Otitis mediaMichael E Pichichero
Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester General Hospital, Rochester, NY 14621, USA
Pediatr Clin North Am 60:391-407. 2013
..Antibiotic prophylaxis has fallen into disfavor as a preventative strategy for AOM recurrences...
- Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children
Michael E Pichichero
Rochester General Hospital Research Institute, Rochester, NY, USA
Hum Vaccin Immunother 8:799-805. 2012
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- Booster vaccinations: can immunologic memory outpace disease pathogenesis?
Michael E Pichichero
Rochester General Research Institute, Rochester General Hospital, Rochester, New York 14621, USA
Pediatrics 124:1633-41. 2009
..With infectious diseases for which the pace of pathogenesis is slow, immune memory should be sufficient to prevent disease...
- Variations in amoxicillin pharmacokinetic/pharmacodynamic parameters may explain treatment failures in acute otitis media
Michael E Pichichero
Rochester General Research Institute, Legacy Pediatric Group, Rochester, New York, USA
Paediatr Drugs 11:243-9. 2009
..These findings suggest that variability in PK/PD parameters may impact amoxicillin concentrations in serum and MEF, possibly explaining some AOM treatment failures...
Mercury levels in premature and low birth weight newborn infants after receipt of thimerosal-containing vaccinesMichael E Pichichero
University of Rochester, Rochester, NY, USA
J Pediatr 155:495-9. 2009
..We conducted a population-based pharmacokinetic study to assess blood levels and elimination of mercury after vaccination of premature infants born at > or =32 and <37 weeks of gestation and with birth weight > or =2000 but <3000 g...
- Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children
Michael E Pichichero
Rochester General Hospital Research Institue, 1425 Portland Avenue, Rochester, NY 14621, USA
Vaccine 28:7184-92. 2010
..For all 3 proteins serum antibody levels in the convalescent phase of AOM infection were not as high as after NP colonization. Antibodies to protein D and P6 but not OMP26 were bactericidal...
- Haemophilus influenzae vaccine candidate outer membrane protein P6 is not conserved in all strains
Arthur Chang
Rochester General Hospital, Rochester General Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY, USA
Hum Vaccin 7:102-5. 2011
..These results show that NTHi omp P6 is not invariant in its structure among respiratory isolates from children...
- Mercury levels in newborns and infants after receipt of thimerosal-containing vaccines
Michael E Pichichero
Department of Microbiology Immunology, Pediatrics, and Medicine, University of Rochester, Rochester, New York 14642, USA
Pediatrics 121:e208-14. 2008
..We conducted a pharmacokinetic study to assess blood levels and elimination of ethyl mercury after vaccination of infants with thimerosal-containing vaccines...
- Transcriptome signature in young children with acute otitis media due to Streptococcus pneumoniae
Keyi Liu
Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
Microbes Infect 14:600-9. 2012
..In contrast, genes associated with cell-mediated immune responses were broadly down-regulated. The results provide the first human transcriptome data identifying genes differentially regulated at the onset of AOM in children...
- Haemophilus influenzae outer membrane protein P6 molecular characterization may not differentiate all strains of H. Influenzae from H. haemolyticus
Arthur Chang
Rochester General Hospital, Rochester General Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY 14621, USA
J Clin Microbiol 48:3756-7. 2010
..Further testing using RapID NH and multilocus sequence analysis may not help identify some isolates. Translated OMP P6 gene sequences are not conserved among all isolates presumed to be H. influenzae...
Mercury concentrations and metabolism in infants receiving vaccines containing thiomersal: a descriptive studyMichael E Pichichero
Department of Microbiology Immunology, University of Rochester, Rochester, New York, NY, USA
Lancet 360:1737-41. 2002
..We aimed to measure concentrations of mercury in blood, urine, and stools of infants who received such vaccines...
- Serum intercellular adhesion molecule 1 variations in young children with acute otitis media
Keyi Liu
Rochester General Research Institute, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
Clin Vaccine Immunol 17:1909-16. 2010
..We conclude that AOM often causes a systemic inflammatory reaction, as measured by elevation of the serum sICAM-1 level, and that a high variability in sICAM-1 responses occurs with the presence of otopathogens during AOM...
- Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure
Michael E Pichichero
Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, New York 14642, USA
Clin Infect Dis 41:470-8. 2005
..This study describes the safety and efficacy of gatifloxacin when used for treatment of children with recurrent acute otitis media (ROM) or acute otitis media (AOM) treatment failure (AOMTF)...
- Acute otitis media: making sense of recent guidelines on antimicrobial treatment
Michael E Pichichero
University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
J Fam Pract 54:313-22. 2005
..Key factors for enhancing compliance are taste of suspension, dosing frequency, and duration of therapy...
- Otitis media
Michael E Pichichero
Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, NY 14642, USA
Expert Opin Pharmacother 3:1073-90. 2002
..Best-practice for management of acute OM continues to advocate antibiotic therapy with careful, accurate diagnosis and consideration of the major pathogens and their mechanisms of resistance...
