Sreekumar G Pillai

Summary

Publications

  1. ncbi Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease
    Sreekumar G Pillai
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Am J Respir Crit Care Med 182:1498-505. 2010
  2. ncbi A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci
    Sreekumar G Pillai
    Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, NC, USA
    PLoS Genet 5:e1000421. 2009
  3. ncbi Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease
    Guohua Zhu
    Genetics, GlaxoSmithKline R and D, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Hum Mol Genet 18:2053-62. 2009
  4. ncbi Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema
    Xiangyang Kong
    Research and Development, GlaxoSmithKline, 709 Swedeland Road, UW2230, King of Prussia, PA 19406, USA
    Am J Respir Crit Care Med 183:43-9. 2011
  5. ncbi Interleukin 18 receptor 1 gene polymorphisms are associated with asthma
    Guohua Zhu
    Genetics, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Eur J Hum Genet 16:1083-90. 2008
  6. ncbi The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations
    Guohua Zhu
    GlaxoSmithKline R and D, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 176:167-73. 2007
  7. ncbi Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast
    Michael Klotsman
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709 3398, USA
    Pharmacogenet Genomics 17:189-96. 2007

Detail Information

Publications7

  1. ncbi Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease
    Sreekumar G Pillai
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Am J Respir Crit Care Med 182:1498-505. 2010
    ....
  2. ncbi A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci
    Sreekumar G Pillai
    Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, NC, USA
    PLoS Genet 5:e1000421. 2009
    ..1371/journal.pgen.1000429). The CHRNA 3/5 and the HHIP loci make a significant contribution to the risk of COPD. CHRNA3/5 is the same locus that has been implicated in the risk of lung cancer...
  3. ncbi Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease
    Guohua Zhu
    Genetics, GlaxoSmithKline R and D, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Hum Mol Genet 18:2053-62. 2009
    ..02 < or = P < or = 0.03). Significant haplotype associations supported the results of single SNP analyses. Thus, polymorphisms in the TRPV4 gene are associated with COPD...
  4. ncbi Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema
    Xiangyang Kong
    Research and Development, GlaxoSmithKline, 709 Swedeland Road, UW2230, King of Prussia, PA 19406, USA
    Am J Respir Crit Care Med 183:43-9. 2011
    ..Pulmonary emphysema is a major but variable component of COPD; familial data suggest that different components of COPD, such as emphysema, may be influenced by specific genetic factors...
  5. ncbi Interleukin 18 receptor 1 gene polymorphisms are associated with asthma
    Guohua Zhu
    Genetics, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Eur J Hum Genet 16:1083-90. 2008
    ..Three intronic SNPs (rs1420099, rs1362348 and rs1974675) showed replicated association for at least one asthma-related phenotype. These results demonstrate significant association between polymorphisms in IL18R1 and asthma...
  6. ncbi The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations
    Guohua Zhu
    GlaxoSmithKline R and D, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 176:167-73. 2007
    ....
  7. ncbi Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast
    Michael Klotsman
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709 3398, USA
    Pharmacogenet Genomics 17:189-96. 2007
    ..Genetic variability in 5-lipoxygenase biosynthetic and receptor pathway gene loci may influence cysteinyl-leukotriene production and subsequent response to leukotriene modifiers...