Elizabeth J Phillips

Summary

Publications

  1. ncbi request reprint HLA and drug-induced toxicity
    Elizabeth J Phillips
    Royal Perth Hospital and PathWest, Department of Clinical Immunology and Immunogenetics, Western Australia, Australia
    Curr Opin Mol Ther 11:231-42. 2009
  2. ncbi request reprint Drug hypersensitivity in HIV
    Elizabeth Phillips
    Centre for Pharmacology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia
    Curr Opin Allergy Clin Immunol 7:324-30. 2007
  3. pmc Individualization of antiretroviral therapy
    Rebecca Pavlos
    Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia
    Pharmgenomics Pers Med 5:1-17. 2012
  4. doi request reprint HLA and pharmacogenetics of drug hypersensitivity
    Rebecca Pavlos
    The Institute for Immunology and Infectious Diseases, Murdoch University, Western Australia
    Pharmacogenomics 13:1285-306. 2012
  5. pmc Drug hypersensitivity: pharmacogenetics and clinical syndromes
    Elizabeth J Phillips
    Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia
    J Allergy Clin Immunol 127:S60-6. 2011
  6. pmc Pharmacogenetics of drug hypersensitivity
    Elizabeth J Phillips
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
    Pharmacogenomics 11:973-87. 2010
  7. doi request reprint Successful translation of pharmacogenetics into the clinic: the abacavir example
    Elizabeth Phillips
    Institute for Immunology and Infectious Diseases, Murdoch University and Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Western Australia, Australia
    Mol Diagn Ther 13:1-9. 2009
  8. doi request reprint HLA-B*5701 screening for hypersensitivity to abacavir
    Simon Mallal
    Royal Perth Hospital and Murdoch University, Perth, Australia
    N Engl J Med 358:568-79. 2008
  9. doi request reprint Pharmacogenetics and the potential for the individualization of antiretroviral therapy
    Elizabeth J Phillips
    Centre for Clinical Pharmacology and Infectious Diseases, Royal Perth Hospital, Murdoch University, Perth, Australia
    Curr Opin Infect Dis 21:16-24. 2008
  10. ncbi request reprint External quality assessment of HLA-B*5701 reporting: an international multicentre survey
    Emma Hammond
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Australia
    Antivir Ther 12:1027-32. 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint HLA and drug-induced toxicity
    Elizabeth J Phillips
    Royal Perth Hospital and PathWest, Department of Clinical Immunology and Immunogenetics, Western Australia, Australia
    Curr Opin Mol Ther 11:231-42. 2009
    ....
  2. ncbi request reprint Drug hypersensitivity in HIV
    Elizabeth Phillips
    Centre for Pharmacology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia
    Curr Opin Allergy Clin Immunol 7:324-30. 2007
    ..This review focuses on the current knowledge of the epidemiology, pathophysiology and clinical features of drug hypersensitivity reactions of drugs used in the management of the HIV-infected patient...
  3. pmc Individualization of antiretroviral therapy
    Rebecca Pavlos
    Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia
    Pharmgenomics Pers Med 5:1-17. 2012
    ....
  4. doi request reprint HLA and pharmacogenetics of drug hypersensitivity
    Rebecca Pavlos
    The Institute for Immunology and Infectious Diseases, Murdoch University, Western Australia
    Pharmacogenomics 13:1285-306. 2012
    ..The ultimate translation of the knowledge of how drugs interact with HLA would be applicable to preclinical drug screening programs to improve the safety and cost-effectiveness of drug design and development...
  5. pmc Drug hypersensitivity: pharmacogenetics and clinical syndromes
    Elizabeth J Phillips
    Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia
    J Allergy Clin Immunol 127:S60-6. 2011
    ..International collaborative consortia have been formed with the goal of developing phenotypic standardization and undertaking HLA and genome-wide analyses in diverse populations with these syndromes...
  6. pmc Pharmacogenetics of drug hypersensitivity
    Elizabeth J Phillips
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
    Pharmacogenomics 11:973-87. 2010
