Robert F Place

Summary

Publications

  1. pmc Defining features and exploring chemical modifications to manipulate RNAa activity
    Robert F Place
    Helen Diller Comprehensive Cancer Center, Department of Urology, University of California, PO Box 589001, San Francisco, CA 94158 9001, USA
    Curr Pharm Biotechnol 11:518-26. 2010
  2. pmc Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression
    Robert F Place
    1 Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, California, USA 2 RNA Therapeutics, Inc, San Francisco, California, USA
    Mol Ther Nucleic Acids 1:e15. 2012
  3. doi request reprint Non-coding RNAs turn up the heat: an emerging layer of novel regulators in the mammalian heat shock response
    Robert F Place
    Anvil Biosciences, 3475 Edison Way, Ste J, Menlo Park, CA, 94025, USA
    Cell Stress Chaperones 19:159-72. 2014
  4. pmc HDACs and the senescent phenotype of WI-38 cells
    Robert F Place
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA
    BMC Cell Biol 6:37. 2005
  5. pmc MicroRNA-373 induces expression of genes with complementary promoter sequences
    Robert F Place
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 105:1608-13. 2008
  6. pmc miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells
    Emily J Noonan
    Center for Molecular Biology in Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    Oncotarget 1:349-58. 2010
  7. pmc Hsp70B' regulation and function
    Emily J Noonan
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269 3125, USA
    Cell Stress Chaperones 12:393-402. 2007
  8. doi request reprint Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    Cancer Res 68:2736-44. 2008
  9. pmc Hsp70B' regulation and function
    Emily J Noonan
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269 3125, USA
    Cell Stress Chaperones 12:219-29. 2007
  10. doi request reprint Double stranded-RNA-mediated activation of P21 gene induced apoptosis and cell cycle arrest in renal cell carcinoma
    Jared M Whitson
    University of California San Francisco, Department of Urology, San Francisco, CA 94121, USA
    Int J Cancer 125:446-52. 2009

