Jussi Pihlajamaki

Summary

Publications

  1. doi request reprint Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans
    Jussi Pihlajamaki
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    J Hepatol 56:663-70. 2012
  2. doi request reprint Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    Metabolism 59:866-72. 2010
  3. ncbi request reprint Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome
    Urpu Salmenniemi
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Circulation 110:3842-8. 2004
  4. ncbi request reprint Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study
    Olli Laukkanen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 89:6286-90. 2004
  5. ncbi request reprint Visceral obesity is associated with high levels of serum squalene
    Paula Peltola
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Obesity (Silver Spring) 14:1155-63. 2006
  6. ncbi request reprint Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects
    Eija Ruotsalainen
    University of Kuopio, Department of Medicine, 70210 Kuopio, Finland
    Atherosclerosis 197:271-7. 2008
  7. doi request reprint Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans
    Jarno Rutanen
    Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    Obesity (Silver Spring) 15:2902-7. 2007
  8. pmc Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men
    Yuvaraj Mahendran
    Department of Medicine, University of Eastern Finland, Kuopio, Finland
    Diabetes 62:3618-26. 2013
  9. ncbi request reprint The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study
    Boryana Todorova
    Department of Medicine, University of Kuopio, 70210 Kuopio
    J Clin Endocrinol Metab 89:2019-23. 2004
  10. ncbi request reprint The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Obes Res 11:912-7. 2003

