Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humansJussi Pihlajamaki
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
J Hepatol 56:663-70. 2012
..In this study, we investigated the benefits of measuring serum interleukin 1 receptor antagonist (IL-1RA) levels...
- Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding
Jussi Pihlajamaki
Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
Metabolism 59:866-72. 2010
..We conclude that decrease in cholesterol absorption is a novel beneficial effect of RYGB. Together with an improved control of blood glucose, this may contribute to a better cardiovascular risk profile after RYGB...
Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention StudyOlli Laukkanen
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
J Clin Endocrinol Metab 89:6286-90. 2004
..2 gene...
- Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans
Jarno Rutanen
Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
Obesity (Silver Spring) 15:2902-7. 2007
..No differences in BMI, waist circumference, or glucose or insulin levels in an oral glucose tolerance test among the genotypes were found. In conclusion, SNPs of MCHR1 did not have effects on metabolic variables in humans...
- The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study
Boryana Todorova
Department of Medicine, University of Kuopio, 70210 Kuopio
J Clin Endocrinol Metab 89:2019-23. 2004
..001). We conclude that the G-250G genotype of the LIPC gene is a risk factor for type 2 diabetes. Therefore, genes regulating lipid and lipoprotein metabolism may be potential candidate genes for type 2 diabetes...
- Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects
Eija Ruotsalainen
University of Kuopio, Department of Medicine, Kuopio, Finland
Atherosclerosis 210:536-41. 2010
..To investigate the changes in the levels of cytokines and adhesion molecules in response to acute hyperinsulinemia in the offspring of type 2 diabetic subjects...
- The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity
Jussi Pihlajamaki
Department of Medicine, University of Kuopio, Kuopio, Finland
Obes Res 11:912-7. 2003
..We investigated whether the effect of the G-308A polymorphism of the TNF-alpha gene on insulin action depends on BMI...
- HLA genotyping is useful in the evaluation of the risk for coeliac disease in the 1st-degree relatives of patients with coeliac disease
Hannele Karinen
Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
Scand J Gastroenterol 41:1299-304. 2006
....
- Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects
Jarno Rutanen
Departments of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
J Clin Endocrinol Metab 92:1112-7. 2007
..The Thr/Thr 6 and Val/Val81 [corrected] polymorphisms of the MC3R gene have been previously associated with high insulin levels and obesity in children...
Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolismDorota Kaminska
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
Diabetes 61:2807-13. 2012
..Our study shows that the short TCF7L2 mRNA variant in subcutaneous fat is regulated by weight loss and is associated with hyperglycemia and impaired insulin action in adipose tissue...
- Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population
Anne M Koivisto
Department of Neurology, Kuopio University Hospital, Kuopio, Finland
Dement Geriatr Cogn Disord 22:449-53. 2006
..026). These results suggest that the PPARgamma gene may modify the age of onset in LOAD...
- Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects
Eija Ruotsalainen
University of Kuopio, Department of Medicine, 70210 Kuopio, Finland
Atherosclerosis 197:271-7. 2008
..Inflammatory markers and adhesion molecules were correlated suggesting that low-grade inflammation may precede the elevation of levels of adhesion molecules...
- The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain
Jarno Rutanen
Department of Medicine, Kuopio University Hospital, PB 1777, 70211 Kuopio, Finland
Obes Res 12:1060-6. 2004
..The melanocortin-4 receptor (MC4R) regulates energy intake. On the basis of animal studies, it may also regulate energy expenditure...
- SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
Jarno Rutanen
Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
Diabetes 59:829-35. 2010
..No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is associated with energy expenditure and insulin sensitivity...
- Cholesterol synthesis prevails over absorption in metabolic syndrome
Helena Gylling
Department of Clinical Nutrition, Food and Health Research Centre, Institute of Biomedicine, University of Kuopio, Kuopio, Finland
Transl Res 149:310-6. 2007
..The perturbations of cholesterol metabolism seem to be related to abdominal obesity, and weight reduction might normalize cholesterol metabolism...
- Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome
Maarit Hallikainen
Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
Clin Chim Acta 383:126-32. 2007
..The purpose of this study was to investigate whether cholesterol metabolism is associated with serum adipokines and inflammatory markers...
- Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake
Markku Vänttinen
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
Diabetes 54:3587-91. 2005
..Our results give evidence that SNPs of PPARD regulate insulin sensitivity particularly in skeletal muscle...
- The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia
Agata Kubaszek
Department of Medicine, University of Kuopio, Finland
Diabetes Care 26:464-7. 2003
..To investigate the relationship of the K121Q polymorphism of the plasma cell glycoprotein 1 (PC-1) gene with insulin resistance, insulin secretion, and lipids and lipoproteins...
- Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients
Urpu Salmenniemi
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
J Clin Endocrinol Metab 90:4216-23. 2005
..Adiponectin is an adipose-specific secretory protein abundantly present in the circulation. The role of adiponectin in the control of energy expenditure and substrate utilization has not yet been established...
- Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men
Jussi Pihlajamaki
Department of Medicine, University of Kuopio, Kuopio, Finland
J Lipid Res 45:507-12. 2004
....
- Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland
Anne Lumiaho
Department of Medicine, Kuopio University Hospital, Finland
Scand J Urol Nephrol 37:352-8. 2003
..To characterize, for the first time, the phenotype and clinical course of autosomal dominant polycystic kidney disease (ADPKD) in Finnish patients...
- The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism
Jussi Pihlajamaki
Departments of Medicine and Clinical Nutrition, University of Kuopio, Kuopio, Finland and the Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
Metabolism 52:643-6. 2003
..003). In conclusion, the Leu7Pro polymorphism of the NPY gene associates with alterations in FFA metabolism but does not have an impact on insulin sensitivity, insulin secretion, or glucose metabolism...
- The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood
Jussi Pihlajamaki
Department of Medicine, University of Kuopio, Kuopio, Finland
Obes Res 12:187-90. 2004
..In this study, the effect of the Pro12Ala polymorphism on long-term changes in weight and body composition was investigated...
- Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass
M Simonen
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
Obes Surg 22:1473-80. 2012
..Laparoscopic Roux-en-Y gastric bypass (RYGB) induces a more favorable metabolic profile than expected by weight loss alone. In this study, we investigated the effect of RYGB on serum bile acid levels and their relation to clinical outcomes...
- Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: the effect of improved glycemic control
Chaiyasit Sittiwet
Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland
Atherosclerosis 194:465-72. 2007
..From a clinical point of view, the better the glycemic control, the more antiatherogenic cholesterol metabolism may be in type 1 diabetes...
- Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity
Helena Gylling
Department of Clinical Nutrition, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
J Lipid Res 45:1660-5. 2004
..Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene...
- Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population
Anne M Koivisto
Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
J Neurogenet 19:155-61. 2005
..Interestingly, the G allele frequency was lower in our population in both AD patients and in controls compared to Southern European populations...
- Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease
Hannele Karinen
Department of Medicine, University of Kuopio, Kuopio, Finland
Scand J Gastroenterol 41:191-9. 2006
..Conflicting data have been published on the gene dose effect of these HLA alleles on the risk and severity of CD. In this study the aim was to investigate the association between the number of HLA risk alleles and the severity of CD...
- Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men
Alena Stancakova
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
Diabetes 61:1895-902. 2012
..Only one single nucleotide polymorphism regulating hyperglycemia was significantly associated with amino acid levels...
- The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity
Agata Kubaszek
Department of Medicine, University of Kuopio, Finland
Diabetes 52:558-61. 2003
..Whether this polymorphism is a risk factor for obesity or type 2 diabetes can be estimated only in prospective population-based studies...
- Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study
Agata Kubaszek
Department of Medicine, University of Kuopio, Kuopio, Finland
Diabetes 52:1872-6. 2003
..Furthermore, this polymorphism seems to have a gene-gene interaction with the C-174C genotype of the IL-6 gene...
- The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study
Markku Vänttinen
Department of Medicine, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
J Clin Endocrinol Metab 90:4249-54. 2005
..Obesity is a major risk factor for insulin resistance, but the association of the Pro(12)Ala polymorphism with body weight has been controversial. Furthermore, obesity may modulate the effect of this polymorphism on insulin sensitivity...
- Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
Alena Stancakova
Department of Medicine, University of Kuopio and University Hospital, 70210 Kuopio, Finland
J Clin Endocrinol Metab 93:1924-30. 2008
..CDKAL1 is a recently discovered susceptibility gene for type 2 diabetes...
- Insulin resistance is related to left ventricular hypertrophy in patients with polycystic kidney disease type 1
Anne Lumiaho
Department of Medicine, Kuopio University Hospital Kuopio, Finland
Am J Kidney Dis 41:1219-24. 2003
..Although insulin resistance contributes to cardiac hypertrophy, the relationship between insulin resistance and LVH in patients with ADPKD has not been previously studied...
- Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis
Eija Pirinen
Department of Medicine, University of Kuopio, P O Box 1777, 70211, Kuopio, Finland
Amino Acids 38:549-60. 2010
..In summary, activated-polyamine catabolism is a novel mechanism to regulate bile acid synthesis. Therefore, polyamine catabolism could be a potential therapeutic target to control hepatic CYP7A1 expression...
- Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects
Maija Kossila
A I Virtanen Institute for Molecular Sciences, Kuopio Department of Medicine, University of Kuopio, Kuopio, Finland
Diabetes Care 26:179-82. 2003
..In this study, we determined the effects of these polymorphisms on insulin secretion and insulin sensitivity...