- Changes in frequency and pathogens causing acute otitis media in 1995-2003
Janet R Casey
Elmwood Pediatric Group, Department of Pediatrics, University of Rochester, Rochester, NY, USA
Pediatr Infect Dis J 23:824-8. 2004
..Fewer S. pneumoniae AOM isolates are penicillin-resistant and more H. influenzae are beta-lactamase-producing...
- New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine
Janet R Casey
Department of Pediatrics, University of Rochester, Rochester, NY, USA
Pediatr Infect Dis J 29:304-9. 2010
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- Frequency of symptomatic relapses of group A beta-hemolytic streptococcal tonsillopharyngitis in children from 4 pediatric practices following penicillin, amoxicillin, and cephalosporin antibiotic treatment
Janet R Casey
Legacy Pediatrics, University of Rochester, Rochester, New York, USA
Clin Pediatr (Phila) 47:549-54. 2008
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- Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006
Michael E Pichichero
University of Rochester Medical Center and Legacy Pediatrics, Rochester, New York 14642, USA
Clin Pediatr (Phila) 47:901-6. 2008
..influenzae produced beta-lactamase, respectively. Although H. influenzae remains the most frequently isolated pathogen in children with AOMTF or recurrent AOM, S. pneumoniae that are PNSP are reemerging as important organisms...
- Diagnostic inaccuracy and subject exclusions render placebo and observational studies of acute otitis media inconclusive
Michael E Pichichero
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Pediatr Infect Dis J 27:958-62. 2008
..Diagnostic accuracy and appropriate inclusion/exclusion criteria representative of children at greatest risk is of paramount importance in trials to evaluate placebo or observation as an option for acute otitis media (AOM) management...
- Seven-year follow-up of vaccine response in extremely premature infants
Khaver I Kirmani
Department of Pediatrics, Strong Children's Research Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Pediatrics 109:498-504. 2002
..CONCLUSIONS: At 7 years of age, PT children had lower antibody titers to many vaccine antigens than FT children. However, most PT children maintained antibody titers in the protective range...
- Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis media
Ravinder Kaur
Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, University of Rochester School of Medicine, Rochester, NY, USA
Pediatr Infect Dis J 29:741-5. 2010
..Conventional culture methods detect these pathogens in only 60% to 70% of cases of AOM. Alloiococcus otitidis, another potential pathogen, has often been ignored...
- Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era
Michael E Pichichero
Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA urmc rochester edu
Pediatr Infect Dis J 26:S12-6. 2007
..Expansion of the number of serotypes included in pneumococcal conjugate vaccines is needed to sustain a long-term benefit from immunization against these bacteria...
- Comparison of study designs for acute otitis media trials
Michael E Pichichero
University of Rochester, School of Medicine, Department of Microbiology Immunology, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, United States
Int J Pediatr Otorhinolaryngol 72:737-50. 2008
..A framework for evaluating the efficacy of antibiotics in development as well as those currently approved for acute otitis media (AOM) is needed...
- Evolving shifts in otitis media pathogens: relevance to a managed care organization
Michael E Pichichero
University of Rochester Medical Center, Rochester, NY, USA
Am J Manag Care 11:S192-201. 2005
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- Pathogen shifts and changing cure rates for otitis media and tonsillopharyngitis
Michael E Pichichero
Department of Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, Elmwood Pediatric Group, Rochester, New York 14642, USA
Clin Pediatr (Phila) 45:493-502. 2006
..Recent results with amoxicillin suggest its efficacy is also waning. Cephalosporins have the highest bacteriologic and clinical efficacy. This has implications for optimal antibiotic therapy...
- Comparison of performance by otolaryngologists, pediatricians, and general practioners on an otoendoscopic diagnostic video examination
Michael E Pichichero
Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
Int J Pediatr Otorhinolaryngol 69:361-6. 2005
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- Rethinking the total cost of care in AOM and ABS: The impact of improved diagnostic accuracy and antibiotic treatment where high efficacy and adherence are achievable
Michael E Pichichero
University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
Am J Manag Care 12:S283-91. 2006
- A review of recommended antibiotic therapies with impact on outcomes in acute otitis media and acute bacterial sinusitis
Michael E Pichichero
University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
Am J Manag Care 12:S292-302. 2006
- White blood cell count can aid judicious antibiotic prescribing in acute upper respiratory infections in children
Janet R Casey
Elmwood Pediatric Group, Rochester, NY 14642, USA
Clin Pediatr (Phila) 42:113-9. 2003
..With this approach, return office visits in the following 2 weeks were infrequent (13% of 737 patients), and no child had significant bacterial illness that was missed. With selective use of WBC count testing..
- Symptomatic relapse of group A beta-hemolytic streptococcal tonsillopharyngitis in children
Janet R Casey
University of Rochester School of Medicine, Elmwood Pediatric Group, Rochester, New York, USA
Clin Pediatr (Phila) 46:307-10. 2007
..02). Clinicians should be aware that the rate of symptomatic failures after antibiotic therapy for group A beta-hemolytic streptococcal tonsillopharyngitis differs by drug and is not an uncommon event...
