1. Ganguly D, Cai C, Sims M, Yang C, Thomas M, Cheng J, et al. APELA Expression in Glioma, and Its Association with Patient Survival and Tumor Grade. Pharmaceuticals (Basel). 2019;12: pubmed publisher
    ..Consequently, APELA may play an important role in glioblastoma tumorigenesis and may be a future therapeutic target. ..
  2. Zhao X, Zou Y, Gu Q, Zhao G, GRAY H, Pfeffer L, et al. Lentiviral Vector Mediated Claudin1 Silencing Inhibits Epithelial to Mesenchymal Transition in Breast Cancer Cells. Viruses. 2015;7:2965-79 pubmed publisher
    ..Our data demonstrated that lentiviral vector mediated CLDN1 RNA interference has great potential in breast cancer gene therapy by inhibiting EMT and controlling tumor cell growth. ..
  3. Wu Z, Pfeffer L. MicroRNA regulation of F-box proteins and its role in cancer. Semin Cancer Biol. 2016;36:80-7 pubmed publisher
    ..The area of miRNAs and the F-box proteins that they regulate in cancer is an emerging field and will inform new strategies in cancer treatment. ..
  4. Banerjee S, Wang J, Pfeffer S, Ma D, Pfeffer L, Patil S, et al. Design, Synthesis and Biological Evaluation of Novel 5H-Chromenopyridines as Potential Anti-Cancer Agents. Molecules. 2015;20:17152-65 pubmed publisher
    ..The moderate cytotoxic activity of 5H-thiochromenopyridines shows the promise of developing chromenopyridines as potential anticancer agents. ..
  5. Yang C, Li K, Pfeffer S, Pfeffer L. The Type I IFN-Induced miRNA, miR-21. Pharmaceuticals (Basel). 2015;8:836-47 pubmed publisher
  6. Krutilina R, Sun W, Sethuraman A, Brown M, Seagroves T, Pfeffer L, et al. MicroRNA-18a inhibits hypoxia-inducible factor 1? activity and lung metastasis in basal breast cancers. Breast Cancer Res. 2014;16:R78 pubmed publisher
    ..The results of this study reveal a novel role for miR-18a in targeting HIF1A and repressing metastasis of basal-like breast tumors. ..
  7. Pfeffer S, Grossmann K, Cassidy P, Yang C, Fan M, Kopelovich L, et al. Detection of Exosomal miRNAs in the Plasma of Melanoma Patients. J Clin Med. 2015;4:2012-27 pubmed publisher
  8. Yang C, Pfeffer S, Sims M, Yue J, Wang Y, Linga V, et al. The oncogenic microRNA-21 inhibits the tumor suppressive activity of FBXO11 to promote tumorigenesis. J Biol Chem. 2015;290:6037-46 pubmed publisher
    ..Our results identify FBXO11 as a novel miR-21 target gene, and demonstrate that the oncogenic miRNA miR-21 decreases the expression of FBXO11, which normally acts as a tumor suppressor, and thereby promotes tumorigenesis. ..
  9. Wang R, Davidoff A, Pfeffer L. Bortezomib sensitizes human glioblastoma cells to induction of apoptosis by type I interferons through NOXA expression and Mcl-1 cleavage. Biochem Biophys Res Commun. 2016;478:128-134 pubmed publisher
    ..Our findings may provide an important rationale for combining type I interferons with bortezomib for glioblastoma therapy. ..

More Information


  1. Pfeffer S, Fan M, Du Z, Yang C, Pfeffer L. Unphosphorylated STAT3 regulates the antiproliferative, antiviral, and gene-inducing actions of type I interferons. Biochem Biophys Res Commun. 2017;490:739-745 pubmed publisher
    ..These results suggest that unphosphorylated STAT3 plays an important role in the IFN response pathway. ..
  2. Du Z, Cai C, Sims M, Boop F, Davidoff A, Pfeffer L. The effects of type I interferon on glioblastoma cancer stem cells. Biochem Biophys Res Commun. 2017;491:343-348 pubmed publisher
    ..In addition, we show that IFN induces transient STAT3 activation in GSCs, while induction of astrocytic differentiation in GSCs results in sustained STAT3 activation. ..