Vieyres G, Pietschmann T. HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit. Cells. 2019;8: pubmed publisher
Pietschmann T, Brown R. Hepatitis C Virus. Trends Microbiol. 2019;27:379-380 pubmed publisher
..Approximately 71 million people are chronically infected and 1.7 million new infections occur annually. Treatment-induced cure does not protect from viral reinfection. A prophylactic vaccine is under development. ..
Banda D, Perin P, Brown R, Todt D, Solodenko W, Hoffmeyer P, et al
. A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors. J Hepatol. 2019;: pubmed publisher
..It defines viral properties that determine sensitivity to these molecules and thus provides information to identify patients that may benefit from treatment with membrane fusion inhibitors. ..
Khera T, Behrendt P, Bankwitz D, Brown R, Todt D, Doepke M, et al
. Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants. J Hepatol. 2019;70:593-602 pubmed publisher
Banse P, Moeller R, Bruening J, Lasswitz L, Kahl S, Khan A, et al
. CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells. Viruses. 2018;10: pubmed publisher
..We demonstrate that a cholesterol-coordinating glutamate residue in CD81, which hCD9 lacks, promotes HCV infection. This work highlights the hCD81 non-LEL regions as additional HCV susceptibility-determining factors. ..
Bankwitz D, Vieyres G, Hueging K, Bitzegeio J, Doepke M, Chhatwal P, et al
. Role of hypervariable region 1 for the interplay of hepatitis C virus with entry factors and lipoproteins. J Virol. 2014;88:12644-55 pubmed publisher
..Furthermore, these findings highlight separable functions of SR-BI during HCV cell entry and reveal a novel role of HVR1 for the properties of virus-associated lipoproteins. ..
Tarr A, Khera T, Hueging K, Sheldon J, Steinmann E, Pietschmann T, et al
. Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design. Viruses. 2015;7:3995-4046 pubmed publisher
..Here we review current knowledge of HCV envelope protein structure, integrating knowledge of genetic, antigenic and functional diversity to inform rational immunogen design. ..
Haid S, Grethe C, Bankwitz D, Grunwald T, Pietschmann T. Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System. J Virol. 2015;90:3065-73 pubmed publisher
..Therefore, this system will be highly useful to study hRSV cell entry and host factor usage and to explore antiviral strategies targeting hRSV cell entry. ..
Anggakusuma -, Brown R, Banda D, Todt D, Vieyres G, Steinmann E, et al
. Hepacivirus NS3/4A Proteases Interfere with MAVS Signaling in both Their Cognate Animal Hosts and Humans: Implications for Zoonotic Transmission. J Virol. 2016;90:10670-10681 pubmed publisher
..Therefore, cleavage of MAVS is a common strategy of hepaciviruses, and human MAVS is likely unable to limit replication of these nonhuman viruses upon zoonotic exposure. ..