- Diagnostic accuracy, tympanocentesis training performance, and antibiotic selection by pediatric residents in management of otitis media
Michael E Pichichero
Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, New York 14642, USA
Pediatrics 110:1064-70. 2002
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- Impact of a birth dose of hepatitis B vaccine on the reactogenicity and immunogenicity of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b combination vaccination
Michael E Pichichero
University of Rochester Medical Center, Rochester, NY 14642, USA
Pediatr Infect Dis J 21:854-9. 2002
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- Efficacy of penicillin vs. amoxicillin in children with group A beta hemolytic streptococcal tonsillopharyngitis
Correne Curtin-Wirt
Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Clin Pediatr (Phila) 42:219-25. 2003
..84, 95% confidence interval 1.02-3.29); the same was true for dinical cure (OR = 1.99, 95% CI = 1.02-3.87). Amoxicillin may be superior to penicillin for bacteriologic and clinical cure of GABHS tonsillopharyngitis...
- Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS)
Marie Lynd Murphy
Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
Arch Pediatr Adolesc Med 156:356-61. 2002
..CONCLUSION: To our knowledge, this is the first prospective study to confirm that PANDAS is associated with acute GABHS tonsillopharyngitis and responds to appropriate antibiotic therapy at the sentinel episode...
- A review of evidence supporting the American Academy of Pediatrics recommendation for prescribing cephalosporin antibiotics for penicillin-allergic patients
Michael E Pichichero
University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
Pediatrics 115:1048-57. 2005
..Specific recommendations for the treatment of patients on the basis of their responses to previously prescribed agents are summarized...
- Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children
Michael E Pichichero
University of Rochester and Legacy Pediatrics, Rochester, New York, USA
JAMA 298:1772-8. 2007
..Concern has been raised about the possible emergence of a bacterial strain that is untreatable by US Food and Drug Administration (FDA)-approved antibiotics and that causes acute otitis media (AOM) in children...
- Preferred antibiotics for treatment of acute otitis media: comparison of practicing pediatricians, general practitioners, and otolaryngologists
Michael E Pichichero
Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
Clin Pediatr (Phila) 44:575-8. 2005
..After instruction that provides the rationale for guideline-recommended agents based on pharmacokinetics/pharmacodynamics and double tympanocentesis trials, endorsement of recommended antibiotics significantly improved to >90%...
- Acellular pertussis vaccine booster combined with diphtheria and tetanus toxoids for adolescents
Michael E Pichichero
University of Rochester Medical Center, Rochester, NY 14642, USA
Pediatrics 117:1084-93. 2006
..Recently licensed in the United States for use in adolescents, acellular pertussis vaccines will provide an immunogenic and safe option for booster immunization against pertussis...
- Prevention of cervical cancer through vaccination of adolescents
Michael E Pichichero
Department of Microbiology and Immunology, Pediatrics, and Medicine, University of Rochester Medical Center, Elmwood Pediatric Group, Rochester, New York 14642, USA
Clin Pediatr (Phila) 45:393-8. 2006
- Novel type of Streptococcus pneumoniae causing multidrug-resistant acute otitis media in children
Qingfu Xu
University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Emerg Infect Dis 15:547-51. 2009
..pneumoniae in which all strains had 6 of the same alleles as ST-156. The multidrug-resistant strains related to ST-156 expressed different capsular serotypes: 9V, 14, 11A, 15C, and 19F...
- Probability of achieving requisite pharmacodynamic exposure for oral beta-lactam regimens against Haemophilus influenzae in children
Michael E Pichichero
Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
Paediatr Drugs 10:391-7. 2008
..influenzae isolates using Monte Carlo simulation...
- Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules
Michael E Pichichero
Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
Clin Pediatr (Phila) 45:613-20. 2006
..Seroprotective levels and antibody concentrations were comparable regardless of prior DTaP/DTwP vaccine history. A sixth sequential dose of Tdap after 5 doses of DTaP appears safe and immunogenic...
- Immunogenicity and safety of a combination diphtheria, tetanus toxoid, acellular pertussis, hepatitis B, and inactivated poliovirus vaccine coadministered with a 7-valent pneumococcal conjugate vaccine and a Haemophilus influenzae type b conjugate vaccine
Michael E Pichichero
University of Rochester Medical Center, Rochester, New York 14642, USA
J Pediatr 151:43-9, 49.e1-2. 2007
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- Who should get the HPV vaccine?
Michael E Pichichero
Department of Microbiology and Immunology, Pediatrics, and Medicine, University of Rochester Medical Center, Elmood Pediatric Group, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
J Fam Pract 56:197-202. 2007
- Systematic review of factors contributing to penicillin treatment failure in Streptococcus pyogenes pharyngitis
Michael E Pichichero
University of Rochester Medical Center, Rochester, NY 14642, USA
Otolaryngol Head Neck Surg 137:851-857. 2007
..Review the evidence for various explanations for microbiologic treatment failure following use of penicillin in group A streptococcal (GAS) tonsillopharyngitis...
- Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6
Albert Sabirov
Department of Microbiology Immunology, University of Rochester, Rochester, New York 14627, USA
Pediatr Res 66:565-70. 2009
..Higher serum IgG might facilitate protection against AOM and NP colonization in breast-fed children...