    ..HLA-B*5701 screening to prevent abacavir hypersensitivity syndrome is an example of a test now in widespread routine clinical use in the developed world...
  7. doi request reprint Successful translation of pharmacogenetics into the clinic: the abacavir example
    Elizabeth Phillips
    Institute for Immunology and Infectious Diseases, Murdoch University and Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Western Australia, Australia
    Mol Diagn Ther 13:1-9. 2009
    ..The abacavir 'example' can be applied to other drugs to facilitate the development and operationalization of genetic tests that may be useful to predict and prevent otherwise unpredictable drug reactions...
  8. doi request reprint HLA-B*5701 screening for hypersensitivity to abacavir
    Simon Mallal
    Royal Perth Hospital and Murdoch University, Perth, Australia
    N Engl J Med 358:568-79. 2008
    ..This study was designed to establish the effectiveness of prospective HLA-B*5701 screening to prevent the hypersensitivity reaction to abacavir...
  9. doi request reprint Pharmacogenetics and the potential for the individualization of antiretroviral therapy
    Elizabeth J Phillips
    Centre for Clinical Pharmacology and Infectious Diseases, Royal Perth Hospital, Murdoch University, Perth, Australia
    Curr Opin Infect Dis 21:16-24. 2008
    ....
  10. ncbi request reprint External quality assessment of HLA-B*5701 reporting: an international multicentre survey
    Emma Hammond
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Australia
    Antivir Ther 12:1027-32. 2007
    ..We tested the proficiency of HLA-B*5701 typing among laboratories using sequence-specific primer PCR...
  11. ncbi request reprint Cytokine profiling in abacavir hypersensitivity patients
    Coral Ann M Almeida
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Australia
    Antivir Ther 13:281-8. 2008
    ..We have analysed the cytokine profile in antigen-presenting cells and the T-lymphocytes that are involved in the pathological immune response to abacavir...
  12. ncbi request reprint A sensitive and rapid alternative to HLA typing as a genetic screening test for abacavir hypersensitivity syndrome
    Annalise M Martin
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia 6000, Australia
    Pharmacogenet Genomics 16:353-7. 2006
    ..To facilitate routine screening, we have developed a rapid flow cytometry method for HLA-B57 phenotyping using commercially available B17 monoclonal antibodies...
  13. ncbi request reprint Immune responses to abacavir in antigen-presenting cells from hypersensitive patients
    Annalise M Martin
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia 6000, Australia
    AIDS 21:1233-44. 2007
    ..HLA-B*5701 and Hsp70 493T alleles have been shown to predict susceptibility to this hypersensitivity...
  14. ncbi request reprint Pharmacogenetics of antiretroviral therapy: genetic variation of response and toxicity
    Annalise M Martin
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia
    Pharmacogenomics 5:643-55. 2004
    ..g., major histocompatibility complex alleles associated with abacavir hypersensitivity). The current and potential clinical utility of pharmacogenetic testing in HIV management will also be emphasized...
  15. pmc Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
    Annalise M Martin
    Centre for Clinical Immunology and Biomedical Statistics, Murdoch University, Second Floor, North Block, Royal Perth Hospital, Perth 6000, Australia
    Proc Natl Acad Sci U S A 101:4180-5. 2004
    ..These data indicate that the concurrence of HLA-B*5701 and Hsp70-Hom M493T alleles is necessary for the development of abacavir hypersensitivity, which is likely to be mediated by an HLA-B*5701-restricted immune response to abacavir...
  16. ncbi request reprint Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts
    Annalise M Martin
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia
    AIDS 19:97-9. 2005
    ..These data suggest that HLA-DRB1*0101 and the CD4 status may determine susceptibility to nevirapine hypersensitivity, consistent with a CD4 T-cell-dependent immune response to nevirapine-specific antigens...