Phuc V Pham



  1. Truong N, Bui K, Van Pham P. Characterization of Senescence of Human Adipose-Derived Stem Cells After Long-Term Expansion. Adv Exp Med Biol. 2018;: pubmed publisher
    ..In conclusion, hASCs exhibited some particular characteristics of aged stem cells when the number of subculture cells increased. However, up to passage 10, ASCs also retained almost all of the characteristics of MSCs. ..
  2. Phuc P, Ngoc V, Lam D, Tam N, Viet P, Ngoc P. Isolation of three important types of stem cells from the same samples of banked umbilical cord blood. Cell Tissue Bank. 2012;13:341-51 pubmed publisher
  3. Van Pham P, Thi My Nguyen P, Thai Quynh Nguyen A, Minh Pham V, Nguyen Tu Bui A, Thi Tung Dang L, et al. Improved differentiation of umbilical cord blood-derived mesenchymal stem cells into insulin-producing cells by PDX-1 mRNA transfection. Differentiation. 2014;87:200-8 pubmed publisher
    ..These results indicate that PDX-1 mRNA may offer a promising approach to produce safe IPCs for clinical diabetes mellitus treatment. ..
  4. Van Pham P, Phan N. Production of good manufacturing practice-grade human umbilical cord blood-derived mesenchymal stem cells for therapeutic use. Methods Mol Biol. 2015;1283:73-85 pubmed publisher
    ..The obtained UCB-MSCs are free of allogenous or xenogenous proteins. In addition, these MSCs could maintain the MSC phenotype in long-term culture. ..
  5. Pham T, Nguyen T, Van Bui A, Nguyen M, Van Pham P. Fetal heart extract facilitates the differentiation of human umbilical cord blood-derived mesenchymal stem cells into heart muscle precursor cells. Cytotechnology. 2016;68:645-58 pubmed publisher
    ..These properties are similar to properties of heart muscle precursor cells in vivo. These results demonstrated that the fetal HE facilitates the differentiation process of human UCB-MSCs into heart muscle precursor cells. ..
  6. Nhung T, Nam N, Nguyen N, Nghia H, Van Thanh N, Ngoc P, et al. A comparison of the chemical and liver extract-induced hepatic differentiation of adipose derived stem cells. In Vitro Cell Dev Biol Anim. 2015;51:1085-92 pubmed publisher
    ..This study reveals the potential of mesenchymal stem cell differentiation in the liver extract, which supports further preclinical and clinical research on the application of ADSCs in ESLD treatment. ..
  7. Van Pham P, Tran N, Phan N, Vu N, Phan N. Vitamin C stimulates human gingival stem cell proliferation and expression of pluripotent markers. In Vitro Cell Dev Biol Anim. 2016;52:218-27 pubmed publisher
    ..More importantly, GSCs also maintained their stemness with MSC phenotypes and failed to cause tumors in nude athymic mice. Our results show that AA is a suitable factor to stimulate GSC proliferation. ..
  8. Van Pham P, Truong N, Le P, Tran T, Vu N, Bui K, et al. Isolation and proliferation of umbilical cord tissue derived mesenchymal stem cells for clinical applications. Cell Tissue Bank. 2016;17:289-302 pubmed publisher
    ..Replacing FBS with aPRP in the culture medium for UC tissues allowed the successful isolation of UC-MSCs that satisfy the minimum standards for clinical applications. ..
  9. Van Pham P. Clinical trials for stem cell transplantation: when are they needed?. Stem Cell Res Ther. 2016;7:65 pubmed publisher
    ..However, the point at which stem cell clinical trials are essential remains unclear. This commentary discusses when stem cell clinical trials are essential for stem cell transplantation therapies. ..

More Information


  1. Van Pham P, Vu N, Dao T, Le H, Phi L, Phan N. Production of endothelial progenitor cells from skin fibroblasts by direct reprogramming for clinical usages. In Vitro Cell Dev Biol Anim. 2017;53:207-216 pubmed publisher
    ..Although the direct conversion efficacy was low (3.12 ± 0.98%), altogether our study demonstrates that functional EPCs can be produced from fibroblasts and can be used in clinical applications. ..
  2. Dang L, Bui A, Le Thanh Nguyen C, Truong N, Bui A, Kim N, et al. Intravenous Infusion of Human Adipose Tissue-Derived Mesenchymal Stem Cells to Treat Type 1 Diabetic Mellitus in Mice: An Evaluation of Grafted Cell Doses. Adv Exp Med Biol. 2018;: pubmed publisher
    ..106 cells. The histochemical analyses also support these results. Thus, a higher (e.g., 2.106) dose of MSCs may be an effective dose for treatment of type 1 diabetes mellitus. ..
  3. Pham P, Phan N, Nguyen N, Truong N, Duong T, Le D, et al. Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy. J Transl Med. 2011;9:209 pubmed publisher
    ..The results of this study highlight a potential new strategy for breast cancer treatment through the targeting of BCSCs. ..
  4. Van Pham P, Vu N, Nguyen H, Dao T, Le H, Phi L, et al. ETV-2 activated proliferation of endothelial cells and attenuated acute hindlimb ischemia in mice. In Vitro Cell Dev Biol Anim. 2017;53:616-625 pubmed publisher
    ..Our findings demonstrate that ETV2 gene therapy is a potentially effective modality for vascular regeneration. ..
  5. Van Pham P, Vu N, Nguyen H, Huynh O, Truong M. Significant improvement of direct reprogramming efficacy of fibroblasts into progenitor endothelial cells by ETV2 and hypoxia. Stem Cell Res Ther. 2016;7:104 pubmed publisher
    ..These cells also formed capillary-like networks in vitro. Our study demonstrates a new simple method to increase the reprogramming efficacy of human fibroblasts to EPCs using ETV2 and hypoxia. ..
  6. Van Pham P, Vu N, Dao T, Le H, Phi L, Huynh O, et al. Extracellular vesicles of ETV2 transfected fibroblasts stimulate endothelial cells and improve neovascularization in a murine model of hindlimb ischemia. Cytotechnology. 2017;69:801-814 pubmed publisher
    ..Our results suggest that EVs derived from ETV2-transfected fibroblasts can be promising non-cellular products for the regeneration of blood vessels. ..