Accelerated up-dosing of subcutaneous immunotherapy with a registered allergoid grass pollen preparationOliver Pfaar
Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Dusseldorf, Germany
Int Arch Allergy Immunol 160:420-4. 2013
..In addition, for patients with multiple pollen allergies, patients coming near the beginning of pollen season, and patients who wish to up-dose faster, an accelerated induction regimen would be helpful...
- Adjuvants for immunotherapy
Oliver Pfaar
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
Curr Opin Allergy Clin Immunol 12:648-57. 2012
..This article gives an overview about the current state of preclinical and clinical studies using different kinds of adjuvants and their effect on allergen-specific immunotherapy (SIT)...
- Immunologic effect and tolerability of intra-seasonal subcutaneous immunotherapy with an 8-day up-dosing schedule to 10,000 standardized quality-units: a double-blind, randomized, placebo-controlled trial
Oliver Pfaar
Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Wiesbaden, Germany
Clin Ther 34:2072-81. 2012
..However, because subjects often present to physicians with allergy symptoms during the pollen season, "within-season" initiation of specific immunotherapy is of special interest...
- Cyclamen europaeum nasal spray, a novel phytotherapeutic product for the management of acute rhinosinusitis: a randomized double-blind, placebo-controlled trial
O Pfaar
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
Rhinology 50:37-44. 2012
..To evaluate the efficacy and safety of a phytotherapeutic nasal spray containing Cyclamen europaeum (CE) in the treatment of acute rhinosinusitis (ARS)...
- A randomized placebo-controlled trial of rush preseasonal depigmented polymerized grass pollen immunotherapy
O Pfaar
Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
Allergy 67:272-9. 2012
..We examined a depigmented polymerized grass pollen extract for immunogenicity and for clinical efficacy in a rush preseasonal regimen...
- Allergen-specific immunotherapy: which outcome measures are useful in monitoring clinical trials?
O Pfaar
Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, 65183 Wiesbaden, Germany
Immunol Allergy Clin North Am 31:289-309, x. 2011
..This article reviews different methods assessing the clinical outcome of trials on both subcutaneous and sublingual immunotherapy, and highlights potential advantages and drawbacks of each method...
- Immunotherapy with depigmented-polymerized mixed tree pollen extract: a clinical trial and responder analysis
O Pfaar
Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
Allergy 65:1614-21. 2010
..Our objective was to examine efficacy and safety of a depigmented-polymerized mixed tree pollen extract...
- Cluster protocols in SCIT: enough evidence for practical use?
Oliver Pfaar
Centre for Rhinology and Allergology Wiesbaden of the Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 65183 Wiesbaden, Germany
Curr Opin Allergy Clin Immunol 10:188-93. 2010
..The review provides a comprehensive evaluation of Cluster schedules in subcutaneous-specific immunotherapy (SCIT) in terms of the safety profile and onset of clinical and immunological effects...
- Sublingual allergen-specific immunotherapy adjuvanted with monophosphoryl lipid A: a phase I/IIa study
Oliver Pfaar
Department of Otorhinolaryngology, University Hospital Mannheim, Center for Rhinology and Allergology, Wiesbaden, Germany
Int Arch Allergy Immunol 154:336-44. 2011
..This is the first reported study of adjuvanted SLIT...
- Safety of a depigmented, polymerized vaccine for the treatment of allergic rhinoconjunctivitis and allergic asthma
Oliver Pfaar
Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, Wiesbaden, Germany
Am J Rhinol Allergy 24:220-5. 2010
..Clinical efficacy of specific immunotherapy (SIT) with depigmented, polymerized allergen extracts is well documented in placebo-controlled trials, and safety data are encouraging although further data are required...
Efficacy and safety of specific immunotherapy with a high-dose sublingual grass pollen preparation: a double-blind, placebo-controlled trialOliver Pfaar
Rhinology and Allergology Center, Wiesbaden, Germany
Ann Allergy Asthma Immunol 100:256-63. 2008
..Sublingual immunotherapy (SLIT) is increasingly being used for the treatment of allergic rhinitis, but there are conflicting study results demonstrating clinically relevant efficacy...
- Safety aspects of Cluster immunotherapy with semi-depot allergen extracts in seasonal allergic rhinoconjunctivitis
Oliver Pfaar
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
Eur Arch Otorhinolaryngol 267:245-50. 2010
..With respect to safety aspects, this accelerated dosage schedule could turn into an interesting alternative for dosage increase during subcutaneous immunotherapy (SCIT)...
- Clinical outcome measures of specific immunotherapy
Oliver Pfaar
Center for Rhinology and Allergology, Wiesbaden, Germany
Curr Opin Allergy Clin Immunol 9:208-13. 2009
..In particular, it focuses on primary and secondary outcome measurements and reviews the advantages and disadvantages of each method...
- Pathophysiology of itching and sneezing in allergic rhinitis
Oliver Pfaar
Center for Allergy and Rhinology, Wiesbaden, Germany
Swiss Med Wkly 139:35-40. 2009
..Further, the role of neuropeptides and neurotrophins with regard to neuronal and immune cell activation which might play a key role in the future treatment of allergic rhinitis are discussed...
- A comparison of immunotherapy delivery methods for allergen immunotherapy
Ludger Klimek
Allergy Center, An den Quellen 10, D 65183 Wiesbaden, Germany
Expert Rev Clin Immunol 9:465-75. 2013
..Conclusion: SIT is accepted to be the only causative treatment option for allergies. New application routes and new immune-modifying agents will allow for different delivery methods in the future...
- Aspirin desensitization in aspirin intolerance: update on current standards and recent improvements
Oliver Pfaar
Center for Allergy and Rhinology, Wiesbaden, Germany
Curr Opin Allergy Clin Immunol 6:161-6. 2006
..In particular, it focuses on current standards and recent improvements in aspirin desensitization. Recent publications on various desensitization protocols and routes of administration are discussed...
