Hilda Pickett

Summary

Publications

  1. Yang S, Sun A, Shi Y, Li F, Pickett H. Structural and functional characterization of the RBBP4-ZNF827 interaction and its role in NuRD recruitment to telomeres. Biochem J. 2018;475:2667-2679 pubmed publisher
    ..These data provide insights into the structural and functional determinants of NuRD activity at ALT telomeres. ..
  2. Lee M, Napier C, Yang S, Arthur J, Reddel R, Pickett H. Comparative analysis of whole genome sequencing-based telomere length measurement techniques. Methods. 2017;114:4-15 pubmed publisher
    ..The aim of this article is to improve the accessibility of WGS telomere length measurement tools, which have the potential to be applied to WGS cohorts for clinical as well as research benefit. ..
  3. Sobinoff A, Allen J, Neumann A, Yang S, Walsh M, Henson J, et al. BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres. EMBO J. 2017;36:2907-2919 pubmed publisher
    ..Our data are consistent with ALT being a conservative DNA replication process, analogous to break-induced replication, which is dependent on BTR and counteracted by SLX4 complex-mediated resolution events. ..
  4. Sobinoff A, Pickett H. Alternative Lengthening of Telomeres: DNA Repair Pathways Converge. Trends Genet. 2017;33:921-932 pubmed publisher
    ..Here, we review recent discoveries regarding the ALT mechanism, and discuss how DNA repair pathways converge to maintain the length and functional integrity of telomeres in ALT cancers. ..
  5. Le T, Pickett H, dos Remedios C, Barbaro P, Kizana E, Chong J. Platelet Derived Growth Factor Receptor-Alpha expressing cardiac progenitor cells can be derived from previously cryopreserved human heart samples. Stem Cells Dev. 2017;: pubmed publisher
    ..These data support cardiac tissue banking as a strategy for improved access to CPCs for future clinical therapies...