tau aggregates: toxic, inert, or protective species?
    Alexis Bretteville
    Columbia University Medical Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, New York, NY 10032, USA
    J Alzheimers Dis 14:431-6. 2008
    ..Here, we will first examine tau aggregation and its putative roles in Alzheimer's disease. We will then review the findings concerning different species of tau and their potential toxicity...
  29. ncbi request reprint Hypothermia and Alzheimer's disease neuropathogenic pathways
    R A Whittington
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, 622 West 168th Street PH 5, New York, NY 10032, USA
    Curr Alzheimer Res 7:717-25. 2010
    ..Here, we review the preclinical data involving hypothermia with tau and Aβ, as well as clinical evidence implicating hypothermia in the development of AD...
  30. pmc Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
    Wendy Noble
    Center for Dementia Research, Nathan S Kline Institute, New York University, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Proc Natl Acad Sci U S A 102:6990-5. 2005
    ..These results support the idea that kinases are involved in tauopathy progression and that kinase inhibitors may be effective therapeutically...
  31. ncbi request reprint Untangling memory deficits
    Karen Duff
    Nat Med 11:826-7. 2005
  32. ncbi request reprint U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy
    Shigetsugu Hatakeyama
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Fukuoka, Japan
    J Neurochem 91:299-307. 2004
    ..Thus, CHIP is a ubiquitin ligase for four-repeat tau and maintains neuronal survival by regulating the quality control of tau in neurons...