Oliver Pfaar

Summary

Publications

  1. doi Allergen-specific immunotherapy: which outcome measures are useful in monitoring clinical trials?
    O Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, 65183 Wiesbaden, Germany
    Immunol Allergy Clin North Am 31:289-309, x. 2011
  2. doi Accelerated up-dosing of subcutaneous immunotherapy with a registered allergoid grass pollen preparation
    Oliver Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Dusseldorf, Germany
    Int Arch Allergy Immunol 160:420-4. 2013
  3. doi Adjuvants for immunotherapy
    Oliver Pfaar
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Curr Opin Allergy Clin Immunol 12:648-57. 2012
  4. doi Immunologic effect and tolerability of intra-seasonal subcutaneous immunotherapy with an 8-day up-dosing schedule to 10,000 standardized quality-units: a double-blind, randomized, placebo-controlled trial
    Oliver Pfaar
    Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Wiesbaden, Germany
    Clin Ther 34:2072-81. 2012
  5. ncbi Cyclamen europaeum nasal spray, a novel phytotherapeutic product for the management of acute rhinosinusitis: a randomized double-blind, placebo-controlled trial
    O Pfaar
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Rhinology 50:37-44. 2012
  6. doi A randomized placebo-controlled trial of rush preseasonal depigmented polymerized grass pollen immunotherapy
    O Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Allergy 67:272-9. 2012
  7. doi Immunotherapy with depigmented-polymerized mixed tree pollen extract: a clinical trial and responder analysis
    O Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Allergy 65:1614-21. 2010
  8. doi Cluster protocols in SCIT: enough evidence for practical use?
    Oliver Pfaar
    Centre for Rhinology and Allergology Wiesbaden of the Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 65183 Wiesbaden, Germany
    Curr Opin Allergy Clin Immunol 10:188-93. 2010
  9. doi Sublingual allergen-specific immunotherapy adjuvanted with monophosphoryl lipid A: a phase I/IIa study
    Oliver Pfaar
    Department of Otorhinolaryngology, University Hospital Mannheim, Center for Rhinology and Allergology, Wiesbaden, Germany
    Int Arch Allergy Immunol 154:336-44. 2011
  10. doi Safety of a depigmented, polymerized vaccine for the treatment of allergic rhinoconjunctivitis and allergic asthma
    Oliver Pfaar
    Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, Wiesbaden, Germany
    Am J Rhinol Allergy 24:220-5. 2010