Collaborators

Detail Information

Publications24

  1. pmc Defining features and exploring chemical modifications to manipulate RNAa activity
    Robert F Place
    Helen Diller Comprehensive Cancer Center, Department of Urology, University of California, PO Box 589001, San Francisco, CA 94158 9001, USA
    Curr Pharm Biotechnol 11:518-26. 2010
    ..These findings reveal functional features of RNAa that may be utilized to augment saRNA function for mechanistic studies or the development of RNAa-based drugs...
  2. pmc Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression
    Robert F Place
    1 Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, California, USA 2 RNA Therapeutics, Inc, San Francisco, California, USA
    Mol Ther Nucleic Acids 1:e15. 2012
    ..Our results provide proof-of-principle that RNAa in conjunction with lipidioids may represent a novel approach for stimulating gene expression in vivo to treat disease...
  3. doi request reprint Non-coding RNAs turn up the heat: an emerging layer of novel regulators in the mammalian heat shock response
    Robert F Place
    Anvil Biosciences, 3475 Edison Way, Ste J, Menlo Park, CA, 94025, USA
    Cell Stress Chaperones 19:159-72. 2014
    ..It is our hope that much of what is discussed herein may help researchers in integrating the fields of heat shock and ncRNA in mammals. ..
  4. pmc HDACs and the senescent phenotype of WI-38 cells
    Robert F Place
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA
    BMC Cell Biol 6:37. 2005
    ..Here we examine the influence of HDAC inhibitors on the expression of senescent markers in pre- and post-senescent WI-38 cells...
  5. pmc MicroRNA-373 induces expression of genes with complementary promoter sequences
    Robert F Place
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 105:1608-13. 2008
    ..In conclusion, we have identified a miRNA that targets promoter sequences and induces gene expression. These findings reveal a new mode by which miRNAs may regulate gene expression...
  6. pmc miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells
    Emily J Noonan
    Center for Molecular Biology in Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    Oncotarget 1:349-58. 2010
    ..These data indicate that miR-449a is a miRNA component of the Rb pathway and its tumor suppressor-like effects, in part, depends on Rb status in prostate cancer cells...
  7. pmc Hsp70B' regulation and function
    Emily J Noonan
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269 3125, USA
    Cell Stress Chaperones 12:393-402. 2007
    ..These findings are likely to be important in pathological conditions in which Hsp70B' contributes to cell survival...
  8. doi request reprint Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification
    Shahana Majid
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    Cancer Res 68:2736-44. 2008
    ..Altogether, our data provide new insights into the epigenetic mechanism of the action of genistein that may contribute to the chemopreventive activity of this dietary isoflavone and have important implications for epigenetic therapy...
  9. pmc Hsp70B' regulation and function
    Emily J Noonan
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269 3125, USA
    Cell Stress Chaperones 12:219-29. 2007
    ..These findings are likely to be important in pathological conditions in which Hsp70B' contributes to cell survival...
  10. doi request reprint Double stranded-RNA-mediated activation of P21 gene induced apoptosis and cell cycle arrest in renal cell carcinoma
    Jared M Whitson
    University of California San Francisco, Department of Urology, San Francisco, CA 94121, USA
    Int J Cancer 125:446-52. 2009
    ..This is the first report that demonstrates dsRNA mediated gene activation in renal cell carcinoma and suggests that forced over-expression of p21 may lead to an increase in apoptosis through a survivin dependent mechanism...
  11. pmc Ago1 Interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells
    Vera Huang
    Department of Urology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003821. 2013
    ..Our findings reveal the first landscape of human Ago1-chromosomal interactions, which may play a role in the oncogenic transcriptional program of cancer cells. ..
  12. doi request reprint Targeted induction of endogenous NKX3-1 by small activating RNA inhibits prostate tumor growth
    Shancheng Ren
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA
    Prostate 73:1591-601. 2013
    ..We used saRNA as a molecular tool to examine NKX3-1's role as a tumor suppressor and tested in vitro and in vivo antitumor effects of NKX3-1 induction by saRNA...
  13. pmc Upregulation of Cyclin B1 by miRNA and its implications in cancer
    Vera Huang
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA
    Nucleic Acids Res 40:1695-707. 2012
    ..Such phenotypes were recapitulated by overexpression of Ccnb1. Our findings reveal an endogenous system by which miRNA functions to activate Ccnb1 expression in mouse cells and manipulate in vivo tumor development/growth...
  14. pmc Prognostic value and function of KLF4 in prostate cancer: RNAa and vector-mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration
    Ji Wang
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA
    Cancer Res 70:10182-91. 2010
    ..These results suggest that KLF4 functions as an inhibitor of tumor cell growth and migration in prostate cancer and decreased expression has prognostic value for predicting prostate cancer metastasis...
  15. pmc RNAa is conserved in mammalian cells
    Vera Huang
    Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 5:e8848. 2010
    ..Thus far, RNAa has only been demonstrated in human cells and is unclear whether it is conserved in other mammals...
  16. doi request reprint Antitumor effect of dsRNA-induced p21(WAF1/CIP1) gene activation in human bladder cancer cells
    Zhong Chen
    Department of Urology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Cancer Ther 7:698-703. 2008
    ..In conclusion, p21 activation by RNAa has antitumor activity in vitro in bladder cancer cells. These results suggest that RNAa could be used for cancer treatment by targeted activation of tumor suppressor genes...
  17. ncbi request reprint Epigenetic modifications of RASSF1A gene through chromatin remodeling in prostate cancer
    Ken Kawamoto
    Department of Urology, Veterans Affairs Medical Center and University of California School of Medicine, San Francisco, California 94121, USA
    Clin Cancer Res 13:2541-8. 2007
    ..The present study was designed to investigate the mechanisms of inactivation of the RASSF1A gene through the analysis of CpG methylation and histone acetylation and H3 methylation associated with the RASSF1A promoter region...
  18. doi request reprint Intravesical delivery of small activating RNA formulated into lipid nanoparticles inhibits orthotopic bladder tumor growth
    Moo Rim Kang
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Cancer Res 72:5069-79. 2012
    ..Our results provide preclinical proof-of-concept for a novel method to treat bladder cancer by intravesical administration of LNP-formulated RNA duplexes...
  19. pmc Small dsRNAs induce transcriptional activation in human cells
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 103:17337-42. 2006
    ..These findings reveal a more diverse role for small RNA molecules in the regulation of gene expression than previously recognized and identify a potential therapeutic use for dsRNA in targeted gene activation...
  20. ncbi request reprint Chromatin changes on the GSTP1 promoter associated with its inactivation in prostate cancer
    Steven T Okino
    Department of Urology, San Francisco Veterans Affairs Medical Center and the University of California San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 46:839-46. 2007
    ..We conclude that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and the DNA becomes methylated and inaccessible resulting in transcriptional silencing...
  21. pmc Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation
    Xiaoling Wang
    Department of Urology, University of California San Francisco, San Francisco, CA 94158, USA
    Biochem J 443:821-8. 2012
    ..Ectopic overexpression of NANOG via lentiviral transduction further recapitulates saRNA results, providing proof-of-concept that RNAa may be utilized to activate development-related genes and manipulate cell fate...
  22. ncbi request reprint HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha
    Robert F Place
    Department of Molecular and Cellular Biology, University of Connecticut, 91 North Eagleville Road, U 3125, Storrs, CT 06269 3125, USA
    Biochem Pharmacol 70:394-406. 2005
    ..This information may be useful for the further development and targeting of HDAC inhibitors as anti-neoplastic and anti-inflammatory agents...
  23. ncbi request reprint Cell number-dependent regulation of Hsp70B' expression: evidence of an extracellular regulator
    Emily J Noonan
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Cell Physiol 210:201-11. 2007
    ....
  24. ncbi request reprint Induced stabilization of IkappaBalpha can facilitate its re-synthesis and prevent sequential degradation
    Robert F Place
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269, USA
    J Cell Physiol 195:470-8. 2003
    ..We propose that cytokine stabilization of newly synthesized IkappaBalpha in some cell types is a critical homeostatic mechanism that limits inflammatory gene expression...