Collaborators

Detail Information

Publications47

  1. doi request reprint Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans
    Jussi Pihlajamaki
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    J Hepatol 56:663-70. 2012
    ..In this study, we investigated the benefits of measuring serum interleukin 1 receptor antagonist (IL-1RA) levels...
  2. doi request reprint Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    Metabolism 59:866-72. 2010
    ..We conclude that decrease in cholesterol absorption is a novel beneficial effect of RYGB. Together with an improved control of blood glucose, this may contribute to a better cardiovascular risk profile after RYGB...
  3. ncbi request reprint Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome
    Urpu Salmenniemi
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Circulation 110:3842-8. 2004
    ..Detailed metabolic defects in glucose and energy metabolism and abnormalities in a variety of cardiovascular risk factors are largely unknown in subjects with the metabolic syndrome...
  4. ncbi request reprint Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study
    Olli Laukkanen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 89:6286-90. 2004
    ..2 gene...
  5. ncbi request reprint Visceral obesity is associated with high levels of serum squalene
    Paula Peltola
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Obesity (Silver Spring) 14:1155-63. 2006
    ..To investigate the impact of visceral obesity on cholesterol metabolism in normoglycemic offspring of patients with type 2 diabetes...
  6. ncbi request reprint Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects
    Eija Ruotsalainen
    University of Kuopio, Department of Medicine, 70210 Kuopio, Finland
    Atherosclerosis 197:271-7. 2008
    ..Inflammatory markers and adhesion molecules were correlated suggesting that low-grade inflammation may precede the elevation of levels of adhesion molecules...
  7. doi request reprint Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans
    Jarno Rutanen
    Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    Obesity (Silver Spring) 15:2902-7. 2007
    ..No differences in BMI, waist circumference, or glucose or insulin levels in an oral glucose tolerance test among the genotypes were found. In conclusion, SNPs of MCHR1 did not have effects on metabolic variables in humans...
  8. pmc Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men
    Yuvaraj Mahendran
    Department of Medicine, University of Eastern Finland, Kuopio, Finland
    Diabetes 62:3618-26. 2013
    ..In conclusion, high levels of KBs predicted subsequent worsening of hyperglycemia, and a common variant of GCKR was significantly associated with BHB levels. ..
  9. ncbi request reprint The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study
    Boryana Todorova
    Department of Medicine, University of Kuopio, 70210 Kuopio
    J Clin Endocrinol Metab 89:2019-23. 2004
    ..001). We conclude that the G-250G genotype of the LIPC gene is a risk factor for type 2 diabetes. Therefore, genes regulating lipid and lipoprotein metabolism may be potential candidate genes for type 2 diabetes...
  10. ncbi request reprint The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Obes Res 11:912-7. 2003
    ..We investigated whether the effect of the G-308A polymorphism of the TNF-alpha gene on insulin action depends on BMI...
  11. doi request reprint Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects
    Eija Ruotsalainen
    University of Kuopio, Department of Medicine, Kuopio, Finland
    Atherosclerosis 210:536-41. 2010
    ..To investigate the changes in the levels of cytokines and adhesion molecules in response to acute hyperinsulinemia in the offspring of type 2 diabetic subjects...
  12. ncbi request reprint Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects
    Jarno Rutanen
    Departments of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 92:1112-7. 2007
    ..The Thr/Thr 6 and Val/Val81 [corrected] polymorphisms of the MC3R gene have been previously associated with high insulin levels and obesity in children...
  13. pmc Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in Finnish men
    Henna Cederberg
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 8:e67406. 2013
    ..In conclusion, the levels of some, but not all non-cholesterol sterols are markers of the worsening of hyperglycemia and type 2 diabetes. ..
  14. ncbi request reprint HLA genotyping is useful in the evaluation of the risk for coeliac disease in the 1st-degree relatives of patients with coeliac disease
    Hannele Karinen
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Scand J Gastroenterol 41:1299-304. 2006
    ....
  15. ncbi request reprint Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome
    Maarit Hallikainen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Clin Chim Acta 383:126-32. 2007
    ..The purpose of this study was to investigate whether cholesterol metabolism is associated with serum adipokines and inflammatory markers...
  16. ncbi request reprint Cholesterol synthesis prevails over absorption in metabolic syndrome
    Helena Gylling
    Department of Clinical Nutrition, Food and Health Research Centre, Institute of Biomedicine, University of Kuopio, Kuopio, Finland
    Transl Res 149:310-6. 2007
    ..The perturbations of cholesterol metabolism seem to be related to abdominal obesity, and weight reduction might normalize cholesterol metabolism...
  17. pmc Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism
    Dorota Kaminska
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Diabetes 61:2807-13. 2012
    ..Our study shows that the short TCF7L2 mRNA variant in subcutaneous fat is regulated by weight loss and is associated with hyperglycemia and impaired insulin action in adipose tissue...
  18. ncbi request reprint Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population
    Anne M Koivisto
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Dement Geriatr Cogn Disord 22:449-53. 2006
    ..026). These results suggest that the PPARgamma gene may modify the age of onset in LOAD...
  19. pmc SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
    Jarno Rutanen
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 59:829-35. 2010
    ..No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is associated with energy expenditure and insulin sensitivity...
  20. ncbi request reprint The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain
    Jarno Rutanen
    Department of Medicine, Kuopio University Hospital, PB 1777, 70211 Kuopio, Finland
    Obes Res 12:1060-6. 2004
    ..The melanocortin-4 receptor (MC4R) regulates energy intake. On the basis of animal studies, it may also regulate energy expenditure...
  21. ncbi request reprint Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects
    Eija Ruotsalainen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes Care 29:2714-20. 2006
    ..We sought to determine whether levels of inflammatory markers and different cytokines are abnormal in nondiabetic offspring of type 2 diabetic subjects...
  22. ncbi request reprint Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake
    Markku Vänttinen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 54:3587-91. 2005
    ..Our results give evidence that SNPs of PPARD regulate insulin sensitivity particularly in skeletal muscle...
  23. ncbi request reprint The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia
    Agata Kubaszek
    Department of Medicine, University of Kuopio, Finland
    Diabetes Care 26:464-7. 2003
    ..To investigate the relationship of the K121Q polymorphism of the plasma cell glycoprotein 1 (PC-1) gene with insulin resistance, insulin secretion, and lipids and lipoproteins...
  24. ncbi request reprint Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients
    Urpu Salmenniemi
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 90:4216-23. 2005
    ..Adiponectin is an adipose-specific secretory protein abundantly present in the circulation. The role of adiponectin in the control of energy expenditure and substrate utilization has not yet been established...
  25. pmc Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes
    Maija Vaittinen
    Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Diabetes 62:3747-50. 2013
    ..To conclude, CPPED1 is a novel molecule involved in AT biology, and CPPED1 is involved in glucose uptake in adipocytes. ..
  26. ncbi request reprint Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns
    Paula Peltola
    Department of Medicine, University of Kuopio, P O Box 1777, 70211 Kuopio, Finland
    J Mol Med (Berl) 83:638-46. 2005
    ....
  27. ncbi request reprint Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio, Kuopio, Finland
    J Lipid Res 45:507-12. 2004
    ....
  28. ncbi request reprint Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland
    Anne Lumiaho
    Department of Medicine, Kuopio University Hospital, Finland
    Scand J Urol Nephrol 37:352-8. 2003
    ..To characterize, for the first time, the phenotype and clinical course of autosomal dominant polycystic kidney disease (ADPKD) in Finnish patients...
  29. ncbi request reprint The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism
    Jussi Pihlajamaki
    Departments of Medicine and Clinical Nutrition, University of Kuopio, Kuopio, Finland and the Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Metabolism 52:643-6. 2003
    ..003). In conclusion, the Leu7Pro polymorphism of the NPY gene associates with alterations in FFA metabolism but does not have an impact on insulin sensitivity, insulin secretion, or glucose metabolism...
  30. ncbi request reprint The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Obes Res 12:187-90. 2004
    ..In this study, the effect of the Pro12Ala polymorphism on long-term changes in weight and body composition was investigated...
  31. ncbi request reprint Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia
    Juha Vakkilainen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Hum Genet 10:547-52. 2002
    ..Our results suggest a polygenic background for LDL size with a recessive major gene that may contribute to large LDL peak particle size in women. Serum TG and HDL-C concentrations predict the majority of variations in LDL particle size...
  32. doi request reprint Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass
    M Simonen
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Obes Surg 22:1473-80. 2012
    ..Laparoscopic Roux-en-Y gastric bypass (RYGB) induces a more favorable metabolic profile than expected by weight loss alone. In this study, we investigated the effect of RYGB on serum bile acid levels and their relation to clinical outcomes...
  33. ncbi request reprint Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: the effect of improved glycemic control
    Chaiyasit Sittiwet
    Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland
    Atherosclerosis 194:465-72. 2007
    ..From a clinical point of view, the better the glycemic control, the more antiatherogenic cholesterol metabolism may be in type 1 diabetes...
  34. ncbi request reprint Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population
    Anne M Koivisto
    Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    J Neurogenet 19:155-61. 2005
    ..Interestingly, the G allele frequency was lower in our population in both AD patients and in controls compared to Southern European populations...
  35. ncbi request reprint Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity
    Helena Gylling
    Department of Clinical Nutrition, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    J Lipid Res 45:1660-5. 2004
    ..Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene...
  36. doi request reprint Desmosterol in human nonalcoholic steatohepatitis
    Marko Simonen
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Finland
    Hepatology 58:976-82. 2013
    ..Whether desmosterol has a more specific role in the pathophysiology of NASH compared to other cholesterol precursors needs to be investigated...
  37. ncbi request reprint Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease
    Hannele Karinen
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Scand J Gastroenterol 41:191-9. 2006
    ..Conflicting data have been published on the gene dose effect of these HLA alleles on the risk and severity of CD. In this study the aim was to investigate the association between the number of HLA risk alleles and the severity of CD...
  38. pmc Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men
    Alena Stancakova
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Diabetes 61:1895-902. 2012
    ..Only one single nucleotide polymorphism regulating hyperglycemia was significantly associated with amino acid levels...
  39. ncbi request reprint Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study
    Agata Kubaszek
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Diabetes 52:1872-6. 2003
    ..Furthermore, this polymorphism seems to have a gene-gene interaction with the C-174C genotype of the IL-6 gene...
  40. ncbi request reprint The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity
    Agata Kubaszek
    Department of Medicine, University of Kuopio, Finland
    Diabetes 52:558-61. 2003
    ..Whether this polymorphism is a risk factor for obesity or type 2 diabetes can be estimated only in prospective population-based studies...
  41. ncbi request reprint The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study
    Markku Vänttinen
    Department of Medicine, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    J Clin Endocrinol Metab 90:4249-54. 2005
    ..Obesity is a major risk factor for insulin resistance, but the association of the Pro(12)Ala polymorphism with body weight has been controversial. Furthermore, obesity may modulate the effect of this polymorphism on insulin sensitivity...
  42. doi request reprint Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
    Alena Stancakova
    Department of Medicine, University of Kuopio and University Hospital, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 93:1924-30. 2008
    ..CDKAL1 is a recently discovered susceptibility gene for type 2 diabetes...
  43. doi request reprint Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss
    Dorota Kaminska
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Yliopistonranta 1, P O Box 1627, 70210, Kuopio, Finland
    Diabetologia 57:347-51. 2014
    ..INSR-A promotes cell growth whereas INSR-B predominantly regulates glucose homeostasis. In this study we investigated whether weight loss regulates INSR alternative splicing and the expression of splicing factors in adipose tissue...
  44. ncbi request reprint Insulin resistance is related to left ventricular hypertrophy in patients with polycystic kidney disease type 1
    Anne Lumiaho
    Department of Medicine, Kuopio University Hospital Kuopio, Finland
    Am J Kidney Dis 41:1219-24. 2003
    ..Although insulin resistance contributes to cardiac hypertrophy, the relationship between insulin resistance and LVH in patients with ADPKD has not been previously studied...
  45. doi request reprint Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis
    Eija Pirinen
    Department of Medicine, University of Kuopio, P O Box 1777, 70211, Kuopio, Finland
    Amino Acids 38:549-60. 2010
    ..In summary, activated-polyamine catabolism is a novel mechanism to regulate bile acid synthesis. Therefore, polyamine catabolism could be a potential therapeutic target to control hepatic CYP7A1 expression...
  46. doi request reprint Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease
    Henna Martiskainen
    Kuopio University Hospital, Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio, Finland
    Expert Opin Ther Targets 17:781-94. 2013
    ..Based on the prevailing amyloid cascade hypothesis, it is conceivable that lowering the β-amyloid (Aβ) levels is sufficient to slow down the disease process, if started early enough...
  47. ncbi request reprint Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects
    Maija Kossila
    A I Virtanen Institute for Molecular Sciences, Kuopio Department of Medicine, University of Kuopio, Kuopio, Finland
    Diabetes Care 26:179-82. 2003
    ..In this study, we determined the effects of these polymorphisms on insulin secretion and insulin sensitivity...