Detail Information

Publications16

  1. doi Allergen-specific immunotherapy: which outcome measures are useful in monitoring clinical trials?
    O Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, 65183 Wiesbaden, Germany
    Immunol Allergy Clin North Am 31:289-309, x. 2011
    ..This article reviews different methods assessing the clinical outcome of trials on both subcutaneous and sublingual immunotherapy, and highlights potential advantages and drawbacks of each method...
  2. doi Accelerated up-dosing of subcutaneous immunotherapy with a registered allergoid grass pollen preparation
    Oliver Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Dusseldorf, Germany
    Int Arch Allergy Immunol 160:420-4. 2013
    ..In addition, for patients with multiple pollen allergies, patients coming near the beginning of pollen season, and patients who wish to up-dose faster, an accelerated induction regimen would be helpful...
  3. doi Adjuvants for immunotherapy
    Oliver Pfaar
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Curr Opin Allergy Clin Immunol 12:648-57. 2012
    ..This article gives an overview about the current state of preclinical and clinical studies using different kinds of adjuvants and their effect on allergen-specific immunotherapy (SIT)...
  4. doi Immunologic effect and tolerability of intra-seasonal subcutaneous immunotherapy with an 8-day up-dosing schedule to 10,000 standardized quality-units: a double-blind, randomized, placebo-controlled trial
    Oliver Pfaar
    Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Wiesbaden, Germany
    Clin Ther 34:2072-81. 2012
    ..However, because subjects often present to physicians with allergy symptoms during the pollen season, "within-season" initiation of specific immunotherapy is of special interest...
  5. ncbi Cyclamen europaeum nasal spray, a novel phytotherapeutic product for the management of acute rhinosinusitis: a randomized double-blind, placebo-controlled trial
    O Pfaar
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Rhinology 50:37-44. 2012
    ..To evaluate the efficacy and safety of a phytotherapeutic nasal spray containing Cyclamen europaeum (CE) in the treatment of acute rhinosinusitis (ARS)...
  6. doi A randomized placebo-controlled trial of rush preseasonal depigmented polymerized grass pollen immunotherapy
    O Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Allergy 67:272-9. 2012
    ..We examined a depigmented polymerized grass pollen extract for immunogenicity and for clinical efficacy in a rush preseasonal regimen...
  7. doi Immunotherapy with depigmented-polymerized mixed tree pollen extract: a clinical trial and responder analysis
    O Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Allergy 65:1614-21. 2010
    ..Our objective was to examine efficacy and safety of a depigmented-polymerized mixed tree pollen extract...
  8. doi Cluster protocols in SCIT: enough evidence for practical use?
    Oliver Pfaar
    Centre for Rhinology and Allergology Wiesbaden of the Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 65183 Wiesbaden, Germany
    Curr Opin Allergy Clin Immunol 10:188-93. 2010
    ..The review provides a comprehensive evaluation of Cluster schedules in subcutaneous-specific immunotherapy (SCIT) in terms of the safety profile and onset of clinical and immunological effects...
  9. doi Sublingual allergen-specific immunotherapy adjuvanted with monophosphoryl lipid A: a phase I/IIa study
    Oliver Pfaar
    Department of Otorhinolaryngology, University Hospital Mannheim, Center for Rhinology and Allergology, Wiesbaden, Germany
    Int Arch Allergy Immunol 154:336-44. 2011
    ..This is the first reported study of adjuvanted SLIT...
  10. doi Safety of a depigmented, polymerized vaccine for the treatment of allergic rhinoconjunctivitis and allergic asthma
    Oliver Pfaar
    Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, Wiesbaden, Germany
    Am J Rhinol Allergy 24:220-5. 2010
    ..Clinical efficacy of specific immunotherapy (SIT) with depigmented, polymerized allergen extracts is well documented in placebo-controlled trials, and safety data are encouraging although further data are required...
  11. ncbi Efficacy and safety of specific immunotherapy with a high-dose sublingual grass pollen preparation: a double-blind, placebo-controlled trial
    Oliver Pfaar
    Rhinology and Allergology Center, Wiesbaden, Germany
    Ann Allergy Asthma Immunol 100:256-63. 2008
    ..Sublingual immunotherapy (SLIT) is increasingly being used for the treatment of allergic rhinitis, but there are conflicting study results demonstrating clinically relevant efficacy...
  12. doi Safety aspects of Cluster immunotherapy with semi-depot allergen extracts in seasonal allergic rhinoconjunctivitis
    Oliver Pfaar
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    Eur Arch Otorhinolaryngol 267:245-50. 2010
    ..With respect to safety aspects, this accelerated dosage schedule could turn into an interesting alternative for dosage increase during subcutaneous immunotherapy (SCIT)...
  13. doi Clinical outcome measures of specific immunotherapy
    Oliver Pfaar
    Center for Rhinology and Allergology, Wiesbaden, Germany
    Curr Opin Allergy Clin Immunol 9:208-13. 2009
    ..In particular, it focuses on primary and secondary outcome measurements and reviews the advantages and disadvantages of each method...
  14. ncbi Aspirin desensitization in aspirin intolerance: update on current standards and recent improvements
    Oliver Pfaar
    Center for Allergy and Rhinology, Wiesbaden, Germany
    Curr Opin Allergy Clin Immunol 6:161-6. 2006
    ..In particular, it focuses on current standards and recent improvements in aspirin desensitization. Recent publications on various desensitization protocols and routes of administration are discussed...
  15. doi Pathophysiology of itching and sneezing in allergic rhinitis
    Oliver Pfaar
    Center for Allergy and Rhinology, Wiesbaden, Germany
    Swiss Med Wkly 139:35-40. 2009
    ..Further, the role of neuropeptides and neurotrophins with regard to neuronal and immune cell activation which might play a key role in the future treatment of allergic rhinitis are discussed...
  16. doi A comparison of immunotherapy delivery methods for allergen immunotherapy
    Ludger Klimek
    Allergy Center, An den Quellen 10, D 65183 Wiesbaden, Germany
    Expert Rev Clin Immunol 9:465-75. 2013
    ..Conclusion: SIT is accepted to be the only causative treatment option for allergies. New application routes and new immune-modifying agents will allow for different delivery methods in the future...